Patents Assigned to E. R. Squibb & Sons
  • Method of reducing pre- and post-ischemic myocardial arrhythmias and fibrillation
    Patent number: 4931464
    Abstract: Zofenopril, fosinopril, (S)-1-[6-amino-2-[[hydroxy(4-phenylbutyl)phosphinyl]oxy]-oxohexyl]-L-proli ne or a pharmaceutically acceptable salt thereof alone or in combination with a thrombolytic, antiarrhythmic, or antifibrillatory agent is employed to reduce pre- and post- ischemic myocardial arrhythmias and fibrillations as well as reducing arrhythmias associated with congestive heart failure.
    Type: Grant
    Filed: February 15, 1989
    Date of Patent: June 5, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gary J. Grover, James L. Bergey
  • Method for preventing or treating anxiety employing an ACE inhibitor
    Patent number: 4931430
    Abstract: A method is provided for inhibiting onset of or treating anxiety by administering an ACE inhibitor, such as captopril, fosinopril, zofenopril or SQ 29,852, alone or in combination with a calcium channel blocker such as diltiazem or nifedipine, over a prolonged period of treatment.
    Type: Grant
    Filed: November 14, 1988
    Date of Patent: June 5, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Abraham Sudilovsky, Zola P. Horovitz
  • Post-ischemic myocardial dysfunction using thromboxane A.sub.2 antagonists
    Patent number: 4931460
    Abstract: A method is provided for improving post-ischemic myocardial dysfunction such as contractile dysfunction or reperfusion injury by administering a thromboxane A.sub.2 antagonist before, during or immediately after an ischemic attack.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: June 5, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gary J. Grover, Irvin E. Fulmor, III
  • Method of disposal of articles by flushing
    Patent number: 4930942
    Abstract: Flexible, soft objects such as ostomy pouches, wound dressings, bandages, diapers, etc. can be flushed down a conventional toilet by wrapping or enclosing the article within a material that rapidly becomes slimy or exudes a slimy material on contact with the water in a toilet bowl or by adding such materials directly to the bowl.
    Type: Grant
    Filed: October 11, 1988
    Date of Patent: June 5, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Denis E. Keyes, Marvin S. Aronoff
  • Method of treating skin injuries using thromboxane A.sub.2 receptor antagonists
    Patent number: 4925873
    Abstract: A method for treating skin injuries is provided by administering a thromboxane A.sub.2 receptor antagonist systemically or topically to the skin area to be treated.
    Type: Grant
    Filed: September 1, 1988
    Date of Patent: May 15, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Lawrence T. Friedhoff, Laura L. Bolton
  • Phosphorus-containing squalene synthetase inhibitors, new intermediates and method
    Patent number: 4924024
    Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## wherein Q is ##STR2## or a bond; Z is --(CH.sub.2).sub.n -- or --(CH.sub.2).sub.p --CH.dbd.CH--(CH.sub.2).sub.m --, wherein n is 1 to 5; p is 0, 1 or 2; m is 0, 1 or 2;R, R.sup.1 and R.sup.1a are the same or different and are H, lower alkyl or a metal ion; andR.sup.2 and R.sup.3 may be the same or different and are H or halogen.New intermediates used in preparing the above compounds and method for preparing same, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.
    Type: Grant
    Filed: June 1, 1989
    Date of Patent: May 8, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Scott A. Biller
  • Apparatus for tending a stoma
    Patent number: 4923452
    Abstract: The subject matter of the invention is an apparatus for tending a stoma comprising a base plate made of a hypoallergic material or of an adhesive film and a snap ring to which a bag for taking up the excreta is attached with a snap closure. The connection between the base plate and the snap ring is a flexible cylindrical connector piece of little height and a diameter which compared with the base plate is as large as possible. The three-dimensional connector piece extends normal to the base plate and may have also the form of a steep truncated cone.
    Type: Grant
    Filed: October 20, 1987
    Date of Patent: May 8, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Gerd Hunger
  • Apparatus for tending a stoma
    Patent number: 4917690
    Abstract: The subject matter of the invention is an apparatus for tending a stoma comprising a base plate made of a hypoallergic material or of an adhesive film and a self sustaining but flexible ring to which an adhesive bag for taking up the excreta is attached. The connection between the base plate and the ring is a flexible cylindrical connector piece of little height and a diameter which compared with the base plate is as large as possible. The three-dimensional connector piece extends normal to the base plate and may have also the form of a steep truncated cone.
