Abstract: Resistive random access memory (RRAM) based multiplexers and field programmable gate arrays (FPGAs) are provided. The RRAM-based multiplexers and FPGAs include a 4T1R programming structure to program the RRAMs. The programming structure includes two programming transistors connected between the power supply and the top electrode of the RRAM and two programming transistors connected between the power supply and the bottom electrode of the RRAM. The programming transistors are used to set and rest the RRAMs. In the RRAM-based multiplexer programming transistors connected to the bottom electrodes are shared between a plurality of RRAMs. The shared programming transistors and an output inverter of the RRAM are provided in a deep N-well of the RRAM-based multiplexer. The programming transistors connected to the top electrodes of the RRAMs and a plurality of input inverters are provided in a regular well of the RRAM-based multiplexer.

Abstract: Block copolymers containing charged blocks or chemical moieties sensitive to oxidation or hydrolysis have been developed. We describe the use of such block copolymers in supramolecular structures, e.g., micelles or vesicles, and pharmaceutical compositions and in methods of preparing the supramolecular structures and pharmaceutical compositions. The invention is particularly useful for the delivery of pharmaceutical agents, e.g., nucleic acids, to cells.

Abstract: The present invention relates to a reflective optical objective (1) comprising: —a first reflecting element (3) including a front surface (3a) and a hack surface (3b), the front surface (3a) including a convex reflecting surface (11); and —a second reflecting element (5) including a concave reflecting surface (13) facing the convex reflecting surface (11) of the first reflecting element (3), the second reflecting element (5) including a transmissive section (7) permitting electromagnetic radiation to pass through the concave reflecting surface (13) of the second reflecting element (5) to the first reflecting element (3). The reflective optical objective (1) is characterized in that the reflective optical objective (1) includes a carrier material (9) embedding at least the front surface (3a) of the first reflecting element (3) and defining the distance (d) between the first (3) and second (5) reflecting elements.

Abstract: The present invention relates to photoanodes, solar cells and methods and processes for producing the same. In some embodiments, the solar cells of the invention can do without a sintered nanoporous scaffold layer, making it possible to produce the solar cells in low-temperature procedures. In some embodiments, the invention encompasses organic-inorganic perovskite sensitizers, deposited on a smooth metal oxide layer. In some embodiments, the organic-inorganic perovskite sensitizers are deposited in a two-step sequential process.

Abstract: A mechanical teleoperated device for remote manipulation includes a slave unit having a number of slave links interconnected by a plurality of slave joints; an end-effector connected to the slave unit; a master unit having a corresponding number of master links interconnected by a plurality of master joints; and a handle connected to a distal end of the master unit. The device further includes first device arranged to kinematically connect the slave unit with the master unit, second device arranged to kinematically connect the end-effector with the handle, and a mechanical constraint device configured to ensure that one master link of the master unit is guided along its longitudinal axis so that the corresponding slave link of the slave unit always translates along a virtual axis parallel to the longitudinal axis of the guided master link in the vicinity of the remote manipulation when the mechanical teleoperated device is operated.

Abstract: Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an external physician controller. The implantable stimulation unit has an array of electrodes disposed on one or more flexible substrates configured to conform to a patient's anatomy at the pelvic plexus. Post-implantation, the physician controller may direct the stimulation unit to stimulate with select electrode(s) of the array to determine which electrode configuration provides optimal sexual arousal. The patient controller may be used to cause the stimulation unit to stimulate using the optimal electrode configuration at desired times.

Abstract: The present invention describes methods and apparatuses for creating superposition shape images by superposed base and revealing layers of lenslet gratings. The superposition shape images form a message recognizable by a human observer or by an image acquisition and computing device such as a smartphone. The superposition shape images may be created by different superposition techniques ranging from 1D moiré, 2D moiré and level-line moiré superposition techniques to lenticular image and phase shift superposition techniques. Moiré superposition techniques enable creating superposition shape images at different apparent depth levels. Applications comprise the protection of documents and valuable articles against counterfeits, the creation of eye-catching advertisements as well as the decoration of buildings and exhibitions.

