Abstract: The invention refers to a method for analyzing reflected light of an object. First a light angle distribution for a point of the object is determined. Then a plenoptic projector is controlled to illuminate the point of the object with the determined light angle distribution. Then the reflected light intensity of the point of the object is measured and the measured reflected light is analyzed in dependence of the determined light angle distribution.

Abstract: According to one aspect, the invention relates to a device (100) for remote polarimetric characterization of a sample (S). It comprises a source (10) for emitting at least one incident light wave at at least one first wavelength (?E); a monomode optical fiber (30) in which the incident light wave is intended to propagate; a polarization state generator (PSG) arranged on the proximal side of the optical fiber; a reflector (40) intended to be arranged on the distal side of the optical fiber; a polarization state analyzer (PSA) arranged on the proximal side of the optical fiber and allowing, for each probe state of the incident wave generated by the polarization state generator, the polarization of the light wave obtained after propagation of the incident wave in the optical fiber (30), reflection from the distal side of the optical fiber and reverse propagation in the optical fiber (30), to be analyzed.

Abstract: A novel mechanical system, based on a new cable driven mechanical transmission, able to provide sufficient dexterity, stiffness, speed, precision and payload capacity to actuate multi-DOF micro-manipulators. Besides the possibility of being used in several articulated surgical instruments and robotic systems for surgery or other applications involving remote manipulation, it enables the design of a novel fully mechanical surgical instrument, which offer the advantages of conventional laparoscopy (low cost, tactile feedback, high payload capacity) combined with the advantages of single port surgery (single incision, scarless surgery, navigation through several quadrants of the abdominal cavity) and robotic surgery (greater degrees of freedom, short learning curve, high stiffness, high precision, increased intuition).

Abstract: The invention concerns a device (1) for aggregating cells comprising at least one cavity (2), wherein said cavity comprises a plurality of microwells (3) for receiving at least one cell, wherein each said well comprises a vertical sidewall and a curved bottom.

Abstract: The present invention relates to use of inhibitors of Notch signalling pathway selected from the group consisting of 6-(4-Tert-Butylphenoxy)Pyridin-3-Amine (I3), its derivatives, in treating and/or preventing cancers.

Abstract: The present invention relates to a bicistronic expression vector for silencing a gene specifically in astrocytes and neurons, comprising two expression cassettes comprising a first and a second silencer sequence, respectively, wherein the expression of said first silencer sequence within astrocytes is regulated by an astrocyte-specific promoter and the expression of said second silencer sequence within neurons is regulated by a neuron-specific promoter. In a preferred embodiment, said first and second silencer sequences are SOD1 silencer sequences. Pharmaceutical composition comprising said bicistronic vector and the use of the same in the treatment of motoneuron diseases are further described.

Abstract: Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired. Methods and uses of the compositions for induction of immune tolerance are also disclosed herein.

Abstract: The invention relates to electrochemical devices comprising complexes of cobalt comprising at least one ligand with a 5- or six membered, N-containing heteroring. The complex are useful as p- and n-dopants, as over of electrochemical devices, in particular in organic semiconductors. The complexes are further useful as over-discharge prevention and overvoltage protection agents.

Abstract: Systems and methods for imaging ear tissue include: directing illumination radiation to pass through an intact biological structure and be incident on ear tissue that does not include an exogenous fluorophore, at a plurality of locations, the illumination radiation including a plurality of light pulses each having a temporal duration of 500 femtoseconds or less; for each one of the plurality of locations, using a detector to detect radiation emitted from the location that passes through the intact biological structure; and forming an image of the tissue based on the detected radiation at each of the plurality of locations, where the emitted radiation corresponds to endogenous two-photon fluorescence of the tissue.

Abstract: The present invention relates to a method for assessing the quality, utility and applicability of a cell according to the said method comprising the following steps: a) analyzing the expression of the TEs of said cell in order to set up an expression profile of the TEs of said cell; b) comparing the expression profile obtained in step a) to a reference.

Abstract: Microfluidic system comprising a space for containing a liquid and at least one lateral chamber in communication with said space, said lateral chamber containing a metal electrode. The lateral chamber and the space are designed to be filled by the same or different liquid when the system is active.