    Type: Grant
    Filed: October 20, 1987
    Date of Patent: April 17, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Gerd Hunger
  • Purinyl and pyrimidinyl cyclobutanes and their use as antiviral agents
    Patent number: 4918075
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## its pharmaceutically acceptable salts thereof wherein R.sub.2 and R.sub.3 are independently hydrogen, --PO.sub.3 H.sub.2 or ##STR2## and R.sub.1 is either a purine, pyrimidine or an analog thereof.
    Type: Grant
    Filed: December 20, 1988
    Date of Patent: April 17, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert Zahler, Glenn A. Jacobs
  • Culpin
    Patent number: 4914245
    Abstract: Cultivation of a strain of the microorganism, Preussia sp., that has been deposited in the American Type Culture Collection as A.T.C.C. No. 20,923, yields a novel antibiotic substance, culpin, that has activity against a selected spectrum of microorganisms.
    Type: Grant
    Filed: April 5, 1989
    Date of Patent: April 3, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gordon W. Robinson, Joseph O'Sullivan, Edward Meyers, Jerry S. Wells, Janice H. Del Mar
  • Process for stereochemically inverting a hydroxy function of an ester by a modified Mitsunobu reaction process
    Patent number: 4912230
    Abstract: A process is provided for inverting a hydroxy function of a L-trans-hydroxy proline derivative to the corresponding L-cis-hydroxy proline sulfonate by a Modified Mitsunobu reaction process.
    Type: Grant
    Filed: September 16, 1988
    Date of Patent: March 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Neal G. Anderson, Christopher M. Cimarusti, David A. Lust
  • Process for preparing (trans)-4-phenyl-L-proline derivatives
    Patent number: 4912231
    Abstract: A process is provided for preparing (trans)-4-phenyl-L-proline derivatives with excellent stereospecificity, which are useful in preparing certain ACE inhibitors, which process involves reacting a proline derivative of the structure ##STR1## whereing R is a nitrogen protecting group, R.sub.1 is H, aryl, arylalkyl or lower alkyl, and X is a leaving group such as fluorine, an alkyl sulfonate, arylsulfonate or cycloalkyl sulfonate is reacted with an aromatic nucleophile, such as benzene, in the presence of a Lewis acid such as AlCl.sub.
    Type: Grant
    Filed: June 17, 1988
    Date of Patent: March 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David Kronenthal, Paula L. Kuester, Richard H. Mueller
  • Method for preventing or treating depression employing an ace inhibitor
    Patent number: 4912096
    Abstract: A method is provided for inhibiting onset of or treating depression by administering an ACE inhibitor, which is (S)-1-[6-amino-2-[[hydroxy-(4-phenylbutyl)phosphenyl]oxy]-1-oxohexyl]-L-pr oline, fosinopril or zofenopril, alone or in combination with an antidepressant drug such as lithium, over a prolonged period of treatment.
    Type: Grant
    Filed: June 26, 1989
    Date of Patent: March 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Abraham Sudilovsky
  • Wound dressing system
    Patent number: 4909243
    Abstract: A novel two-piece wound dressing, providing protection during dressing changes to the delicate healing skin directly surrounding the wound, is provided according to the present invention. The dressing comprises a baseplate having an adhesive surface for contacting surrounding skin, and has an aperture extending completely through it over which a wound pad of a desired wound dressing material can be placed. Means are also provided for attaching the wound pad to the baseplate.
    Type: Grant
    Filed: July 20, 1988
    Date of Patent: March 20, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Margaret A. Frank, Frank M. Freeman, George Cherry
  • Method of inhibiting leukotriene biosynthesis by oral administration of p-aminophenols or derivatives thereof
    Patent number: 4910208
    Abstract: A method is provided for inhibiting leukotriene biosynthesis and thus treating asthma, psoriasis or inflammation by oral administration of p-aminophenols having the structure ##STR1## wherein m is 0 to 5; X is CH or N; R.sup.1 and R.sup.2 may be the same or different and are H, lower alkyl, aryl, hydroxy, hydroxyalkyleneoxy, alkylthio, alkoxy, alkanoyloxy, aryloxy, halo, carboxy, alkoxycarbonyl or amido; R.sup.3 is H, lower alkyl, alkanoyl or aroyl; and R.sup.4 is H, lower alkyl, benzoyl or alkanoyl, and including acid-addition salts thereof, with the proviso that when R.sup.4 is benzoyl, R.sup.2 is other than H.
