Abstract: A fluid mixing method using a micromixing apparatus which includes a mixing microchannel having a channel length and a continuously variable channel width defined by a first sidewall surface and an opposing second sidewall surface. The channel width varies from a minimum channel width h to a maximum channel width H in a ratio of H:h?1.1:1.0. A first inlet injects a first fluid and a second inlet a second fluid into the mixing microchannel which both flow in a flow direction in the mixing microchannel along the channel length. The first sidewall surface includes first curved surface portions and the second sidewall surface includes second curved surface portions. The first and second curved surface portions are non-overlapping to provide the variable channel width. The flow velocity profile is passively varied and exclusively controlled by the continuously variable channel width.
Type:
Grant
Filed:
March 29, 2013
Date of Patent:
February 16, 2016
Assignee:
University of Central Florida Research Foundation, Inc.
Inventors:
Ehsan Yakhshi Tafti, Hyoung Jin Cho, Ranganathan Kumar
Abstract: A method of reducing virulence in a bacterium comprising at least one of a GacS/GacA-type system, a HrpX/HrpY-type system, a T3SS-type system, and a Rsm-type system, the method comprising contacting the bacterium with an effective amount of a compound described herein.
Type:
Grant
Filed:
February 16, 2011
Date of Patent:
February 16, 2016
Assignees:
UWM Research Foundation, Duke University
Inventors:
Ching-Hong Yang, Xin Chen, Eric J. Toone
Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.
Type:
Grant
Filed:
June 18, 2013
Date of Patent:
February 16, 2016
Assignee:
University of Iowa Research Foundation
Inventors:
Beverly L. Davidson, Haibin Xia, Qinwen Mao, Henry Paulson, Ryan Boudreau, Scott Harper
Abstract: A flow through filter assembly includes a trivalent and tetravalent metal ion capturing agent and a flow controller providing a predetermined flow rate which allows capture of the trivalent and tetravalent metal ions by the capturing agent.
Type:
Grant
Filed:
February 21, 2014
Date of Patent:
February 16, 2016
Assignees:
The University of Kentucky Research Foundation, The Curators of the University of Missouri, Alkymos, Inc.
Inventors:
Robert A. Yokel, Wesley R. Harris, Christopher D. Spilling, Robert Joseph Kuhn, Vasiliy Paul Abramov, Jason Matthew Lone
Abstract: The present invention provides a method for manufacturing a metal/composite hybrid wheel for a vehicle by molding an inner rim of a composite material by compression and, at the same time, bonding an outer rim of a metal material to the inner rim to induce compressive residual stress in the bonding area by a difference in thermal expansion coefficient between the outer rim and the inner rim, thereby increasing the adhesive strength of the bonding area and the durability of the wheel. The present invention further provides a metal/composite hybrid wheel for a vehicle manufactured by the method.
Type:
Grant
Filed:
November 29, 2010
Date of Patent:
February 16, 2016
Assignees:
Hyundai Motor Company, Chung-Ang University Industry-Academy Cooperation Foundation
Inventors:
Tae Seong Lim, Min Soo Kim, Seung Hwan Chang, Seong Hwan Yoo
Abstract: A sintered structure and method for forming it are disclosed. The method includes obtaining core-shell particles having a core material and a shell material, forming the particles into a powder compact, and annealing the powder compact at an annealing temperature. The shell material is a metal that diffuses faster than the core material at the annealing temperature and diffuses to the contacts between the core-shell particles during annealing to form sintered interfaces between the core-shell particles. The sintered structure can have discontinuous regions of shell material between the sintered interfaces. The core material can be a metal, semiconductor or ceramic. The core material can be copper and the shell material can be silver. The sintered interfaces can be almost purely shell material. The annealing temperature can be significantly lower than the temperature needed to form interfaces between particles of the core material without the shell material.
Type:
Grant
Filed:
June 17, 2013
Date of Patent:
February 16, 2016
Assignee:
Purdue Research Foundation
Inventors:
Carol Anne Handwerker, Suk Jun Kim, Eric A. Stach
Abstract: An apparatus and a system for automatically tracking data speed are disclosed. An embodiment of the invention provides a transmitting apparatus for automatically tracking data speed that includes: an encoder configured to convert parallelized input data according to a preset signal rule into a first signal and a second signal, where the input data is inputted as a unit of n bits, the encoder outputs the first signal and the second signal such that, if the input data includes identical bit values consecutively, one of the first signal and the second signal is converted to include transition information instead of following a differential rule with respect to the other signal; a serializer configured to serialize the first signal and the second signal; and a transmitting part configured to transmit the serialized first signal and second signal.
