Abstract: An outlet pipe or tap is secured to a liquid containing bag by trapping the bag outlet region between inner and outer nested funnels. A leak proof seal is provided by disposing an O-ring sealing means between the funnels and moving one funnel axially relative to the other.

Abstract: In accordance with the present invention an improved process for preparing resolved compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or acetyl.

Abstract: Novel cyclopropyl aza prostaglandin analogs are disclosed having the formula ##STR1## wherein A can be carbonyl, sulfonyl or a single bond. These compounds are useful, for example, as thromboxane antagonists.

Abstract: This process enables preparation of the preferred (+)-threo enantiomer by resolution of its racemic mixture of a compound of the formula ##STR1## wherein Y.sup.1 and Y.sup.2 are each independently lower alkyl and R.sup.1 is hydrogen or lower alkyl. The compound is treated with a chiral acid (tartaric aicd preferred) in an organic solvent (ethanol preferred) to yield the (+)-threo enantiomer, which is then recovered from the reaction mixture. This enantiomer may then be used to produce the preferred (+)-cis enantiomer of certain benzothiazepine cardiovascular agents.

Abstract: Compounds of the formula ##STR1## wherein Y is O or NH and X is ##STR2## will inhibit the action of neutral endopeptidase. As a result, such compounds produce diuresis, natriuresis, and lower blood pressure as well as being useful in the treatment of congestive heart failure, relieving pain, and diarrhea when administered to a mammalian host.

Abstract: An ostomy coupling has two co-operating coupling elements. One is for attachment to a medical grade adhesive and the other is for attachment to an ostomy pouch. Each element is of close loop form and includes a tapering member extending around a stomal orifice. Each such member tapers in a radially outward direction and has a flat surface located in a plane at right angles to the coupling axis. The coupling also has a means of clamping which can be tightened onto the tapering members to hold them together. When held their respective flat surfaces are in face-to-face arrangement. Hence, two coupling elements can be held together and released without the application of any axial pressure forces or pulling forces to the wearer of the ostomy appliance.

Abstract: Zofenopril, fosinopril, (S)-1-[6-amino-2-[[hydroxy (4-phenylbutyl) phosphinyl]oxy]-1-oxohexyl]-L-proline or a pharmaceutically acceptable salt thereof alone or in combination with a thrombolytic, antiarrhythmic, or antifibrillatory agent is employed to reduce pre-and post- ischemic myocardial arrhythmias and fibrillations as well as reducing arrhythmias associated with congestive heart failure.

Abstract: Componds having the formula ##STR1## and pharmaceutically acceptable salts thereof, exhibit antibacterial activity wherein R is ##STR2##

Abstract: Phenylsulfone alkenoic acids and derivatives thereof are provided which have the structure ##STR1## wherein Ar represents an aryl group including phenyl or naphthyl which may or may not include one or more substituents, X is COOR wherein R is hydrogen, alkali metal or lower alkyl or X is 5-tetrazolyl or ##STR2## wherein R' is lower alkyl or aryl; n is 2, 3 or 4 and m is 2, 3 or 4. These compounds are cardiovascular agents which exhibit thromboxane antagonist activity and thus are useful in the treatment of thrombotic and vasospastic disease.

Abstract: A process is provided for preparing a 7-oxabicycloheptane amino alcohol intermediate of the general structure ##STR1## (wherein the above structures represents (D) or (L) isomers)which is useful in preparing thromboxane A.sub.2 receptor antagonists. This intermediate is prepared by reacting mesanhydride with an aryl amine ##STR2## wherein R is alkyl, CH.sub.2 OH, CO.sub.2 H or CO.sub.2 alkyl, to form the acid ##STR3## which is reduced by treatment with lithium aluminum hydride or diisobutylaluminum hydride or Red-Al to form the alcohol ##STR4## wherein R.sup.1 is CH.sub.2 OH when R is CO.sub.2 H, CO.sub.2 alkyl or CH.sub.2 OH, and R.sup.1 is alkyl when R is alkyl; where in the above alcohol R.sup.1 is CH.sub.2 OH, such alcohol compound is treated with an alkyl chloroformate in the presence of base such as an alkali metal alkoxide to form the alcohol ##STR5## which undergoes cleavage by treatment with alkali metal, ammonia and acid to form the amino alcohol intermediate.Where in the above alcohol R.sup.

Abstract: Novel compounds of the formula ##STR1## exhibit calcium channel blocking activity and are useful as cardiovascular agents.

Abstract: An ostomy coupling has a pair of coupling rings. The body side ring has a flange attached to a medical grade adhesive pad and a chute wall surrounding a stomal aperture. The bag side ring has a rib member and a seal strip. To provide easy disengagement, the bag side ring has an integral flexible latching arm having a hook portion positioned to engage under a hook flange on the body side ring when the rings are coupled. The hook portion is disengagable from the hook flange by a lifting movement of the latching arm.

