Patents Assigned to Ecole Polytechnique
  • Patent number: 9879062
    Abstract: Embodiments of the invention are described, including materials and methods for making molecules and materials that have a specific binding domain of a PlGF2. Embodiments include, for instance, medicaments, biomaterials, biomolecules, molecular fusions, and vaccines.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: January 30, 2018
    Assignee: Ecole Polytechnique Federale De Lausanne
    Inventors: Jeffrey A. Hubbell, Mikael Martino, Priscilla S. Maithili Briquez
  • Patent number: 9878048
    Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.
    Type: Grant
    Filed: August 9, 2016
    Date of Patent: January 30, 2018
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Jeffrey A. Hubbell, Stephan Kontos, Karen Y. Dane
  • Patent number: 9876931
    Abstract: We propose new methods for creating color varying prints with classical cyan, magenta, yellow inks on a metallic specularly reflecting or on a white diffusely reflecting substrate. We use a special cross-line halftone with optimized surface coverages of the inks to create cross-halftone prints whose colors change when rotating the print in-plane under specular reflection. These prints enable viewing at the same location a first image with a first set of colors and upon in-plane rotation of the print or displacement of the observer, a similar or a different image whose parts are colored with a different set of colors. Applications comprise counterfeit prevention, art, advertisement, decoration, exhibitions and surprising displays in amusement parks.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: January 23, 2018
    Assignee: Ecole Polytechnique Fédérale Lausanne (EPFL)
    Inventors: Petar Pjanic, Roger D. Hersch
  • Patent number: 9871948
    Abstract: A multimode waveguide illuminator and imager relies on a wave front shaping system that acts to compensate for modal scrambling and light dispersion by the multimode waveguide. A first step consists of calibrating the multimode waveguide and a second step consists in projecting a specific pattern on the wave guide proximal end in order to produce the desire light pattern at its distal end. The illumination pattern can be scanned or changed dynamically only by changing the phase pattern projected at the proximal end of the waveguide. The third and last step consists in collecting the optical information, generated by the sample, through the same waveguide in order to form an image. Known free space microscopy technique can be adapted to endoscopy with multimode waveguide, such as, but not limited to, fluorescence imaging or Raman spectros copy or imaging, 3D linear scattering imaging or two-photon imaging. Super-resolution, i.e.
    Type: Grant
    Filed: March 28, 2013
    Date of Patent: January 16, 2018
    Assignee: Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Ioannis Papadopoulos, Salma Farahi, Christophe Moser, Demetri Psaltis
  • Patent number: 9850296
    Abstract: Peptides that specifically bind erythrocytes are described. These are provided as peptidic ligands having sequences that specifically bind, or as antibodies or fragments thereof that provide specific binding, to erythrocytes. The peptides may be prepared as molecular fusions with therapeutic agents, tolerizing antigens, or targeting peptides. Immunotolerance may be created by use of the fusions and choice of an antigen on a substance for which tolerance is desired.
    Type: Grant
    Filed: August 15, 2014
    Date of Patent: December 26, 2017
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Jeffrey A. Hubbell, Stéphane Kontos, Karen Y. Dane
  • Patent number: 9846154
    Abstract: A method for analyzing a metalloprotein and/or the interaction with its environment comprising the following steps: (a) Providing a medium that enhances the detection of the electromagnetic cross-section signal of metalloproteins, (b) Incorporating a metalloprotein to analyse into said medium, (c) Contacting said medium with electromagnetic radiation, (d) Obtaining the electromagnetic cross-section spectrum of said metalloprotein, (e) Determining from said electromagnetic cross-section spectrum at least one parameter related to one or several analytes of interest.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 19, 2017
    Assignee: Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Guillaume Suárez, Christian Santschi, Olivier Martin
  • Publication number: 20170339301
    Abstract: We propose new methods for creating color varying prints with classical cyan, magenta, yellow inks on a metallic specularly reflecting or on a white diffusely reflecting substrate. We use a special cross-line halftone with optimized surface coverages of the inks to create cross-halftone prints whose colors change when rotating the print in-plane under specular reflection. These prints enable viewing at the same location a first image with a first set of colors and upon in-plane rotation of the print or displacement of the observer, a similar or a different image whose parts are colored with a different set of colors. Applications comprise counterfeit prevention, art, advertisement, decoration, exhibitions and surprising displays in amusement parks.
