Patents Assigned to DSM
  • Lipolytic enzyme variants
    Patent number: 11667902
    Abstract: The present disclosure describes a variant polypeptide having lipolytic activity, wherein the variant has an amino acid sequence which, when aligned with the amino acid sequence as set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid residue at a position corresponding to any of the positions 113, 122, 138, 141, 179, 282, 284, 286, 295, said positions being defined with reference to SEQ ID NO: 2, and wherein said variant has at least 70% identity with the mature polypeptide having lipolytic activity as set out in SEQ ID NO: 2. Such a variant polypeptide may be used in the preparation of a baked product.
    Type: Grant
    Filed: December 2, 2020
    Date of Patent: June 6, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Rene Marcel De Jong, Chantal Christis, Neil Carr
  • Fermentation process for improved glycerol and acetic acid conversion
    Patent number: 11667935
    Abstract: The invention relates to a process for producing a fermentation product that comprises fermentation of a carbon source in a reactor with a cell, capable of converting sugar, glycerol and acetic acid, wherein the carbon source comprises sugar and acetic acid, comprising the following steps: a) Inoculating a optionally diluted carbon source with the cell; b) optionally fermenting the reactor in batch mode; c) adding carbon source comprising glycerol and optionally sugar gradually to the reactor; d) after sufficient fermentation time, isolation of fermentation product from the reactor, e) optionally keeping the remaining fraction after isolation of step d) as spent broth; and f) optionally using the spent broth in step a) to dilute the carbon source.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: June 6, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Hans Marinus Charles Johannes De Bruijn, Wilhelmus Theodorus Antonius Maria De Laat, Paul Klaassen
  • Recombinant yeast cell
    Patent number: 11667886
    Abstract: The present invention describes a recombinant yeast cell functionally expressing one or more heterologous nucleic acid sequences encoding for ribulose-1,5-phosphate carboxylase/oxygenase (EC4.1.1.39; Rubisco), and optionally one or more molecular chaperones for Rubisco, and one or more phosphoribulokinase (EC2.7.1.19; PRK), wherein one or more genes of the non-oxidative branch of the pentose phosphate pathway are overexpressed and/or wherein said yeast cell comprises a deletion or disruption of a glycerol-3-phosphate dehydrogenase (GPD) gene.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: June 6, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ioannis Papapetridis, Jacobus Thomas Pronk
  • Oil comprising at least one polyunsaturated fatty acid having at least 20 carbon atoms (LC-PUFA)
    Patent number: 11666062
    Abstract: The present invention relates to an oil comprising at least one polyunsaturated fatty acid having at least 20 carbon atoms (LC-PUFA). It is found that LC-PUFA-containing oil are susceptible to gelling by formation of microscopic crystals during storage ultimately resulting in unfavorable quality and handling properties. This problem has been particularly observed with a microbial oil comprising at least about 25% by weight LC-PUFA and a moisture content of 0.2 to 5% by weight. Surprisingly, it has been found that a LC-PUFA-containing oil as described above is effectively stable and does not show gelling properties under conventional storage conditions, if the oil composition as such contains less than about 8% preferably less than about 5% by weight of free fatty acid in the residual moisture of the oil.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: June 6, 2023
    Assignees: DSM IP ASSETS B.V., EVONIK OPERATIONS GMBH
    Inventors: Martin Heining, Vinod Tarwade, Viktor Stefan Wallimann
  • Radially expanding debridement tools
    Patent number: 11660100
    Abstract: Disclosed are radially expanding debridement tools configured to pass through an access channel present in a first tissue of a living being, expand radially, and create a void in a second tissue of the living being upon being advanced distally through the access channel and into the second tissue while being rotated, wherein the shape of the void comprises at least one step. Further disclosed are debridement systems and methods of treating tissue defects in living beings.
    Type: Grant
    Filed: January 25, 2019
    Date of Patent: May 30, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: William T. Fisher, Timothy Ringeisen, Gino Bradica
  • Oligosaccharide compositions for use as animal feed and methods of producing thereof
    Patent number: 11653676
    Abstract: Described herein are methods of producing animal feed made up of oligosaccharide compositions, as well as methods of producing such oligosaccharide compositions and animal feed compositions, and methods of using such animal feed compositions to enhance animal growth.
