Abstract: The present invention relates to (i) novel fluoroionic compounds capable of dispersing particulate filler compositions into a fluoropolymer; (ii) novel particulate compositions in which particulates are surface-functionalized with a fluoroionic compound; (iii) fluoropolymer composite materials containing the surface-functionalized particulates of (ii) incorporated into a fluoropolymer; (iv) crosslinked versions of (iii); v) methods for producing the crosslinked material of (iv); and (vi) articles of manufacture containing the compositions (iii) and (iv).
Type:
Grant
Filed:
October 3, 2013
Date of Patent:
February 9, 2016
Assignee:
The Research Foundation for The State University of New York
Inventors:
Benjamin S. Hsiao, Benjamin Chu, Jie Wei, Hongyang Ma, Feng Zuo
Abstract: The present invention provides surface-stabilized amorphous pharmaceuticals comprising an amorphous pharmaceutical substrate coated with a biocompatible immobilizing material. Amorphous pharmaceutical substrates that are prone to surface enhanced crystallization benefit from the present coatings. The coated amorphous pharmaceuticals of the present invention maintain their amorphous state and, therefore, their solubility over extended periods of time, relative to uncoated pharmaceuticals.
Type:
Grant
Filed:
March 21, 2008
Date of Patent:
February 9, 2016
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Lian Yu, Melgardt M. De Villiers, Tian Wu
Abstract: The present invention relates to a use of Substance-P for the manufacture of a medicament for mobilization or proliferation of Mesenchymal stem cells (MSCs) from the bone marrow, or facilitating said mobilization or proliferation, and use of Substance-P for the manufacture of a medicament for wound-healing or facilitating wound-healing.
Type:
Grant
Filed:
September 5, 2013
Date of Patent:
February 9, 2016
Assignees:
Korea Institute of Radiological & Medical Sciences, Chung-Ang University Industry-Academy Cooperation Foundation
Inventors:
Young Sook Son, Hyun Sook Hong, Jae Chan Kim
Abstract: Disclosed are compounds and methods for manipulating proteins in general and membrane proteins in particular. The compounds can be prepared from cholic acid, deoxycholic acid, lithocholic acid, or derivatives thereof. The compounds typically possess critical micelle concentrations lower than those of known detergents such as CHAPS and CHAPSO. Accordingly, lower amounts of the compounds are required for effective solubilization of membrane proteins. The compounds can be used aid the solubilization, isolation, purification, stabilization, crystallization, and/or structural determination of membrane proteins.
Abstract: An antibody capable of potentiating immune responses and modifying existing states of immune responsiveness is described, as is the sequence of the antibody. Also described are compositions containing the antibody, as well as methods for using the antibody and the compositions to enhance immune responses, to enhance DC function, to modify an existing state of immune responsiveness, to immunize individuals, or to treat or inhibit conditions such as allergic asthma.
Type:
Grant
Filed:
April 17, 2012
Date of Patent:
February 9, 2016
Assignee:
Mayo Foundation for Medical Education & Research
Inventors:
Larry R. Pease, Virginia Van Keulen, Bogoljub Ciric
Abstract: Disclosed is a sensor for detecting a target material. The sensor includes a ferromagnetic metal and a molecular recognition reagent coupled to the ferromagnetic metal. The molecular recognition reagent is operable to expand upon exposure to vapor or liquid from the target material such that the molecular recognition reagent changes a tensile stress upon the ferromagnetic metal. The target material is detected based on changes in the magnetic switching characteristics of the ferromagnetic metal caused by the changes in the tensile stress.
Type:
Grant
Filed:
September 23, 2014
Date of Patent:
February 9, 2016
Assignees:
Consolidated Nuclear Security, LLC, University of Tennessee Research Foundation
Inventors:
Vincent E. Lamberti, Layton N. Howell, Jr., David K. Mee, Michael J. Sepaniak
Abstract: The present invention relates to the use of inhibitors of leukotriene B4 receptor BLT2 for treating asthma. More particularly, the present invention relates to a pharmaceutical composition for treating asthma comprising BLT2 inhibitors and a method for treating asthma using BLT2 inhibitors.