    Type: Application
    Filed: May 23, 2016
    Publication date: November 23, 2017
    Applicant: Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Petar Pjanic, Roger D. Hersch
  • Patent number: 9821163
    Abstract: Systems and methods are provided for treating a sexual disorder such as erectile dysfunction (ED) or female sexual arousal disorder (FSAD). An electrical stimulation system may include an implantable stimulation unit, an external patient controller, and an external physician controller. The implantable stimulation unit has an array of electrodes disposed on one or more flexible substrates configured to conform to a patient's anatomy at the pelvic plexus. Post-implantation, the physician controller may direct the stimulation unit to stimulate with select electrode(s) of the array to determine which electrode configuration provides optimal sexual arousal. The patient controller may be used to cause the stimulation unit to stimulate using the optimal electrode configuration at desired times.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: November 21, 2017
    Assignee: Ecole Polytechnique Federal De Lausanne (EPFL)
    Inventors: Rodrigo Araujo Fraga Da Silva, Nikolaos Stergiopulos
  • Patent number: 9826625
    Abstract: Stretchable electronic structure comprising one intrinsically fragile thin film integrated on or within a soft heterogeneous substrate. The invention also relates to a process for manufacturing such a structure.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: November 21, 2017
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Hugues Vandeparre, Stephanie Lacour
  • Patent number: 9825677
    Abstract: Using a transformation based at least in part on a non-simple orthogonal or unitary matrix, data may be transmitted over a data bus in a manner that is resilient to one or more types of signal noise, that does not require a common reference at the transmission and acquisition points, and/or that has a pin-efficiency that is greater than 50% and may approach that of single-ended signaling. Such transformations may be implemented in hardware in an efficient manner. Hybrid transformers that apply such transformations to selected subsets of signals to be transmitted may be used to adapt to various signal set sizes and/or transmission environment properties including noise and physical space requirements of given transmission environments.
    Type: Grant
    Filed: March 15, 2016
    Date of Patent: November 21, 2017
    Assignee: Ecole Polytechnique Fédérale De Lausanne
    Inventors: Harm Cronie, Amin Shokrollahi
  • Patent number: 9816133
    Abstract: Provided herein are microfluidic circuits that include at least one device for forming a quantity of drops of a solution in a carrier fluid and at least one storage zone for storing drops produced by the microfluidic device. Such microfluidic circuits are useful, for example, for the analysis of a solution containing a biological sample.
    Type: Grant
    Filed: October 8, 2013
    Date of Patent: November 14, 2017
    Assignees: École Polytechnique, Centre national de la recherche scientifique
    Inventors: Charles Baroud, Remi Dangla, Paul Abbyad, Silvan Turkcan
  • Patent number: 9812658
    Abstract: The present invention relates to compounds of formula (I) based on a porphyrin core and a ?-conjugated linker or acceptor introduced between the porphyrin core and an anchoring group having a high absorption coefficient covering the whole UV-Visible and near-infrared spectral response, and their use as sensitizer or dye and an electrochemical or optoelectronic device including a compound of the invention.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: November 7, 2017
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Chenyi Yi, Fabrizio Giordano, Shaik Mohammad Zakeeruddin, Michael Graetzel
  • Patent number: 9791684
    Abstract: The invention relates to an optical coherence microscopy system for fast, phase resolved imaging by means of optical coherence microscopy with decoupled illumination and detection apertures, producing a dark-field effect with an enhanced optical contrast. The setup uses a light source with an appropriate temporal coherence, an interferometer and an array detector combined with a spectrometer. The dark-field effect is produced by optical filter means in the illumination and detection paths, positioned in conjugated planes of the sample microscope objective. These optical means comprise for example refractive or diffractive elements, amplitude or phase masks, or programmable spatial light modulators. The object is scanned via a scanning unit allowing a point scan of the object.
    Type: Grant
    Filed: January 4, 2011
    Date of Patent: October 17, 2017
    Assignee: Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Martin Villiger, Christophe Pache, Theo Lasser
  • Publication number: 20170291697
    Abstract: An aerial vehicle, configured to transport cargo, and including a propulsion system and a foldable cage is described. The foldable cage is substantially linear while in a folded configuration, and substantially circular while in a deployed configuration. Moreover, the foldable cage includes a rods that form isosceles triangles. The rods are coupled together by flexible joints.
    Type: Application
    Filed: April 8, 2016
    Publication date: October 12, 2017
    Applicant: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Przemyslaw Mariusz Kornatowski, Stefano Mintchev, Dario Floreano
  • Patent number: 9779879
    Abstract: The present invention provides an improved redox couple for electrochemical and optoelectronic devices. The redox couple is based on a complex of a first row transition metal, said complex containing at least one mono-, bi-, or tridentate ligand comprising a substituted or unsubstituted ring or ring system comprising a five-membered N-containing heteroring and/or a six-membered ring comprising at least two heteroatoms, at least one of which being a nitrogen atom, said five- or six-membered heteroring, respectively, comprising at least one double bond. The invention also relates to electrolytes and to the devices containing the complex, and to the use of the complex as a redox couple. The invention further provides electrochemical and/or optoelectronic devices comprising a first and a second electrode and, between said first and second electrode, a charge transport layer, said a charge transport layer comprising tetracyanoborate ([B(CN)4]?) and a cationic metal complex functioning as redox-couple.
