Abstract: The invention relates to personal care, home care and fabric care compositions based on hyperbranched condensation polymers having in the polymer backbone at least one unit comprising an amide bond attached to a trismethylene-aminomethane group and to novel hyperbranched condensation polymers.
Type:
Grant
Filed:
June 15, 2007
Date of Patent:
March 12, 2013
Assignee:
DSM IP Assets B.V.
Inventors:
Raphael Beumer, Franciscus Johannes M. Derks
Abstract: The present invention is concerned with novel cosmetic or pharmaceutical compositions. More particularly, the invention is concerned with novel cosmetic or pharmaceutical compositions for treating or preventing any symptoms caused by negative developments of the physiological homeostasis of healthy skin, as well as for the promotion of hair growth and protection from hair loss.
Abstract: This invention is related to the use of hydroxytyrosol (“HT”), or an olive juice extract containing hydroxytyrosol as an agent to improve muscle differentiation and thus improve or maintain the body's adaptation to exercise. It is also related to the use of hydroxytyrosol (“HT”), or an olive juice extract containing hydroxytyrosol as an agent to improve calcium signaling and to improve skeletal muscle contraction and relaxation. It also relates to pharmaceutical and nutraceutical compositions useful for conditions characterized by altered muscle differentiation especially under inflammatory conditions, such as delayed onset muscle soreness subsequent to strenuous exercise or sarcopenia.
Type:
Application
Filed:
July 17, 2012
Publication date:
March 7, 2013
Applicant:
DSM IP ASSETS, B.V.
Inventors:
Angelika FRIEDEL, Daniel Raederstorff, Franz Roos, Christine Toepfer, Karin Wertz
Abstract: The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 93% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 93% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
Type:
Application
Filed:
February 11, 2011
Publication date:
March 7, 2013
Applicant:
DSM IP ASSETS
Inventors:
Cornelis Maria Jacobus Sagt, Margot Elisabeth Francoise Schoonneveld-Bergmans, Johannes Andries Roubos, Alrik Pieter Los
Abstract: The present invention relates to a cell suitable for production of one or more fermentation product from a sugar composition comprising glucose, galactose, arabinose and xylose, wherein the cell comprises two to fifteen copies of one or more xylose isomerase gene or two to fifteen copies of one or more xylose reductase and xylitol dehydrogenase, and two to ten copies of araA, araB and araD, genes, wherein these genes are integrated into the cell genome.
Type:
Application
Filed:
April 19, 2011
Publication date:
March 7, 2013
Applicant:
DSM IP ASSETS B.V.
Inventors:
Paul Klaassen, Bianca Elisabeth Maria Gielesen, Gijsberdina Pieternella Van Suylekom, Wilbert Herman Marie Heijne
Abstract: The present invention relates to a method to improve the secretion of a protein of interest by a filamentous fungal cell comprising inducing a phenotype in the cell selected from the group consisting of a lowered ERAD, an elevated UPR that does not induce an elevated ERAD, wherein ERAD preferably is lowered. The invention further relates to the filamentous fungal cell comprising the phenotype described above. The invention also relates to polynucleotides and polypeptides whose expression can be modulated in the filamentous fungal cell to obtain the above-described phenotype.
Type:
Grant
Filed:
October 31, 2007
Date of Patent:
March 5, 2013
Assignee:
DSM IP Assets B.V.
Inventors:
Cornelis Maria Jacobus Sagt, Cornelis Theodorus Verrips, Walraven Henry Muller, Noël Nicolaas Maria Elisabeth Van Peij
Abstract: The present invention relates to a method for preparing cyclohexanone from phenol in a first process, the first process being a cyclohexanone production process comprising hydrogenating phenol to form a product stream comprising cyclohexanone, phenol and side-products (RSP), including cyclohexanol and undesirable side-product; separating at least part of the product stream having a lower boiling point than cyclohexanone have been removed, into a first fraction comprising cyclohexanone and a second fraction comprising phenol, cyclohexanol and RSP, using distillation; and separating the second fraction into a third fraction, rich in cyclohexanol and comprising RSP, and a fourth fraction, rich in phenol and comprising RSP, using distillation. The invention further relates to an installation for carrying out a method of the invention.
Type:
Grant
Filed:
December 16, 2008
Date of Patent:
March 5, 2013
Assignee:
DSM IP Assets B.V.
Inventors:
Rudy Francois Maria Jozef Parton, Johan Thomas Tinge
Abstract: The invention relates to a flexible article having resistance against ballistic impacts wherein said article comprises a stack of at least two unconnected plies, each ply containing at least two connected monolayers containing polymeric tapes and wherein said monolayers are free of any matrix material.
