Abstract: The present invention relates to a composition for preventing or treating cellular senescence-associated diseases comprising salinomycin as an active ingredient, which acts differently depending on the type of senescent cells, and it was confirmed that salinomycin exhibits a senomorphics effect of restoring the function and morphology of fibroblasts and vascular endothelial cells in which senescence is induced and exhibits a senolytics effect of selectively killing aging-induced retinal pigmented epithelial cells, and exhibits a senomorphics effect of restoring the function and morphology of cells, and thus the salinomycin acts differently depending on the type of cells to effectively prevent or treat senile eye disease, tissue fibrosis disease, atherosclerosis, osteoarthritis, degenerative brain disease, chronic skin damage, obesity and diabetes caused by cellular aging and can be provided as a composition for life extension.

Abstract: The present disclosure relates generally to compounds that simultaneously bind both mutant huntingtin protein (mHTT) and an ubiquitin E3 ligase and their use as therapeutic agents, for example, in treating diseases, such as neurodegenerative disorders caused by aggregation of mHTT.

Abstract: Disclosed are nucleic acid sequences comprising a modified HIV Gag sequence, wherein the modified HIV Gag sequence comprises, from 5? to 3?, a matrix domain (MA), capsid (CA) domain, SP1 region, nucleocapsid (NC) domain, SP2 region, and p6 domain, wherein the modified HIV Gag sequence further comprises an exogenous sequence of interest between the NC domain and the SP2 region. Disclosed are methods of producing a recombinant lentivirus comprising transfecting a cell with a plasmid comprising the nucleic acid sequence of one or more of the disclosed nucleic acid sequences in combination with an envelope plasmid. Disclosed are methods of monitoring lentivirus assembly, budding, and/or maturation comprising transfecting a cell with a plasmid comprising any one of the disclosed nucleic acid sequences in combination with an envelope plasmid, wherein the exogenous sequence of interest encodes a detection agent.

Abstract: A method of encoding and decoding memory data for software security, includes: encoding the memory data using a machine language into which an encoding function is injected and storing the encoded memory data in the memory area; and decoding the encoded memory data in the memory area using a machine language into which a decoding function is injected and branching the decoded memory data to an address designated by a value of the memory data.

Abstract: A video decoding apparatus predicts a target block in a current picture to be decoded. The apparatus comprises a predictor configured to: determine first and second reference pictures and first and second motion vectors for bi-prediction by decoding a bitstream; generate a first reference block from the first reference picture referenced by the first motion vector and generate a second reference block from the second reference picture referenced by the second motion vector; and generate a prediction block of the target block using the first and second reference blocks. The predictor includes a first coding tool configured to generate the prediction block of the target block by performing a bi-directional optical flow process using the first and second reference blocks.

Abstract: Described herein are chemically defined, adherent culture protocols for generating functional motor neurons characteristic of diverse hindbrain and spinal cord regions, with high efficiency.

Abstract: A symbolic execution device, a symbolic execution method, and a probability distribution update method for symbolic execution are provided. The symbolic execution device includes a storage unit for storing at least one of a first probability distribution and a second probability distribution and a processor for sampling and obtaining a weight vector from the first probability distribution, for sampling and obtaining a removal rate from the second probability distribution, for adding the weight vector to at least one feature vector obtained from at least one candidate state to obtain a score for each of the at least one candidate state, and for selecting a state to be removed from among the at least one candidate state by using the score of each of the at least one candidate state and the removal rate.

Abstract: This document provides antibodies against tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) short, and more particularly to humanized TRAILshort antibodies that can neutralize TRAILshort. For example, materials and methods for using one or more humanized TRAILshort antibodies to induce apoptosis (e.g., via TRAIL mediated cell death, natural killer (NK) cytotoxicity, and/or CD8+ T cell killing) are provided.

Abstract: Anchor delivery systems and methods for repairing a valve inside a body, such as an atrioventricular valve, may include an anchor delivery device including a sheath for at least partially retaining an anchor in a collapsed form. The anchor delivery device may be configured to deliver the anchor to the atrioventricular valve. The anchor and an adjacent anchor may be connectable to each other in an expanded form, to link a series of anchors implanted at least partially around the atrioventricular valve. In some embodiments, the anchors may be connectable by a connecting member, such as a pledget, or a material disposable on a bulb of the anchor. In other embodiments, a bulb of the anchor and a bulb of the adjacent anchor may be configured to be directly interlocked.

Abstract: An apparatus and method for separating single cells. The apparatus includes: a fluid channel having an upper panel, a lower panel, and a flow path formed therebetween that is configured to convey a sample including a single cell; a single cell measuring unit including first and second electrodes provided on the fluid channel in a predetermined spaced relationship for applying electrical signals to the sample in the flow path, and a detection electrode provided between the first and second electrodes to detect the single cell in the sample in the flow path, such that the single cell measuring unit applies the electrical signals to the sample in the flow path, detects the electrical signals of the sample, and detects whether there is the single cell in the sample; and a single cell separation control device which outputs a single cell separation control signal when the single cell is detected by the detection electrode.