Abstract: A bioadhesive composition is provided which may be employed as an oral drug delivery system and includes a freeze-dried polymer mixture formed of the copolymer poly(methyl vinyl ether/maleic anhydride) and gelatin, which is dispersed in an ointment base such as mineral oil containing dispersed polyethylene. Such bioadhesive compositions may be used to deliver oral mucosa active ingredients such as steroids, anti-fungal agents, anti-bacterial agents and the like.

Abstract: The crystalline anhydrous form of [3S-[3.alpha.(Z), 4.beta.]]-3-[[(2-amino-4-thiazolyl) [(1-carboxy-1-methylethoxy)imino]acetyl]amino]-4-methyl-2-oxo-1-azetidines ulfonic acid is prepared.

Abstract: Vasodilating activity is exhibited by compounds having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein X is --CH.sub.2 -- or --S--;R.sub.1 is ##STR2## or --O--Y.sub.3 ; R.sub.2 is heterocyclo or heteroaryl;R.sub.3 and R.sub.4 are each independently hydrogen, halogen, alkyl, alkoxy, aryloxy, arylalkoxy, arylalkyl, cyano, hydroxy, alkanoyloxy, ##STR3## fluoro-substituted alkoxy, fluoro-substituted alkyl, (cycloalkyl)alkoxy, --NO.sub.2, --NY.sub.10 Y.sub.11, --S(O).sub.k alkyl, --S(O).sub.k aryl ##STR4## n is 0, 1, 2 or 3; m is 0, 1, 2 or 3;k is 0, 1 or 2;Y.sub.1 and Y.sub.2 are each independently hydrogen or alkyl; or Y.sub.1 is hydrogen and Y.sub.2 is alkenyl, alkynyl, aryl, heteroaryl, or cycloalkyl; or Y.sub.1 and Y.sub.2, together with the carbon atom to which they are attached, are cycloalkyl;Y.sub.3 is hydrogen, alkyl, alkanoyl, alkenyl, arylcarbonyl, heteroarylcarbonyl, or ##STR5## Y.sub.8 and Y.sub.9 are each independently hydrogen, alkyl, aryl, or heteroaryl; or Y.sub.

Abstract: A three part filter is provided for attachment to an ostomy bag. One part includes a synthetic plastics base member having a central aperture and one flat surface whereby the filter can be attached to the bag wall. There are two walls upstanding from the other side of the base member to define a channel. The inner wall defines a shallow recess. The second part is a pad of filtering medium. The third part is a lid member of synthetic plastics material, with apertures through its top wall; the lid being a snug push fit within the channel. With this arrangement the lid member is readily removable to allow replacement of the filter pad.

Abstract: A member in the form of an overfilm or molded housing affixed to the pouch wall has a plurality of isolated vent passages. A separate filter assembly is situated in each of the passages. Adhesive coated covers are situated to obstruct the flow through all but a selected one of the passages. After the filter in the unobstructed passage has lost its effectiveness, the cover is removed from another passage and placed over the passage containing the used filter to obstruct same. The filter in each passage is used, in turn, by appropriate movement of the cover, until all of the filters have been used.

Abstract: Antibiotic activity is exhibited by .beta.-lactams having an ##STR1## substituent (and analogs thereof) in the 1-position and an acylamino substituent in the 3-position.

Abstract: The housing is mounted on and sealed around an opening in the pouch wall. The disc-like base of the housing has a central, axially extending entrance passageway aligned with the pouch opening. A portion of the base extends radially outwardly beyond the seal and has a second axial passageway therethrough. The cover of the housing defines a filter receiving recess aligned with the entrance passageway. The recess has a connecting channel extending radially therefrom. The cover is removably mounted on the base for relative rotational movement between a first position in which the connecting channel aligns with the exit passageway, so as to permit venting of the gases from the pouch, and a second position wherein the connecting channel is out of alignment with the exit passageway, closing the vent.

Abstract: A process is provided for preparing (trans)-4-phenyl-DL-proline derivatives, which are useful in preparing certain angiotensin converting enzyme inhibitors, which process involves reacting an ester of the structure ##STR1## wherein X is a leaving group such as tosylate, R.sup.3 is lower alkyl, R is cyclohexyl, phenyl or substituted phenyl, and R.sup.1a is a protecting group, with a potassium amide base such as potassium hexamethyldisilazide under reduced temperatures to form the trans-4-substituted proline ester derivative of the structure ##STR2## then hydrolyzing the proline ester to the acid of the structure ##STR3## and removing the R.sup.