Type:
Application
Filed:
May 2, 2011
Publication date:
February 28, 2013
Applicant:
DSM IP Assets B.V.
Inventors:
Roelof Marissen, Leonard Josef Arnold Nielaba
Abstract: The invention relates to a process for the catalytic conversion of a carbohydrate, an alcohol, an aldehyde or a polyhydroxy compound in the presence of a catalyst containing gold in a solvent.
Abstract: There is disclosed use of hyperbranched polyester amides as a foamer to stabilize mixtures of oil and water especially for mixtures found in gas and/or oil wells to facilitate extraction of the well contents.
Type:
Application
Filed:
November 25, 2010
Publication date:
February 21, 2013
Applicant:
DSM IP ASSETS B.V.
Inventors:
Stijn Witters, Franciscus Johannes Marie Derks
Abstract: There is disclosed a process for preparing organic nano-particles comprising the steps of: (a) preparing a solution comprising an unsaturated polyester and/or a vinyl ester resin and a hydrophobic monomer; (b) dispersing the solution obtained in step (a) in an aqueous phase to form a stable emulsion where the aqueous phase is the continuous phase; and (c) using an initiator to cure the emulsion obtained in step (b) in the presence of a water soluble inhibitor to form a dispersion of nano-particles. The invention further provides organic nano-particles obtainable by the process according to the invention; various uses of said nano-particles; such as in paper, dye, toner and personal care compositions and topical medicaments comprising said nano-particles.
Abstract: The invention relates to a method for preparing pelletized ammonium sulfate particles, the method comprising—providing ammonium sulfate crystals;—isolating a fraction comprising crystals having an intermediate size from crystals having a small size and from crystals having a large size, thereby obtaining remaining crystals comprised of crystals having small size and crystals having large size; and—pelletizing through a die at least part of the remaining crystals, i.e. at least part of the crystals from which the fraction comprising crystals having the intermediate size have been isolated, thereby forming pelletized ammonium sulfate particles.
Type:
Grant
Filed:
July 22, 2009
Date of Patent:
February 19, 2013
Assignee:
DSM IP Assets B.V.
Inventors:
Steven Huffman, James Franklin Parkinson, Justice Fine
Abstract: The invention relates to a host cell comprising at least four different heterologous polynucleotides chosen from the group of polynucleotides encoding cellulases, hemicellulases and pectinases, wherein the host cell is capable of producing the at least four different enzymes chosen from the group of cellulases, hemicellulases and pectinases, wherein the host cell is a filamentous fungus and is capable of secretion of the at least four different enzymes. This host cell can suitably be used for the production of an enzyme composition that can be used in a process for the saccharification of cellulosic material.
Type:
Application
Filed:
February 11, 2011
Publication date:
February 14, 2013
Applicant:
DSM IP ASSETS B.V.
Inventors:
Alrik Pieter Los, Cornelis Maria Jacobus Sagt, Margot Elisabeth Francoise Schoonneveld-Bergmans, Robbertus Antonius Damveld
Abstract: The present invention relates to a method for the production of atorvastatin having decreased levels of impurities of general formulae (3) and (4) by means of a concentrating step.
Abstract: The invention relates to a process for the production of cells which are capable of converting arabinose, comprising the following steps: a) Introducing into a host strain that cannot convert arabinose, the genes AraA, araB and araD, this cell is designated as constructed cell; b) Subjecting the constructed cell to adaptive evolution until a cell that converts arabinose is obtained, c) Optionally, subjecting the first arabinose converting cell to adaptive evolution to improve the arabinose conversion; the cell produced in step b) or c) is designated as first arabinose converting cell; d) Analysing the full genome or part of the genome of the first arabinose converting cell and that of the constructed cell; e) Identifying single nucleotide polymorphisms (SNP's) in the first arabinose converting cell; and f) Using the information of the SNP's in rational design of a cell capable of converting arabinose; g) Construction of the cell capable of converting arabinose designed in step f).
Type:
Application
Filed:
April 19, 2011
Publication date:
February 14, 2013
Applicant:
DSM IP ASSETS
Inventors:
Paul Klaassen, Bianca Elisabeth Maria Gielesen, Wilbert Herman Marie Heijne, Gijsberdina Pieternella Van Suylekom
Abstract: The present invention relates to a method for the production of atorvastatin having decreased levels of impurity (3) by means of a pH-controlling step.