Patents Assigned to Foundation
  • Functional and therapeutic effects of PAR4 cleavage by cathepsin G
    Patent number: 12077607
    Abstract: Disclosed herein are a synthetic peptide mimetic and compositions comprising the synthetic peptide mimetic that induce activation of and signaling through PAR4. Also disclosed herein are methods of treating a bleeding disorder comprising administering the synthetic peptide.
    Type: Grant
    Filed: September 23, 2022
    Date of Patent: September 3, 2024
    Assignee: UNIVERSITY OF UTAH RESEARCH FOUNDATION
    Inventors: Paul F. Bray, Robert A. Campbell, Michelle Stoller
  • Engineered microorganisms for production of 2?fucosyllactose and l-fucose
    Patent number: 12077792
    Abstract: Compositions and methods are provided for producing 2?fucosyliaciose and L-fucose from recombinant microorganisms.
    Type: Grant
    Filed: May 15, 2019
    Date of Patent: September 3, 2024
    Assignees: The Board of Trustees of the University of Illinois, Korea University Research and Business Foundation
    Inventors: Yong-Su Jin, Jingjing Liu, Sora Yu, Eun Ju Yun, Suryang Kwak, Kyoung Heon Kim, Jaewon Lee
  • Methods and systems for depositing active ingredients on substrates
    Patent number: 12076444
    Abstract: Systems and methods for delivering active ingredients, such as pharmaceutically active ingredients, to substrates are described herein. The active ingredients are delivered as fluids to a fluid-dispensing device for the creation of one or more drops for deposition onto substrates such as for the creation of microdoses. The invention further includes microdoses made by such processes.
    Type: Grant
    Filed: January 10, 2023
    Date of Patent: September 3, 2024
    Assignee: Purdue Research Foundation
    Inventors: Arun V. Giridhar, Michael Harris, Gintaras V. Reklaitis, Lynne S. Taylor, Zoltan K. Nagy, Elcin Icten, Frederick Fiesser, Laura Hirshfield
  • Transfer of nanostructures using crosslinkable copolymer films
    Patent number: 12077438
    Abstract: Methods of transferring nanostructures from a first substrate to another substrate using a copolymer polymerized from one or more non-crosslinking monomers and one or more comonomers bearing crosslinkable groups as a transfer medium are provided. Relative to a poly(methyl methacrylate) homopolymer, the crosslinkable copolymers bond more strongly to the first substrate and, as a result, are able to transfer even very narrow nanostructures between substrates with high transfer yields.
    Type: Grant
    Filed: March 23, 2021
    Date of Patent: September 3, 2024
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael Scott Arnold, Robert Michael Jacobberger, Padma Gopalan, Jonathan H. Dwyer
  • Systems and methods for implementing permissionless network consensus for using blockchain
    Patent number: 12082145
    Abstract: Provided herein are systems and methods for implementing a network consensus for a blockchain network that is characterized by one or more, or all, of the following attributes: (1) implementation of a Proof-of-Coverage scheme; (2) lack of permission for nodes to participate in the network; (3) decentralization, with lack of incentives to centralize; (4) byzantine fault tolerance; (5) based on useful work to the network; (6) high confirmed transaction rate; and (7) censor-resistant transactions.
    Type: Grant
    Filed: October 17, 2022
    Date of Patent: September 3, 2024
    Assignee: DECENTRALIZED WIRELESS FOUNDATION, INC.
    Inventors: Amir Haleem, Andrew Thompson, Andrew Allen, Marc Nijdam, Jay Kickliter
  • Systems, methods and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data
    Patent number: 12076120
    Abstract: In accordance with some embodiments, systems, methods, and media for estimating compensatory reserve and predicting hemodynamic decompensation using physiological data are provided. In some embodiments, a system for estimating compensatory reserve is provided, the system comprising: a processor programmed to: receive a blood pressure waveform of a subject; generate a first sample of the blood pressure waveform with a first duration; provide the sample as input to a trained CNN that was trained using samples of the first duration from blood pressure waveforms recorded from subjects while decreasing the subject's central blood volume, each sample being associated with a compensatory reserve metric; receive, from the trained CNN, a first compensatory reserve metric based on the first sample; and cause information indicative of remaining compensatory reserve to be presented.
    Type: Grant
    Filed: July 21, 2020
    Date of Patent: September 3, 2024
    Assignees: Mayo Foundation for Medical Education and Research, The Government of the United States, as Represented by the Secretary of the Army
    Inventors: Robert W. Techentin, Timothy B. Curry, Michael J. Joyner, Clifton R. Haider, David R. Holmes, III, Christopher L. Felton, Barry K. Gilbert, Charlotte Sue Van Dorn, William A. Carey, Victor A. Convertino
  • Motion assistance apparatus
    Patent number: 12076290
    Abstract: A motion assistance apparatus includes a force transmitting frame configured to support a distal part of a user, a slider configured to slide in the force transmitting frame, and a driving frame connected to the slider and configured to slide with respect to a proximal part of the user.
