Patents Assigned to E. R. Squibb & Sons
  • Ostomy bag including a multiple layer filter
    Patent number: 5074851
    Abstract: A bag or pouch for receiving discharge from the human body is made of two superposed sheets of synthetic plastics material joined around their edges and has a filter attached to an upper part of an interior surface of one of the walls, there being a hole or slit in the wall to allow gases exiting the filter to pass to the exterior of the bag or pouch, and an intervening wall is included to separate the filter region from the remainder of the interior of the bag or pouch, said wall being characterized by having a series of scattered holes therein, there being from 100 to 300 holes per square inch (155000 to 465000 holes per square meter) and each hole having a maximum dimension of from 130 to 340 microns.
    Type: Grant
    Filed: July 3, 1990
    Date of Patent: December 24, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ronald A. Plass, Gerald T. Whiting, Peter L. Steer
  • Process for preparing highly substituted phenyls
    Patent number: 5072023
    Abstract: A process is described in which a lactone ##STR1## is reacted with an alkylester X.sup.1 --CH.sub.
    Type: Grant
    Filed: February 15, 1990
    Date of Patent: December 10, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Jeffrey A. Robl
  • Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use
    Patent number: 5070099
    Abstract: Arylthioalkylphenylcarboxylic acids are provided which have the structure ##STR1## wherein Ar represents an aryl group including phenyl or naphthyl which may or may not include one or more substituents, X is COOR where R is hydrogen, alkali metal, or lower alkyl, or X is 5-tetrazolyl or ##STR2## wherein R.sup.1 is lower alkyl or aryl, p is 1 to 5, and m is 1 to 4. These compounds are cardiovascular agents which exhibit thromboxane antagonist activity and thus are useful in the treatment of thrombotic and vasospastic diseases.
    Type: Grant
    Filed: February 4, 1991
    Date of Patent: December 3, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Steven E. Hall, Philip D. Stein
  • Boronic acid adducts of technetium-.sup.99m dioxime-imine complexes
    Patent number: 5069900
    Abstract: Boronic acid adducts of technetium-.sup.99m imine-dioxime complexes are useful for imaging the myocardium, hepatobiliary system, brain and blood pool in humans and other mammalian species.
    Type: Grant
    Filed: August 28, 1989
    Date of Patent: December 3, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karen E. Linder
  • Pyranyl quinoline calcium channel blockers
    Patent number: 5070088
    Abstract: Novel calcium channel blockers having the formula ##STR1## wherein X is oxygen or sulfur and wherein R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 are as defined herein, are disclosed. These compounds are useful, for example, as anti-ischemic agents.
    Type: Grant
    Filed: December 19, 1989
    Date of Patent: December 3, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Certain (2-carboxy or 2-propenoic or 2-carbonyl)-3-halo-4,5-dioxy pyridine intermediates and the corresponding 1,4-dihydro-4-pyridones)
    Patent number: 5068331
    Abstract: Compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof, exhibit antibacterial activity wherein R is ##STR2##
    Type: Grant
    Filed: July 13, 1990
    Date of Patent: November 26, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Uwe D. Treuner
  • Method of preventing or reducing adverse reactions to protamine using a thromboxane A.sub.2 receptor antagonist
    Patent number: 5066480
    Abstract: A method is provided for preventing reducing or reversing adverse reactions, such as pulmonary hypertension produced when protamine interacts with heparin, by administering a thromboxane A.sub.2 receptor antagonist.
    Type: Grant
    Filed: April 11, 1988
    Date of Patent: November 19, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Martin L. Ogletree, William A. Schumacher, Gary J. Grover, Lawrence T. Friedhoff
  • Process for preparing an optically active cyclobutane nucleoside
    Patent number: 5064961
    Abstract: A process for the preparation of the optically active compound [IR-(1.alpha., 2.beta., 3.alpha.)]-2-amino-9-[2,3-bis(hydroxymethyl)cyclobutyl]-6H-purin-6-one, represented by the formula: ##STR1## and novel intermediates are described.
