Abstract: A refractive index distribution estimating system includes an illumination optical system configured to illuminate a sample, an imaging optical system configured to form an optical sample image, an image sensor configured to capture optical images of the sample, and a processor configured to reconstruct a refractive index distribution of the sample from images.

Abstract: An inverted microscope system provided with a transillumination subsystem that illuminates a sample includes: an eyepiece lens; an objective; a tube lens; a projection device, disposed below the objective, that projects a projected image based on projected image data onto an image plane where an optical image is formed; a first modulation element included in the transillumination subsystem; a second modulation element disposed between the objective and the tube lens; and a processor and a memory, the processor being configured to perform the following steps: generating an analysis result that specifies a candidate cell that is a reproductive cell suitable for fertilization, based on at least the digital image data acquired by the imaging device; and generating the projected image data based on the generated analysis result, wherein the projected image includes a first assisting image that specifies the candidate cell as an assisting image that assists with micro-insemination.

Abstract: An endoscope device includes an imaging optical system including two incident light paths formed by two optical systems respectively having optical axes eccentric with respect to an imaging center of an imaging element, an optical action member configured to change a convergence angle, and a processor configured to control a state of the optical action member in the imaging optical system. The processor changes the convergence angle by controlling the state of the optical action member in the imaging optical system.

Abstract: An insertion state determination system includes a sensor unit including a first sensor and the system includes a second sensor and a processor. The first sensor is configured to determine a first rotation amount indicating a rotation amount of an elongated insertion unit of an endoscope device around a center axis of the insertion unit. A hole through which the insertion unit passes is formed in the sensor unit. The second sensor is disposed in the sensor unit or an object fixed to the sensor unit and is configured to determine a second rotation amount indicating a rotation amount of the sensor unit around the center axis when the insertion unit is inserted into the subject. The processor is configured to calculate a corrected rotation amount by correcting the first rotation amount based on the second rotation amount.

Abstract: A microscope system includes an incoherent light source, a detection optical system, and an imager. The incoherent light source is a light source that emits light that is temporally not coherent. In a sample, a plurality of coherent illuminations are performed simultaneously by light emitted from the incoherent light source. The coherent illuminations are illumination by light that is spatially coherent. The direction in which the sample is irradiated with a light beam is different for each coherent illumination. In a pupil plane of the detection optical system, the respective light beams of the coherent illuminations pass through first regions different from each other. Each of the first regions satisfies the following Condition (1). At least one distance among distances between the two adjacent first regions satisfies the following Condition (2). LS<PS×10?3??(1) 0.

Abstract: An estimation system has a memory and a processor. The memory stores first wave front information and second wave front information. The first wave front information is information on the wave front that is obtained based on first illumination light that has passed through an object. The second wave front information is information on the wave front that is obtained based on second illumination light that has passed through the object. The wavelength at which the intensity of the second illumination light is highest is shorter than the wavelength at which the intensity of the first illumination light is highest. The processor performs an estimation process of estimating a three-dimensional optical property of the object. The three-dimensional optical property is a refractive index distribution or an absorbance distribution. The estimation process uses both the first wave front information and the second wave front information.

Abstract: A data processing method includes an input step S1 of inputting measurement data into a neural network, an estimation step S2 of generating estimation data from the measurement data, a restoration step S3 of generating restoration data from the estimation data, and a calculation step S4 of calculating a confidence level of the estimation data, based on the measurement data and the restoration data. The neural network is a trained model, the measurement data is data obtained by measuring light transmitted through an object, the estimation data is data of a three-dimensional optical characteristic of the object estimated from the measurement data, and the three-dimensional optical characteristic is a refractive index distribution or an absorptance distribution.

Abstract: In a three-dimensional image display method, a processor acquires first three-dimensional data and second three-dimensional data of a subject from a recording medium. The processor converts a first three-dimensional coordinate system of the first three-dimensional data and a second three-dimensional coordinate system of the second three-dimensional data into a three-dimensional common coordinate system on the basis of structure information related to a geometric structure of the subject. The processor displays an image of the first three-dimensional data in the common coordinate system and an image of the second three-dimensional data in the common coordinate system on a display.

Abstract: A microscope system includes an eyepiece-side observation optical system that forms an image of a sample on an object side of an eyepiece, a camera-side observation optical system that forms an image of the sample on an image sensor, a diaphragm that limits a numerical aperture on the emission side of the camera-side observation optical system, and a processor that analyzes the image of the sample captured by the image sensor. In a case where a numerical aperture on an object side of an objective lens is denoted by NA, the numerical aperture on the emission side of the camera-side observation optical system determined by a light flux emitted from the camera-side observation optical system toward the image sensor at capturing the image is denoted by NA?, and a total magnification of the camera-side observation optical system is denoted by M1, the following is satisfied.

