Abstract: A system and method of coupling a Branch Target Buffer (BTB) content of a BTB with an instruction cache content of an instruction cache. The method includes: tagging a plurality of target buffer entries that belong to branches within a same instruction block with a corresponding instruction block address and a branch bitmap to indicate individual branches in the block; coupling an overflow buffer with the BTB to accommodate further target buffer entries of instruction blocks, distinct from the plurality of target buffer entries, which have more branches than the bundle is configured to accommodate in the corresponding instruction's bundle in the BTB; and predicting the instructions or the instruction blocks that are likely to be fetched by the core in the future and fetch those instructions from the lower levels of the memory hierarchy proactively by means of a prefetcher.

Abstract: A navigation system including a vehicle dynamic model (VDM) that serves as the main process model within a navigation filter is described. When used in an unmanned aerial vehicle (UAV), the navigation system may work in communication with inertial measurement units (IMUs) and environment dependent sensors such as GNSS receivers. Particularly, the navigation system is beneficial in the case of GNSS signal reception outages, where conventional IMU coasting drifts quickly. Yet, the navigation system may also be employed in other scenarios, for example during GNSS presence for improved positioning, velocity and attitude determination, or in combination with GNSS when no IMU is available by design or due to a failure. In the navigation system, a solution to VDM equations provides an estimate of position, velocity, and attitude, which can be updated within a navigation filter based on available observations, such as IMU data or GNSS measurements.

Abstract: It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.

Abstract: A routing architecture for fast interconnections between Look-Up Tables (LUTs) in a group of Basic Logic Elements (BLEs), whereby a size of the group ranges from 1 to k+1, where k is the number of inputs of a LUT, and LUTs in the group are indexed from 1 to k+1, and whereby (a) an output of a LUTi, 1?i?k, connects to one of the inputs of routing multiplexers of LUTj, i<j?k+1, hence creating a fast interconnection between LUTs, each routing multiplexer of LUTm, 2?m?k+1, has only one input that is connected to the output of an other LUT, the output of LUT(k+1) being devoid of any connection to any one of the inputs of the routing multiplexers; (b) a subset of the inputs of LUT1 are connected to the outputs of other LUTs by means of fast interconnections, leaving the remaining inputs of LUT1 free of any fast interconnection, whereby for LUTp, 2?p?k+1, p?1 inputs of the LUTp are connected to the outputs of LUTq, 1?q?j, by means of fast interconnections; and (c) a cluster-based logic block contains at least one

Abstract: A bending compensation device for a waveguide, including a direction changing device configured to maintain a constant bending angle to the waveguide, a distal end of the waveguide having a first orientation, and the proximal end of the waveguide having a second orientation, and a motion device connected to the direction changing device, the motion device configured to move the direction changing device upon a movement of the waveguide.

Abstract: The present invention relates to a bicyclic inhibitor of the coagulation enzyme activated factor XII (FXIIa) comprising or consisting of the peptide) (X1)(X2)(X3)n(X4)RL(X5)(X6)m(X7)(X9)l(X10)(X11)(X12)(X13)(X14)k(X15)(X16), wherein (X1) is present or absent and, if present, is an amino acid; (X2) is an amino acid with a side chain; (X3) is an amino acid and n is between 0 and 3, preferably 0 or 1 and most preferably 0; (X4) is an aliphatic L-amino acid or a cyclic L-amino acid, preferably L, P or an aromatic L-amino acid, and most preferably an aromatic L-amino acid; (X5) is an amino acid; (X6) is an amino acid and m is between 0 and 3, preferably 0 or 1 and most preferably 0; (X7) is an amino acid with a side chain; (X9) is an amino acid and l is between 0 and 3, preferably 0 or 1 and most preferably 0; (X10) is an amino acid; (X11) is an amino acid, preferably Q; (X12) is a hydrophobic L-amino acid, preferably an aliphatic L-amino acid, and is most preferably L; (X13) is an amino acid; (X14) is an amino ac

Abstract: The invention relates to the field of in vitro detection methods using luminescence. Provided is a sensor molecule for detecting an analyte of interest in a sample using bioluminescence resonance energy transfer (BRET), the sensor molecule comprising a proteinaceous moiety tethered to a synthetic regulatory molecule. Also provided is an analytical device comprising a sensor and methods using the sensor molecule.

Abstract: Provided herein is a cell encapsulation device comprising an internal chamber suitable for holding biological agents, wherein the internal chamber is disposed between a first semipermeable layer and a second semi-permeable layer, and the first and second semi-permeable layers are mounted on a supporting frame surrounding a perimeter of the internal chamber; wherein the supporting frame comprises a first frame element and a second frame element, and the first and second frame elements co-operate to position the first and second semipermeable layers at a predetermined separation distance between the layers.

