Abstract: The present invention relates a variant polypeptide having geranylgeranyl pyrophosphate synthase activity, which variant polypeptide comprises an amino acid sequence which, when aligned with a geranylgeranyl pyrophosphate synthase comprising the sequence set out in SEQ ID NO: 1, comprises at least one substitution of an amino acid residue corresponding to any of amino acids at positions 92, 100 or 235 said positions being defined with reference to SEQ ID NO: 1 and wherein the variant has one or more modified properties as compared with a reference polypeptide having geranylgeranyl pyrophosphate synthase activity. A variant polypeptide of the invention may be used in a recombinant host for the production of steviol or a steviol glycoside.
Type:
Grant
Filed:
December 3, 2021
Date of Patent:
October 10, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
Viktor Marius Boer, Priscilla Zwartjens, Johannes Gustaaf Ernst Van Leeuwen
Abstract: The present invention relates to a method of manufacturing spray-dried powders. During the process, a solvent is used. The process is done in multiple steps such that the emulsification mass ratio is low when removal of the solvent is started. Preferred solvents are isopropyl acetate and ethyl acetate. The invention also relates to a set-up to run the inventive process at industrial scale.
Type:
Grant
Filed:
April 26, 2019
Date of Patent:
October 3, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
André Hunziker, Renè Lang, David Schaffner, Thomas Zwick
Abstract: The present invention discloses a soluble native rapeseed protein isolate having improved color, a method for preparing a soluble native rapeseed protein isolate having improved color and use of said rapeseed protein isolate in a food product.
Type:
Grant
Filed:
December 4, 2018
Date of Patent:
October 3, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
Nienke Nina Hylkema, Gerardus Johannes Franciscus Smolders
Abstract: A waterproof seal for electrical assemblies wherein an outer sheath of an electrical cable is removed to expose the wires and the insulation is removed from the wires to form a window of exposed electrical conductor, the electrical conductors being maintain apart from each other and contained in a cover that may comprise a connector, an epoxy applied to the electrical conductors to fill in all the space in and around the electrical conductors and the cover to form a waterproof seal that prevents water from wicking past the waterproof seal via an interior of the electrical cable.
Abstract: The invention relates to a process for the continuous production of an adsorption product of a nitrooxy-functional organic compound adsorbed on the surface of a particulate adsorbent material, the process comprising the steps of: continuously feeding particulate adsorbent material into an elongated cavity; continuously conveying the material within the cavity in a downstream direction; continuously spraying a liquid adsorbate onto the particulate adsorbent material, wherein the liquid adsorbate comprises the nitrooxy-functional organic compound; continuously agitating the mixture thus obtained to form the adsorption product; and continuously removing the adsorption product from the cavity. The invention further relates to an adsorption product obtained by such process and the use of such adsorption product in ruminant nutrition.
Abstract: Cell that is genetically modified comprising: a) one or more nucleotide sequence encoding a NAD+-dependent acetylating acetaldehyde dehydrogenase (E.C. 1.2.1.10); b) one or more nucleotide sequence encoding a acetyl-CoA synthetase (E.C. 6.2.1.1); c) one or more nucleotide sequence encoding a glycerol dehydrogenase (E.C. 1.1.1.6); and d) one or more nucleotide sequence encoding a dihydroxyacetone kinase (E.C. 2.7.1.28 or E.C. 2.7.1.29).
Type:
Grant
Filed:
July 12, 2019
Date of Patent:
September 12, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
Paul Klaassen, Wouter Willem Antonius Hartman
Abstract: Methods for the synthesis of arginine-containing peptides are provided. The methods include a deprotection step that minimizes the transfer of by-products deriving from cleaved sulfonyl-5 based side chain protecting groups from arginine to amino acids carrying electron rich side chains.
