Abstract: Systems and methods are described for laser ablation of an analyte from a specimen and capturing of the analyte in a dispensed solvent to form a testing solution. A solvent dispensing and extraction system can form a liquid microjunction with the specimen. The solvent dispensing and extraction system can include a surface sampling probe. The laser beam can be directed through the surface sampling probe. The surface sampling probe can also serve as an atomic force microscopy probe. The surface sampling probe can form a seal with the specimen. The testing solution including the analyte can then be analyzed using an analytical instrument or undergo further processing.
Type:
Application
Filed:
July 24, 2013
Publication date:
November 14, 2013
Applicants:
University of Tennessee Research Foundation, UT-Batelle, LLC
Inventors:
Gary J. VAN BERKEL, Vilmos KERTESZ, Olga S. OVCHINNIKOVA
Abstract: A device for extraction or isolation of an analyte, such as a nucleic acid, a protein, or a cell, from a sample, and in particular from a biological sample, is described. Methods of using the device are also described. Further processes, such as amplification of the isolated analyte, may also be carried out within the device.
Type:
Application
Filed:
May 7, 2013
Publication date:
November 14, 2013
Applicants:
Northwestern University, Northwestern Global Health Foundation, Quidel Corporation
Inventors:
Abhishek K. Agarwal, Renana Ashkenazi, Mark J. Fisher, Paul J. Gleason, Jacqueline R. Groves, Henry H. Hsu, David M. Kelso, Sally M. McFall, Mark E. Mossberg, Zaheer Parpia, Kunal Sur, Tom Westberg
Abstract: A silica precursor having a selective adsorptivity with respect to cobalt ions is disclosed. The silica precursor includes a cross-linked 2,6-diamino pyridine group obtained by using 2,6-diamino pyridine, phosgene and 3-aminopropyltriethoxysilane.
Type:
Application
Filed:
September 5, 2012
Publication date:
November 14, 2013
Applicant:
Pusan National University Industry-University Cooperation Foundation
Inventors:
Chang-Sik Ha, Sang Hyun Lee, Sung Soo Park
Abstract: The present invention relates to methods for making a fatty acid N-acylalkanolamine having the formula: One of the methods comprises the steps of providing a vinyl ester of a fatty acid having the formula: providing a primary or secondary alkanolamine having the formula: NHR1R2; and reacting the vinyl ester of the fatty acid with the alkanolamine under conditions effective to form the fatty acid N-acylalkanolamine. The other method comprises the steps of providing a fatty acid; purifying the fatty acid; providing a primary or secondary alkanolamine having the formula: NHR1R2; reacting the fatty acid with the alkanolamine under conditions effective to form the fatty acid N-acylalkanolamine; and purifying the formed fatty acid N-acylalkanolamine.
Type:
Application
Filed:
April 24, 2013
Publication date:
November 14, 2013
Applicant:
Iowa State University Research Foundation, Inc.
Abstract: Disclosed herein are novel antibodies specific to Tnk1 or variants thereof. Also disclosed are methods of using such antibodies. The methods include therapeutic methods against certain types of cancers or infections involving administration of novel antibodies or fragments thereof. Also, methods of using highly selective antibodies for detecting aberrant Tnk1 or functionally deficient Tnk1.
Type:
Application
Filed:
November 15, 2011
Publication date:
November 14, 2013
Applicant:
University of Florida Research Foundation, Inc.
Inventors:
Hoare Kishalay, William Stratford May, Sarasija Hoare
Abstract: A rigid, flat plate diaphragm for an acoustic device is illustrated. The internal supporting structure of the diaphragm provides a combination of torsional and translational stiffeners, which resemble a number of crossbars. These stiffeners brace and support the diaphragm motion, thus causing its response to not be adversely affected by fabrication stresses and causing it to be very similar in dynamic response to an ideal flat plate operating in a frequency range that extends well beyond the audible.
Type:
Grant
Filed:
January 25, 2011
Date of Patent:
November 12, 2013
Assignee:
The Research Foundation of State University of New York
Abstract: A peripheral device comprises a first entity and a second entity. In operation, the first/second entities are configured to respectively: receive a first/second entity-related message from at least one other device to indicate the availability of the at least one other device for attachment, send, to the at least one other device, a first/second entity-related message indicating the availability for communication with the at least one other device, receive, from the at least one other device, a first/second entity-related signal including a first/second entity-related peripheral device identifier, send a first/second entity-related response to the at least one other device, receive, from the at least one other device, a first/second entity-related device response, and send, to the at least one other device, a first/second entity-related second peripheral response including the first/second entity-related peripheral device identifier.
