Abstract: Systems and methods are provided for classifying an impact to a head of a human being as one of a plurality of event classes. A sensor interface is configured to determine an acceleration at a location of interest on the human being from provided sensor data in response to the impact. A feature calculation component is configured to calculate a plurality of impact parameters from the determined acceleration at the location of interest. A pattern recognition classifier is configured to associate the impact with an associated event class of at least three associated event classes according to the calculated plurality of impact parameters. A post-processing component is configured to communicate the associated event class an observer via an associated output device.

Abstract: A stage circuit includes a first driver, a second driver, a first output unit and a second output unit. The first driver controls voltages of first and second nodes, according to a first power source, a start signal or a carry signal of a previous stage supplied to a first input terminal, a first clock signal supplied to a second input terminal, and a second clock signal supplied to a third input terminal. The second driver controls a voltage of a third node, according to the first power source, a start signal or a carry signal of a previous stage supplied to a first input terminal, a carry signal of a next stage supplied to a fourth input terminal, and the voltage of the second node.

Abstract: The present invention relates to a use of a human small leucine zipper protein in the adipocyte differentiation procedure. More specifically, sLZIP binds with PPAR?2 to induce the formation of a complex of HDAC3 and PPAR?2, thereby functioning as a corepressor to negatively inhibit the transcriptional activity of PPAR?2 and suppress the differentiation to adipocytes, and thus can be used as a marker for treating diabetes and obesity and developing new medicines therefor.

Abstract: Described herein is the synthesis of adhesive from simple adhesive coacervates and their uses thereof. The adhesives are produced by (a) preparing a solution comprising (1) a polyelectrolyte, wherein the polyelectrolyte comprises a polyanion or polycation but not a combination thereof, the polyeletrolyte comprises at least one crosslinking group, and (2) a sufficient amount of a complimentary counterion to produce a simple adhesive coacervate; and (b) crosslinking the simple adhesive coacervate to produce the adhesive. The adhesives have numerous medical and non-medical applications.

Abstract: A storage system for organizing and maintaining metadata in a distributed network. The system includes: a network; a plurality of distributed nodes configured to communicate through the network; a plurality of block devices configured to communicate with the plurality of distributed nodes through the network; and a management server configured to communicate with each of the plurality of distributed nodes and block devices and further configured to arbitrarily associate metadata and data to any of the plurality of distributed nodes such that a global copy of the metadata does not exist in one or more fixed locations known to all distributed nodes.

Abstract: Methods and systems for producing prescribed unit size azido-poly(3-hydroxyalkanoate) (azido-PHA) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of PHA or lack enzymes to degrade PHA once synthesized, metabolize short to long chain fatty acids without induction, and express an (R)-specific enoyl-CoA hydratase and a PHA synthase, the (R)-specific enoyl-CoA hydratase and PHA synthase having wide substrate specificities. The recombinant bacteria are fed at least one ?-azidofatty acid substrate that is equal in carbon length to the prescribed or desired unit size of an azido-PHA polymer to be produced. Azido-PHA polymers or azido-PHA co-polymers can be conjugated via copper-catalyzed alkyne-azide cycloaddition (CuAAC) or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions. The prescribed unit size conjugated azido-PHA polymer or orthogonally conjugated azido-PHA co-polymer that is produced is then isolated and/or purified.

Abstract: A gateway apparatus includes a first network controller, a second network controller, and a time synchronization control unit. The first network controller has a first timer time-synchronized with nodes within a first network domain. The second network controller has a second timer time-synchronized with nodes within a second network domain. The time synchronization control unit includes a processor configured to store the observed times of the switching points of synchronized time slots within the first network domain, based on system time within the second network domain, and adjusts the rate of the second timer based on a comparison of a time difference between the successive observed times and a nominal length of the time slots.

Abstract: Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines.

Abstract: Microelectromechanical system are disclosed that include at least one electrode, microelectrode or combination thereof, wherein the at least one electrode comprises a carbon material, a glassy carbon material or a combination thereof. Contemplated systems are suitable for ?-ECoG arrays. Additional microelectromechanical systems are disclosed that include at least one electrode, microelectrode or combination thereof, wherein the at least one electrode comprises a carbon material, a glassy carbon material or a combination thereof; at least one substrate, surface, layer or a combination thereof, wherein the at least one electrode, microelectrode or combination thereof is disposed on, coupled with or otherwise layered on the at least one substrate, surface, layer or a combination thereof; and at least one bump pad, wherein the at least one electrode, microelectrode or combination thereof is coupled with the at least one bump pad via at least one conductive metal.

Abstract: A wireless device and method for managing a multicast group within a wireless network are disclosed. The wireless device is included in a first multicast group in which data is directly sent between member devices or data is sent using hopping between the member devices. The wireless device includes a reception unit, a determination unit, and a transmission unit. The reception unit receives a join request for joining a second multicast group from a joining device that attempts to join the second multicast group. The determination unit extracts information about the second multicast group from the join request, and determines whether the second multicast group is identical with the first multicast group based on the information about the second multicast group. The transmission unit forwards the join request to another device or sends a response to the join request to the joining device based on a result of the determination.

Abstract: Several aromatic hydrocarbons di-substituted with a polyamine are described according to formulas selected from compounds 4, 7, 10, 15 and pharmaceutically acceptable salts thereof. The novel dimeric polyamines of the present invention demonstrate enhanced penetration into cells having an upregulated polyamine transport system, such as various types of cancer cells. The disclosed aromatic polyamine dimers provide highly efficient drugs for targeting cancer cells with active polyamine transporters.