Abstract: A device and method for absorbing electromagnetic waves can include a honeycomb sheet formed by a plurality of interconnected hexagon cells arranged in rows. The hexagon cells are made up of sidewalls, each sidewall formed by two surfaces that converge at a top of the sidewall and diverge from the top to a bottom of the sidewall such that a thickness of the sidewalls increases from top to bottom and an angle forms between the two surfaces at the top of the sidewall. In an example, the angle is about 8 degrees. The honeycomb sheet can be coated with a magnetic, composite coating to increase electromagnetic shielding. An example coating includes magnetic multi-granular nanoclusters (MGNC) and multi-walled carbon nanotubes (MWCNT). A base layer can be attached to the honeycomb sheet for mechanical stability and additional absorption. The device is suitable for radar absorbing materials (RAM) for aerospace and military applications.

Abstract: A photovoltaic system is formed as a window that is constructed of at least one polymer layer that is filled or decorated with metal nanoparticles and a window frame that includes one or more photovoltaic cells. The metal nanoparticles have a shape and size such that they display surface plasmon resonance frequencies in the near-infrared and/or the near-ultraviolet. The near-infrared and/or the near-ultraviolet radiations are scattered such that they are transmitted parallel to the face of the window to the photovoltaic cells, where an electrical current is generated.

Abstract: A display apparatus includes a plurality of pixels. A pixel includes a first capacitor connected between a first voltage line receiving a first driving signal and a first node, a first transistor comprising a control electrode connected to the first node, a first electrode connected to a second voltage line receiving a first power source signal and a second electrode connected to a second node, an organic light emitting diode comprising an anode electrode connected to the second node and a cathode electrode receiving a second power source signal, a second capacitor connected between an m-th data line and the second node (wherein, ‘m’ is a natural number) and a second transistor comprising a control electrode connected to an n-th scan line (wherein, ‘n’ is a natural number), a first electrode connected to the first node and a second electrode connected to the second node.

Abstract: Provided are a phospholipid-photothermal nanoparticle having a cancer cell surface-specific antibody bound to the surface thereof, which can specifically bind to cancer cells, has a small particle size and excellent stability, and can effectively induce cancer cell apoptosis by exerting a photothermal effect when irradiated with near-infrared rays, and wherein the antibody or a fragment thereof is site-specifically conjugated to the phospholipid-photothermal nanoparticle, and thus the cancer cell binding ability and the photothermal cancer therapeutic effect of the phospholipid-photothermal nanoparticle are improved, and the phospholipid-photothermal nanoparticle having an antibody bound to the surface thereof are advantageously utilized for cancer therapy.

Abstract: An optical imaging system includes a first lens group, a second lens group, a third lens group, and a fourth lens group sequentially disposed in ascending numerical order along an optical axis of the optical imaging system from an object side of the optical imaging system toward an image side of the optical imaging system, at least one lens group among the first lens group to the fourth lens group being configured to be movable along the optical axis; and a reflective member disposed on an object side of the first lens group and comprising a reflective surface configured to change an optical path, wherein the first lens group has a positive refractive power, and 0.8?Fnot/Fnow?1.3 is satisfied, where Fnot is an F-number of the optical imaging system in a telephoto mode, and Fnow is an F-number of the optical imaging system in a wide-angle mode.

Abstract: The present invention relates to humanized antibodies having good binding ability to digoxigenin and uses thereof. When an antibody or antigen-binding fragment thereof specifically recognizing digoxigenin according to one aspect of the present invention is used, the concentration of the drug in the body is adjusted as needed through a complex (DOligobody) containing the same, or the concentration of the drug in vivo It is expected that the half-life can be increased.

Abstract: The present invention relates to a transition metal complex catalyst composition for polymerization of a monomer having a cyclic ester group and a method of producing a polymer using the same. More particularly, the invention provides a catalyst composition comprising a transition metal complex containing aminopyridine and aminoquinoline ligands, and a method of producing a polymer having high heterotacticity with high conversion rate even at room temperature by using the same. Since the catalyst composition for polymerization of a monomer having a cyclic ester group according to the invention comprises a transition metal compound that is chemically stable in air, it is capable of effectively producing a polymer having high heterotacticity (Pr) with high conversion rate at room temperature or below room temperature without satisfying high-temperature conditions.

Abstract: The present invention relates to a method of simultaneously diagnosing active tuberculosis and latent tuberculosis infection (LTBI) using one or more biomarkers selected from a white blood cell count, a hemoglobin concentration, a neutrophil count, a lymphocyte count, a monocyte count, a procalcitonin concentration, a C-reactive protein concentration, an ?1-acid glycoprotein concentration and an erythrocyte sedimentation rate, or a combination thereof. The present invention may provide a diagnostic method for simultaneously differentiating active tuberculosis and LTBI without a separate additional test on a patient diagnosed as positive by a conventional tuberculosis infection assay such as a tuberculin skin test (TST) or an interferon-T release assay (IGRA).

Abstract: There is provided a method for estimating a pose of an object using 3 dimensional modeling transform by transforming a 3D partial point cloud including partial points for the object to a 3D full point cloud for the object.

Abstract: The present invention relates to a strain that produces neoagarooligosaccharides from agarose, which is a representative polysaccharide constituting red algae, using Saccharomyces boulardii, which is a probiotic yeast, a production method thereof, and a use thereof. The present invention aims to achieve synbiotics through the production of prebiotic substances using probiotic strains and can be used as an intestinal microbial factory.