Abstract: Various embodiments provide methods and related compositions for increasing the population size of hematopoietic stem cells (HSCs) in patients that may benefit from reconstitution of stem cells and/or differentiated cells of the blood lineage. The present methods enable the production of HSCs ex vivo and in vivo by reducing latexin expression and/or latexin activity within HSC exposed to various antagonists. Inhibition of latexin expression and/or latexin activity by various antagonists can promote HSC proliferation and/or inhibit HSC apoptosis. Antagonists that can reduce latexin expression and/or latexin activity can be utilized to regenerate endogenous HSCs within patients affected with disorders, diseases, cancers, or therapies for such conditions, that result in the depletion or reduction in HSCs.

Abstract: A plasma system includes a plasma device, an ionizable media source, and a power source. The plasma device includes an inner electrode and an outer electrode coaxially disposed around the inner electrode. The inner electrode includes a distal portion and an insulative layer that covers at least a portion of the inner electrode. The ionizable media source is coupled to the plasma device and is configured to supply ionizable media thereto. The power source is coupled to the inner and outer electrodes, and is configured to ignite the ionizable media at the plasma device to form a plasma effluent having an electron sheath layer about the exposed distal portion.

Abstract: In one aspect, the invention relates to substituted 1H-benzo[d][1,2,3]triazol-1-ol analgoues, derivatives thereof, and related compound; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders, e.g. various tumors and cancers, associated with ?-catenin/Tcf protein-protein interaction dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present invention relates to an aptazyme comprising an aptamer for hepatitis C virus (HCV) RNA-encoding component; a hammerhead ribozyme comprising an antisense sequence to microRNA at the site released by self-cleavage; and a communication module sequence that connects the aptamer and hammerhead ribozyme and triggers a self-cleavage activity of the hammerhead ribozyme upon binding of the aptamer with the HCV RNA-encoding component. The present aptazyme inhibits microRNA activity specifically in HCV proliferating cells and thus a composition of the present invention comprising the aptazyme can be effectively used for treatment of HCV-related diseases.

Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. A first substance is frozen in a cryopreservation fluid in a first well of a lid. The lid includes a first surface communicating with a first port of the first well and a second surface communicating with a second port of the first well. A porous membrane is affixed to the first surface so as to overlap the first port and a non-porous membrane is affixed to the second surface so as to overlap the second port. The first substance may be dialytically freed from the cryopreservation fluid at a user desired time. Thereafter, the lid may be moved from a first position wherein the lid is spaced from a base to a second position wherein the lid is adjacent the channel in the base such that the first substance communicates with the input of the channel.

Abstract: A method for a relay node (RN) to avoid inter-cell interference (ICI) in a wireless access system is provided. The method includes: overhearing a PDCCH transmitted by a plurality of BSs sharing the RN to terminals of each BS in the nth subframe; decoding the PDCCH from the n+1th subframe to the n+2th subframe; reallocating resource area to the terminals; transmitting control information representing the reallocated resource area to each BS; overhearing and decoding a PUSCH to each BS in the n+4th subframe; transmitting the decoding result to each BS; overhearing a PDCCH updated at n+8th subframe; and retransmitting the PUSCH transmitted at the n+4th subframe to a BS(NACK) in the n+12th sub frame.

Abstract: According to example embodiments, a method of forming a multilayer graphene structure includes forming a sacrificial layer on the growth substrate, growing a first graphene layer on the sacrificial layer using a chemical vapor deposition (CVD) method, and growing at least one more graphene layer on the growth substrate. The growing at least one more graphene layer includes removing at least a part of the sacrificial layer.

Abstract: Improved neuromodulation control of neurological abnormalities associated with effector organs in vertebrate beings using direct current stimulation for modulating spinal cord excitability, having a peripheral-current supplying component for providing direct current peripheral nerve stimulation and a spinal-current supplying component providing direct current for spinal stimulation, and a controller managing such functions.

Abstract: Provided are a multi-selective polishing slurry composition and a semiconductor element production method using the same. A silicon film provided with element patterns is formed on the uppermost part of a substrate having a first region and a second region. The element pattern density on the first region is higher than the element pattern density on the second region. Formed in sequence on top of the element patterns are a first silicon oxide film, a silicon nitride film and a second silicon oxide film. The substrate is subjected to chemical-mechanical polishing until the silicon film is exposed, by using a polishing slurry composition containing a polishing agent, a silicon nitride film passivation agent and a silicon film passivation agent.

