Patents Assigned to EMBL
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Patent number: 7554725Abstract: The invention relates to a microscope, in which a layer of the sample is illuminated by a thin strip of light (11) and the sample is viewed (5) perpendicular to the plane of the strip of light. The depth of the strip of light (11) thus essentially determines the depth of focus of the system. To record the image, the object (4) is displaced through the strip of light (11), which remains fixed in relation to the detector (8), and fluorescent and/or diffused light is captured by a planar detector. Objects (4) that absorb or diffuse a large amount of light are viewed from several spatial directions. The three-dimensional images, which are captured from each direction can be combined retrospectively to form one image, in which the data is weighted according to its resolution. The resolution of the combined image is then dominated by the lateral resolution of the individual images.Type: GrantFiled: June 6, 2003Date of Patent: June 30, 2009Assignee: Europaeisches Laboratorium fuer Molekularbiologie (EMBL)Inventors: Ernst H. K. Stelzer, Sebastian Enders, Jan Huisken, Steffen Lindek, James H. Swoger
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Publication number: 20080051327Abstract: The present invention relates to crystals of phosphorylated Aurora-A kinase fragment alone and in complex with a ligand, amino acid residues 1-43 of human TPX2. This invention also relates to methods for designing and selecting ligands, in particular allosteric inhibitors of Aurora-A, that bind to the Aurora-A kinase and their use. Further, the present invention relates to certain indene and indole derivatives. The present invention relates to crystals of phosphorylated Aurora-A kinase alone and in complex with a ligand, amino acid residues 1-43 of human TPX2. This invention also relates to methods for designing and selecting ligands that bind to the Aurora-A kinase and their use. Further, the present invention relates to certain indene and indole derivative.Type: ApplicationFiled: October 11, 2004Publication date: February 28, 2008Applicant: EMBLInventors: Elena Conti, Richard Bayliss, Carsten Schultz, Isabelle Vernos, Teresa Sardon
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Patent number: 7312619Abstract: A local probe measuring device is provided for effecting local measurements of a sample. This device includes first and second local probes for local measurements with respect to a sample or a reference surface. A measurement condition adjustment arrangement is adapted to commonly adjust first and second measurement conditions of the respective first and second local probes with respect to the sample or the reference surface. A detection arrangement is provided that includes a first detection arrangement associated with the first local probe adapted to independently detect first measurement data referring to local measurements reflected by first local probe and a second detection arrangement associated with the second local probe adapted to independently detect second measurement data referring to local measurements effected by second local probe. Further, methods for effecting local measurements and local manipulations using multiple local probes are provided.Type: GrantFiled: July 17, 2006Date of Patent: December 25, 2007Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Stephan Maxmilian Altmann, Johann Karl Heinrich Hörber
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Publication number: 20070109633Abstract: The invention relates to a microscope in which a layer of the sample is illuminated by a plurality of thin strips of light (11) passed through a grid (34) and the sample is viewed (5) perpendicular to the plane of the strips of light. To record the image, the object (4) is displaced through the strips of light (11). At least three different images of the objects (4) are made at different phase angles. The images can be combined to form a single combined image.Type: ApplicationFiled: November 3, 2006Publication date: May 17, 2007Applicant: EUROPAEISCHES LABORATORIUM FUER MOLEKULARBIOLOGIE (EMBL)Inventor: Ernst Stelzer
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Publication number: 20060255818Abstract: The invention provides a local probe measuring device for effecting local measurements referring to a sample, comprising a first local probe for local measurements with respect to a sample or a reference surface, a second local probe for local measurements with respect to the sample or the reference surface, a measurement condition adjustment arrangement adapted to commonly adjust a first measurement condition of the first local probe with respect to the sample or the reference surface and a second measurement condition of the second local probe with respect to the sample or the reference surface, a detection arrangement comprising a first detection arrangement associated with the first local probe adapted to independently detect first measurement data referring to local measurements reflected by said first local probe and a second detection arrangement associated with the second local probe adapted to independently detect second measurement data referring to local measurements effected by said second local pType: ApplicationFiled: July 17, 2006Publication date: November 16, 2006Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Stephan Altmann, Johann Horber
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Patent number: 7098678Abstract: A local probe measuring device is provided for effecting local measurements of a sample. This device includes first and second local probes for local measurements with respect to a sample or a reference surface. A measurement condition adjustment arrangement is adapted to commonly adjust first and second measurement conditions of the respective first and second local probes with respect to the sample or the reference surface. A detection arrangement is provided that includes first detection arrangement associated with the first local probe adapted to independently detect first measurement data referring to local measurements reflected by first local probe and a second detection arrangement associated with the second local probe adapted to independently detect second measurement data referring to local measurements effected by second local probe. Further, methods for effecting local measurements and local manipulations using multiple local probes are provided.Type: GrantFiled: April 22, 2005Date of Patent: August 29, 2006Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Stephan Maxmilian Altmann, Johann Karl Heinrich Hörber
