Abstract: The present invention relates to a drug delivery system comprising a core and a shell in which the core comprises a hydrolytically degradable polymer X which polymer backbone comprises pendant ester and acid functionalities and in which the shell comprises a hydrolytic degradable polymer Y. The hydrolytic degradable polymers X and Y are different polymers. Polymer X further comprises amino-acids in the polymer backbone and degrades via zero order degradation kinetics for a period of at least 3 months. Polymer Y degrades via auto-acceleration degradation kinetics.
Type:
Grant
Filed:
December 18, 2015
Date of Patent:
October 8, 2019
Assignee:
DSM IP ASSETS, B.V.
Inventors:
George Mihov, Guy Draaisma, Silvana Rensina Antonnietta Di Silvestre, Tristan Handels
Abstract: The present invention pertains to a method for manufacturing a laminated textile product comprising providing a first intermediate product comprising a primary backing having a front surface and a back surface, and yarns stitched into the primary backing, the yarns extending from the front surface of the backing material, feeding the intermediate product along a body having a heated surface, the back surface being pressed against the said heated surface, to at least partly melt the yarns present in the intermediate product to bond the yarns to the backing, wherein the part of the back surface that is pressed against the heated surface has a relative speed with respect to the heated surface, so as to provide a second intermediate product having a calendered back surface, providing a dimensionally stable carrier sheet or secondary backing, and connecting the second intermediate product to the carrier sheet by providing a hot melt adhesive between the calendered surface and the sheet, and pressing the sheet to t
Type:
Grant
Filed:
February 13, 2017
Date of Patent:
October 1, 2019
Assignee:
DSM IP ASSETS B.V
Inventors:
Michel Poul Tichelaar, Cornelis Eme Koning, Jan Henderikus Udding, Wilhelmina Westerhof, Chris Reutelingsperger, Adriaan Hofland
Abstract: The present invention relates to an aqueous coating composition comprising dispersed polymer particles, wherein (i) the dispersed polymer particles are polyurethane-vinyl polymer hybrid particles obtained by free-radical polymerization of at least one vinyl monomer in the presence of a polyurethane, (ii) the polyurethane and the vinyl polymer in the hybrid particles are present in a weight ratio of polyurethane to vinyl polymer ranging from 1:1 to 20:1, (iii) the polyurethane is the reaction product of at least the following components: (a) from 5 to 40 wt. % of at least one organic difunctional isocyanate, (b) from 0.5 to 4 wt. % of an isocyanate-reactive compound containing ionic or potentially ionic water-dispersing groups having a molecular weight of from 100 to 500 g/mol, (c) from 40 to 80 wt. % of at least one diol having a molecular weight from 500 to 5000, (d) from 0 to 10 wt.
Type:
Grant
Filed:
December 22, 2015
Date of Patent:
October 1, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Roel Johannes Marinus Swaans, Ronald Tennebroek, Gerardus Cornelis Overbeek, Paul De Kok
Abstract: This invention includes malleable, biodegradable, fibrous compositions for application to a tissue site in order to promote or facilitate new tissue growth. One aspect of this invention is a fibrous component that provides unique mechanical and physical properties. The invention may be created by providing a vessel containing a slurry, said slurry comprising a plurality of natural or synthetic polymer fibers and at least one suspension fluid, wherein the polymer fibers are substantially evenly dispersed and randomly oriented throughout the volume of the suspension fluid; applying a force, e.g., centrifugal, to said vessel containing said slurry, whereupon said force serves to cause said polymer fibers to migrate through the suspension fluid and amass at a furthest extent of the vessel, forming a polymer material, with said polymer material comprising polymer fibers of sufficient length and sufficiently viscous, interlaced, or interlocked to retard dissociation of said polymer fibers.
Type:
Grant
Filed:
February 28, 2017
Date of Patent:
September 24, 2019
Assignee:
DSM IP ASSETS, B.V.
Inventors:
Timothy A Ringeisen, William Christopher Wattengel
Abstract: The present invention relates a variant polypeptide having geranylgeranyl pyrophosphate synthase activity, which variant polypeptide comprises an amino acid sequence which, when aligned with a geranylgeranyl pyrophosphate synthase comprising the sequence set out in SEQ ID NO: 1, comprises at least one substitution of an amino acid residue corresponding to any of amino acids at positions 92, 100 or 235 said positions being defined with reference to SEQ ID NO: 1 and wherein the variant has one or more modified properties as compared with a reference polypeptide having geranylgeranyl pyrophosphate synthase activity. A variant polypeptide of the invention may be used in a recombinant host for the production of steviol or a steviol glycoside.