Abstract: A hypodermic needle system and method for reducing the incidence of infections due to administering fluids by injection to humans or animals is provided. The hypodermic needle system may include a needle with an insert disposed within its hollow channel to substantially prevent bacteria, fungi and/or other organisms/contaminants, which may be present on the exterior surface to be penetrated, from adhering to the inner surfaces of the needle's channel or become trapped in the needle bore. The hypodermic needle system may include a film that covers at least one surface of the needle or insert, and/or have a bent or curved tip to reduce the ability of infectious agents to adhere to said surface/space within the needle. Additionally, the hypodermic needle system may include an anti-infection agent, such as an antibiotic or antiseptic to further reduce the incidence of infections, and may include an attachment member which reduces the risk of infection.

Abstract: Cyano-substituted anthracene containing polyamines were synthesized and shown to be efficient polyamine transporter ligands. Moreover, these compounds (3 and 4) had improved fluorescence properties over previously known anthryl-polyamine conjugates, which facilitated their intracellular trafficking by confocal microscopy and fluorescence methods. These cytotoxic fluorescent agents may find use as molecular probes which traffic into cells via the polyamine transport system and may also be viable anticancer drugs which are readily quantified in human tissues due to their excellent fluorescence properties: (excitation: ? 405 nm) and emission (420 nm) occurs in the visible light range. The ability to excite and emit in the visible range provides an advantage to these probes as these wavelengths are considered non-toxic to human cells (versus ultraviolet mediated excitations, ?<400 nm) and visible light lasers are less costly to purchase and operate than UV laser sources.

Abstract: Provided are a method and apparatus for detecting an abnormal movement. The apparatus includes a feature tracing unit configured to extract features of a moving object in an input image, trace a variation in position of the extracted features according to time, and ascertain trajectories of the extracted features; a topic online learning unit configured to classify the input image in units of documents which are bundles of the trajectories, and ascertain probability distribution states of topics, which constitute the classified document, by using an online learning method which is a probabilistic topic model; and a movement pattern online learning unit configured to learn a velocity and a direction for each of the ascertained topics, and learn a movement pattern by inferring a spatiotemporal correlation between the ascertained topics.

Abstract: The present invention provides continuous, non-hazardous sterilization and anti-microorganism protection by the generation of interactive, emission responsive surfaces, coatings, and coating systems.

Abstract: A tactile display comprises a contact pad, operable to engage a target area of a user's skin. A restraining system is operable to restrain a portion of the user's skin distal from the target area of the skin. An actuation system is operably coupled to one of: i) the contact pad and the ii) restraining system. The actuation system is capable of moving the contact pad and the restraining system relative to one another to create a shear force across the target area of the user's skin to thereby provide tactile information to the user.

Abstract: The present application relates to a method for dispersing quantum dots (QDs) or quantum wires in zeolite, to zeolite containing quantum dots or quantum wires dispersed by the method, and to a method for stabilizing quantum dots or quantum wires in zeolite.

Abstract: Graphene nanoribbon arrays, methods of growing graphene nanoribbon arrays and electronic and photonic devices incorporating the graphene nanoribbon arrays are provided. The graphene nanoribbons in the arrays are formed using a scalable, bottom-up, chemical vapor deposition (CVD) technique in which the (001) facet of the germanium is used to orient the graphene nanoribbon crystals along the [110] directions of the germanium.

Abstract: Provided is a neural device including a nanowire and a support layer. Further, provided is a neural device including: a substrate, at least one nanowire which is fixed on the substrate at a lengthwise end thereof to extend vertically and inserted into nerves to obtain electrical signals from nerve fibers or apply electrical signals to the nerve fibers; and a support layer which is formed on the substrate and which surrounds and supports at least one portion of the nanowire.

Abstract: The present invention provides a meter retrofit and method for use thereof, utilizing a transducer with an encoder driven by a rotating shaft of a meter reading dial, the transducer including a plurality of encoder contacts surrounding a rotation axis, with each encoder contact connected to a magnetic switch. A wiper connects to the shaft and rotates around the rotation axis, sequentially contacting the plurality of encoder contacts, providing a variable signal to a monitoring device.

Abstract: A system includes a vibration unit that provides independent adjustability of vibration characteristics such as frequency and amplitude and may provide a first motor that rotates an eccentric and can adjust vibration frequency and a second motor that that may move the eccentric within the vibration unit in a manner that adjusts amplitude of the vibration.

Abstract: Novel 3?-deoxy-3?-acylaminospectinomycin compounds are described. Also described are methods of using the 3?-deoxy-3-acylaminospectinomycin compounds and other spectinomycin analogs in treating tuberculosis and in treating microbial infections.