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Publication number: 20060169917Abstract: The present invention relates to a sample holder for a mass spectrometer onto which a mixture of silicone and graphite is applied.Type: ApplicationFiled: January 16, 2004Publication date: August 3, 2006Applicant: Europaeisches Laboratorium Fuer Molekularbiologie (EMBL)Inventor: Thomas Franz
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Patent number: 6987609Abstract: The invention relates to a microscope comprising a microscope housing (18), an optics system (16) consisting of at least one lens system that contains at least one respective lens (48) and is positioned at one end of a passage (19) of the microscope housing (18), at least one observation device, in particular an ocular, located at the other end of the passage (19), an illumination device, whose light forms at least one illumination beam (44), originating from a plane of incidence (45) that vertically intersects the passage (19), said beam traversing the lens system and striking an object carrier (36) at a predetermined angle (?). According to the invention, the illumination beam or beams (44) originating from the plane of incidence (45) is/are provided by an optical device, whose cross-section lying in the vicinity of the passage (19) is substantially smaller than the cross-section of said passage (19).Type: GrantFiled: September 4, 2002Date of Patent: January 17, 2006Assignee: Europaisches Laboratorium fur Mole kularbiologie (EMBL)Inventors: Christian Tischer, Ernst-Ludwig Florin
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Patent number: 6943574Abstract: The invention provides a local probe measuring device for effecting local measurements referring to a sample, having a first local probe for local measurements with respect to a sample, a second local probe for local measurements with respect to the sample, a measurement condition adjustment arrangement adapted to commonly adjust a first measurement condition of the first local probe with respect to the sample and a second measurement condition of the second local probe with respect to the sample, a detection arrangement having a first detection arrangement associated with the first local probe adapted to independently detect first measurement data referring to local measurements reflected by the first local probe and a second detection arrangement associated with the second local probe adapted to independently detect second measurement data referring to local measurements effected by the second local probe.Type: GrantFiled: September 17, 2004Date of Patent: September 13, 2005Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Stephan Maximilian Altmann, Johann Karl Heinrich Hörber
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Publication number: 20050184746Abstract: The invention provides a local probe measuring device for effecting local measurements referring to a sample, comprising a first local probe for local measurements with respect to a sample or a reference surface, a second local probe for local measurements with respect to the sample or the reference surface, a measurement condition adjustment arrangement adapted to commonly adjust a first measurement condition of the first local probe with respect to the sample or the reference surface and a second measurement condition of the second local probe with respect to the sample or the reference surface, a detection arrangement comprising a first detection arrangement associated with the first local probe adapted to independently detect first measurement data referring to local measurements reflected by said first local probe and a second detection arrangement associated with the second local probe adapted to independently detect second measurement data referring to local measurements effected by said second local pType: ApplicationFiled: April 22, 2005Publication date: August 25, 2005Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Stephan Altmann, Johann Karl Horbe
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Patent number: 6927399Abstract: A device is proposed for the precision rotation of samples on a diffractometer, especially for X-ray or synchrotron radiation diffraction experiments, comprising: a centering element (26) which is held at one end of a motor-driven rotating shaft (22) and can be displaced in a plane orthogonal to the axis of rotation of the rotating shaft (22), a sample holder (30) which is fixed to the centering element (26) or integral with the latter for holding a sample (32) substantially centrally with respect to the axis of rotation in an X-ray or synchrotron radiation beam (S), at least one micrometer finger (36) which is arranged in the region of the centering element (26) and can be positioned orthogonally with respect to the axis of rotation of the rotating shaft (22) by means of a micrometer finger drive device.Type: GrantFiled: July 22, 2003Date of Patent: August 9, 2005Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Florent Cipriani, Jean Charles Castagna
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Publication number: 20050040836Abstract: The invention provides a local probe measuring device for effecting local measurements referring to a sample, comprising a first local probe for local measurements with respect to a sample or a reference surface, a second local probe for local measurements with respect to the sample or the reference surface, a measurement condition adjustment arrangement adapted to commonly adjust a first measurement condition of the first local probe with respect to the sample or the reference surface and a second measurement condition of the second local probe with respect to the sample or the reference surface, a detection arrangement comprising a first detection arrangement associated with the first local probe adapted to independently detect first measurement data referring to local measurements reflected by said first local probe and a second detection arrangement associated with the second local probe adapted to independently detect second measurement data referring to local measurements effected by said second local pType: ApplicationFiled: September 17, 2004Publication date: February 24, 2005Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Stephan Altmann, Johann Horber