    Type: Grant
    Filed: May 18, 2022
    Date of Patent: September 3, 2024
    Assignees: Samsung Electronics Co., Ltd., Research & Business Foundation Sungkyunkwan University
    Inventors: Minhyung Lee, Byungjune Choi, Jeonghun Kim, Se-Gon Roh, Youn Baek Lee, Jongwon Lee, Hyun Do Choi, Jung Yun Choi, Hyouk Ryeol Choi
  • Method for biocatalytic protein-oligonucleotide conjugation
    Patent number: 12077795
    Abstract: A composition comprising a polypeptide ligated to an oligonucleotide through a sterol linker. A method of ligating a polypeptide to an oligonucleotide, comprising a polypeptide having a hedgehog steroyl transferase catalytic domain at the C-terminal of the polypeptide with an electrophilic residue, e.g., glycine, between polypeptide and the hedgehog steroyl transferase catalytic domain, and a steroylated oligonucleotide in solution, and permitting a reaction to cleave the hedgehog steroyl transferase catalytic domain from the polypeptide while ligating the steroylated oligonucleotide to the glycine at the C-terminal of the polypeptide. The oligonucleotide may be, for example, a therapeutic, diagnostic, or affinity ligand.
    Type: Grant
    Filed: August 10, 2020
    Date of Patent: September 3, 2024
    Assignee: The Research Foundation for The State University of New York
    Inventors: Brian Callahan, Timothy Owen
  • Peptides and other agents for treating pain and increasing pain sensitivity
    Patent number: 12077610
    Abstract: Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and/or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative/post-operative pain, or a combination thereof.
    Type: Grant
    Filed: September 29, 2022
    Date of Patent: September 3, 2024
    Assignee: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
    Inventors: Arindam Bhattacharjee, Kerri Pryce
  • Prosthetic heart valve with tri-leaflet design for use in percutaneous valve replacement procedures
    Patent number: 12076236
    Abstract: A transcatheter prosthetic heart valve includes a stent frame and at least one sheet of leaflet material formed in to a tube, which includes a lower portion disposed on an exterior of the stent frame and an upper edge portion disposed within the stent frame. The upper edge portion includes at least a portion configured to wrap around a first portion of the top edge of the stent frame and fold towards an exterior of the stent frame. The upper edge portion also includes at least another portion configured to weave through the stent frame and fold towards the interior of the stent frame.
    Type: Grant
    Filed: December 7, 2021
    Date of Patent: September 3, 2024
    Assignee: Ohio State Innovation Foundation
    Inventors: Lakshmi Prasad Dasi, Atieh Yousefi Koupaei, Megan Kristine Heitkemper
  • Use of resected liver serum for whole liver-engineering
    Patent number: 12076461
    Abstract: The disclosure provides a method of using blood or fractions thereof, e.g., serum, obtained from a mammal subjected to liver surgery, for example, obtained following a partial hepatectomy, to increase the engraftment, proliferation and/or functionality of cells on a biocompatible scaffold.
    Type: Grant
    Filed: February 7, 2022
    Date of Patent: September 3, 2024
    Assignees: Miromatrix Medical Inc., Mayo Foundation for Medical Education & Research, Mayo Medical Ventures
    Inventors: Jeffrey Ross, Anne Young, Allie Haarstad, Scott Nyberg
  • Computer implemented program specialization
    Patent number: 12079607
    Abstract: A computerized technique for program simplification and specialization combines a partial interpretation of the program based on a subset of program functions to obtain variable states with concrete values at a program “neck.” These concrete values are then propagated as part of an optimization transformation that simplifies the program based on these constant values, for example, by eliminating branches that are never taken based on the constant values.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: September 3, 2024
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Mohannad Alhanahnah, Vaibhav Rastogi, Somesh Jha, Thomas Reps
  • Anti-ROS1 antibody and use thereof
    Patent number: 12077599
    Abstract: The present invention relates to an anti-ROS1 antibody improved in specificity for ROS1 and a use thereof and, more particularly, provides an anti-ROS1 antibody or an antigen-binding fragment thereof and a use thereof in cancer diagnosis.
