Patents Assigned to Foundation
  • Expression system
    Patent number: 8415148
    Abstract: The present invention relates generally to methods and compositions for expression of polypeptides or delivery of interfering RNAs in various cell types.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: April 9, 2013
    Assignee: San Diego State University Foundation
    Inventor: Jacques Perrault
  • Elasticity imaging device with improved characterization of seed displacement calculations
    Patent number: 8417475
    Abstract: The identification of preferred seed calculations used to guide the determination of displacement vectors in elasticity imaging may evaluate seeds using a combination of a measure of the similarity of the data of the seed in pre- and post-compression data and continuity of the data in a path in the neighborhood of the seed. This dual evaluation helps avoid downstream error propagation.
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: April 9, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jingfeng Jiang, Timothy J. Hall
  • Devices and methods for the collection and detection of substances
    Patent number: 8414846
    Abstract: The present invention is a single self-contained device for collecting, transferring, extracting, and testing for the presence of a target analyte in a sample obtained from a surface by swabbing, solid materials (pills, capsules, unknown powders), air samples and biological and non-biological fluids. The device includes a swab, a retention well including eluent fluid, and analysis technologies which can include but are not limited to lateral flow testing analysis. The major improvement is the invention of rinsing the swab with proprietary elution fluid prior to testing thereby not compromising the chemistry and allowing for a wide variety of applications under extremely hot or cold field conditions. Also, the device is in one self-contained unit instead of having a separate water dropper or spray.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: April 9, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Mark S. Gold, David M. Martin, Steven T. Gold, Bruce A. Goldberger
  • Corpus callosum neuromodulation assembly
    Patent number: 8417345
    Abstract: Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.
    Type: Grant
    Filed: March 4, 2010
    Date of Patent: April 9, 2013
    Assignee: The Cleveland Clinic Foundation
    Inventors: Andre Machado, Ali R. Rezai
  • Microcontact printed thin film capacitors
    Patent number: 8414962
    Abstract: The invention relates to thin film single layers, electronic components such as multilayer capacitors which utilize thin film layers, and to their methods of manufacture. Chemical solution deposition and microcontact printing of dielectric and electrode layers are disclosed. High permittivity BaTiO3 multilayer thin film capacitors are prepared on Ni foil substrates by microcontact printing and by chemical solution deposition. Multilayer capacitors with BaTiO3 dielectric layers and LaNiO3 internal electrodes are prepared, enabling dielectric layer thicknesses of 1 ?m or less. Microcontact printing of precursor solutions of the dielectric and electrode layers is used.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: April 9, 2013
    Assignee: The Penn State Research Foundation
    Inventors: Susan Trolier McKinstry, Clive A. Randall, Hajime Nagata, Pascal I. Pinceloup, James J. Beeson, Daniel J. Skamser, Michael S. Randall, Azizuddin Tajuddin
  • Medical personnel alert rules based on grouping
    Patent number: 8416085
    Abstract: A method, a system, and a computer-readable medium are provided for generating an alert based on a physiological characteristic of a patient. A user interface window is configured to allow a user to define a first alert value, an indicator of a physiological characteristic of a patient associated with the first alert value, and an application type indicator for the alert rule indicating a group for which to apply the alert rule. A value and a characteristic indicator of the physiological characteristic of the patient are received. A group indicator associated with the patient is received. The received first alert value is identified by comparing the received characteristic indicator to the indicator. The received value is compared to the identified first alert value, and the received group indicator is compared to the application type indicator. An alert is generated based on the comparison.
    Type: Grant
    Filed: February 18, 2010
    Date of Patent: April 9, 2013
    Assignee: The University of Utah Research Foundation
    Inventor: Ute Gawlick
  • Anti-bacterial drug targeting of genome maintenance interfaces
    Patent number: 8415393
    Abstract: The present invention provides methods for the design and identification of novel antimicrobial compounds, and provides antimicrobial compounds identified using these methods. These antimicrobial compounds inhibit the binding of a prokaryotic single-stranded DNA binding protein to a polypeptide that binds to the prokaryotic single-stranded DNA binding protein. In some examples, the prokaryotic single-stranded DNA binding protein is prokaryotic Exonuclease I. In one embodiment, the antimicrobial compound has the structure wherein Y is selected from the group consisting of CH2, O, and NH, R1 is selected from the group consisting of H, F, Cl, Br, and I, R2 is selected from the group consisting of H and CF3, R3 is selected from the group consisting of H and CO2H, R4 is selected from the group consisting of H and OH, and R5 is selected from the group consisting of H, alkoxy, and NO2.