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Patent number: 6833923Abstract: A method for detecting an object and/or an object's ambience and/or an object's inner space using a scanning particle trapped within a trapping potential. The trapping potential is configured within a position range defined relative to the object or a reference point in a first position determining stage which is associated with a first order of magnitude. In a second position determining stage, which is associated with an order of magnitude less than that of the first order of magnitude, the scanning particle trapped within the trapping potential moves more or less freely in three-dimensions while scanning subjected to the trapping potential to scan the scan volume. A plurality of scanning particle positions assumed as a consequence of scanning are detected within the scan volume.Type: GrantFiled: November 15, 2001Date of Patent: December 21, 2004Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Ernst-Ludwig Florin, Heinrich J. K. Hörber, Ernst H. K. Stelzer
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Publication number: 20040203057Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: ApplicationFiled: May 11, 2004Publication date: October 14, 2004Applicant: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Francis Stewart, Youming Zhang, Frank Buchholz
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Patent number: 6798226Abstract: The invention provides a probe measuring device for effecting local measurements referring to a sample, having a first probe and a second probe, a measurement condition adjustment arrangement adapted to commonly adjust a first measurement condition of the first probe with respect to a sample or a reference surface and a second measurement condition of the second probe with respect to a sample or a reference surface, a detection arrangement having a first detection arrangement associated with the first probe adapted to independently detect first measurement data referring to local measurements effected by the first probe and a second detection arrangement associated with the second probe adapted to independently detect second measurement data referring to local measurements effected by the second probe. Also provided are methods for effecting local measurements and local manipulations using multiple probes.Type: GrantFiled: September 24, 2002Date of Patent: September 28, 2004Assignee: Europäisches Laboratorium für Molekularbiologie (EMBL)Inventors: Stephen Maximilian Altmann, Johann Karl Heinrich Hörber
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Patent number: 6787316Abstract: The invention relates to methods for cloning DNA molecules using recE/recT-mediated homologous recombination mechanism between at least two DNA molecules where one DNA molecule is a circular or linear DNA molecule and the second DNA molecule is a circular DNA molecule, and the second DNA molecule contains two regions with sequence homology to the first DNA molecule. Competent cells and vectors are also described.Type: GrantFiled: August 30, 2002Date of Patent: September 7, 2004Assignee: Europaisches Laboratorium fur Molekularbiologie (EMBL)Inventors: Francis Stewart, Youming Zhang, Frank Buchholz
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Publication number: 20040126319Abstract: The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population, and correlating the traits of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.Type: ApplicationFiled: October 1, 2003Publication date: July 1, 2004Applicants: Baylor College of Medicine, European Molecular Biology Laboratory (EMBL), EnVivo PharmaceuticalsInventors: Edvard Falt, Luis Serrano, Cayetano Gonzalez, Christian Boulin, Christopher J. Cummings, Juan Botas, Huda Zoghbi
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Patent number: 6740511Abstract: The present invention relates to a modified fiber of an adenovirus, comprising at least one mutation at one or more residues within the region of said fiber stretching from pleated sheet A to pleated sheet B, and including loop AB.Type: GrantFiled: July 30, 2001Date of Patent: May 25, 2004Assignees: Transgene S.A., European Molecular Biology Laboratory (EMBL)Inventors: Mark Johan Van Raaij, Stephen Cusack, Valérie Legrand, Philippe Leissner, Majid Mehtali
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Publication number: 20040076583Abstract: The present invention provides a method for screening for the effect of a test agent on a population of biological specimens, preferably insects, comprising the steps of providing a population of specimens, administering at least one test agent to the population, creating a digitized movie showing the movements of members of the population, measuring at least one trait of members of the population, and correlating the traits of the population with the effect of the test agent. The invention also provides a method for preparing a medicament useful for the treatment of a mammalian disease.Type: ApplicationFiled: July 14, 2003Publication date: April 22, 2004Applicants: Baylor College of Medicine, European Molecular Biology Laboratory (EMBL), EnVivo PharmaceuticalsInventors: Edward Faeldt, Luis Serrano, Cayetano Gonzalez, Christian Boulin, Christopher J. Cummings, Juan Botas, Huda Zoghbi
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Publication number: 20040076318Abstract: A method of system is provided for assaying specimens. In connection with such system or method, plural multi-pixel target images of a field of view are obtained at different corresponding points in time over a given sample period. A background image is obtained using a plural set of the plural target images. For a range of points in time, the background image is removed from the target images to produce corresponding background-removed target images. Analysis is performed using at least a portion of the corresponding background-removed target images to identify visible features of the specimens. A holding structure is provided to hold a set of discrete specimen containers. A positioning mechanism is provided to position a plural subset of the containers to place the moving specimens within the plural subset of the containers within a field of view of the camera.Type: ApplicationFiled: July 14, 2003Publication date: April 22, 2004Applicants: Baylor College of Medicine, European Molecular Biology Laboratory (EMBL), EnVivo PharmaceuticalsInventors: Edward Faeldt, Luis Serrano, Cayetano Gonzalez, Christian Boulin, Christopher J. Cummings, Juan Botas, Huda Zoghbi