    Type: Grant
    Filed: February 24, 2012
    Date of Patent: October 3, 2017
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Mohammad Khaja Nazeeruddin, Michael Graetzel, Etienne Baranoff, Florian Kessler, Jun-Ho Yum, Aswani Yella, Hoi Nok Tsao, Shaik Mohammad Zakeeruddin
  • Patent number: 9759805
    Abstract: An acoustic processing method for M acoustic receivers comprising the steps of: Determining a beamforming weight vector with M weights for the M acoustic receivers based on at least one the steering vector of at least one real acoustic source, on steering vectors of image sources of the at least one real acoustic source and on a first matrix depending on the covariance matrix of the noise and/or on at least one interfering sound source, wherein each of the image sources corresponds to one path of the acoustic signal between one of the at least one real source and one of the M acoustic receivers with at least one reflection; and linearly combining the M acoustic signals received at the M acoustic receivers on the basis of the M weights of the beamforming vector.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: September 12, 2017
    Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)
    Inventors: Ivan Dokmanic, Robin Scheibler, Martin Vetterli
  • Patent number: 9760536
    Abstract: A method and device for reducing the computational complexity of a processing algorithm, of a discrete signal, in particular of the spectral estimation and analysis of bio-signals, with minimum or no quality loss, which comprises steps of (a) choosing a domain, such that transforming the signal to the chosen domain results to an approximately sparse representation, wherein at least part of the output data vector has zero or low magnitude elements; (b) converting the original signal in the domain chosen in step (a) through a mathematical transform consisting of arithmetic operations resulting in a vector of output data; (c) reformulating the processing algorithm of the original signal in the original domain into a modified algorithm consisting of equivalent arithmetic operations in the domain chosen in step (a) to yield the expected result with the expected quality quantified in terms of a suitable application metric; (d) combining the mathematical transform of step (b) and the equivalent mathematical operatio
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: September 12, 2017
    Assignee: Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Inventors: Georgios Karakonstantis, Aviinaash Sankaranarayanan, Andreas Burg, Srinivasan Murali, David Atienza Alonso
  • Publication number: 20170244056
    Abstract: The invention relates to a method for manufacturing an electronic device, particularly a device including a flexible and/or low-cost substrate and/or carbon nanotubes, and also relates to electronic devices produced using said method.
    Type: Application
    Filed: October 7, 2015
    Publication date: August 24, 2017
    Applicants: Ecole Polytechnique, Centre National de la Recherche Scientifique, Institut Francais des Sciences et Technologies des Transports de I'Amenagement et des Reseaux
    Inventors: Costel-Sorin Cojocaru, Fatima Zahra Bouanis, Kitchner Max Garry Rose
  • Patent number: 9716240
    Abstract: The present invention relates to novel compounds that are useful as ligands in organometallic dyes. More particularly, the invention relates to dyes comprising the compounds, said dyes being sensitizing dyes useful in solar cell technology. According to an embodiment, the present invention discloses new ruthenium dyes and their application in dye-sensitized solar cells (DSC). The referred ruthenium dyes with new structural features can be easily synthesized, show more than 85% light-to-electricity conversion efficiency and a higher than 9% cell efficiency.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: July 25, 2017
    Assignee: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Feifei Gao, Yuan Wang, Jing Zhang, Peng Wang, Shaik Mohammad Zakeeruddin, Michael Graetzel
  • Publication number: 20170205337
    Abstract: A method for obtaining spectral imaging data comprises at least the steps of receiving a sample set of data generated by sampling a spectral property of an image of an object in a spatial basis, wherein the sampling of the spectral property of the image of the object comprises providing a Spectral Filter Array (SFA) by arranging a plurality of SFA elements together to form a surface; configuring each SFA element of the plurality of SFA elements to filter one or more spectral bandwidths centered each at specific wavelengths corresponding to that SFA element, whereby all of the plurality of SFA elements taken together cover a determined spectral range; and setting the specific wavelengths of each SFA element of the plurality of SFA elements on the surface such to obtain a uniform and aperiodic spatial distribution of all of the plurality of SFA elements across the surface.
    Type: Application
    Filed: July 24, 2015
    Publication date: July 20, 2017
    Applicant: Ecole Polytechnique Federale de Lausanne (EPFL)
    Inventors: Yosef Akhtman, Dragos Constantin