    Type: Grant
    Filed: February 19, 1988
    Date of Patent: March 20, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Raj N. Misra
  • Phenyl hydroxamic acids including a hetero-containing substituent
    Patent number: 4906667
    Abstract: Phenyl hydroxamic acids are disclosed having the general formula ##STR1## or a pharmaceutically acceptable salt thereof, wherein X is NR, oxygen, sulfur, ##STR2## or a single bond, and Y is NR, oxygen, sulfur, ##STR3## or a single bond, where R can be hydrogen or lower alkyl, g can be 1 or 2, and with the proviso that at least one of X and Y is other than a single bond; Z is aryl, aralkyl or cycloalkyl; R.sub.1 is hydrogen, substituted or unsubstituted lower alkyl, cycloalkyl, lower alkenyl or aryl; R.sub.2 is hydrogen, lower alkyl, aroyl or acyl; m is 0 to 4 carbon atoms; and, n is 0 to 4 carbon atoms further providing that if one of X or Y is oxygen, the other of X or Y must be oxygen and further that when X and Y are oxygen Z cannot be aralalkyl.These new compounds have been found to be inhibitors or arachidonic acid 5-lipoxygenase and are therefore useful as antiallergy agents and antipsoriatics.
    Type: Grant
    Filed: May 23, 1988
    Date of Patent: March 6, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Eric M. Gordon, Martin F. Haslanger
  • Heteroaroylhydrazide derivatives of monocyclic beta-lactam antibiotics
    Patent number: 4904775
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof and possessing antibacterial activity, and intermediates to compounds of formula I having the formula
    Type: Grant
    Filed: May 16, 1988
    Date of Patent: February 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph E. Sundeen, Peter H. Ermann
  • 4-diazo-3-methyl-2,5-cyclohexadine-1-one and pharmacetically acceptable salts thereof
    Patent number: 4904764
    Abstract: 4-Diazo-3-methoxy-2,5-cyclohexandien-1-one, and pharmaceutically acceptable salts thereof, are antibiotics having antibacterial activity against a variety of gram positive and gram negative bacteria, particularly against anaerobic bacteria. The compound can be prepared by culturing aerobically Penicillium funiculosum A.T.C.C. No. 20783 in a culture medium containing assimilable sources of carbohydrates and nitrogen.
    Type: Grant
    Filed: December 12, 1985
    Date of Patent: February 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Joseph O'Sullivan, Pushpa Singh
  • Phosphorus-containing HMG-COA reductase inhibitors
    Patent number: 4904646
    Abstract: Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have the structure ##STR1## including salts thereof, wherein R is OH, lower alkoxy or lower alkyl; R.sup.x is H or alkyl;X is --O-- or --NH--;n is 1 or 2Z is a hydrophobic anchor, such as ##STR2## wherein the dotted lines represent optional double bonds. New intermediates used in preparing the above compounds, pharmaceutical compositions containing such compounds and a method for using such compounds to inhibit cholesterol biosynthesis are also provided.
    Type: Grant
    Filed: April 18, 1988
    Date of Patent: February 27, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Donald S. Karanewsky, Scott A. Biller, Eric M. Gordon
  • Benzazepine and benzothiazepine derivatives
    Patent number: 4902684
    Abstract: Vasodilating activity is exhibited by compounds having the formula ##STR1## wherein X can be --S--or --CH.sub.2 --; andR.sub.2 is ##STR2##depending upon the definition of X.
    Type: Grant
    Filed: May 22, 1989
    Date of Patent: February 20, 1990
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David M. Floyd, John T. Hunt, Spencer D. Kimball, John Krapcho, Jagabandhu Das, George C. Rovnyak, Joel C. Barrish