Abstract: A method for modifying an audio scene and/or presenting additional information relevant to the audio scene includes capturing audio signals from the audio scene with a plurality of microphones; outputting an audio signal with a plurality of acoustical transducers; processing the captured audio signals, where the processing comprises one or more of filtering, equalization, echoes processing, and beamforming; separating and distinguishing audio signal sources using the processed audio signals; selecting at least one separated audio signal source; classifying the at least one selected separated audio signal source; retrieving additional information related to the classified audio signal source; and presenting the additional information in a perceptible form.

Abstract: The subject of the present invention is a microfluidic circuit in which are defined microchannels able to contain fluids and including at least one device for forming drops of a solution, guiding the drops to a storage zone in which one of the drops can be brought into contact with a drop of another solution, the walls of the microchannel portion forming the first drop-formation device diverging so as to cause drops of the first solution to detach under the effect of the surface tension of the first solution; the first guide include wall portions of the microchannels that diverge so as to cause the drops to move along under the effect of the surface tension of the first solution.

Abstract: The invention is related to a method allowing a prover holding a secret key (x) to prove its identity to a verifier and to prove to this verifier that he is within a predetermined distance of this verifier, said method comprising an initialization phase during which: the prover picks a first nonce (Np) and communicates this first nonce to the verifier; the verifier picks a first random vector (a), a leak function (L?), and a second nonce (Nv); the verifier uses said leak function (L?) to compute a modified secret (x?) depending on the leak (L?(x)) of said secret; the verifier transmits to said prover said leak function and said second nonce; the prover retrieves said first random vector and said modified secret, wherein said first random vector and said modified secret are used by said prover for computing responses (ri) to challenges (ci).

Abstract: The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

Abstract: A system for the treatment of Alzheimer's disease is provided by moving cerebrospinal fluid containing particles know to contribute to onset of Alzheimer's disease from a source of cerebrospinal fluid to the stomach or bladder, where the particles are safely digested by gastric acid or excreted, the system including an implantable pump, an inlet catheter, an outlet catheter, and a one-way valve. The system further includes at least one filter to filter harmful particles from the cerebrospinal fluid and return the filtered cerebrospinal fluid back to the source of cerebrospinal fluid, where the harmful particles blocked by the filter may be rinsed off the filter and transported to the stomach or bladder.

Abstract: A method for the low-temperature production of radial electronic junction semiconductor nanostructures on a substrate, includes: a) forming on the substrate, metal aggregates capable of electronically doping a first semiconductor material; b) growing, in the vapor phase, doped semiconductor nanowires in the presence of one or more non-dopant precursor gases of the first semiconductor material, the substrate being heated to a temperature at which the metal aggregates are in the liquid phase, the growth of the doped semiconductor nanowires in the vapor phase being catalyzed by the metal aggregates; c) rendering the residual metal aggregates inactive; and d) the chemical vapor deposition, in the presence of one or more precursor gases and a dopant gas, of at least one thin film of a second semiconductor material so as to form at least one radial electronic junction nanostructure between the nanowire and the at least one doped thin film.

Abstract: A method and apparatus for local beam processing using a beam activated gas to etch material are described. Compounds are disclosed that are suitable for beam-induced etching. The invention is particularly suitable for electron beam induced etching of chromium materials on lithography masks. In one embodiment, a polar compound, such as ClNO2 gas, is activated by the electron beam to selectively etch a chromium material on a quartz substrate. By using an electron beam in place of an ion beam, many problems associated with ion beam mask repair, such as staining and riverbedding, are eliminated. Endpoint detection is not critical because the electron beam and gas will not etch significantly the substrate.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

Abstract: The present invention relates to an infrared absorption spectroscopy apparatus including an infrared transparent substrate comprising a first and second surface, an array of plasmonic nano-antennas arranged on the first surface of the infrared transparent substrate, a flow cell for holding a liquid to allow spectroscopy measurements in a liquid environment, the array of plasmonic nano-antennas being located inside the flow cell, an optical source providing an incident light probe signal incident on at least a part of the array of plasmonic nano-antennas via the second surface of the infrared transparent substrate, and an optical element to collect reflected light signal reflected by said part of the array of plasmonic nano-antennas.

Abstract: Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an external physician controller. The implantable stimulation unit has an array of electrodes disposed on one or more flexible substrates configured to conform to a patient's anatomy at the pelvic plexus. Post-implantation, the physician controller may direct the stimulation unit to stimulate with select electrode(s) of the array to determine which electrode configuration provides optimal sexual arousal. The patient controller may be used to cause the stimulation unit to stimulate using the optimal electrode configuration at desired times.

Abstract: System and methods for computing true wind and true current are described. True wind estimation occurs through automatic calibration of data obtained from data acquisition devices (102, 114, 116, 118, 120). Real-time boat performance information is generated through automatic target speed computation. Maneuvers are found in data obtained from the data acquisition devices (102, 114, 116, 118, 120) and, if properly calibrated, wind just prior to a maneuver should be the same as measured wind just after the maneuver. If the measured wind values are not equal, the sum of the wind difference over all maneuvers is minimized.