Type:
Grant
Filed:
July 30, 2014
Date of Patent:
February 16, 2016
Assignee:
Korea University Research and Business Foundation
Abstract: An electrochemical water gas shift system for removing low level carbon monoxide from hydrogen stream. The system including an electrolyzer having a porous anode for absorbing carbon monoxide from a hydrogen stream as a feed stream for a polymer electrolyte membrane fuel cell for generating an electrical energy, a small portion of electricity generated by the fuel cell is applied to the electrolyzer to convert carbon monoxide adsorbed in the porous anode to carbon dioxide and hydrogen via an electrochemical gas shift reaction without oxygen or air input. In an embodiment, the system includes a first electrolyzer operating as a CO adsorber and a second electrolyzer connected in parallel with the first electrolyzer operating as a CO remover. Two electrolyzers can be operated alternatively as CO adsorber and CO remover.
Type:
Grant
Filed:
April 4, 2007
Date of Patent:
February 16, 2016
Assignee:
University of Central Florida Research Foundation, Inc.
Inventors:
Cunping Huang, Ruichun Jiang, Mohamed Elbaccouch, Nazim Muradov, James M. Fenton
Abstract: Provided is an code rearranger and method for a virtual machine that uses a just-in-time-compiler (JITC) to manage a location of machine code stored in a code cache. The apparatus may rearrange consecutively-executable machine codes from among those stored in the code cache to be placed successively.
Type:
Grant
Filed:
July 25, 2011
Date of Patent:
February 16, 2016
Assignees:
Samsung Electronics Co., Ltd., SNU R&DB Foundation
Abstract: A method of inhibiting a binding event between a target protein and a binding protein, comprising administering to a cell in vitro an effective amount of a non-naturally occurring bifunctional inhibitor molecule including (a) protein binding moiety, and (b) an effector region, wherein the protein binding moiety binds to a blocking protein, and wherein the effector region binds to the target protein in order to bind the target protein and the blocking protein and prevent access of the binding protein to the target protein. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Type:
Grant
Filed:
June 15, 2012
Date of Patent:
February 16, 2016
Assignee:
Ohio State Innovation Foundation
Inventors:
Roger Briesewitz, Dehua Pei, Xianghong Wu
Abstract: Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one chemical entity as a single active agent or administering at least one chemical entity in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.
Type:
Grant
Filed:
July 26, 2012
Date of Patent:
February 16, 2016
Assignee:
CHDI Foundation, Inc.
Inventors:
Celia Dominguez, Leticia M. Toledo-Sherman, Stephen Martin Courtney, Michael Prime, William Mitchell, Christopher John Brown, Paula C. De Aguiar Pena, Peter Johnson
Abstract: A method of chemical mechanical polishing (CMP) a diamond containing surface includes providing a slurry including a plurality of particles, at least one oxidizer, and at least one acid, wherein the slurry has a pH?3 or pH greater than 11. At least an outer surface of the plurality of particles is softer than the diamond surface or the particles are diamond particles averaging less than (<) 2 ?m in size. The diamond surface is pressed with respect to a polishing pad providing a Shore D Hardness less than 99 having the slurry in between while rotating the polishing pad relative to the diamond surface to form a smooth diamond surface having a root mean square (rms) surface roughness less than 15 nm.
Type:
Grant
Filed:
September 23, 2014
Date of Patent:
February 16, 2016
Assignees:
Sinmat, inc., University of Florida Research Foundation, Inc.
Inventors:
Rajiv K. Singh, Deepika Singh, Arul Chakkaravarthi Arjunan
Abstract: A dipole microphone assembly for a nearfield sound source has a first microphone and a second microphone. The second microphone is out of phase with the first microphone so as to provide a dipole microphone assembly. Each of the microphones has a port, and a dipole spacing is defined as a distance from the center of the port of the first microphone to the center of the port of the second microphone. The dipole spacing is less than ¼ of a wavelength for the highest frequency of the sound of interest.