Type:
Grant
Filed:
June 6, 2014
Date of Patent:
February 9, 2016
Assignee:
Korea University Research and Business Foundation
Abstract: The invention provides a composition useful to prepare high titer influenza viruses, e.g., in the absence of helper virus, which includes at least five internal genes from an influenza virus isolate that replicates to high titers in embryonated chicken eggs or MDCK cells.
Abstract: The present invention relates to selectively isolating gases using a natrolite-based zeolite, and more particularly, to a novel natrolite-based zeolite and to selectively isolating hydrogen and/or helium gas using a natrolite-based zeolite. The present invention is characterized in that gas containing hydrogen is brought into contact with a natrolite-based zeolite to selectively isolate the hydrogen. The present invention provides a sorbent which can selectively isolate hydrogen and/or helium, and provides a method for isolating the hydrogen and/or helium at room temperature or at a high temperature.
Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The electrode array is maintained on the spinal cord by way of a spring or support structure that is anchored to an anatomical structure outside the spinal cord but near the site of implantation. Suitable anchoring structures include the vertebrae and the dura. Secured in this fashion, the support structure maintains a gentle pressure of the electrode array against the spinal cord so as to stay in electrical contact but minimize injury or inflammation. The device may accommodate and buffer movement of the spinal cord both laterally and in a caudal-rostral fashion so that the electrode array remains in place.
Type:
Grant
Filed:
January 30, 2013
Date of Patent:
February 9, 2016
Assignee:
University of Iowa Research Foundation
Inventors:
Matthew A. Howard, Hiroyuki Oya, Steve Viljoen, Chandan G. Reddy
Abstract: Immunogenic compositions are provided herein that are useful for inducing an immune response specific against group A streptococcus (GAS). Immunogenic compositions provided herein are multivalent and comprise a plurality of immunogenic peptides or fusion polypeptides comprising the immunogenic peptides that induce an immune response against GAS. The immunogenic compositions provided herein induce an immune response against the GAS serotypes represented by an immunogenic peptide (derived from an M protein or Spa protein) comprised within the immunogenic composition and also induce an immune response against serotypes that are unrepresented by any immunogenic peptide included in the immunogenic composition. Methods for using the compositions for inducing an immune response against GAS and for treating or reducing the likelihood of occurrence of a GAS infection are also provided.
Type:
Grant
Filed:
February 10, 2014
Date of Patent:
February 9, 2016
Assignee:
University of Tennessee Research Foundation
Abstract: A cell culture comprising human foreskin cells, the human foreskin cells being capable of maintaining stem cells in an undifferentiated state when co-cultured therewith.
Type:
Grant
Filed:
August 19, 2014
Date of Patent:
February 9, 2016
Assignee:
Technion Research & Development Foundation Limited
Abstract: An intercepting device (e.g. a furniture coaster device) is placed under furniture (bed, sofa, chair. etc.), other climbable object, or the floor adjacent an object to intercept crawling arthropods and other crawling pests. The intercepting device can be used to monitor the presence of crawling arthropods and other crawling pests (such as bed bugs, ants, cockroaches, beetles, spiders, etc.), reduce pest numbers, and monitor efficacy of pest control procedures. The intercepting device includes pitfall trap surfaces that form multiple pitfall traps.
Type:
Grant
Filed:
May 5, 2009
Date of Patent:
February 9, 2016
Assignees:
Purdue Research Foundation, Susan McKnight, Inc.
Abstract: The present invention relates to a positive active material for an electrochemical cell including a compound having a nano-shape and represented by the following Formula 1. Lix[Li1-y-zM1yM2z]O2-?D???[Formula 1] wherein, 0.8?x?1.1, 0?y?0.5, 0?z?0.5, and 0???0.05, M1 and M2 are independently selected from transition elements, and D is selected from the group consisting of O, F, S, P, and combinations thereof. The positive active material of the present invention has high reversible capacity and an excellent cycle life characteristic, and in particular, an excellent cycle life characteristic at a high rate.
