Patents Assigned to DSM
  • Patent number: 12203075
    Abstract: The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: January 21, 2025
    Assignee: DSM IP Assets B.V.
    Inventors: Kirk E. Apt, Leslie Richter, David Simpson, Ross Zirkle
  • Publication number: 20250019743
    Abstract: The invention relates to a method for producing linear DNA molecules with at least two or more repeating units of a target DNA sequence for use as DNA substrate in single-molecule assays, wherein a target DNA is subjected to a ligation reaction and the ligation reaction is stopped when the reaction reaches the end of the linear phase to block circularization of the DNA molecules. Compositions comprising such linear DNA molecules and use of such compositions in single-molecule assays are also provided.
    Type: Application
    Filed: November 21, 2022
    Publication date: January 16, 2025
    Applicant: LUMICKS DSM HOLDING B.V.
    Inventor: Marco SIMONETTA
  • Patent number: 12193456
    Abstract: The present invention relates to a method of reducing methane emissions in ruminants, said method encompassing treating pre-/young ruminants with 3-nitrooxypropanol.
    Type: Grant
    Filed: April 14, 2020
    Date of Patent: January 14, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Stephane Duval, Maik Kindermann, Sarah Jade Meale, Diego Pablo Morgavi
  • Patent number: 12195769
    Abstract: The present invention relates to a variant polypeptide having a lipase activity, wherein the polypeptide may be a polypeptide that has an amino acid sequence which has at least 70% identity to a mature amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 6, wherein the polypeptide comprises an amino acid substitution at position 295 and at least one further amino acid substitution at position 113, 121, 179 and/or 284, wherein the positions are defined with reference to SEQ ID NO: 1 or SEQ ID NO: 6. The invention further relates to a process for preparing a dough wherein a polypeptide as disclosed herein is used and baked product prepared from the dough.
    Type: Grant
    Filed: June 18, 2019
    Date of Patent: January 14, 2025
    Assignee: DSM IP ASSETS B.V.
    Inventors: Joke Anneleen Putseys, Neil Carr, René Marcel De Jong, Aloysius Wilhelmus Rudolphus Hubertus Teunissen
  • Publication number: 20250011841
    Abstract: A method of detecting a biomolecular process is provided. The method comprises: providing a DNA strand (11) comprising one or more luminophores (3) attached to the strand (11) at one or more predetermined positions along the strand; attaching handles (7A, 7B) to the DNA strand; and trapping and/or manipulating the strand (11) by manipulating the handles (7A, 7B) in a trapping setup. The method also comprises determining a position of at least one of the one or more luminophores (3) with respect to at least part of the trapping setup and determining on the basis of the one or more luminophores (3) one or more of: a focus position of at least part of an optical detector and/or an illumination system; a focus position of at least part of an optical manipulator; a position of at least part of the strand (11); a position of a portion of the strand (11) relative to one or more other portions of the strand (11); a reaction or binding position on the strand (11) of a reagent interacting with the strand (11).
    Type: Application
    Filed: November 15, 2022
    Publication date: January 9, 2025
    Applicant: LUMICKS DSM HOLDING B.V.
    Inventors: Marco SIMONETTA, Rosalie Paula Catharina DRIESSEN
  • Patent number: 12188056
    Abstract: The present disclosure relates to the production of sialylated Human Milk Oligosaccharides (HMOs), in particular to the biosynthetic production of 3?-sialyllactose (3?SL), and to genetically engineered cells and methods suitable for said production.
    Type: Grant
    Filed: March 1, 2023
    Date of Patent: January 7, 2025
    Assignee: DSM IP Assets B.V.
    Inventor: Manos Papadakis
  • Publication number: 20250007205
    Abstract: A waterproof seal for electrical assemblies wherein at least two pins extend through the electrical conductor such that the at least two pins extending from a distal end of the electrical conductor and are adapted to interact with openings on a connecter that is detachably connectable with the distal end of the electrical connector, and the at least two pins extend from a proximal end of the electrical connector such that the at least two pins extending from the proximal end are adapted to be interact with openings in a socket formed in the surface of housing where the electrical connector forms a water tight barrier preventing water from entering the housing through the electrical connector or around the electrical connector.