    Type: Grant
    Filed: May 21, 2008
    Date of Patent: April 9, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: James L. Keck, Douglas A. Bernstein
  • Splice system for connecting rebars in concrete assemblies
    Patent number: 8413396
    Abstract: A splice tube assembly and corresponding system for connecting multiple fiber-reinforced polymer rebars include a polymeric tube that is externally covered by a reinforcing layer to control radial expansion of grout within the polymeric tube and of the polymeric tube itself, and the polymeric tube may be internally provided with locking structures for mechanically interlocking with the grout, ensuring that the splice tube assembly functions as a unit for transferring loads from a first rebar, extending from a first end of the polymeric tube, to a second rebar, extending from a second end of the polymeric tube.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: April 9, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Michael G. Oliva, Lawrence C. Bank
  • Ultra-sensitive, portable capillary sensor
    Patent number: 8414844
    Abstract: A portable, lightweight, rugged, easy-to-operate biosensor useful for rapidly detecting cells, viruses, antibodies, and other proteins. A capillary tube has a capture antibody immobilized on its interior surface. The specific capture antibody is selected based upon a desired target analyte to be detected. A sample potentially containing the target antigen is introduced into the capillary tube. Thereafter, a second antibody labeled with a fluorescent dye is introduced. Upon excitation by electromagnetic energy, typically supplied by a laser, the fluorescence of the sample is captured and analyzed. The apparatus is extremely compact and rugged making it ideal for field use. In addition, accurate results may be obtained by relatively unskilled operators directly from a self-contained readout. Optionally, an external device (e.g., a computer) may be connected to the apparatus via an optional interface.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: April 9, 2013
    Assignee: Research Foundation of State University of New York
    Inventors: Omowunmi Sadik, Jason Karasinski
  • RR interval monitoring method and blood pressure cuff utilizing same
    Patent number: 8417326
    Abstract: Disclosed is an apparatus and method for ambulatory, real-time detection of Atrial Fibrillation (AF) providing an overall accuracy that refers to detection of AF, irrespective of the duration of AF and beat-to-beat classification.
    Type: Grant
    Filed: August 4, 2008
    Date of Patent: April 9, 2013
    Assignee: The Research Foundation of State University of New York
    Inventors: Ki Chon, Ernst A. Raeder
  • Methods of and compositions for reducing cell death
    Patent number: 8415327
    Abstract: Methods and compositions involving a class of boron-protected phenylphosphine agents having increased cell permeability and having improved chemical stability for treating or for preventing cell death-related diseases or conditions in a human or a non-human animal.
    Type: Grant
    Filed: February 22, 2010
    Date of Patent: April 9, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Leonard A. Levin, Yun Luo
  • Nanoparticles including metal oxide having catalytic activity
    Patent number: 8415267
    Abstract: Core-shell nanoparticles having a core material and a mesoporous silica shell, and a method for manufacturing the core-shell nanoparticles are provided.
    Type: Grant
    Filed: June 4, 2012
    Date of Patent: April 9, 2013
    Assignee: Korea University Research and Business Foundation
    Inventor: Kwangyeol Lee
  • Method of implementing memristor-based multilevel memory using reference resistor array
    Patent number: 8416604
    Abstract: The present invention relates to a memristor, and more particularly, to a method of implementing a memristor-based multilevel memory using a reference resistor array and a write-in circuit and a read-out/restoration circuit for the memristor-based multilevel memory, in which a memristor can be used as a multilevel memory. In the present invention, a reference resistance value is written in a selected memristor of a memristor array by applying repeatedly the current pulses of which widths are proportional to the difference between the resistances of the selected memristor and the selected node of the reference resistor array.
    Type: Grant
    Filed: January 20, 2011
    Date of Patent: April 9, 2013
    Assignees: Industrial Cooperation Foundation Chonbuk National University, The Regents of the University of California
    Inventors: Hyongsuk Kim, Leon O. Chua
  • Carbon nanotube and nanofiber film-based membrane electrode assemblies
    Patent number: 8415012
    Abstract: A membrane electrode assembly (MEA) for a fuel cell comprising a catalyst layer and a method of making the same. The catalyst layer can include a plurality of catalyst nanoparticles, e.g., platinum, disposed on buckypaper. The catalyst layer can have 1% or less binder prior to attachment to the membrane electrode assembly. The catalyst layer can include (a) single-wall nanotubes, small diameter multi-wall nanotubes, or both, and (b) large diameter multi-wall nanotubes, carbon nanofibers, or both. The ratio of (a) to (b) can range from 1:2 to 1:20. The catalyst layer can produce a surface area utilization efficiency of at least 60% and the platinum utilization efficiency can be 0.50 gPt/kW or less.