    Type: Grant
    Filed: November 30, 2020
    Date of Patent: May 23, 2023
    Assignee: DSM Nutritional Products, LLC
    Inventors: John M. Geremia, Raffi Mardirosian, Michael J. Gidding, Anastasia V. Murphy
  • Oligosaccharide preparations and compositions
    Patent number: 11655267
    Abstract: The present disclosure relates oligosaccharide preparations suitable for use in nutritional compositions such as animal feed and methods of manufacturing the described oligosaccharide preparations. The present disclosure further relates to nutritional compositions that comprise the oligosaccharide preparations. The disclosed oligosaccharide preparations can be advantageous as an animal feed due to, at least in part, their prebiotic utility and the presence of anhydro-subunit containing oligosaccharides, which can be used to detect and/or determine the presence and content of the disclosed oligosaccharide preparations in the nutritional composition.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: May 23, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Manuela Baur, Estel Canet-Martinez, Ruediger Hainz, Ulrich Hoeller, Lisa Ann Laprade, John Michael Geremia, Ghislain Schyns
  • Process for the production of ethanol
    Patent number: 11655485
    Abstract: The invention relates to a process for the production of ethanol comprising fermenting a (optionally liquefied) corn slurry under anaerobic conditions in the presence of a recombinant yeast; and recovering the ethanol, wherein said recombinant yeast functionally expresses a heterologous nucleic acid sequence encoding a glucoamylase having an amino acid sequence according to SEQ ID NO: 1 or which glucoamylase is a functional homologue thereof having a sequence identity of at least 80%, or which glucoamylase is a functional homologue which is derived, by way of one or more amino acid substitutions, deletions or insertions, from the amino acid sequence of SEQ ID NO: 1, and wherein the process comprises dosing a glucoamylase at a concentration of 0.05 g/L or less.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: May 23, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventor: Hans Marinus Charles Johannes De Bruijn
  • Fermentative production of ethanol from glucose, galactose and arabinose employing a recombinant yeast strain
    Patent number: 11649471
    Abstract: The present invention relates to a process for the production of one or more fermentation product from a sugar composition, comprising the following steps: a) fermentation of the sugar composition in the presence of a yeast belonging to the genera Saccharomyces, Kluyveromyces, Candida, Pichia, Schizosaccharomyces, Hansenula, Kloeckera, Schwanniomyces or Yarrowia: and b) recovery of the fermentation product, wherein the yeast comprises the genes araA, araB and araD and the sugar composition comprises glucose, galactose and arabinose.
    Type: Grant
    Filed: March 12, 2021
    Date of Patent: May 16, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paul Klaassen, Gijsberdina Pieternella Van Suylekom, Bianca Elisabeth Maria Gielesen, Nicolette Jasmijn Broers, Beate Wiedemann, Wilhelmus Theodorus Antonius Maria De Laat
  • Enzymatic modification of oil
    Patent number: 11649473
    Abstract: The disclosed subject matter relates generally to a method for modifying oil, and specifically to a process for increasing the concentration of polyunsaturated fatty acid in an oil composition.
    Type: Grant
    Filed: July 29, 2019
    Date of Patent: May 16, 2023
    Assignee: DSM Nutritional Products AG
    Inventors: Jaroslav A. Kralovec, Weijie Wang, James Colin Barrow
  • Synthetic membrane composition comprising a fluorinated polyurethane
    Patent number: 11649353
    Abstract: Disclosed are compositions that may be useful for forming synthetic membranes, methods of forming membranes therefrom, and membranes. In an embodiment, a membrane comprises a free hydrophilic polymer and a polyurethane, the polyurethane comprising a backbone comprising the reaction product of a diisocyanate, a polymeric aliphatic diol, and, optionally, a chain extender, wherein the backbone comprises a C2-C16 fluoroalkyl or C2-C16 fluoroalkyl ether, or the polyurethane comprises an endgroup comprising a C2-C16 fluoroalkyl or C2-C16 fluoroalkyl ether.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: May 16, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jennifer Al-Rashid, John Zupancich, Chad Sugiyama
  • Synthetic membrane composition comprising a polyurethane and a polyoxazoline
    Patent number: 11643551
    Abstract: Disclosed are compositions that may be useful for forming synthetic membranes, methods of forming membranes therefrom, and membranes. In an embodiment, a membrane comprises a free hydrophilic polymer comprising a polyoxazoline, and a polyurethane, the polyurethane comprising a backbone comprising the reaction product of a diisocyanate, a polymeric aliphatic 5 diol, and optionally a chain extender.
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: May 9, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Jennifer Al-Rashid, Jacob Riffey, Chad Sugiyama, John Zupancich
  • UDP-glycosyltransferases
    Patent number: 11639497
    Abstract: The present disclosure relates a polypeptide having UGT activity, which polypeptide comprises an amino acid sequence which, when aligned with a polypeptide having UGT activity comprising the sequence set out in SEQ ID NO: 2, comprises at least one substitution of an amino acid corresponding to any of amino acids at positions 35, 189, 280, 284, 285, 334 or 373, said positions being defined with reference to SEQ ID NO: 2 and wherein the polypeptide has one or more modified properties as compared with a reference polypeptide having UGT activity. A polypeptide according to the disclosure may be used in a recombinant cell for the production of steviol or a steviol glycoside.
