Abstract: A process for manufacturing succinic acid as obtained by fermentation is provided including crystallizing the succinic acid from an aqueous solution, separating the crystals from the mother liquor, treating the mother liquor by nanofiltration and recycling the treated mother liquor to the crystallization step. This process exhibits a high yield in terms of succinic acid crystals recovery and allowing to achieve a final product with a low content of saccharides.
Type:
Grant
Filed:
December 1, 2015
Date of Patent:
January 29, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Baptiste Boit, Guillaume Fiey, Maarten Job Van De Graaf
Abstract: The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I) wherein R1 is a C1C18alkyl group or C2-C18alkenyl group as well as the respective alkyl substituted bis-resorcinyl derivatives of formula (II) wherein R1 is a C1-C18alkyl group or C2-C18alkenyl group and R2 and R3 are independently of each other a C1-C18alkyl group or a C2-C18alkenyl group.
Type:
Grant
Filed:
May 12, 2016
Date of Patent:
January 22, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Nadine Greiner, Sandro Schmid, René Tobias Stemmler
Abstract: The present invention relates to biodegradable polyesteramides (PEAs) comprising hydrophobic alpha-amino acids, diols, aliphatic dicarboxylic acids and optionally diamines whereby at least one of the dicarboxylic acids, diols or diamines comprises disulphide linkages. The present invention also relates to the use of the polyesteramides in medical applications such as cancer treatment, ophthalmic applications, therapeutic cardiovascular applications, veterinary applications, pain management applications, MSK applications and vaccine delivery compositions. The present invention also relates to a drug delivery composition comprising the PEA's and to a drug delivery system such as micro- or nanoparticles, micelles, liposomes, polymerosomes, micro- and nanogels, polymerosomes or nanotubes.
Abstract: The invention relates to an improved process for the manufacture of bis-resorcinyl triazines of formula (I), wherein R1 is hydrogen, a C1-C18 alkyl group or a C2-C18 alkenyl group and R2 is a C1-C18 alkyl group or a C2-C18 alkenyl group.
Type:
Grant
Filed:
May 12, 2016
Date of Patent:
January 15, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Nadine Greiner, Sandro Schmid, René Tobias Stemmler
Abstract: This invention relates to compounds that are selective inhibitors of Matrix Metalloprotease-12 (MMP-12), to cosmetic and pharmaceutical compositions containing them, and to their use in the prevention and/or treatment of ailments associated with MMP-12. Formula (I).
Type:
Grant
Filed:
November 23, 2016
Date of Patent:
January 15, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Stéphanie Boudon, Eileen Jackson, Rolf Schuetz, Jürgen Herbert Vollhardt, Peter Wikstroem, Eliane Ursula Wandeler
Abstract: The invention relates to a resin composition comprising at least an organophosphorous compound and a branched amorphous carboxylic acid functional polyester, said polyester having a Tg of at least 40° C., said polyester comprising at least 1 to 45% mol of 2,2-dimethyl-1,3-propanediol; a C3 to C5 aliphatic diol AD1 not including 2,2-dimethyl-1,3-propanediol; a C6 to C50 aliphatic or cycloaliphatic diol AD2; 0.1 to 10% mol of an at least trifunctional monomer; 1 to 55% mol of terephthalic acid, wherein the % mol is based on the polyester. The powder coatings of the present invention derived upon curing at low temperature of the thermosetting powder coating compositions of the invention that were storage stable and comprised said resin composition and a crosslinker having functional groups that are reactive with the carboxylic acid groups of the polyester, have limited or no blooming, good smoothness sufficient reverse impact resistance and preferably have also good degassing limit.
Type:
Grant
Filed:
March 22, 2012
Date of Patent:
January 15, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Rubin Huang, Jurjen Bolks, Paulus Franciscus Anna Buijsen, Juul Cuijpers, Jean-Paul Van Bregt
Abstract: The invention relates to a process for the hydrolysis of cellulose containing biomass which comprises a liquefaction step in which a first enzyme or first enzyme composition is added to liquefy at least part of the solids present in the biomass and to keep the viscosity of the cellulose containing biomass below 1000 cP, preferably below 800 cP, more preferably below 600 cP in the liquefaction step; followed by a saccharification step in which a second enzyme composition is added to form oligomeric and/or monomeric sugars; and whereby the first enzyme or first enzyme composition is different from the second enzyme composition; whereby the first enzyme or first enzyme composition comprises an endoglucanase; whereby the second enzyme composition comprises a cellulase; and whereby the first enzyme or first enzyme composition comprises more endogluconase than the second enzyme composition (expressed in protein wt %).
Type:
Grant
Filed:
January 9, 2014
Date of Patent:
January 8, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Johannes Petrus Smits, Michael Petrus Jozef Berkhout, Bertus Noordam
Abstract: An edible composition comprising peptides rich in tryptophan, which edible composition further comprises a rapidly available glucose composition and a slowly available glucose composition.