Abstract: The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising electrodes for applying to a subject neuromodulation with adjustable stimulation parameters, the electrodes being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with the electrodes said and providing the electrodes with new stimulation parameters, with minimum delay. The system of the disclosure improves consistency of walking in a subject with a neuromotor impairment.

Abstract: A method of analyzing molecules, comprising: generating ions from a sample of molecules; cooling the generated ions below ambient temperature; fragmenting at least some of the cooled ions by irradiating the ions with light at a plurality of different wavelengths (?) within one or more predetermined spectral intervals; recording a fragment mass spectrum of the fragmented ions comprising a detected signal (I) versus m/z over a predetermined range of m/z values for each of the plurality of different wavelengths (?), thereby recording a two dimensional dependency of the detected signal (I) on m/z and irradiation wavelength (?); and determining from the recorded two dimensional dependency an identity of at least one of the generated ions and/or relative abundances of different generated ions and thereby determining an identity of at least of one of the molecules and/or relative abundances of different molecules in the sample.

Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

Abstract: An aerial vehicle, configured to transport cargo, and including a propulsion system and a foldable cage is described. The foldable cage is substantially linear while in a folded configuration, and substantially circular while in a deployed configuration. Moreover, the foldable cage includes a rods that form isosceles triangles. The rods are coupled together by flexible joints.

Abstract: Gas sensor (2) for measuring properties of a gas (1), including a gas viscosity sensor (4) comprising a gas interface portion (20) in contact with the gas (1) to be measured, and a measuring chamber system (15) comprising a measuring chamber (16), a first resistive passage (18) fluidically connecting the measuring chamber (16) to the gas interface portion (20), a pressure generator (25) configured to generate a change in pressure in the measuring chamber, and a pressure sensor (28) configured to measure a time dependent variation in pressure of gas in the measuring chamber, the time dependent variation of pressure in the measuring chamber due to flow of gas through the resistive passage being correlated to a viscosity of the gas.

Abstract: The present invention relates to a novel method for preparing triazenes. Further, the invention relates to novel triazenes and the use of N2O for preparing a compound comprising a triazene group. Further, the invention relates to the use of the novel triazenes as a medicament, in particular in the treatment of cancer.

Abstract: 2-homopiperazine-1-yl-4H-1,3-bensothiazine-4-one derivatives of formula (I) are provided. They are useful in the treatment of bacterial infections, in particular tuberculosis, buruli ulcer and leprosy. A process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides is also provided.

Abstract: The invention relates to a method for manufacturing an electronic device, particularly a device including a flexible and/or low-cost substrate and/or carbon nanotubes, and also relates to electronic devices produced using said method.

Abstract: The present invention relates to the use of benzimidazole sulfide derivatives and prodrugs thereof in the treatment and/or prevention of tuberculosis.

Abstract: An implantable device for the electrical and/or pharmaceutical stimulation of the central nervous system, especially the spinal cord, is suggested. The device comprises a conformable substrate which is primarily composed of a flexible and stretchable polymer, and a plurality of flexible electrodes and conductive leads embedded in the conformable substrate. Not only the substrate, but also the leads are stretchable. The substrate may consist of PDMS, and the leads may consist of a conductive PDMS, in particular, PDMS with an electrically conductive filler material, and may optionally be metal-coated. The device defines a multi-electrode array which may be employed for neurostimulation in the epidural or subdural space of an animal or human.

Abstract: An article made of an alloy of the general formula Pt1-a-bMa(B1-xMdx)b in which i) M stands for one or a mixture of metallic element(s) of the group Zr, Ti, Fe, Ni, Co, Cu, Pd, Ag, Al; ii) Md stands for one or a mixture of several metalloids of the group Si, P, C, S, As, Ge; iii) a is smaller than 0.2; iv) b is comprised between 0.2 and 0.5; v) x is comprised between 0 and 0.8; vi) the overall P content, if present, is less than 10 atomic percent the proportions of the elements forming the alloy having been selected to confer a hardness of at least 400 HV, a melting point below 1000° C. and improved processibility to the alloy.