    Type: Application
    Filed: September 16, 2024
    Publication date: January 2, 2025
    Applicant: DSM&T COMPANY INC.
    Inventor: Sergio CORONA
  • Patent number: 12171906
    Abstract: Disclosed herein is a method of making a composite fabric for use in or as a medical implant component, the method comprising steps of providing a textile comprising at least one strand having titer of 2-250 dtex and comprising fibers made from a biocompatible and biostable synthetic polymer; determining locations on the textile where a cut is to be made for an intended use of the textile; optionally pretreating the textile at least at the determined locations on at least one side of the textile with a high-energy source to activate the surface; solution coating the textile at least at a determined location with a coating composition comprising a biocompatible and biostable polyurethane elastomer and a solvent for the polyurethane; removing the solvent from the coated textile; and laser cutting the coated textile as obtained at least a one coated location with an ultra-short pulse laser; to result in a composite biotextile wherein polyurethane is present in an amount of 2.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: December 24, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Nicolaes Hubertus Maria De Bont, Noel L. Davison, Mandy Maria Jozefina Wiermans
  • Patent number: 12171905
    Abstract: Disclosed herein is a medical implant component comprising a composite biotextile, which biotextile comprises i) a polyolefin fibrous construct comprising at least one strand with titer of 2-250 dtex, tensile strength of at least 10 cN/dtex and comprising high molar mass polyolefin fibers and ii) a coating comprising a biocompatible and biostable polyurethane elastomer comprising a polysiloxane segment and/or having one or more hydrophobic endgroups, wherein the polyurethane coating is present on at least part of the surface of the biotextile and in an amount of 2.5-90 mass % based on composite biotextile. Such composite biotextile, like a partly coated woven fabric, shows an advantageous combination of good biocompatibility, especially hemocompatibility, high strength and pliability, and laser cuttability; allowing to make pieces of fabric having well-defined regular edges that have high suture retention strength. The invention also provides a method of making said composite biotextile.
    Type: Grant
    Filed: March 2, 2020
    Date of Patent: December 24, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Nicolaes Hubertus Maria De Bont, Noel L. Davison, Mandy Maria Jozefina Wiermans
  • Publication number: 20240409841
    Abstract: Disclosed herein are processes for obtaining a microbial oil comprising one or more polyunsaturated fatty acids (PUFAs) from one or more microbial cells by lysing the cells to form a lysed cell composition, treating the lysed cell composition to form an oil-containing emulsion and then recovering the oil from the oil-containing emulsion. Further disclosed herein is microbial oil comprising one or more PUFAs that is recovered from microbial cells by at least one process described herein.
    Type: Application
    Filed: August 20, 2024
    Publication date: December 12, 2024
    Applicant: DSM IP Assets B.V.
    Inventors: Neil Francis LEININGER, Ginger Marie SHANK, Xiao Daniel DONG, Joseph William PFEIFER, III, Vidya PAI
  • Patent number: 12152223
    Abstract: The present invention relates to a process for reducing haze in a beverage comprising adding a protein arginine deiminase and a proline-specific endoprotease during preparation of the beverage. The invention further relates to a wort or beer comprising a protein arginine deiminase and a proline-specific endoprotease.
    Type: Grant
    Filed: January 11, 2023
    Date of Patent: November 26, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Loes Elizabeth Bevers, Johanna Henrica Gerdina Maria Mutsaers
  • Patent number: 12152261
    Abstract: The present invention relates to a method for reducing fructan in a fructan-containing food product, including adding an invertase belonging to enzyme classification EC 3.2.1.26 to the food product, and incubating the food product with the invertase, wherein fructan in the fructan-containing food product is hydrolysed. The invention further relates to the use of an invertase belonging to enzyme classification EC. 3.2.1.26 for the preparation of a medicament or a dietary supplement for the treatment of a person suffering from irritable bowel syndrome. Invertase (EC 3.2.1.26) may optionally by further combined with inulinase (EC3.2.1.7) and/or beta-fructosidase (EC 3.2.1.80).