Abstract: The invention relates to a method for objectively measuring skin phototype by reflectance spectrophotometry. The improved method correlates well with clinician-based assessments and is non-invasive, rapid and accurate.
Type:
Grant
Filed:
April 27, 2005
Date of Patent:
November 12, 2013
Assignee:
University of Utah Research Foundation
Inventors:
Lynn K. Pershing, Sancy A. Leachman, Laurence J. Meyer
Abstract: Embodiments of this disclosure, among others, encompass methods for generating alkenes under mild thermolytic conditions that can provide almost total conversion of a precursor compound to an alkene without isomerization or the need to chromatographically purify the final product By selectively blocking the amino and carboxy groups of the derivatized amino acid, the methods of the disclosure provide for the synthesis of a peptide having the vinylglycine moiety at either the carboxy or the amino terminus of the peptide The mild conditions for the thermolytic removal of an o-NO2-phenyl substituted aryl group ensure that there is minimal if any damage to thermally sensitive conjugates such as a peptide bearing the vinylglycine The methods of the present disclosure have practical applications for the preparation of unsaturated compounds under mild, thermolytic conditions.
Type:
Grant
Filed:
November 17, 2009
Date of Patent:
November 12, 2013
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Timothy Edward Long, Sravan Kumar Patel
Abstract: A series of celecoxib derivatives defined by Formula I: were prepared and evaluated for their ability to inhibit the gram-negative bacteria Francisella tularensis. Pharmaceutical compositions including celecoxib derivatives and their use in methods for treating or preventing infection by Francisella tularensis in a subject are described.
Type:
Grant
Filed:
September 12, 2012
Date of Patent:
November 12, 2013
Assignee:
The Ohio State University Research Foundation
Inventors:
Ching-Shih Chen, Hao-Chieh Chiu, Samuel Kulp, John S. Gunn, Larry S. Schlesinger
Abstract: Technologies are generally described for usage recommendation for mobile device. In some examples, a method performed under control of a downlink beamforming system may include receiving respective movement information of a plurality of mobile devices, grouping at least some of the mobile devices into one or more groups based on the movement information, and generating beams for the groups, respectively.
Type:
Grant
Filed:
September 29, 2011
Date of Patent:
November 12, 2013
Assignee:
Hankuk University of Foreign Studies Research and Industry-University Cooperation Foundation
Abstract: The present invention relates to a phase change memory device comprising bismuth-tellurium nanowires. More specifically, the bismuth-tellurium nanowires having PRAM characteristics may be prepared by using a porous nano template without any high temperature process and said nanowires may be used in the phase change memory device by using their phase change characteristics to identify memory characteristics.
Type:
Grant
Filed:
January 21, 2011
Date of Patent:
November 12, 2013
Assignee:
Industry-Academic Cooperation Foundation, Yonsei University
Inventors:
Kyung Hwa Yoo, Nal Ae Han, Sung In Kim, Jeong Do Yang
Abstract: Disclosed herein are a DC-DC boost converter circuit, which is capable of preventing power loss and stabilizing switching elements by implementing soft switching and improving efficiency by adding a charge pumping function, and a method for driving the same. The DC-DC boost converter circuit, in which an inductor and an output diode are connected in series and an output capacitor and a load are connected to an output port of the output diode in parallel, includes an output stabilization circuit in which first and second switching elements, a transformer, a plurality of boost capacitors, and a plurality of diodes are connected in series/parallel between the inductor and the output diode.
Type:
Grant
Filed:
December 28, 2010
Date of Patent:
November 12, 2013
Assignees:
LG Display Co., Ltd., Postech Academy-Industry Foundation
Abstract: A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.