Abstract: Antibodies, particularly human antibodies, are disclosed having activity in treatment of demyelinating diseases and diseases of the central nervous system. Neuromodulatory agents are provided comprising a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, and active fragments, monomers and combinations thereof having one or more of the following characteristics: capable of inducing remyelination; binding to neural tissue; promoting Ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells. Amino acid and DNA sequences of exemplary antibodies are disclosed. Methods are described for treating demyelinating diseases, and diseases of the central nervous system, using polyclonal IgM antibodies and human monoclonal antibodies sHIgm22(LYM 22), sHIgm46(LYM46) ebvHIgM MSI19D10, CB2bG8, AKJR4, CB2iE12, CB2iE7, MSI19E5 and MSI10E10, and active fragments thereof.
Type:
Grant
Filed:
March 13, 2013
Date of Patent:
February 16, 2016
Assignee:
Mayo Foundation for Medical Education & Research
Inventors:
Moses Rodriguez, David J. Miller, Larry R. Pease
Abstract: The present disclosure relates to a novel composite structure for artificial photosynthesis reaction and an integrated reaction device for artificial photosynthesis including the same, and a novel composite structure for water splitting reaction and an integrated reaction device for water splitting including the same.
Abstract: A method of chemical mechanical polishing (CMP) a diamond containing surface includes providing a slurry including a plurality of particles, at least one oxidizer, and at least one acid, wherein the slurry has a pH?3 or pH greater than 11. At least an outer surface of the plurality of particles is softer than the diamond surface or the particles are diamond particles averaging less than (<)2 ?m in size. The diamond surface is pressed with respect to a polishing pad providing a Shore D Hardness less than 99 having the slurry in between while rotating the polishing pad relative to the diamond surface to form a smooth diamond surface having a root mean square (rms) surface roughness less than 15 nm.
Type:
Grant
Filed:
November 6, 2012
Date of Patent:
February 16, 2016
Assignees:
Sinmat, Inc., University of Florida Research Foundation, Inc.
Abstract: The present invention provides for methods of producing human monoclonal antibodies to human nucleolin, cells producing such antibodies, and the antibodies themselves. Also provided are methods of using the antibodies in diagnosing and treating malignant and non-malignant diseases wherein cells that express nucleolin on the cell surface contribute to the pathophysiology of the disease.
Type:
Grant
Filed:
November 17, 2010
Date of Patent:
February 16, 2016
Assignee:
MUSC Foundation for Research Development
Inventors:
Natalie Sutkowski, Daniel Fernandes, Brian Hoel, Semyon Rubinchik
Abstract: Aspects of the present invention provide a “SuperTag” cache that manages cache at three granularities: (i) coarse grain, multi-block “super blocks,” (ii) single cache blocks and (iii) fine grain, fractional block “data segments.” Since contiguous blocks have the same tag address, by tracking multi-block super blocks, the SuperTag cache inherently increases per-block tag space, allowing higher compressibility without incurring high area overheads. To improve compression ratio, the SuperTag cache uses variable-packing compression allowing variable-size compressed blocks without requiring costly compactions. The SuperTag cache also stores data segments dynamically. In addition, the SuperTag cache is able to further improve the compression ratio by co-compressing contiguous blocks. As a result, the Super Tag cache improves energy and performance for memory intensive applications over conventional compressed caches.
Abstract: A dynamic predictor usable for rapid and accurate calculation of joint commands of an articulated dynamical mechanism describes the relationship between the joints in the form of a differential equation. The predictor solves this differential equation for predicted joint states by fitting a polynomial equation having free parameters describing the predicted joint states to the differential equations by minimizing the differential equation residuals. This minimization employs a series expansion allowing algorithmic differentiation.
Abstract: In one embodiment, an optical system for amplifying space-multiplexed optical signals includes an input fiber that propagates multiple spatially-separated optical signals and a bulk amplifier formed of a doped material that receives the multiple spatially-separated optical signals and simultaneously amplifies those signals to generate multiple amplified signals.
Type:
Grant
Filed:
October 5, 2012
Date of Patent:
February 16, 2016
Assignee:
University of Central Florida Research Foundation, Inc.
Inventors:
Guifang Li, Ibrahim T. Ozdur, Hong Shu, Michael Bass