Abstract: A method of excitation microscopy, in particular STimulated Emission Depletion (STED) microscopy, ins provided which comprises: providing a sample; trapping an object in the sample at a trapping position, in particular by applying a position dependent trapping force to the object; positioning, in particular focusing, a depletion beam at an interaction position in the sample for illumination of a portion of the sample associated with the trapped object.
Abstract: A waterproof seal for electrical assemblies wherein at least two pins extend through the electrical conductor such that the at least two pins extending from a distal end of the electrical conductor and are adapted to interact with openings on a connecter that is detachably connectable with the distal end of the electrical connector, and the at least two pins extend from a proximal end of the electrical connector such that the at least two pins extending from the proximal end are adapted to be interact with openings in a socket formed in the surface of housing where the electrical connector forms a water tight barrier preventing water from entering the housing through the electrical connector or around the electrical connector.
Abstract: An animal feed comprising an animal feed additive, said additive comprising co-granules, each co-granule comprising at least two classes of enzymes, said co-granules comprising a core unit and a protective coating such that the dose of each of the enzymes in the feed is set in each granule rather than by the level of homogeneity of single-enzyme granules or by the efficiency of the mixing.
Type:
Application
Filed:
December 8, 2022
Publication date:
June 13, 2024
Applicants:
Novozymes A/S, DSM IP Assets B.V.
Inventors:
Flemming Borup, Ivan De Jesus Gaytan Perez
Abstract: The invention relates to an apparatus for the continuous production of a particulate adsorption product, the apparatus comprising: a mixing drum having an elongated cavity for receiving a particulate adsorbent material, an adsorbent inlet and a product outlet, wherein the mixing drum is arranged such that the cavity is inclined in flow direction of the particulate material, and wherein the cavity comprises an initial transport zone adjacent to the inlet and a mixing zone following the initial transport zone; a rotating member extending through the cavity in a longitudinal direction, wherein the rotating member comprises a helical conveying blade at longitudinal positions corresponding to the initial transport zone and mixing instruments at longitudinal positions corresponding to the mixing zone; and one or more injection nozzles for injecting a liquid adsorbate to the mixing zone. The invention further relates to a process for the continuous production of a particulate adsorption product using such apparatus.
Abstract: The invention provides recombinant host organisms (e.g., plants) genetically modified with a polyunsaturated fatty acid (PUFA) synthase system and one or more accessory proteins (e.g., PPTase and/or ACoAS) that allow for and/or improve the production of PUFAs in the host organism. The present invention also relates to methods of making and using such organisms (e.g., to obtain PUFAs) as well as products obtained from such organisms (e.g., oil and/or seed).
Type:
Grant
Filed:
February 11, 2022
Date of Patent:
June 11, 2024
Assignees:
DSM IP Assets B.V., DOW AgroSciences LLC
Inventors:
Terence A. Walsh, Daniel Gachotte, Ann Owens Merlo, Paul G. Roessler, James George Metz, Scott Bevan, Jerry M. Kuner
Abstract: Disclosed herein is a porous hybrid elastomer/polyolefin film, which is a porous polyolefin film wherein at one or more isolated areas of the film pores are at least partly filled with an elastomer. This hybrid film shows improved resistance to tearing, whereas other properties like porosity, polarity, thickness, flexibility, and non-stickiness of the film are substantially retained. Other advantages include improved suture retention. The invention also provides a method to increase tear resistance of a porous polyolefin film comprising steps of providing a porous polyolefin film; identifying one or more locations on the film, at which locations tearing is likely to occur during intended use of the film; applying at the identified locations of the film an amount of a solution of an elastomer in solvent; and substantially removing the solvent; to result in a hybrid elastomer/polyolefin film having one or more isolated areas where pores in the film are at least partly filled with the elastomer.
Type:
Grant
Filed:
April 8, 2019
Date of Patent:
June 4, 2024
Assignee:
DSM IP ASSETS B.V.
Inventors:
Nicolaes Hubertus Maria De Bont, Mandy Maria Jozefina Wiermans, Marc Linssen
Abstract: The present invention relates to a process for reducing an amount of intact phospholipids in a triacylglyceride oil comprising incubating the oil with a polypeptide having phospholipase A1 activity, wherein the polypeptide comprises a polypeptide having at least 80% identity to the mature amino acid sequence of SEQ ID NO: 1.
Abstract: The present invention relates to topical compositions comprising at least one liquid UV-filter and a nano-sized 1,4-di(benzoxazol-2?-yl)benzene.
Type:
Grant
Filed:
March 19, 2019
Date of Patent:
May 28, 2024
Assignee:
DSM IP ASSETS B.V.
Inventors:
Christine Mendrok-Edinger, Alexander Schlifke-Poschalko
Abstract: The present invention relates to novel dicarboxylic diesters as well as the use thereof as for inhibiting the methane production in ruminants.
Type:
Grant
Filed:
April 23, 2019
Date of Patent:
May 21, 2024
Assignee:
DSM IP ASSETS B.V.
Inventors:
Stefan Karl Laeuger, Ulla Letinois, Peter Riebel
Abstract: The subject disclosure features, in one aspect, a method for producing lipids enriched for EPA, comprising modifying a microalga to increase expression of PFA1, and/or PFA3, and culturing the modified microalga under conditions which allow the expression of PFA1, and/or PFA3, wherein lipids enriched for EPA are produced. Also featured is a recombinant microalga in which PFA1, and/or PFA3, is overexpressed. Such recombinant microalgae have been demonstrated herein to produce very favorable fatty acid lipid profiles (e.g., increased levels of EPA, increased ratio of EPA:DHA, decreased levels of DPA n-6, etc.).