    Type: Grant
    Filed: December 18, 1989
    Date of Patent: November 12, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Gregory S. Bisacchi, Toomas Mitt
  • Substituted cyanoimino benzopyranes
    Patent number: 5061813
    Abstract: Novel compounds are disclosed having the formula ##STR1## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are as defined herein. These compounds are useful, for example, as cardiovascular agents and especially as anti-ischemic agents.
    Type: Grant
    Filed: April 2, 1990
    Date of Patent: October 29, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Karnail Atwal
  • Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor
    Patent number: 5061694
    Abstract: A method is provided for slowing the progression of atherosclerosis in coronary arteries in hypertensive or normotensive patients and reducing or eliminating atherosclerotic lesions in such patients in a mammalian species by administering an ACE inhibitor, especially one containing a mercapto moiety, such as captopril or zofenopril.
    Type: Grant
    Filed: October 23, 1989
    Date of Patent: October 29, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: A. K. Gunnar Aberg, Patricia Ferrer, Miguel A. Ondetti
  • Method of preparing adhesive dressings containing a pharmaceutically active ingredient
    Patent number: 5059189
    Abstract: A dressing comprising a flexible backing member and a pressure sensitive adhesive layer. The adhesive layer comprises one or more polyisobutylenes, elastomers, and one or more moisture absorbing, moisture transmitting, water soluble and/or water swellable agents. A dispersion of the active ingredient in a medium compatible with the adhesive layer is laminated to the skin contacting surface.
    Type: Grant
    Filed: September 8, 1987
    Date of Patent: October 22, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rodolfo D. Cilento, Margaret A. Frank, John E. Fairbrother, Frank M. Freeman
  • Purinyl tetrahydrofurans
    Patent number: 5059690
    Abstract: Antiviral activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1 is a purine or pyrimidine base or an analog thereof and R.sub.2 and R.sub.3 are independently hydrogen, --PO.sub.3 H.sub.2 or ##STR2## wherein X.sub.7 is hydrogen, alkyl, substituted alkyl or aryl.
    Type: Grant
    Filed: May 1, 1990
    Date of Patent: October 22, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Robert Zahler, Joseph A. Tino
  • N-morpholino derivatives and their use as anti-hypertensive agents
    Patent number: 5055466
    Abstract: Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.
    Type: Grant
    Filed: December 14, 1989
    Date of Patent: October 8, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Harold N. Weller, III, Denis E. Ryono
  • Process for benzazepine intermediates
    Patent number: 5053504
    Abstract: A process is disclosed for providing benzazepine intermediates of the formulae ##STR1## wherein R.sub.3, R.sub.4 and Y are as defined herein, which intermediates are useful in a process for the preparation of pharmaceutically useful benzazepine derivatives.
    Type: Grant
    Filed: November 29, 1989
    Date of Patent: October 1, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Wen-Sen Li, John K. Thottathil, Michael Murphy
  • 1-aroyl or 1-acyl-2-2pyrrolidinyl-3,5-dihydroxy alkanoic and alkenoic acids, salts, esters and lactones
    Patent number: 5049578
    Abstract: Antihypercholesterolemic activity is exhibited by novel compounds of the formula ##STR1## wherein: Z is ##STR2## X is lower alkyl or lower alenyl; R.sup.1 is aryl or alkyl;R.sup.2 and R.sup.3 are the same or different and are hydrogen, or lower alkyl or aryl, or R.sup.2 and R.sup.3 taken together to form a cycloalkyl group; andR.sup.4 is hydrogen, lower alkyl, or alkali metal (such as sodium, lithium, or potassium) or a radical such as ammonium.Methods of use and novel intermediates of these compounds are also provided.