    Type: Grant
    Filed: February 18, 2020
    Date of Patent: November 26, 2024
    Assignee: DSM IP Assets B.V.
    Inventor: Petrus Jacobus Theodorus Dekker
  • Patent number: 12139456
    Abstract: The present invention relates to a new process of production of menaquinone 4, which is also known as vitamin K2.
    Type: Grant
    Filed: February 16, 2021
    Date of Patent: November 12, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Rolf Kuenzi
  • Patent number: 12139452
    Abstract: The present invention relates to a new process for the production of retinal or hydrogenated form of retinal.
    Type: Grant
    Filed: April 3, 2020
    Date of Patent: November 12, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Marc-André Mueller, Bettina Wuestenberg, Viktor Zimmermann
  • Publication number: 20240365838
    Abstract: The invention relates to an extrusion apparatus for the continuous production of solid food supplements, feed additives or pharmaceutical preparations, which comprise nutritional or pharmaceutical actives homogeneously dispersed in a carrier material matrix. The invention also relates to a method for the production of such preparations by extrusion.
    Type: Application
    Filed: October 7, 2022
    Publication date: November 7, 2024
    Applicant: DSM IP ASSETS B.V.
    Inventors: Patricia DRYJA, Kai URBAN, Tony STEINEBRUNNER, Christian SCHAEFER, Rudolf HOLER
  • Patent number: 12136504
    Abstract: A waterproof seal for electrical assemblies wherein an outer sheath of an electrical cable is removed to expose the wires and the insulation is removed from the wires to form a window of exposed electrical conductor, the electrical conductors being maintain apart from each other and contained in a cover that may comprise a connector, an epoxy applied to the electrical conductors to fill in all the space in and around the electrical conductors and the cover to form a waterproof seal that prevents water from wicking past the waterproof seal via an interior of the electrical cable.
    Type: Grant
    Filed: August 8, 2023
    Date of Patent: November 5, 2024
    Assignee: DSM&T Company Inc.
    Inventor: Sergio Corona
  • Patent number: 12133542
    Abstract: The present invention relates to animal feed compositions comprising at least one probiotic and polypeptides having muramidase activity.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: November 5, 2024
    Assignees: Novozymes A/S, DSM IP Assets B.V.
    Inventors: Rual Lopez-Ulibarri, Estefania Perez Calvo, Wolfgang Schliffka
  • Patent number: 12128158
    Abstract: The disclosure relates to a method of making a bioceramic coating on a fibrous article for use in a medical implant, comprising steps of providing an article comprising fibers made from a biocompatible, non-biodegradable polymer; coating at least the fibers that will be in contact with bone upon use as an implant with a solution of a coating polymer to result in coated fibers having a coating polymer layer; treating the coated fibers with a dispersion of bioactive ceramic particles 0.01-10 ?m in a treating solvent comprising a solvent for the coating polymer in at least one step; and substantially removing the treating solvent; to result in the particles being partly embedded in the coating polymer layer of the coated fibers.
    Type: Grant
    Filed: February 10, 2023
    Date of Patent: October 29, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Noel L. Davison, Henricus Johannes Arts, Aylvin Jorge Angelo Athanasius Dias, Anne Marie Persson, Ruud Jozef Regina Wilhelmus Peters
  • Patent number: D1047912
    Type: Grant
    Filed: August 5, 2021
    Date of Patent: October 22, 2024
    Assignee: DSM&T COMPANY INC.
    Inventor: Sergio Corona
  • Patent number: D1047913
    Type: Grant
    Filed: November 17, 2021
    Date of Patent: October 22, 2024
    Assignee: DSM&T COMPANY INC.
    Inventor: Sergio Corona