    Type: Grant
    Filed: July 17, 2009
    Date of Patent: April 9, 2013
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Jian-ping Zheng, Zhiyong Liang, Ben Wang, Chun Zhang, Wei Zhu
  • Pathway for Th-17 cell development and methods utilizing same
    Patent number: 8414897
    Abstract: The present disclosure demonstrates for the first time that Th-17 cells are the product of a distinct CD4+ T cell lineage with unique developmental and functional characteristics. The developmental signals required for Th-17 commitment and development are also described. As a result, the teachings of the present disclosure provide a basis for understanding the developmental pathway of Th-17 cells and offer novel avenues to modulate (stimulate or inhibit) this developmental program and offer new methods for the treatment and prevention of disease states and conditions related to aberrant activity of Th-17 cells.
    Type: Grant
    Filed: October 2, 2007
    Date of Patent: April 9, 2013
    Assignee: The UAB Research Foundation
    Inventors: Casey T. Weaver, Paul R. Mangan, Laurie E. Harrington
  • Method of compensating for distortion in text recognition
    Patent number: 8417057
    Abstract: A method of compensating for distortion in text recognition is provided, which includes extracting a text region from an image; estimating the form of an upper end of the extracted text region; estimating the form of a lower end of the extracted text region; estimating the form of left and right sides of the extracted text region; estimating a diagram constituted in the form of the estimated upper end, lower end, left and right sides, and including a minimum area of the text region; and transforming the text region constituting the estimated diagram into a rectangular diagram using an affine transform.
    Type: Grant
    Filed: February 12, 2010
    Date of Patent: April 9, 2013
    Assignees: Samsung Electronics Co., Ltd., Industry Foundation of Chonnam National University
    Inventors: Sang-Wook Oh, Seong-Taek Hwang, Hyun-Soo Kim, Sang-Ho Kim, Guee-Sang Lee, Soo-Hyung Kim, Hyung-Jeong Yang, Eui-Chul Kim
  • Peripheral oxistimulator apparatus and methods
    Patent number: 8417351
    Abstract: Apparatus and methods for monitoring a patient's blood oxygen content (through, e.g., an external finger probe using a pulse oximeter). If the patient's blood oxygen content falls below a selected level, a safe, yet effective, level of peripheral nerve stimulation would be delivered to the patient's wrist in the form of a milliamp current to arouse the patient.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: April 9, 2013
    Assignee: Mayo Foundation for Medical Education and Research
    Inventor: Joan M. Kilger
  • Methods and compositions for inhibiting the proliferation of cancer cells
    Patent number: 8415315
    Abstract: A method of decreasing the expression of LIM kinase 1 in a cancer cell comprising; providing an oligonucleotide consisting of the sequence of SEQ ID NO: 1; providing a cancer cell comprising an mRNA encoding LIM kinase 1; and introducing the oligonucleotide into the cancer cell, wherein the oligonucleotide decreases the expression of LIM kinase 1 in the cancer cell. The method also provides compositions of an antisense RNA LIM kinase 1 that can be administered to an individual for the purpose of inhibiting a protein kinase pathway and which further comprises methods for treating and monitoring the proliferation and metastasis of cancer cells. A kit may be used in the detection and treatment of cancer.
    Type: Grant
    Filed: February 16, 2010
    Date of Patent: April 9, 2013
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Ratna Chakrabarti
  • Piezoelectric nanodevices
    Patent number: 8415859
    Abstract: A piezoelectric nanodevice may include a first substrate having formed thereon a multiple number of nanorods and a second substrate having formed thereon a multiple number of piezoelectric nanorods. The first substrate associates with the second substrate to generate friction between the nanorods of the first substrate and the piezoelectric nanorods of the second substrate.
    Type: Grant
    Filed: October 27, 2009
    Date of Patent: April 9, 2013
    Assignee: Korea University Research and Business Foundation
    Inventor: Kwangyeol Lee
  • Synthesis of polycyclic procyanidins
    Patent number: 8415489
    Abstract: The invention provides compounds that are A-type procyanidins. The compounds can be prepared by reacting flavylium salts with catechins or analogs thereof, for example, under anhydrous conditions in alcohol.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: April 9, 2013
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: George A. Kraus, Yi Yuan