    Type: Grant
    Filed: March 9, 1990
    Date of Patent: September 17, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Eric M. Gordon
  • Pharmaceutical composition containing high drug load and method for preparing same
    Patent number: 5049394
    Abstract: A pharmaceutical composition in the form of beads prepared by an extrusion-spheronization technique and containing more than 80% by weight drug, less than 15% by weight non-lipophilic binder-plasticizer, such as microcrystalline cellulose to achieve required plasticity for processing, a starch-based excipient such as sodium starch glycolate or pregelatinized starch to control water/fluid distribution and thereby inhibit agglomeration during processing, and water-soluble binder such as hydrolyzed gelatin to make the final beads less friable. During processing a granulating agent such as ethanol/water is added to improve blend properties and control during spheronization. A method for preparing the above beads is also provided.
    Type: Grant
    Filed: March 15, 1989
    Date of Patent: September 17, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John R. Howard, Anne M. Delargy
  • Method for preventing or treating symptoms resulting from closed head injuries employing an ace inhibitor
    Patent number: 5049553
    Abstract: A method is provided for preventing onset of or treating symptoms resulting from closed head injuries, in hypertensive or normotensive patients, by administering an ACE inhibitor, for example captopril, zofenopril, fosinopril, ceranapril, enalapril or lisinopril.
    Type: Grant
    Filed: January 4, 1990
    Date of Patent: September 17, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Abraham Sudilovsky
  • 2-pyrrolidone substituted dihydroxy alkanoic, alkenoic and alkynoic acids, compositions and HMG-CoA reductase inhibition therewith
    Patent number: 5049577
    Abstract: Antihypercholesterolemic activity has been discovered in compounds of the formula ##STR1## and pharmaceutically acceptable salts thereof, wherein: Z is ##STR2## X is lower alkyl, lower alkenyl, or lower alkenyl; R.sup.1 is hydrogen, alkyl, alkenyl, aryl, alkylaryl, or substituted aryl having one or more substituents; andone of R.sup.2 and R.sup.3 is hydrogen and the other is hydrogen, alkyl, alkenyl, aryl, alkylaryl or alkenyl aryl; or R.sup.2 and R.sup.3 are both lower alkyl; or R.sup.2 and R.sup.3 together complete a substituted or unsubstituted hydrocarbon ring that is cycloalkyl or cycloalkenyl with substituents as defined in the specification.
    Type: Grant
    Filed: January 29, 1990
    Date of Patent: September 17, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ravi K. Varma, Eric M. Gordon, Sam T. Chao
  • Derivatives of pravastatin for inhibiting cholesterol biosynthesis
    Patent number: 5047549
    Abstract: Derivatives of pravastatin are provided which are useful in inhibiting cholesterol biosynthesis and in preparing radiolabeled compounds useful in the radioimmunoassay (RIA) of pravastatin and derivatives thereof. The pravastatin derivatives have the structure ##STR1## wherein R is hydroxy, lower alkylamine, arylamine, arylalkylamine or heterocyclic alkylamine such as histamine, tyramine, O-benzyltyramine, methyl tyrosinate as well as iodinated derivatives thereof.
    Type: Grant
    Filed: April 17, 1989
    Date of Patent: September 10, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Richard A. DiPietro, Jan-I Tu, Noor Z. Turabi
  • Ostomy coupling
    Patent number: 5041102
    Abstract: A coupling element system for an ostomy bag including a bag-side coupling element having a stomal orifice surrounded by a channel shaped member, a body-side coupling element having a stomal orifice surrounded by a rib-like member which can make snap-fit engagement with the channel shaped member, and a locking member. The latter member has radially inwardly deformable arms and is rotatable relative to the body-side coupling. The deformable arms are shaped and positioned so that upon rotation of the locking member in one rotary direction relative to the body-side coupling element they are deformed radially inwardly and over-lie a portion of the bag-side coupling element.The locking member may be generally annular with the arms arcuate in shape each with a blade portion and a leg portion which connects the blade portion to the remainder of the locking member.
    Type: Grant
    Filed: January 18, 1990
    Date of Patent: August 20, 1991
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Peter L. Steer, David J. Auld