Abstract: The current invention relates to a method of separating lipids from a lipids containing biomass by demulsification under mild conditions, to an oil and to a delipidated biomass as obtained by such a method.
Type:
Grant
Filed:
May 2, 2019
Date of Patent:
May 7, 2024
Assignees:
Evonik Operations GmbH, DSM IP Assets B.V.
Abstract: Antihypertensive agents which are crystalline having a general plate shape may be difficult to formulate as they often do not exhibit good flowability properties. Addition of spray-dried riboflavin surprisingly improves flowability of these agents.
Abstract: The application relates to a process for the preparation of a compound of formula (II) by cyclisation of a polyene of formula (I), and to an intermediate of formula (III). The obtained compounds are useful intermediates in the preparation of specific isoprenoids, preferably in the production of vitamin A and derivatives of vitamin A.
Type:
Grant
Filed:
April 3, 2020
Date of Patent:
April 16, 2024
Assignee:
DSM IP ASSETS B.V.
Inventors:
Fabrice Aquino, Werner Bonrath, Marc-André Mueller, Bettina Wuestenberg
Abstract: The current invention relates to a method of separating polyunsaturated fatty acids containing lipids from a lipids containing biomass.
Type:
Grant
Filed:
July 12, 2017
Date of Patent:
April 2, 2024
Assignees:
Evonik Operations GmbH, DSM IP Assets B.V.
Inventors:
Manfred Bärz, Marc Beiser, Georg Borchers, Stephen Robert Cherinko, Mathias Dernedde, Michael Diehl, Xiao Daniel Dong, Jürgen Haberland, Michael Benjamin Johnson, Robert Cody Kertis, Jochen Lebert, Neil Francis Leininger, Kirt Lyvell Matthews, Sr., Holger Pfeifer, Christian Rabe, Shannon Elizabeth Ethier Resop, Ginger Marie Shank, Vinod Tarwade, David Allen Tinsley, Daniel Verkoeijen
Abstract: The present invention relates to a variant polypeptide having maltogenic alpha-amylase activity wherein the polypeptide comprises an amino acid sequence, which, when aligned with an amino acid sequence of SEQ ID NO: 1, comprises an amino acid substitution F188L/I, S200N, and D261G, and optionally a further amino acid substitution T288P, wherein the amino acid substitutions are determined with reference to SEQ ID NO: 1, and wherein the polypeptide has an amino acid sequence which has at least 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, or at least 99% identity to the amino acid sequence of SEQ ID NO: 1. The invention also relates to a process for the preparation of a dough or a baked product wherein the variant polypeptide is used.
Type:
Grant
Filed:
April 4, 2019
Date of Patent:
April 2, 2024
Assignee:
DSM IP ASSETS B.V.
Inventors:
Joke Anneleen Putseys, Aloysius Wilhelmus Rudolphus Hubertus Teunissen, René Marcel De Jong, Jeroen Godefrooij, Helma Arina Stolze-Lagerweij
Abstract: The present invention relates to topical compositions comprising at least one polar oil and a micronized 1,4-di(benzoxazol-2?-yl)benzene having a mean particle size of at most 300 nm as well as to the use of such a micronized 1,4-di(benzoxazol-2?-yl)benzene to reduce the transfer of such oils to surfaces.
Type:
Grant
Filed:
March 19, 2019
Date of Patent:
March 19, 2024
Assignee:
DSM IP ASSETS B.V.
Inventors:
Christine Mendrok-Edinger, Alexander Schlifke-Poschalko
Abstract: The invention concerns a method of sustainably producing an aquaculture meat product by feeding a fish over its dietary cycles an aquaculture feed composition, said method comprising the step of formulating an aquaculture feed composition by replacing all or part of fish oil in the composition with a single microbial source of eicosapentaenoic acid (“EPA”) and docosahex-aenoic acid (“DHA”). In a preferred embodiment, the microbial source comprising DHA and EPA derives from a microorganism/microbe of the genus Schizochytrium or Thraustochytrium.
Type:
Grant
Filed:
December 3, 2020
Date of Patent:
March 19, 2024
Assignee:
DSM IP ASSETS B.V.
Inventors:
Christian Martin, Ester Santigosa, Vivien Verlhac
Abstract: A recombinant host capable of producing a steviol glycoside which overexpresses a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto. A recombinant host capable of producing a steviol glycoside which has been modified, preferably in its genome, to result in a deficiency in the production of a polypeptide which mediates steviol glycoside transport and which polypeptide comprises the amino acid sequence set forth in SEQ ID NO: 29 or an amino acid sequence having at least about 50% sequence identity thereto.
Type:
Grant
Filed:
October 27, 2021
Date of Patent:
March 12, 2024
Assignee:
DSM IP Assets B.V.
Inventors:
Viktor Marius Boer, Priscilla Zwartjens, Eric Van Den Berg
Abstract: The invention relates to a process for manufacturing a plastic-metal hybrid part by plastic overmolding on a metal surface via nano-molding technology (NMT), wherein the moldable plastic material is a polymer composition comprising thermoplastic polyamide, or a thermoplastic polyester, or a blend thereof, and boron silicon glass fibers. The invention also relates to a plastic-metal hybrid part, obtainable by said process, wherein a metal part is overmolded by a polymer composition comprising thermoplastic polyamide, or a thermoplastic polyester, or a blend thereof, and boron silicon glass fibers.
Type:
Grant
Filed:
June 11, 2018
Date of Patent:
March 5, 2024
Assignee:
DSM IP ASSETS B.V.
Inventors:
Frank Peter Theodorus Johannes Van Der Burgt, Ruogu Liao