Abstract: Differential surface-charge-dependent localization of nanoceria in normal cells and cancer cells plays a critical role in the toxicity profile of a nanoceria particle. Engineered surface-coated cerium oxide nanoparticles with different surface charges that are positive, negative and neutral provide therapeutic results for normal and cancer cell lines. Results show that nanoceria with a positive or neutral charge enters most of the cell lines studied, while nanoceria with a negative charge internalizes mostly in the cancer cell lines. Moreover, upon entry into the cells, nanoceria is localized to different cell compartments (e.g. cytoplasm and lysosomes) depending on the nanoparticle surface charge. The internalization and subcellular localization of nanoceria plays a key role in the nanoparticle cytotoxicity profile, exhibiting significant toxicity when they localize in the lysosomes of the cancer cell lines.

Abstract: Microneedles and their use as a physical skin permeation enhancement technique facilitate drug delivery across the skin in therapeutically relevant concentrations. Micropores created in the skin by MNs reseal because of normal healing processes of the skin, thus limiting the duration of the drug delivery window. Pore lifetime enhancement strategies can increase effectiveness of MNs as a drug delivery mechanism by prolonging the delivery window. Fluvastatin (FLU) was used to enhance pore lifetime by inhibiting the synthesis of cholesterol, a major component of the stratum corneum lipids. The skin recovered within a 30-45-min time period following the removal of occlusion, and there was no significant irritation observed due to the treatment compared to the control sites. Thus, it can be concluded that localized skin treatment with FLU can be used to extend micropore lifetime and deliver drugs for up to 7 days across MN-treated skin.

Abstract: The invention provides a cement paste composition comprising cement, cellulose nanocrystals, and optionally water. The cellulose nanocrystals can be present in an amount sufficient and effective to increase the flexural strength of cured cement prepared from the cement paste composition. The cellulose nanocrystals can also be present in an amount sufficient and effective to increase the workability of a cement paste prepared from the cement paste composition. The invention further provides a water reducing additive that reduces the amount of water required for desired workability of a cement composition. Use of the presence of the cellulose nanocrystals also results in an increased degree of hydration and cumulative heat evolution in comparison to a corresponding composition without the cellulose nanoparticles, thereby resulting in a higher total cure of the cement paste composition upon curing.

Abstract: The GESTURE RECOGNITION APPARATUSES, METHODS AND SYSTEMS FOR HUMAN-MACHINE INTERACTION (“GRA”) discloses vision-based gesture recognition. GRA can be implemented in any application involving tracking, detection and/or recognition of gestures or motion in general. Disclosed methods and systems consider a gestural vocabulary of a predefined number of user specified static and/or dynamic hand gestures that are mapped with a database to convey messages. In one implementation, the disclosed systems and methods support gesture recognition by detecting and tracking body parts, such as arms, hands and fingers, and by performing spatio-temporal segmentation and recognition of the set of predefined gestures, based on data acquired by an RGBD sensor. In one implementation, a model of the hand is employed to detect hand and finger candidates.

Abstract: The present invention relates to a reference frame selection technique for an error resilience of video codec using multiple reference frames. The reference frame selection technique for an error resilience of video codec using multiple reference frames according to the present invention comprises the steps of: performing a motion estimation individually in each of the multiple reference frames so as to search a reference macroblock of the macroblock to be coded; checking the degree of match between the reference macroblock region found by the motion estimation and the intra-coded macroblock of the reference frame; and selecting the motion vector (MV) of the reference macroblock which is relatively best matched to the intra-coded macroblock of the reference frame from among the reference macroblocks found in each of the multiple reference frames.

Abstract: There is provided a vibration generating device including: a housing having an internal space; a base member installed in the housing to be disposed in a central portion of the housing; a first plate installed on the base member; a first piezoelectric element installed on an upper surface of the first plate; a second piezoelectric element disposed to face the first piezoelectric element through a connection member; a second plate installed on the second piezoelectric element; and a vibration amplifying part installed on an upper surface of the second plate.

Abstract: Disclosed are a homography estimation apparatus and method. A down-sampling unit reduces the reference image and the target image to the same size to generate down-sampled images. A feature point extraction unit extracts feature points from the reference image and the target image down-sampled to the same size, respectively. An outlier removal unit matches the feature points extracted from the reference image with the feature points extracted from the target image, and detects and removes outliers, which are feature points that do not match, from the matched feature points. A homography estimation unit estimates a homography using feature points from which outliers are removed. A reference image correction unit corrects the reference image using the estimated homography.

Abstract: Embodiments relate to systems and methods for magnetized stent having growth-promoting properties. A stent assembly comprising a tubular elongated body having a magnetized region and a tissue nidus area is inserted beneath the orifice of a vascular aneurysm. The magnetic region can serve to attract and position both residual red blood cells and magnetically nano-ireated growth-promoting cells to the orifice area of the aneurysm. The outer circumference of the tubular elongated body can act as a floor or scaffold for regenerated smooth vascular muscle cells. In embodiments, the tissue nidus area can be provided on the exterior stent, while the magnetized region is provided on the interior stent, of a stent-in-stent structure. In embodiments, the exterior stent is made of biodegradable material which gradually dissolves or dissipates in situ.

Abstract: Described are ?/?-peptide mimics of Z-domain scaffold peptides, methods of making them, and methods of using them. The ?/?-peptide mimics include ?-amino acid residues and, optionally, disulfide bonds to stabilize the conformation of the mimics. The compounds may be truncated as compared to conventional Z-domain scaffold peptides and are resistant to proteolytic degradation due to the presence of ?-amino acid residues. The mimics can be made so as to bind selectively to a desired target.