Type:
Grant
Filed:
April 9, 2009
Date of Patent:
January 8, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Rudolf Van Beck-hoven, Alexander Duchateau, Luppo Edens, Franciscus Kleinherenbrink, Joris Kloek, Andre L. Ross De
Abstract: The present invention relates to a polyester resin obtained by reaction in a process (I) between the following components A to E to obtain a polyester P (the polyester comprising an alkyd resin and/or a saturated polyester resin), where (A) Component A (also referred to herein as the Imide and/or Imide Component) comprises one or more cyclic imides of Formula (1); where R? represents a divalent optionally substituted saturated C1-30 organo moiety; and R represents H or a monovalent optionally substituted saturated C1-30 organo moiety; (A?) Optional Component A? comprises saturated dicarboxylic acid and/or saturated hydroxyacid and that is not optional in case component A does not comprise a dicarboxylic acid or a hydroxyacid; 1(B) Component B (also referred to herein as the Polyol and/or Polyol Component) comprises at least one saturated polyhydric alcohol; (C) Optional Component C (also referred to herein as the Rosin and/or Rosin Component) comprises naturally occurring rosin, the rosin comprising from 40 t
Type:
Grant
Filed:
October 13, 2014
Date of Patent:
January 1, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Adrianus Jozephus Hendricus Lansbergen, Cornelis Eme Koning, Paulus Franciscus Anna Buijsen, Johannes Wilhelmus Maria Hendriks, Alwin Papegaaij
Abstract: An aqueous polymer composition which when in the form of a film shows excellent elongation at break comprising (i) 5 to 30 wt. % of polyurethane where the acid value of the polyurethane is between 3 to 40 mg KOH/g; (ii) 70 to 95 wt. % of vinyl polymer comprising 20 to 90 wt. % of vinyl polymer with Tg<20° C.; 10 to 80 wt. % of vinyl polymer with Tg?20° C.; where at least one of the vinyl polymers contains acid functional groups with acid value in the range of from 15 and 240 mg KOH/g.
Type:
Grant
Filed:
April 23, 2015
Date of Patent:
January 1, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Rajasingham Satgurunathan, Jurgen Scheerder, Gerardus Cornelis Overbeek, Roel Johannes Marinus Swaans, Ronald Tennebroek, Tijs Nabuurs, Maud Kastelijn, Hinrike Malda
Abstract: The invention relates to a polypeptide having chymosin activity which: a. is capable of hydrolyzing bovine alpha s1-casein at position F23F24 so as to form ?s1-I CN (f24-199) more rapidly than camel chymosin; and b. has a C/P ratio higher than the C/P ratio of bovine chymosin.
Type:
Grant
Filed:
May 3, 2013
Date of Patent:
January 1, 2019
Assignee:
DSM IP ASSETS B.V.
Inventors:
Petrus Jacobus Theodorus Dekker, Rene Marcel De Jong, Michael Dennis Tabeling, Cornelis Marinus Muijlwijk
Abstract: The invention relates to a radome wall comprising a multilayer sheet, the multilayer sheet comprising: a) at least one sheet layer A comprising at least two monolayers, the monolayers comprising polymeric fibers, and b) at least one first film layer B1 comprising a polyolefin, wherein the multilayer sheet has a thickness of at least 0.05 mm and at most 0.8 mm. The invention also relates to a radome comprising the radome wall, the radome preferably being a non-ballistic radome, preferably suitable for telecommunications.
Type:
Application
Filed:
December 15, 2016
Publication date:
December 27, 2018
Applicant:
DSM IP ASSETS B.V.
Inventors:
Danielle G.I. PETRA, William A.C. ROOVERS
Abstract: There is disclosed certain hyperbranched polyester amides with end groups selected from: esters or amides of betaine-type end groups useful in various end uses such as a flocculent.
Type:
Grant
Filed:
June 20, 2014
Date of Patent:
December 18, 2018
Assignee:
DSM IP ASSETS B.V.
Inventors:
Henricus Johannes Arts, Thomas Dikken, Remco Dinkelberg
Abstract: The present invention relates to the field of reduction of methane emission in ruminants. Particularly, it relates to the use of a feed composition or a feed additive comprising at least one antibiotic and at least one organic molecule substituted at any position with at least one nitrooxy group for reducing the production of methane emanating from the digestive activities of ruminants, and/or to improve the ruminant performance.
Abstract: An apparatus and method for additive fabrication which helps to prevent the newly hardened layer from being separated from the previously formed layer of the object while the foil is peeled from the newly hardened layer is provided. In one embodiment, use of a peel angle helps prevent the newly hardened layer from being separated from the previously formed layer during peeling by distributing the peeling force so that less of the z-direction component of the peeling force is applied to the newly hardened layer. In another embodiment, the object can be oriented to initiate the peel at an area, of the object which results in a lesser initial peeling force applied to the newly hardened layer.
Abstract: Composite radome wall structures (10) exhibit both antiballistic and radar transparency properties and include an antiballistic internal solid, void-free core (12) and external antireflective (AR) surface layers (14-1, 14-2) which sandwich the core. The antiballistic core can be a compressed stack of angularly biased unidirectional polyethylene monolayers formed of tapes and/or fibers. Face sheets (16-1, 16-2) and/or one or more impedance matching layers (27, 28) may optionally be positioned between the antiballistic core and one (or both) of the external AR layers so as to bond the core to the AR surface layer(s) and/or selectively tune the radome wall structure to the frequency of transmission and reception associated with the radar system.
Abstract: The invention relates to a continuous or repetitive batch process for the hydrogenation of levulinic acid (LA) or esters thereof to at least gamma valerolactone (GVL) in a reactor comprising a feed stream and an outlet stream, in the presence of a solid Ru catalyst, said process comprising (a) pretreating said solid Ru catalyst with a reductant; and (b) reacting levulinic acid with hydrogen and the pretreated solid Ru catalyst obtained in step (a) at a temperature and residence time suitable to form at least GVL, characterized in that the pretreatment is in the presence of a first solvent which comprises water. This process is stable and little or no Ru will leak form the support.
Type:
Grant
Filed:
February 16, 2016
Date of Patent:
December 4, 2018
Assignee:
DSM IP ASSETS B.V.
Inventors:
Barthel Engendahl, Roel Wim Wiertz, Jan Van Der Spoel