Abstract: Provided herein are compositions and methods for the design of synthetic regulatory sequences and for subsequent modulation of neural pathways.

Abstract: A method for producing a powder comprising at least one polymer for use in a method for the additive manufacture of a three-dimensional object is described. The method includes the step of mechanically treating the powder in a mixer with at least one rotating mixing blade, wherein the powder is exposed to a temperature TB and TB is at least 30° C. and is below the melting point Tm of the polymer (determined according to DIN EN ISO 11357) if the polymer is a semi-crystalline polymer, or wherein TB is at least 30° C. and wherein TB is at most 50° C. above the glass transition temperature Tg of the polymer (determined according to DIN EN ISO 11357) if the polymer is a melt-amorphous polymer.

Abstract: A method for post-treating a three-dimensional object (2) produced by selectively solidifying, layer by layer, of a building material (15) in powder form and/or unsolidified building material (13) in which the three-dimensional object (2) is embedded, wherein the three-dimensional object (2) produced and/or the unsolidified building material (13) are treated with a liquid (33). The liquid (33) comprises a liquid carrier substance and at least one further substance that reduces the surface tension of the carrier substance.

Abstract: A dual roller powder spreader assembly for use in layerwise manufacture in a powder bed fusion additive manufacture process utilizes in an embodiment tilting of the dual roller assembly such that a lead roller is raised upwardly relative to the powder bed in a sweep. This is accomplished using a mechanical cam-like engagement initiated at each end of the assembly's travel, causing what will then be the lead roller to rise as a whole relative to the now following roller, the latter pushing the powder pile across the powder bed. The tilt process is reversed at each end of travel.

Abstract: An additive manufacturing method for manufacturing a three-dimensional object (2) in an additive manufacturing apparatus (1) by a layer-wise selective solidification of building material (13) by means of an irradiation with laser radiation, wherein: in a process chamber (3) repeatedly a layer of building material is applied on a previously selectively solidified building material layer and is scanned with laser radiation at positions corresponding to the cross-section of the object in this layer, the laser radiation is generated by means of a laser light source (21) and is directed onto the building material layer via a number of optical components, wherein an optics compartment that is encased by an optics compartment housing (20a) accommodates the optical components, is characterized in that a defined gas atmosphere is maintained inside of the optics compartment, wherein the relative humidity of the defined gas atmosphere is kept below 3%.

Abstract: A control method serves for controlling at least one solidification device of an additive manufacturing device for manufacturing a three-dimensional object by means of an additive layer build method in which at least one object is manufactured by repeated application of a layer of a building material, to a build area and by selective solidification of the applied layer at positions corresponding to a cross-section of the object to be manufactured, wherein a gas having a plurality of flow directions which essentially are not aligned in the same direction flows across the build area.

Abstract: The present invention provides an aqueous electrolyte for use in rechargeable zinc-halide storage batteries that possesses improved stability and durability and improves zinc-halide battery performance (e.g., energy efficiency, Coulombic efficiency, and/or the like). One aspect of the present invention provides an electrolyte for use in a secondary zinc bromine electrochemical cell comprising from about 30 wt % to about 40 wt % of ZnBr2 by weight of the electrolyte; from about 5 wt % to about 15 wt % of KBr; from about 5 wt % to about 15 wt % of KCl; and one or more quaternary ammonium agents, wherein the electrolyte comprises from about 0.5 wt % to about 10 wt % of the one or more quaternary ammonium agents.

Abstract: The invention relates to a computer-assisted method for generating a control data set for an additive layer manufacturing device. In a first step, a layer data set is accessed, wherein points are marked in the data model which correspond to an object cross-section and at which the bid-up material should be solidified. In a second step, the layer data set is modified in such a way that for at least a portion of the object cross-section, the number of beams required for solidifying the build-up material inside said portion is determined preferably automatically, according to quality specifications of the portion and/or a manufacturing time of the object. In a third step, the modified layer data set is provided as a control data set for the additive layer manufacturing device.

Abstract: A recoater for applying a building material in a device for manufacturing a three-dimensional object within a build area by solidifying layers of the building material at the points corresponding to the respective cross-section of the object is suitable for applying a building material layer by moving across the build area in a movement direction. The recoater comprises a first scanning device including a first line sensor, for capturing at least a subarea of the build area.

Abstract: A method of manufacturing a three-dimensional object by selectively solidifying layers of a powdery material (3a) at the locations corresponding to the cross-section of the object (3) in the respective layers by impact of electromagnetic radiation (7a) is provided, where in a plastic powder, preferably polyamide, is used as powder, wherein the non-solidified powder (3a?) is subjected to a treatment by water or water vapour at increased temperatures after manufacturing the object, subsequently dried and thereafter used again to build-up a new object.

Abstract: A process for 3D printing a material by successively solidifying layers of the material to form a cross section of an object. The process includes providing a layer of the material, preheating the material to a preheating temperature, below the temperature at which the material is solidified, and solidifying a layer of the material by electromagnetic radiation or particle radiation. In the solidification step, during a predetermined period of time starting with the beginning of the solidification step, the heat introduced per unit area is reduced over time and can be described by a function which decreases monotonously depending on the time.