Type:
Grant
Filed:
November 30, 2012
Date of Patent:
November 12, 2013
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: Compounds and methods for reducing the occurrence of a post-surgical adhesion are provided. The compounds can include acrylic acid groups and ethylene glycol groups, and can be directed to an area of damaged tissue by the incorporation of a fibrin targeting peptide. The compounds can further include a brush-like portion, capable of creating a steric barrier between a damaged tissue or organ and adjacent tissues or organs, and a targeting portion, capable of directing the compounds to a damaged tissue or organ. Methods of detecting damaged tissue and kits are also provided.
Type:
Grant
Filed:
November 19, 2009
Date of Patent:
November 12, 2013
Assignee:
University of Kentucky Research Foundation
Inventors:
Thomas Dziubla, Eugene Kaplan, John Mark Medley, Jr.
Abstract: An apparatus and a method for diagnosing optic neuropathic diseases including glaucoma, are provided. The apparatus for diagnosing optical neuropathic diseases measures a thickness of a retinal nerve fiber layer (RNFL) using methods such as optical coherence tomography (OCT) and scanning laser polarimetry, and includes a scanning unit which scans along an optic nerve margin in the proximity of an optic nerve head, a pattern analyzing unit which analyzes a pattern of the RNFL scanned by the scanning unit, and a disease determining unit which determines a presence of the disease based on the pattern of the RNFL analyzed by the pattern analyzing unit.
Type:
Grant
Filed:
October 15, 2010
Date of Patent:
November 12, 2013
Assignee:
Catholic University Industry Academic Cooperation Foundation
Abstract: A semiconductor light emitting component including an epitaxial structure, a first electrode, a second electrode, a first cutout structure and a second cutout structure is provided. The epitaxial structure includes a first type doped layer, a light emitting portion and a second type doped layer. The first electrode is formed on a surface of the first type doped layer. The second electrode is formed on a surface of the second type doped layer. The first cutout structure is formed in the first type doped layer to expose at least a portion of the first electrode. The second cutout structure is formed in the first type doped layer, the light emitting portion and the second type doped layer so as to expose at least a portion of the second electrode.
Type:
Grant
Filed:
March 14, 2013
Date of Patent:
November 12, 2013
Assignees:
NCKU Research and Development Foundation, Phostek, Inc.
Abstract: The invention is directed to a method of preventing or ameliorating a neuropsychiatric or neurodegenerative disease or disorder in a subject. The method includes administering a composition comprising equol in an amount sufficient to prevent or ameliorate the neuropsychiatric or neurodegenerative disease or disorder. The equol may be a racemic mixture of R-equol and S-equol. The equol may be enantiomerically enriched with R-equol or enantiomerically enriched with S-equol.
Type:
Grant
Filed:
August 18, 2006
Date of Patent:
November 12, 2013
Assignees:
Brigham Young University, Children's Hospital Medical Center, Colorado State University Research Foundation
Inventors:
Edwin Douglas Lephart, Trent D. Lund, Kenneth David Reginald Setchell, Robert J. Handa
Abstract: A nozzle and an electrostatic field induction ink-jet nozzle are disclosed. In accordance with an embodiment of the present invention, the nozzle includes a concave part, which is formed along an outer circumference of the nozzle and in which the outer circumference is adjacent to a liquid discharging surface. The discharging nozzle can minimize the overflow and damping by a liquid during a process of discharging the liquid and thus maintain the discharging performance constant despite an extended operation of the nozzle.
Type:
Grant
Filed:
February 26, 2010
Date of Patent:
November 12, 2013
Assignee:
Sungkyunkwan University Foundation For Corporate Collaboration
Inventors:
Yong Jae Kim, Sukhan Lee, Hanseo Ko, Sang Uk Son, Soo Hong Lee, Ki Chul An, Jaeyong Choi
Abstract: A bell mouth for a scroll case according to an exemplary embodiment of the present invention is a bell mouth which is provided on the top plate of the scroll case to form an air inlet in order to allow air flow into the scroll case by a centrifugal blower installed inside the scroll case, and the volume of two parts of the bell mouth in respect to a rotation shaft of the centrifugal blower is different from each other. According to the present invention, it is possible to minimize generation of reverse flow of inflow air by increasing or decreasing a variation of the cross-section area of the bell mouth according to an increase in the pressure of the flow rate.
Type:
Grant
Filed:
July 28, 2010
Date of Patent:
November 12, 2013
Assignee:
Industry-University Cooperation Foundation Sunmoon University