Abstract: The present patent application relates to novel red-orange coated particles, which are mainly used in (dry) formulations for instant beverages. The advantage of these coated particles is that they are red to orange as such (also in the formulations for instant beverages, wherein they can be identified by the naked eye as individual discrete colored particles), but upon dissolution of the instant beverage powder, the particles will dissolve as well and will not interfere with or change the intended color of the ready-to drink instant beverages made from the instant beverage dry powders.
Type:
Grant
Filed:
March 15, 2017
Date of Patent:
September 5, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
Markus Beck, Elger Funda, Simone König-Grillo
Abstract: The present invention is related to a powderous composition which comprises lutein and which is used in infant food formulations or premixes for infant food formulations.
Type:
Grant
Filed:
March 27, 2014
Date of Patent:
August 22, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
Markus Beck, Andrea Hitzfeld, Bernd Schlegel, Christian Schaefer
Abstract: A promoter or variant thereof has increased relative expression efficiency, in particular a formate dehydrogenase promoter variant has increased relative expression efficiency, and a method provides for recombinant protein production and for increasing the relative expression efficiency of a nucleotide sequence having promoter activity.
Abstract: The present invention describes a method for producing a set-type yogurt snack, said method comprising allowing said yogurt snack to set in a mold or block and wherein said yogurt snack comprises at least 12% (w/w) protein and at least 35% (w/w) total solids.
Type:
Grant
Filed:
April 18, 2019
Date of Patent:
August 15, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
Regina Marie Draper, Kayla Marie Polzin, David Jay Williams
Abstract: The present invention relates to a recombinant microorganism comprising one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity, whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol.
Abstract: This invention relates to a method of using a two-step serial centrifugation process in extracting nutritive oil from a fermentation broth, this novel method prevents oil yield losses while preserving product quality.
Type:
Grant
Filed:
August 9, 2018
Date of Patent:
August 15, 2023
Assignees:
DSM IP ASSETS B.V., EVONIK OPERATIONS GMBH
Inventors:
Neil Francis Leininger, Holger Pfeifer, David Allen Tinsley, Jochen Lebert, Marc Beiser
Abstract: The present invention relates to a novel synthetic pathway for alpha-tocopherol. The invention discloses different reactions yielding some new intermediates in a very high yield and stereoselectivity.
Type:
Grant
Filed:
May 3, 2021
Date of Patent:
August 15, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
Ulla Letinois, Thomas Netscher, August Ruettimann
Abstract: Preparations of glycan polymers and variations thereof, pharmaceutical compositions, medical foods, supplements, foods, food ingredients, feed ingredients, and feed additives thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same.
Type:
Grant
Filed:
November 3, 2018
Date of Patent:
July 11, 2023
Assignee:
DSM Nutritional Products, LLC
Inventors:
John M. Geremia, Christopher Matthew Liu, Anastasia V. Lioubomirov
Abstract: The present patent application relates to solid particles comprising at least one fatsoluble vitamin, which are more stable when compressed into tablets.
Abstract: The present invention relates to a starter culture comprising at least two Streptococcus thermophilus strains, wherein a first and a second Streptococcus thermophilus strain are chosen from RGP group 1, RGP group 2, RGP group 3 and RGP group 4, with the proviso that the first and second Streptococcus thermophilus strains do not belong to the same RGP group.
Type:
Grant
Filed:
December 14, 2017
Date of Patent:
June 13, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
Roelof Hendrik Matthijs Kouwen, Douwe Van Sinderen, Brian McDonnell, Pieter Emiel Verloren Van Themaat, Jennifer Mahony
Abstract: A refined oil comprising at least one polyunsaturated fatty acid (PUFA), wherein the oil has a fatty acid ester of monochloropropanediol, epoxypropanol, and mixtures thereof in an amount of 10 ppm or less, and processes for producing the oil. The oil is preferably a microbial or marine oil.
Type:
Grant
Filed:
August 25, 2016
Date of Patent:
June 13, 2023
Assignee:
DSM IP ASSETS B.V.
Inventors:
Michael Lenn Stefanski, Nasrin Tabayehnejad, Chris Connor Luigart