Patents Assigned to EMBL
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Patent number: 8931357Abstract: A two-part coaxial needle for a pipetting device, in particular for use in microscopy of cell probes, makes it possible both to inject a liquid into a pipetting container and to remove by suction a liquid from the pipetting container. Both the drive for lowering the coaxial needle into the pipetting container, and injection and removal by suction of the liquid take place pneumatically by way of only one pressure source. The design of the coaxial needle and of the drive systems makes possible fast and reliable pipetting with high metering accuracy and a particularly compact pipetting unit which without mutual interference can be used with a multitude of widely-used microscope types.Type: GrantFiled: December 3, 2009Date of Patent: January 13, 2015Assignee: EMBL European Molecular Biology LaboratoryInventors: Siegfried Winkler, Christian Conrad
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Publication number: 20140156449Abstract: The present invention provides a method and system for recommending one or more products and recommending one or more sales channel to a user. The method and apparatus disclosed provides a mechanism for generating a personalized and customized catalog of relevant products to be presented to the user along with a plurality of sales channels showing availability of the recommended products. Various embodiments of the present invention teaches a mechanism for generating the product recommendation based on at least the user shopping context information, user preference information, and the body profile information. The one or more products are correlated with the user information and the most relevant products are recommended to the user. The invention also teaches a method for virtually trying a product recommended by the recommendation engine of the present invention before purchasing through the one or more recommended sales channels.Type: ApplicationFiled: December 2, 2013Publication date: June 5, 2014Applicant: EMBL RETAIL INC.Inventors: Anand GANESAN, Shabari RAJE, Mukul KELKAR
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Publication number: 20140073764Abstract: The present invention relates to unnatural amino acids comprising a cyclooctynyl or trans-cyclooctenyl analog group and having formula (I) or an acid or base addition salt thereof. The invention also relates to the use of said unnatural amino acids, kits and processes for preparation of polypeptides that comprise one or more than one cyclooctynyl or trans-cyclooctenyl analog group. These polypeptides can be covalently modified by in vitro or in vivo reaction with compounds comprising an azide, nitrile oxide, nitrone, diazocarbonyl or 1,2,4,5-tetrazine group.Type: ApplicationFiled: February 3, 2012Publication date: March 13, 2014Applicant: EMBLInventors: Edward Lemke, Carsten Schultz, Tilman Plass, Sigrid Milles, Christine Koehler
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Publication number: 20140042339Abstract: A microscope and imaging method in which a layer of the sample is illuminated by a thin strip of light and the sample is viewed perpendicular to the plane of the strip of light. The depth of the strip of light thus essentially determines the depth of focus of the system. To record the image, the object is displaced through the strip of light, which remains fixed in relation to the detector, and fluorescent and/or diffused light is captured by a planar detector. Objects that absorb or diffuse a large amount of light are viewed from several spatial directions. The three-dimensional images, which are captured from each direction can be combined retrospectively to form one image, in which the data is weighted according to its resolution. The resolution of the combined image is then dominated by the lateral resolution of the individual images.Type: ApplicationFiled: January 22, 2013Publication date: February 13, 2014Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)Inventors: Ernst H.K. Stelzer, Sebastian Enders, Jan Huisken, Steffen Lindek, James H. Swoger
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Publication number: 20130102601Abstract: The present invention relates to a compound having the general formula II, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: ApplicationFiled: October 18, 2012Publication date: April 25, 2013Applicants: F. HOFFMANN-LA ROCHE LTD, EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL), SAVIRA PHARMACEUTICALS GMBHInventors: F. HOFFMANN-LA ROCHE LTD, SAVIRA PHARMACEUTICALS GMBH, EUROPEAN MOLECULAR BIOLOGY LABORAT
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Publication number: 20130102600Abstract: The present invention relates to a compound having the general formula I, optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which is useful in treating, ameliorating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.Type: ApplicationFiled: October 18, 2012Publication date: April 25, 2013Applicants: F. HOFFMANN-LA ROCHE LTD, EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL), SAVIRA PHARMACEUTICALS GMBHInventors: F. HOFFMANN-LA ROCHE LTD, SAVIRA PHARMACEUTICALS GMBH, EUROPEAN MOLECULAR BIOLOGY LABORAT