Abstract: A manufacturing method for generatively manufacturing a three-dimensional object by a layer-by-layer application and selective solidification of a building material. The method includes applying a layer of the building material to a build area by a recoater and selectively solidifying the applied layer of the building material at points corresponding to a cross-section of the object to be manufactured by a solidification device. The steps of applying and solidifying are repeated until the three-dimensional object is completed. A heating element locally introduces thermal energy into the newly applied layer of the building material and/or into the layer of the building material which is already selectively solidified. In the course of this, the thermal energy released by the heating element is adjustable depending on the position of this point in the build area.

Abstract: A device for an adjustment of a heater control in an additive manufacturing device, in which a heater control regulates the heating of an applied building material layer by means of a heating device (17) up to a work temperature (TA) comprises: a nominal parameter provision unit (201) designed such that it provides at least one nominal parameter value, meaning the setpoint of a controlled variable and/or its change with time and/or the setpoint of a heater parameter and/or its change with time, an actual parameter detection unit (202) designed such that it is able to detect for at least one of the nominal parameter values the corresponding actual parameter value in the heater control or in the additive manufacturing device, wherein an actual parameter value is the actual value of a controlled variable and/or the actual value of its change with time and/or the actual value of a heater parameter and/or the actual value of its change with time, and a control change unit (203) that automatically changes at lea

Abstract: A device (1) for producing a three-dimensional object (2) through layer-wise solidifying of build-up material (13) at positions (43) corresponding to a cross-section of the object (2) to be produced in a respective layer comprises a coating device (12-14) for applying a layer of the build-up material (13) on a working plane (10), a solidifying device (20) for the selective solidifying of the build-up material (13) in the applied layer and a gas suction nozzle (34) for extracting gas from the device (1) by suction. The gas suction device (34) is thereby movably arranged and the device (1) is designed to control or to regulate a movement and/or orientation of the gas suction nozzle (34) as a function of a number of reference positions (51, 53, 55a, 55b, 55c, 55d).

Abstract: Method for calibrating an apparatus for manufacturing a three-dimensional object by layer-wise selective solidification of building material with the step of generating an substantially periodic first modulation pattern in a first sub-area of the build area, the step of generating an substantially periodic second modulation pattern in a second sub-area of the build area, wherein in the overlap zone, the first modulation pattern and the second modulation pattern form an substantially periodic superposition pattern, whose period is larger than the period of the first modulation pattern and the period of the second modulation pattern, the step of detecting the superposition pattern, and the step of determining the deviation of the position of the superposition pattern on the build area from a reference position.

Abstract: An optical communication system includes a free space optical transceiver within a housing to transmit and receive optical communication signals along an optical pathway through a window in the housing. Heating elements applied to the interior surface of the window substantially uniformly heat the window such that the window is kept free from condensation and ice without introducing significant distortions in the wavefront. Accordingly, the heating elements are designed and placed on the window such that the obscuration caused by the presence of the heating elements within the optical pathway and the wavefront distortion caused by temperature gradients within the cross-section of the window in the optical pathway cause less than 1 decibel (dB) in transmission loss as compared to the same system without the heating elements on the window.

Abstract: A recoating unit (40) serves for equipping or retrofitting a device (1) for additive manufacturing of a three-dimensional object (2) by selectively solidifying a building material (15), preferably a powder, layer by layer. The device (1) comprises a recoater (16) movable across a build area (8) for applying a layer (31b, 32b) of the building material (15) within the build area (8) and a solidification device (20) for selectively solidifying the applied layer (31b, 32b) at positions corresponding to a cross-section of the object (2) to be manufactured. The device (1) is formed and/or controlled to repeat the steps of applying and selectively solidifying until the object (2) is completed. The recoating unit (40) comprises at least two recoating rollers (41, 42) spaced apart from each other in a first direction (B1) and extending into a second direction transversely, preferably perpendicularly, to the first direction.

Abstract: A method for producing a three-dimensional object by applying layers of a pulverulent construction material and by selectively solidifying said material by the action of energy comprises the steps: a layer of the pulverulent construction material is applied to a support or to a layer of the construction material that has been previously applied and at least selectively solidified; an energy beam from an energy source sweeps over points on the applied layer corresponding to a cross-section of the object to be produced in order to selectively solidify the pulverulent construction material; and a gas flow is guided in a main flow direction (RG) over the applied layer during the sweep of the energy beam. The main flow direction (RG) of the gas flow (G) and the sweep direction (RL) of the energy beam are adapted to one another at least in one region of the cross-section to be solidified.

Abstract: A lip balm applicator product comprises upper and lower portions that are connectable together to define the applicator product being of a substantially spherical shape. A support platform is located in the lower portion and accommodates a quantity of lip balm having an arcuate surface. A lip balm comprises a composition of waxes and oils in solid form and formed to have an arcuate surface. The composition is formed to have the arcuate surface using a hot pour process. A method of manufacturing a lip balm comprises providing a receptacle having a concave arcuate surface. A lip balm material in a heated, liquefied phase is poured into the receptacle. Once poured, the heated, liquefied phase is allowed to solidify such that a surface of the solidified lip balm material has an arcuate configuration that corresponds to the concave arcuate surface of the receptacle.

Abstract: A method of manufacturing a permanent magnet, including providing a powder composition, of which a first fraction includes ferromagnetic metal particles and a second fraction includes thermoplastic polymer particles; using the powder composition in a powder-bed based additive manufacturing process to form a part including ferromagnetic metal particles embedded in a fused thermoplastic polymer body; and subsequently conferring magnetism on the built part by arranging the finished part in a magnetic field.