Type:
Application
Filed:
October 26, 2017
Publication date:
September 19, 2019
Applicant:
DSM IP ASSETS B.V.
Inventors:
Viktor Marius BOER, Priscilla ZWARTJENS, Johannes Gustaaf Ernst VAN LEEUWEN
Abstract: This invention relates to a medicament or a dietary supplement comprising the Aspergillus niger aspergilloglutamic peptidase that is capable of hydrolyzing plant food allergens, and more particularly, alpha-amylase/trypsin inhibitors, thereby treating diseases due to an innate immune response in humans, and/or allowing to delay the onset of said diseases. The present invention relates to the discovery that the Aspergillus niger aspergilloglutamic peptidase is capable of hydrolyzing alpha-amylase/trypsin inhibitors that are present in wheat and related cereals said inhibitors being strong inducers of innate immune response. Furthermore, the present invention relates to a method for hydrolyzing alpha-amylase/trypsin inhibitors comprising incubating a composition for food consumption comprising alpha-amylase/trypsin inhibitors with the Aspergillus niger aspergilloglutamic peptidase, wherein the inhibitors are hydrolyzed.
Type:
Grant
Filed:
December 11, 2014
Date of Patent:
September 17, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Maaike Johanna Bruins, Luppo Edens, Helena Maria Nan
Abstract: The disclosure relates to a heat curable powder coating composition suitable for being cured at a temperature from 60 to 130° C. containing: a thermal initiation system and a resin system, wherein the reactivity of the thermal initiation system is such that the thermal initiation system provides a geltime between 2.5 and 1000 minutes at 60° C. in butane diol-dimethacrylate as measured according to DIN 16945 using 1 wt % of the thermal initiation system in 99 wt % of butane dioldimethacrylate, wherein the amount of thermal initiation system is chosen such that when the powder coating composition is applied to a substrate and cured at a temperature of 130° C. for 20 minutes.
Type:
Grant
Filed:
September 23, 2015
Date of Patent:
September 3, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Johan F. G. A. Jansen, Leendert Jan Molhoek, Jan Pieter Drijfhout
Abstract: The invention relates to a process to make films and tapes from ultrahigh molecular weight polyethylene (UHMWPE) in the solid state. The films and tapes according to the invention have an improved thickness whereby the coefficient of variation of the thickness of the film of at most 6%.
Type:
Grant
Filed:
June 29, 2012
Date of Patent:
August 20, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Reinard Jozef Maria Steeman, Marcel Jongedijk
Abstract: The invention relates to a laser-markable polyamide composition comprising: a first phase comprising Sb2O3 and an aliphatic polyamide with an amide density AD1, and a second phase comprising an aliphatic polyamide with an amide density AD2, wherein AD1-AD2 is at least 0.01, and wherein the amount of Sb2O3 is between 0.1 and 5 wt %, a halogen-free flame retardant in an amount of between 1 to 25 wt %, wherein the amount in weight percentage are based on the total amount of composition. The invention also relates to a process for preparing a laser-markable polyamide composition, as well as laser-marked products comprising the composition.
Type:
Grant
Filed:
May 18, 2015
Date of Patent:
August 13, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Raul Marcelino Perez Graterol, Franciscus Gerardus Henricus Van Duijnhoven, Franciscus Wilhelmus Maria Gelissen, Johannes Hoekstra
Abstract: The invention relates to a yarn comprising a copolyamide in an amount of at least 90 wt % with respect to the total weight of the yarn, which copolyamide comprises a) at least 95 wt % by weight with respect to the total weight of copolyamide, monomeric units derived from hexamethylene diamine and adipic acid and b1) cyclic monomeric units derived from a diamine X, and cyclic monomeric units derived from a diacid Y, and/or b2) cyclic monomeric units derived from an amino acid Z, in which the summed amount of monomeric units derived from X,Y and Z is between 0.1 to 4.5 wt % by weight with respect to the total weight of the copolyamide and wherein the yarn has a tensile strength of at least 80 cN/tex as measured according to ASTM D885-04. The invention also relates to a process for preparing the yarn.