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Publication number: 20120208277Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: ApplicationFiled: January 3, 2012Publication date: August 16, 2012Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Francis STEWART, Youming ZHANG, Frank BUCHHOLZ
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Publication number: 20120206798Abstract: A microscope is described, having an illumination light path for illuminating a sample or object and a viewing light path for viewing the sample. The microscope includes an illumination light path focussing arrangement in the illumination light path, defining a substantially two-dimensional sample or object illumination region extending along an illumination direction of the illumination light path and transversely thereto. The microscope further includes an illumination region-confining device in the illumination light path for selectively illuminating a portion of the substantially two-dimensional object illumination region, wherein the portion of the substantially two-dimensional object illumination region is confined at least in the illumination direction and/or in the direction transversely thereto.Type: ApplicationFiled: February 13, 2012Publication date: August 16, 2012Applicant: EUROPEAN MOLECULAR BIOLOGY LABORATORY (EMBL)Inventors: Michael Knop, Malte Wachsmuth, Jérémie Capoulade
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Publication number: 20120149060Abstract: The present invention relates to a nucleic acid containing at least one homing endonuclease site (HE) and at least one restriction enzyme site (X) wherein the HE and X sites are selected such that HE and X result in compatible cohesive ends when cut by the homing endonuclease and restriction enzyme, respectively, and the ligation product of HE and X cohesive ends can neither be cleaved by the homing endonuclease nor by the restriction enzyme. Further subject-matter of the present invention relates to a vector comprising the nucleic acid of the present invention, host cells containing the nucleic acid and/or the vector, a kit for cloning and/or expression of multiprotein complexes making use of the vector and the host cells, a method for producing a vector containing multiple expression cassettes, and a method for producing multiprotein complexes.Type: ApplicationFiled: March 8, 2010Publication date: June 14, 2012Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventor: Imre Berger
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Patent number: 8199407Abstract: An immersion objective for microscopic investigation of a specimen is provided wherein an outer lens is disposed in an objective body. A delivery device including a cap that is disposed over the objective body so as to form a space adapted to receive an immersion liquid is also provided. The cap is open in a region of the outer lens so as to form a gap with the outer lens. The cap includes at least one connector configured to provide a continuous supply of the immersion liquid to the space so that the immersion liquid emerges through the gap to a region between the outer lens and at least one of the specimen and a specimen slide.Type: GrantFiled: September 7, 2007Date of Patent: June 12, 2012Assignees: Leica Microsystems CMS GmbH, EMBL European Molecular Biology LaboratoryInventors: Urban Liebel, Siegfried Winkler, Frank Sieckmann
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Publication number: 20120095024Abstract: The present invention provides novel compounds that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)-mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition comprising a compound of the invention and a second therapeutic agent or radiation useful for the treatment or prevention of the mentioned diseases or disorders. In a first aspect the present invention relates to a compound having a structure according to formula (I).Type: ApplicationFiled: December 30, 2009Publication date: April 19, 2012Applicants: Elara Pharmaceuticals GmbH, European Molecular Biology Laboratory (EMBL)Inventors: Jorge Alonson, Arantxa Encionas Lopez, Marcel Muelbaler, Lochen Ammenn, Bernd Vendt, Joe Lewis, Christoph Schultes, Bernd Janssen
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Publication number: 20120079613Abstract: The present invention relates to the human homeobox transcription factor Bsx protein, nucleic acids encoding for said protein, vectors and cells comprising the nucleic acids, antibodies directed against Bsx, and methods for identifying compounds binding to Bsx, as well as to the use of proteins, nucleic acids, vectors, cells, and interacting compounds for treating obesity and related diseases.Type: ApplicationFiled: April 2, 2007Publication date: March 29, 2012Applicants: Deutsches Institut fur Ernahrungsforschung (DIFE), European Molecular Biology Laboratory (EMBL)Inventors: Mathias Treier, Maria Sakkou, Petra Wiedmer, Matthias Tschoep
