Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.

Abstract: A method for obtaining spectral imaging data comprises at least the steps of receiving a sample set of data generated by sampling a spectral property of an image of an object in a spatial basis, wherein the sampling of the spectral property of the image of the object comprises providing a Spectral Filter Array (SFA) by arranging a plurality of SFA elements together to form a surface; configuring each SFA element of the plurality of SFA elements to filter one or more spectral bandwidths centered each at specific wavelengths corresponding to that SFA element, whereby all of the plurality of SFA elements taken together cover a determined spectral range; and setting the specific wavelengths of each SFA element of the plurality of SFA elements on the surface such to obtain a uniform and aperiodic spatial distribution of all of the plurality of SFA elements across the surface.

Abstract: The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

Abstract: A soliton generation apparatus comprising: an optical resonator; a pumping laser for providing light at a pumping wavelength into the optical resonator; a generator for generating multiple solitons in the optical resonator; a detuning device for changing the wavelength detuning between the pumping laser wavelength and an optical resonance wavelength of the optical resonator to remove at least one soliton of the generated multiple solitons to provide (i) a plurality of solitons that comprises at least one less soliton than that of the generated multiple solitons or (ii) a single soliton in the optical resonator.

Abstract: An aerial vehicle, configured to transport cargo, and including a propulsion system and a foldable cage is described. The foldable cage is substantially linear while in a folded configuration, and substantially circular while in a deployed configuration. Moreover, the foldable cage includes a rods that form isosceles triangles. The rods are coupled together by flexible joints.

Abstract: A device for collimation or focusing of a relativistic electron packet, obtained in particular by laser-plasma acceleration, including a gas cloud and a laser capable of emitting a laser pulse focused in the gas cloud in order to create therein a wave of focusing electric and magnetic fields. The invention also relates to a device for emission of a collimated or focused relativistic electron packet. The invention further relates to a collimation or focusing method for a relativistic electron packet, and to methods for emission of a collimated or focused relativistic electron packet.

Abstract: An actuator device including a plurality of transducer actuators, and a common pneumatic actuation mechanism for shaping the plurality of transducer actuators, wherein each actuator of the plurality of transducer actuators includes a shape memory polymer membrane, an integrated stretchable heater, and a pressure interface to the common pneumatic actuation mechanism.

Abstract: A plasma thruster includes extraction of a stream of positive ions. The plasma thruster includes a single ionization stage; injecting ionizable gas for said ionization stage comprising injecting a first gas and an electronegative second gas; creating an RF electric field to cause the gases to ionize in the ionization stage creating a first zone called the hot zone, in the ionization stage; the first gas being distributed in the hot first zone, the second gas being distributed in a second zone less hot than said first zone; extracting a stream of negative ions and a stream of positive ions, these being both connected to the ionization stage; and the extraction of a stream of positive ions and the extraction of a stream of negative ions, ensuring that the thruster is electrically neutral.

Abstract: An active skull replacement system including an implant having an area A, an upper surface, and a bottom surface, adapted to be implanted at least in part into a skull of a subject so to substitute a portion of the skull, the bottom surface arranged to face at least in part a cranial cavity, and having a first wireless bidirectional data communication device, a device operably connected to the bottom surface of the implant, the device adapted to at least one of stimulate a physiological response and record a physiological parameter of the subject, and an external reader adapted to be placed on the scalp of the subject and including a second wireless bidirectional data communication device configured to communicate with the first wireless bidirectional data communication device of the implant to operate the device, wherein the external reader and the implant are fixed and aligned among each other through a magnetic device.

Abstract: Gas sensor (2) for measuring properties of a gas (1), including a gas viscosity sensor (4) comprising a gas interface portion (20) in contact with the gas (1) to be measured, and a measuring chamber system (15) comprising a measuring chamber (16), a first resistive passage (18) fluidically connecting the measuring chamber (16) to the gas interface portion (20), a pressure generator (25) configured to generate a change in pressure in the measuring chamber, and a pressure sensor (28) configured to measure a time dependent variation in pressure of gas in the measuring chamber, the time dependent variation of pressure in the measuring chamber due to flow of gas through the resistive passage being correlated to a viscosity of the gas.

Abstract: The present invention concerns a method of segmenting a media item comprising media elements.

Abstract: The present invention relates to a novel method for preparing triazenes. Further, the invention relates to novel triazenes and the use of N2O for preparing a compound comprising a triazene group. Further, the invention relates to the use of the novel triazenes as a medicament, in particular in the treatment of cancer.

Abstract: The present invention relates to engineered extra-cellular vesicle internalizing receptors that have the ability to enhance uptake, processing, and presentation to T-cells of tumor-associated antigens by an antigen-presenting cell. It further relates to vectors or antigen presenting cells expressing said receptors, composition and uses thereof for the prevention and/or treatment of a cancer.

Abstract: A method for creating isotopes using laser beams, including the steps: 1) placing a target under plasma conditions, 2) bombarding the target under plasma conditions with particles generated using a bundle of laser beams, the bundle of laser beams being synchronized with the development of the plasma conditions, the fuel and the particles being selected in such a way that the interaction between the target under plasma conditions and the particles generates nuclear reactions, and 3) recovering the isotopes generated by the nuclear reactions.

Abstract: A tunneling field effect transistor for light detection, including a p-type region connected to a source terminal, a n-type region connected to a drain terminal, an intrinsic region located between the p-type region and the n-type region to form a P-I junction or an N-I junction with the n-type region or the p-type region, respectively, a first insulating layer and a first gate electrode, the first gate electrode covering a portion of the intrinsic region on one side, and a second insulating layer and a second gate electrode, the second insulating layer and the second gate electrode covering an entire other side of the intrinsic region opposite to the one side, wherein an area of the intrinsic region that is not covered by the first gate electrode forms a non-gated intrinsic area configured for light absorption.

Abstract: Single- or multilayered coating, such as a selective solar absorber coating or a coating being part of an integrated electronic circuit, comprising one or more layers containing germanium (Ge) doped VO2+x, where ?0.1?x?0.1.

Abstract: Ionic polymers (IP) are made of anions and a polymeric backbone containing cations. The ionic polymers are incorporated in membranes or attached to solid supports and use of the ionic polymers in processing of biomass.