Abstract: A routing architecture for fast interconnections between Look-Up Tables (LUTs) in a group of Basic Logic Elements (BLEs), whereby a size of the group ranges from 1 to k+1, where k is the number of inputs of a LUT, and LUTs in the group are indexed from 1 to k+1, and whereby (a) an output of a LUTi, 1?i?k, connects to one of the inputs of routing multiplexers of LUTj, i<j?k+1, hence creating a fast interconnection between LUTs, each routing multiplexer of LUTm, 2?m?k+1, has only one input that is connected to the output of an other LUT, the output of LUT(k+1) being devoid of any connection to any one of the inputs of the routing multiplexers; (b) a subset of the inputs of LUT1 are connected to the outputs of other LUTs by means of fast interconnections, leaving the remaining inputs of LUT1 free of any fast interconnection, whereby for LUTp, 2?p?k+1, p?1 inputs of the LUTp are connected to the outputs of LUTq, 1?q?j, by means of fast interconnections; and (c) a cluster-based logic block contains at least one

Abstract: The invention relates to the field of in vitro detection methods using luminescence. Provided is a sensor molecule for detecting an analyte of interest in a sample using bioluminescence resonance energy transfer (BRET), the sensor molecule comprising a proteinaceous moiety tethered to a synthetic regulatory molecule. Also provided is an analytical device comprising a sensor and methods using the sensor molecule.

Abstract: A method for modifying an audio scene and/or presenting additional information relevant to the audio scene includes capturing audio signals from the audio scene with a plurality of microphones; outputting an audio signal with a plurality of acoustical transducers; processing the captured audio signals, where the processing comprises one or more of filtering, equalization, echoes processing, and beamforming; separating and distinguishing audio signal sources using the processed audio signals; selecting at least one separated audio signal source; classifying the at least one selected separated audio signal source; retrieving additional information related to the classified audio signal source; and presenting the additional information in a perceptible form.

Abstract: The invention is related to a method allowing a prover holding a secret key (x) to prove its identity to a verifier and to prove to this verifier that he is within a predetermined distance of this verifier, said method comprising an initialization phase during which: the prover picks a first nonce (Np) and communicates this first nonce to the verifier; the verifier picks a first random vector (a), a leak function (L?), and a second nonce (Nv); the verifier uses said leak function (L?) to compute a modified secret (x?) depending on the leak (L?(x)) of said secret; the verifier transmits to said prover said leak function and said second nonce; the prover retrieves said first random vector and said modified secret, wherein said first random vector and said modified secret are used by said prover for computing responses (ri) to challenges (ci).

Abstract: The application provides fluorescent dyes, which are cyanine dyes that incorporate additional aza moieties in the indolenium heterocycles and/or in the methine chains connecting them. Symmetrical and unsymmetrical chemically reactive azacyanine dyes are described for conjugation, as well as their bioconjugates for in-vitro and in-vivo assays and fluorescence imaging.

Abstract: A system for the treatment of Alzheimer's disease is provided by moving cerebrospinal fluid containing particles know to contribute to onset of Alzheimer's disease from a source of cerebrospinal fluid to the stomach or bladder, where the particles are safely digested by gastric acid or excreted, the system including an implantable pump, an inlet catheter, an outlet catheter, and a one-way valve. The system further includes at least one filter to filter harmful particles from the cerebrospinal fluid and return the filtered cerebrospinal fluid back to the source of cerebrospinal fluid, where the harmful particles blocked by the filter may be rinsed off the filter and transported to the stomach or bladder.

Abstract: A method and apparatus for local beam processing using a beam activated gas to etch material are described. Compounds are disclosed that are suitable for beam-induced etching. The invention is particularly suitable for electron beam induced etching of chromium materials on lithography masks. In one embodiment, a polar compound, such as ClNO2 gas, is activated by the electron beam to selectively etch a chromium material on a quartz substrate. By using an electron beam in place of an ion beam, many problems associated with ion beam mask repair, such as staining and riverbedding, are eliminated. Endpoint detection is not critical because the electron beam and gas will not etch significantly the substrate.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.

Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.