Abstract: A lens-barrel device includes: a relay optical system that relays a primary image formed by an imaging lens to an object plane of an eyepiece to form a secondary image; a first reflection optical system that reflects and bends the light flux from the imaging lens; a second reflection optical system that reflects and bends the light flux that has passed through the first reflection optical system; a third reflection optical system that reflects and bends the light flux that has passed through the second reflection optical system; an additional optical system that transmits the light flux for forming an image different from the secondary image, on the object plane of the eyepiece; and a compositing optical element that guides the light flux from the additional optical system to a light path to the object plane of the eyepiece.

Abstract: An endoscopic device includes: an insertion portion that is inserted into a test subject and includes an imaging element; an operation receiving unit; and a processor. The processor, during recording processing of a moving image including a plurality of frame images generated on the basis of an imaging signal output from the imaging element, adds, as a tag, information regarding an operation to a frame image corresponding to a timing when the operation receiving unit receives the operation, and adds, as a tag, information regarding a specific feature image to a frame image recognized as the specific feature image, and extracts a frame image from among the plurality of frame images included in the moving image on the basis of a tag.

Abstract: A laser scanning microscope includes a scanner that scans a sample with laser light; a detector having a silicon photomultiplier (SiPM); and a processor that executes image processing of removing dark count noise based on an appearance frequency of the dark count noise in the SiPM on a scanned image.

Abstract: An observation vessel includes a holding portion configured to hold an observation object and an accommodation portion at least partially formed of a transparent curved surface and configured to position the holding portion. The holding portion is configured to hold the observation object at a set position separated from the curved surface toward a center of curvature of the curved surface in a first state of being positioned at a first position by the accommodation portion.

Abstract: A system includes a control device including a processor. The processor is configured to record a log into a log file, the log regarding information on an event having occurred in the system such that an operation state of the system at a point in time of the occurrence of the event is allowed to be specified as any of a plurality of operation states and an operation state different from the plurality of operation states. Here, the plurality of operation states correspond to a plurality of pieces of sequence processing previously defined. The processor is configured to extract the log from the log file, based on information designating a particular operation state as the operation state of the system, in units of operation states of the system such that the log includes information on an event having occurred in the particular operation state.

Abstract: A specimen analysis apparatus includes: a light source; an imager configured to capture, at predetermined time intervals, images of the specimen and sequentially generate image data; a processor configured to sequentially detect the core tissue that appears in an image corresponding to the sequentially generated image data, sequentially calculate a tissue amount of the core tissue based on the sequentially detected core tissue, and determine whether the tissue amount of the core tissue is smaller than a threshold value set in advance every time the processor calculates the tissue amount; an isolator configured to isolate the core tissue from the specimen; and a drive controller configured to cause the isolator to perform the isolation operation when the tissue amount is smaller than the threshold value, and cause the isolator to stop the isolation operation when the tissue amount is equal to or larger than the threshold value.

Abstract: An observation device includes: first objective lenses arranged in a row so as to be parallel to one another; second objective lenses arranged in a row so as to be parallel to one another; and image capturing elements for capturing first images formed by the first objective lenses and second images formed by the second objective lenses, respectively, wherein each of the objective lenses is a magnifying objective lens, a first axis of light incident on the first objective lenses and a second axis of light incident on the second objective lenses are parallel to one another, fields of view of the first objective lenses and fields of view of the second objective lenses are arranged alternately in a row on an observation line, and the first images and the second images are arranged in a row in image-forming regions that are disposed at positions different from each other.

Abstract: An image pickup apparatus includes a signal acquisition unit and a rotation unit. The signal acquisition unit includes an illumination unit including a light source and configured to irradiate a sample with a light beam, a photodetector including a plurality of light-receiving portions two-dimensionally arranged, and a detection optical system configured to guide light having been irradiated from the illumination unit to the sample and passed through the sample, to the photodetector. The rotation unit rotates the sample and the signal acquisition unit relative to each other, about a first axis intersecting an optical axis of the detection optical system in the sample. The illumination unit irradiates the sample with light beams at two or more incident angles in a plane including the optical axis and the first axis.

Abstract: A microscope system includes an observation optical system that forms an optical image of a specimen on an object side of an ocular lens; a projection device that superimposes information on an image plane on which the optical image is formed, an imaging device that is provided on an imaging optical path branched from an observation optical path, and a processor. The processor controls the projection device to superimpose, on the image plane, focus information based on a captured image of the specimen acquired by the imaging device and analysis information regarding a result of image analysis on the captured image, the image analysis being different from focus analysis.

Abstract: An objective includes: an objective barrel; a plurality of lens sub-assemblies stacked in an optical axis direction of the objective in the objective barrel, each of the plurality of lens sub-assemblies including a lens and a lens frame holding the lens; and a screw member screwed into the objective barrel, the screw member pressing the plurality of lens sub-assemblies against the objective barrel along the optical axis direction of the objective. The screw member has three or more concave portions into which a jig is fitted when the screw member is screwed into the objective barrel.

Abstract: An ocular tube for a microscope, to which an ocular lens is to be attached, includes a superimposition device that superimposes an assistive image on an image plane on which an optical image is formed with light from the microscope.