Type:
Grant
Filed:
September 19, 2008
Date of Patent:
February 9, 2016
Assignee:
Industry-University Cooperation Foundation, Hanyang University
Abstract: Fumaric acid or a salt thereof, such as a fumaryl halide (e.g. fumaryl chloride), which contains unsaturated carbon-carbon double bonds that can be used for in situ crosslinking, is copolymerized with poly(caprolactone)diol in the presence of an alkali metal salt. The resulting photocrosslinkable biocompatible and bioresorbable poly(caprolactone fumarate) biomaterial is useful in the fabrication of injectable an in-situ hardening scaffolds for application in skeletal reconstruction.
Type:
Grant
Filed:
November 10, 2005
Date of Patent:
February 9, 2016
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Shanfeng Wang, Lichun Lu, Michael J. Yaszemski
Abstract: The invention provides methods for the detection of M. tuberculosis proteins in or on exosomes derived from infected individuals. The methods can use a proteomic approach including mass spectroscopy, data mining and multiplex reaction monitoring to quickly examine a large amount of M. tuberculosis proteins to determine the best biomarkers for use in diagnostic tests to identify active TB patients.
Type:
Grant
Filed:
October 11, 2013
Date of Patent:
February 9, 2016
Assignees:
University of Notre Dame du Lac, Colorado State University Research Foundation
Abstract: Provided is a particle that includes a first porous region and a second porous region that differs from the first porous region. Also provided is a particle that has a wet etched porous region and that does have a nucleation layer associated with wet etching. Methods of making porous particles are also provided.
Type:
Application
Filed:
November 11, 2014
Publication date:
February 4, 2016
Applicants:
Board of Regents of the University of Texas System, The Ohio State University Research Foundation
Abstract: A door checker for a vehicle includes a hinge rotatably connecting a door to a vehicle body and having a shaft, a slider penetratingly inserted into the shaft and linearly moving with rotational force of the shaft, and a checking unit linearly reciprocating in a radial direction of the shaft by the slider. By implementing a manipulation feeling in opening and closing a door by increasing a section for checking the door by converting a rotational movement of the door into a linear movement based on a screw principle, operability can be improved to enhance marketability, and durability can be enhanced by increasing the section for implementing operating force for opening and closing a door.
Type:
Application
Filed:
December 15, 2014
Publication date:
February 4, 2016
Applicants:
Hyundai Motor Company, Pusan National University Industry-University Cooperation Foundation
Inventors:
Yoong Ho Jung, Hyung Don KIM, Sung Min SON
Abstract: A three-phase alternating current (AC) to direct current (DC) converter may include a three-phase AC filter receiving a three-phase AC power supply, a plurality of three-phase current source rectifiers (CSR) connected in parallel with each other and connected to a three-phase AC filter, and an output filter connected to the CSR's to generate a DC output. Each of the CSRs may include six switches and a free-wheeling diode. Each of the three filtered AC inputs from the three-phase AC filter may be connected via a switch of the six switches to selectably send current into a positive line, and each of three filtered AC inputs from the three-phase AC filter may be connected via another switch of the six switches to selectably receive current from a negative line. The free-wheeling diode may have a cathode connected to the positive line and an anode connected to the negative line.
Type:
Application
Filed:
October 7, 2015
Publication date:
February 4, 2016
Applicant:
University of Tennessee Research Foundation
Inventors:
Leon Monroe Tolbert, Ben Guo, Fan Xu, Fei Wang, Benjamin J. Blalock
Abstract: An inductive wireless power transfer and communication system includes an electrostatic shield for one of the coils. The electrostatic shield is inductively coupled with the coil and is configured as an open circuit. A signal processing element or elements, especially a modulator or a demodulator, are connected across the electrical discontinuity in the electrostatic shield. Because the electrostatic shield is inductively coupled to the coil, the modulator or demodulator can operate on the signal on the coil.
Type:
Application
Filed:
July 30, 2015
Publication date:
February 4, 2016
Applicant:
Alfred E. Mann Foundation for Scientific Research