Type:
Grant
Filed:
February 23, 2016
Date of Patent:
August 6, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Martinus Joseph Maria Keulers, Roman Stepanyan, Hao Chen
Abstract: The present invention relates to frozen and freeze dried starter culture compositions comprising microorganisms. The invention also relates to methods of producing the frozen and freeze dried starter culture compositions and methods of using them.
Abstract: The invention relates to a woven fabric comprising a weft yarn and at most two warp yarns A and B, wherein the weft yarn comprises a high performance fiber; the warp yarn A comprises at least 50 wt % of a natural fiber; the warp yarn B comprises a high performance fiber; and wherein the fabric has an outside layer comprising the warp yarn A and an inside layer comprising the warp yarn B and said outside and inside layers being at least partially interconnected by the weft yarn. The invention also relates to products comprising said woven fabric such as clothing, lining, sport apparel, gloves, curtains, upholstery fabric and floor covering.
Type:
Grant
Filed:
November 4, 2014
Date of Patent:
August 6, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Giovanni Joseph Ida Henssen, Guelfo Valerio Bagordo, Flavio Berto
Abstract: Processes are disclosed for preparing biaxially oriented film by forming a polymer melt of a composition which includes at least 50 wt % with respect to the total amount of the composition of a copolyamide having at least 75 wt. % monomeric units derived from either (i) caprolactam or (ii) hexamethylene diamine and adipic acid, each of which further includes units derived from diamines X and/or diacids Y and/or aminoacids Z in a summed amount of between 0.2 to 25 wt %, followed sequentially by casting and quenching a film of the polymer melt, MD-stretching of the film, TD-stretching the film, cooling the film after TD-stretching, and heat setting the biaxially oriented film. The resulting biaxially oriented film exhibits attributes suitable for use as food packaging.
Type:
Grant
Filed:
November 12, 2015
Date of Patent:
July 30, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Hao Chen, Alexander Antonius Marie Stroeks, Roman Stepanyan
Abstract: The present invention relates to a recombinant host cell which is capable of producing a dicarboxylic acid and which comprises a mutant malate dehydrogenase resulting in an increased production of the dicarboxylic acid. The invention also relates to a process for producing a dicarboxylic acid, which method comprises fermenting said recombinant host cell in a suitable fermentation medium and producing the dicarboxylic acid.
Type:
Application
Filed:
July 11, 2017
Publication date:
July 25, 2019
Applicant:
DSM IP ASSETS B.V.
Inventors:
Alrik Pieter LOS, Rene Marcel DE JONG, Remko Tsjibbe WINTER, Ben DEN DULK
Abstract: The invention relates to a radiation curable resin composition comprising a cationically polymerizable component, a cationic photoinitiator, a hydroxy component, an impact modifier and wherein the resin composition after full cure has a modulus of >2 GPa; a yield stress <70 MPa; and a K1c value >1.3 MPa·(m)1/2 or an Izod value >0.45 J/cm. The resin composition can preferably be used in the preparation of three dimensional objects.
Type:
Grant
Filed:
May 4, 2017
Date of Patent:
July 23, 2019
Assignee:
DSM IP ASSETS, B.V.
Inventors:
Paulus Antonius Maria Steeman, Beert Jacobs Keestra, Marco Marcus Matheus Driessen, Debra Lynn Fish Repko, Melvin Zussman
Abstract: Methods for treating/preventing conditions associated with an increased level of eotaxin in a human with 25-hydroxyvitamin D3 (calcifediol) are provided. Optionally, vitamin D3 may be used together with 25-hydroxyvitamin D3.
Type:
Grant
Filed:
December 28, 2016
Date of Patent:
July 23, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Stephanie Krammer-Lukas, Elisabeth Stoecklin, Joseph Schwager, Swen Wolfram
Abstract: The invention relates to a preformed sheet comprising mono-layers from a fibrous network with fibers having a tensile strength of at least about 1.2 GPa and preferably a binder, and a separating film on at least one of its outer surfaces, the separating film having an areal density of between 1 and 10 g/m2 and a surface tension of less than 35 mN/m at the surface faced to the fibrous network and the separating film has a crystallinity of between 50 and 90%.