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Publication number: 20110277565Abstract: A two-part coaxial needle for a pipetting device, in particular for use in microscopy of cell probes, makes it possible both to inject a liquid into a pipetting container and to remove by suction a liquid from the pipetting container. Both the drive for lowering the coaxial needle into the pipetting container, and injection and removal by suction of the liquid take place pneumatically by way of only one pressure source. The design of the coaxial needle and of the drive systems makes possible fast and reliable pipetting with high metering accuracy and a particularly compact pipetting unit which without mutual interference can be used with a multitude of widely-used microscope types.Type: ApplicationFiled: December 3, 2009Publication date: November 17, 2011Applicant: EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Siegfried Winkler, Christian Conrad
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Publication number: 20110164246Abstract: The invention relates to a method for sorting particles and a corresponding sorting device, Thereby the particles comprise at least one constituent and the particles are provided by a flow cytometry device. By using coherent anti-Stokes Raman spectroscopy (CARS) certain characteristics of the at least one constituent are detected. A subsequent sorting of the particles bases on the detection results from the CARS.Type: ApplicationFiled: June 10, 2009Publication date: July 7, 2011Applicant: EMBL HEIDELBERGInventor: Andy Riddell
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Publication number: 20110060043Abstract: The present invention provides novel compounds that inhibit cell proliferation and uses of these compounds for treating, ameliorating or preventing diseases, conditions or disorders benefiting from the inhibition hyperproliferation.Type: ApplicationFiled: March 2, 2009Publication date: March 10, 2011Applicant: European Molecular Biology Laboratory (EMBL)Inventors: George Reid, Maria Polycarpou-Schwarz, Frank Gannon
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Publication number: 20100317061Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: ApplicationFiled: April 9, 2010Publication date: December 16, 2010Applicant: EUROPAISCHES LABORATORIUM FUR MOLEKULARBIOLOGIE (EMBL)Inventors: FRANCIS STEWART, YOUMING ZHANG, FRANK BUCHHOLZ
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Patent number: 7736851Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: GrantFiled: May 11, 2004Date of Patent: June 15, 2010Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Francis Stewart, Youming Zhang, Frank Buchholz
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Publication number: 20100103253Abstract: A method for scanning a sample using an electrically or electronically controllable microscope, includes scanning the sample so as to generate a plurality of images of the sample, each of the plurality of images corresponding to at least one of a different region of the sample and a different time. The microscope is controlled via a control computer during the scanning. The plurality of images are analyzed using at least one second computer connected via a network. The plurality of images are classified and/or the scanning is influenced based on the analyzing.Type: ApplicationFiled: September 6, 2007Publication date: April 29, 2010Applicants: LEICA MICROSYSTEMS CMS GMBH, EMBL EUROPEAN MOLECULAR BIOLOGY LABORATORYInventors: Frank Sieckmann, Urban Liebel
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Publication number: 20100027109Abstract: An immersion objective for microscopic investigation of a specimen is provided wherein an outer lens is disposed in an objective body. A delivery device including a cap that is disposed over the objective body so as to form a space adapted to receive an immersion liquid is also provided. The cap is open in a region of the outer lens so as to form a gap with the outer lens. The cap includes at least one connector configured to provide a continuous supply of the immersion liquid to the space so that the immersion liquid emerges through the gap to a region between the outer lens and at least one of the specimen and a specimen slide.Type: ApplicationFiled: September 7, 2007Publication date: February 4, 2010Applicants: Leica Microsystems CMS GmbH, EMBL European Molecular Biology LaboratoryInventors: Urban Liebel, Siegfried Winkler, Frank Sieckmann
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Publication number: 20090225413Abstract: The invention relates to a microscope, in which a layer of the sample is illuminated by a thin strip of light (11) and the sample is viewed (5) perpendicular to the plane of the strip of light. The depth of the strip of light (11) thus essentially determines the depth of focus of the system. To record the image, the object (4) is displaced through the strip of light (11), which remains fixed in relation to the detector (8), and fluorescent and/or diffused light is captured by a planar detector. Objects (4) that absorb or diffuse a large amount of light are viewed from several spatial directions. The three-dimensional images, which are captured from each direction can be combined retrospectively to form one image, in which the data is weighted according to its resolution. The resolution of the combined image is then dominated by the lateral resolution of the individual images.Type: ApplicationFiled: May 19, 2009Publication date: September 10, 2009Applicant: EUROPAEISCHES Laboratorium fuer Molekularbiologie (EMBL)Inventors: Ernst H.K. Stelzer, Sebastian Enders, Jan Huisken, Steffen Lindek, James H. Swoger