    Type: Grant
    Filed: March 6, 2018
    Date of Patent: September 3, 2024
    Assignees: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION, NATIONAL CANCER CENTER, THE ASAN FOUNDATION, UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION
    Inventors: Junho Chung, Eugene C. Yi, Ji Eun Kim, Hwa Kyoung Lee, Junyeong Jin, Jong Bae Park, Hyori Kim
  • Automated quality assessment of ultra-widefield angiography images
    Patent number: 12079987
    Abstract: Systems and methods are provided for fully automated quality assessment of ultra-widefield angiography images. A series of ultra-widefield angiography images of a retina of a patient are obtained and each of the series of ultra-widefield angiography images are provided to a neural network trained on a set of labeled images to generate a quality parameter for each of the series of ultra-widefield angiography images representing a quality of the image. Each of the set of labeled images are assigned to one of a plurality of classes representing image quality. A user interface provides an instruction to a user to obtain a new series of ultra-widefield angiography images of the retina of the patient if no image of the series of ultra-widefield angiography images has a quality parameter that meets a threshold value.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: September 3, 2024
    Assignee: THE CLEVELAND CLINIC FOUNDATION
    Inventors: Justis P. Ehlers, Sunil K. Srivastava
  • Functional deep neural network for high-dimensional data analysis
    Patent number: 12080426
    Abstract: Various examples of methods and systems are provided related to functional deep neural networks (FDNNs), which can be used for high dimensional data analysis. In one example, a FDNN can be trained with a training set of omic data to produce a trained FDNN model. The likelihood of a condition can be determined based upon output indications of the FDNN corresponding to the one or more phenotypes, with the output indications based upon analysis of omic data including a multi-level omic profile from an individual by the trained FDNN. The FDNN model can include a series of basis functions as layers to capture complexity between the omic data with disease phenotypes. A treatment or prevention strategy for the individual can be identified based at least in part upon the likelihood of the condition.
    Type: Grant
    Filed: March 30, 2021
    Date of Patent: September 3, 2024
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Qing Lu, Shan Zhang, Tingting Hou
  • Stowable step assembly
    Patent number: 12078014
    Abstract: A stowable step assembly for climbing a structure is disclosed which includes an articulating step, including a step, the step has at least one cam surface, allowing articulation of the step from i) a deployed position allowing a user to place weight on the step, to ii) a stowed position, at least one cam stop configured to stop the cam motion of the step when in the deployed position; a hanger, including a connector configured to interface with the step, wherein the connector includes at least one counterpart cam surface to the at least one cam surface of the step and wherein the connector includes at least one counterpart cam stop to the at least one cam stop of the step, at least one hook configured to interface with a counterpart attachment arrangement of a structure; and a fastener configured to couple the connector to the step.
    Type: Grant
    Filed: August 6, 2020
    Date of Patent: September 3, 2024
    Assignee: Purdue Research Foundation
    Inventors: Elvin Garayev, Andrew James Bowman, Dalton Garrett, William Andrew Yount
  • Vaccines comprising mutant attenuated influenza viruses
    Patent number: 12076387
    Abstract: The invention provides a vaccine comprising an effective amount of an isolated recombinant influenza virus comprising a mutant M gene segment that is mutated so that upon viral replication the mutant M gene expresses a functional M1 protein and a mutant M2 protein with a deletion of the cytoplasmic tail and either lacking a transmembrane domain or having a mutated transmembrane domain.
    Type: Grant
    Filed: April 13, 2021
    Date of Patent: September 3, 2024
    Assignee: Wisconsin Alumni Research Foundation (WARF)
    Inventors: Shinji Watanabe, Tokiko Watanabe, Yoshihiro Kawaoka
  • Wave control apparatus using elastic modulus change of thermoresponsive material
    Patent number: 12081186
    Abstract: The present invention relates to a wave control apparatus using change of elastic modulus of thermoresponsive material, comprising: a wave modulation member having thermoresponsive material whose elastic modulus changes according to temperature variation, a wave source propagating wave through the wave modulation member, and a heating unit forming a wave modulation region by heating the wave modulation member, wherein the wave propagating through the wave modulation member from the wave source is configured to change wave characteristics when the wave passes through the wave modulation region heated by the heating unit.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: September 3, 2024
    Assignee: Korea University Research and Business Foundation
    Inventors: Won-Joon Choi, Sang-Jun Lee, Haun-Min Lee
  • Cold sintering ceramics and composites
    Patent number: 12077478
    Abstract: Cold sintering of materials includes using a process of combining at least one inorganic compound, e.g., ceramic, in particle form with a solvent that can partially solubilize the inorganic compound to form a mixture; and applying pressure and a low temperature to the mixture to evaporate the solvent and densify the at least one inorganic compound to form sintered materials.
    Type: Grant
    Filed: April 9, 2021
    Date of Patent: September 3, 2024
    Assignee: The Penn State Research Foundation
    Inventors: Clive A. Randall, Jing Guo, Amanda Baker, Michael Lanagan, Hanzheng Guo
  • Ceria nanoparticles and ceria nanoparticles preparation method
    Patent number: 12077448
    Abstract: A ceria nanoparticles preparation method is provided. The method includes preparing a mixed solution containing a cerium precursor and an imidazole derivative and preparing ceria nanoparticles by stirring the mixed solution.
    Type: Grant
    Filed: October 15, 2021
    Date of Patent: September 3, 2024
    Assignee: Research & Business Foundation Sungkyunkwan University
    Inventors: Jaeyun Kim, Seung Woo Choi