    Type: Grant
    Filed: June 26, 2018
    Date of Patent: May 2, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Viktor Marius Boer, Johannes Gustaaf Ernst Van Leeuwen
  • Yeast cell wall derived flavour
    Patent number: 11627752
    Abstract: The present invention relates to a method for producing a flavour composition comprising providing a slurry of yeast cell walls and contacting the slurry of yeast cell walls with a glucanase and with an endoprotease, followed by separating a liquid fraction by solid/liquid separation to provide the liquid flavour composition.
    Type: Grant
    Filed: March 8, 2022
    Date of Patent: April 18, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Bernadette Theresia Morel, Marco Alexander Van Den Berg
  • Glycerol free ethanol production
    Patent number: 11624057
    Abstract: The invention relates to a recombinant cell, preferably a yeast cell comprising: a) one or more heterologous genes encoding a glycerol dehydrogenase activity; b) one or more genes encoding a dihydroxyacetone kinase (E.C. 2.7.1.28 and/or E.C. 2.7.1.29); c) one or more heterologous genes encoding a ribulose-1,5-biphosphate carboxylase oxygenase (EC 4.1.1.39, RuBisCO); and d) one or more heterologous genes encoding a phosphoribulokinase (EC 2.7.1.19, PRK); and optionally e) one or more heterologous genes encoding for a glycerol transporter. This cell can be used for the production of ethanol and advantageously produces little or no glycerol.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: April 11, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Paulus Petrus De Waal, Ingrid Maria Vugt-Van Lutz, Jozef Petrus Johannes Schmitz, Hans Marinus Charles Johannes De Bruijn
  • Process for the production of a thermoplastic elastomer and the thermoplastic elastomer
    Patent number: 11623976
    Abstract: A process for the production of a thermoplastic elastomer containing hard segments (a) of a polyester and soft segments (b) containing repeating units derived from an aliphatic carbonate, in which process a precursor thermoplastic elastomer is subjected to solid state post condensation at a temperature between 140 and 170° C. Also claimed is the thermoplastic elastomer.
    Type: Grant
    Filed: November 12, 2020
    Date of Patent: April 11, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Ellen Van Hemelrijck, Wilhelmus Petrus Johannes Appel
  • All-trans polyene amphoteric macrolide
    Patent number: 11623939
    Abstract: The present invention is directed to a process for purifying natamycin, to an all-trans polyene amphoteric macrolide, to a composition comprising said polyene amphoteric macrolide and to a process for preparing said polyene amphoteric macrolide.
    Type: Grant
    Filed: August 15, 2019
    Date of Patent: April 11, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Alexander Lucia Leonardus Duchateau, Peter Philip Lankhorst, Willebrordus Bernardus Van Scheppingen
  • Formulation
    Patent number: 11607420
    Abstract: The present invention relates to a new formulation of specific nutritional ingredients (nutraceuticals) and/or pharmaceutical compounds.
    Type: Grant
    Filed: June 6, 2019
    Date of Patent: March 21, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Elger Funda, Odile Krainz
  • Steviol glycoside transport
    Patent number: 11608364
    Abstract: The disclosure provides a recombinant cell capable of producing a steviol glycoside, wherein the cell comprises a nucleic acid coding for a variant of a parent polypeptide, wherein the variant has steviol glycoside transport mediating activity, wherein the variant comprises an amino acid sequence which, when aligned with the amino acid sequence of the parent polypeptide, comprises at least one modification of the amino acid residue corresponding to any of the amino acids in the amino acid sequence of the parent polypeptide, wherein the variant has an improved ability to produce rebaudioside M and optionally other steviol glycosides extracellularly if compared with the parent polypeptide when measured under the same conditions.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: March 21, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Johannes Gustaaf Ernst Van Leeuwen, Viktor Marius Boer, Priscilla Zwartjens, Jos Van Vugt, René Marcel De Jong
  • Delivery system
    Patent number: 11602503
    Abstract: The present invention relates to a new delivery system for nutritional ingredients (nutraceuticals). These nutritional ingredients are useful for gut and metabolic health in monogastric animals, especially in humans.
    Type: Grant
    Filed: October 30, 2018
    Date of Patent: March 14, 2023
    Assignee: DSM IP ASSETS B.V.
    Inventors: Elger Funda, Odile Krainz, Robert Steinert