Abstract: A method of generating an image or video of a field of interest of a sample which includes obtaining i) a first RGB image from a field of interest of a sample, and ii) hyperspectral data from a subarea of the field of interest, extracting an RGB image of the subarea from the first RGB image of the field of interest, applying the hyperspectral data of the subarea to conduct a spectroscopic analysis of a sample thereby generating spectral parameters, inputting i) the spectral parameters, and ii) the first RGB image, collectively as training input data to a deep learning model (DLM), training the DLM with the training input data thus generating a trained DLM, obtaining and inputting a second RGB image of about the field of interest to the trained DLM, and outputting from the trained DLM a spectral map for the field of interest.

Abstract: A method and system use mathematical models and available patient information to virtualize a continuous glucose monitoring trace for a period of time. Such a method and system can generate the virtualized trace when episodic patient data is incomplete. Such a method and system can also rely on self-monitored blood glucose measurement information to improve the virtualized continuous glucose monitoring trace.

Abstract: The invention provides a method for (a) increasing skeletal muscle mass; (b) reducing skeletal muscle atrophy; (c) increasing muscular strength; (d) promoting muscle growth; (e) decreasing muscle wasting; or (f) increasing strength per unit of muscle mass in an animal identified or having been identified to be in need of one or more of (a)-(f), the method comprising administering to the animal an effective amount of a compound of formula: or a stereoisomer, solvate, or pharmaceutically acceptable salt thereof, thereby accomplishing one or more of (a)-(f).

Abstract: A method of in situ point spread function (PSF) retrieval is disclosed which includes encoding 3D location of molecules into PSFs, receiving molecule-generated images containing PSFs, segmenting the images into sub-PSF, initializing template PSFs from a pupil function, determining a statistical measure of a predetermined function between the sub- and template PSFs, associating each of the sub-PSFs with a template PSF, aligning and averaging the sub-PSF, applying a phase retrieval algorithm to the averaged sub-PSFs to update the pupil function, regenerating the template PSFs, repeating until a difference between a new and a prior generation pupil function is below a predetermined threshold, generating in situ PSFs from the last pupil function, and applying a maximum likelihood estimation algorithm based on the in situ PSFs and the sub-PSF to thereby generate lateral and axial locations of molecules.

Abstract: In some aspects, mutant or variant Fc domains are provided that exhibit increased binding to FcRn and increased half-life after administration in vivo. The Fc domain may be comprised in a glycosylated or aglycosylated antibody. Methods for using the mutant or variant Fc domains or polypeptides comprising the mutant or variant Fc domains are also provided.

Abstract: The present invention relates to an oleaginous yeast Yarrowia lipolytica sur2 mutant strain and a method for producing and secreting, onto cell surfaces, sphingoid-based precursors, sphingosine and sphingolipids by using same. It has been identified that when a ceramidase gene is additionally introduced into a Ylsur2 deficient mutant strain, the secretion and production of dihydrosphingosine and sphingosine are increased and, further, it is has been identified that when a Ylsld1sur2 double mutant strain in which a SLD1 gene is additionally deficient in a Ylsur2 deficient mutant strain is prepared, growth recovery and sphingosine and human-type glucosylceramide secretion and production are increased.

Abstract: Provided are silica-coated cellulose nanofibers modified with a hydrophobic group capable of improving the mechanical properties of a pressure-sensitive adhesive while maintaining the adhesive performance of the pressure-sensitive adhesive; and a pressure-sensitive adhesive including the same.

Abstract: An auto-injector includes a housing and an actuation assembly. The housing includes a central cavity, opposing ends, and a longitudinal axis defined spanning between the opposing ends. The actuation assembly is shaped to position within the central cavity. The actuation assembly is configured to at least partially internally house a spring, a spring compression member, a needle operable to eject a fluid therefrom, a firing member selectively translatable between an unfired position and a fired position, and a firing initiation member. While in the unfired position, the needle is held within the central cavity of the housing. While in the fired position, the needle is extended outward from the central cavity of the housing.

Abstract: Disclosed is a system for advanced user authenticated key management for 6G-based industrial applications with respect to user authentication and management scheme to secure a 6G-enabled Network-In-a-Box (NIB). The system includes: a registration unit configured to perform registration of smart industrial device, content server, and user by using a trusted authority and an ID of the trusted authority; a user login unit configured to compute whether a Hamming distance between a biometric secret key provided to the registration unit and a currently recognized biometric secret key is equal to or less than a pre-defined error tolerance threshold; and a user authentication unit configured to perform mutual authentication among a pre-registered user Ux, a content server CSy, and an accessed smart industrial device SDz. Accordingly, a 6G-enabled Network-In-a-Box (NIB) can be secured.

Abstract: The disclosure provides compositions and methods for producing micro-dystrophin proteins, and the use thereof (e.g., in gene therapy). The disclosure also provides skeletal muscle-specific promoters and the use thereof (e.g., in gene therapy). The disclosure further provides catheter-based methods of delivering gene therapy vectors to skeletal muscle and/or cardiac muscle.

Abstract: The present invention relates to a composition for an electrochromic device having improved optical transmission and elasticity, and a manufacturing method of an electrochromic member, wherein the composition for an electrochromic device according to an embodiment of the present invention includes a light-transmitting polymer resin, a plasticizer, and an electrochromic material.

Abstract: The invention provides a tissue cutting device comprising a handle, a first blade. and a second blade. The second blade is coupled to the handle. The second blade is rotatable relative to the first blade such that the second blade is configured to rotate between a first position and a second position. The second blade is in a same plane as the first blade when the second blade is in the first position. The second blade is rotated into a different plane from the first blade when the second blade is rotated from the first position toward the second position.

Abstract: Mutant thioesterases having enhanced medium chain substrate activity, polynucleotides encoding and configured to express the mutant thioesterases in a transformed host cell, host cells transformed to contain the polynucleotides, and methods of using same.

Abstract: Emerging evidence indicates that diminished activity of the vasoprotective axis of the renin-angiotensin system, constituting angiotensin converting enzyme2 (ACE2) and its enzymatic product, angiotensin-(1-7) [Ang-(1-7)] contribute to pulmonary hypertension (PH). However, clinical success for long-term delivery of ACE2 or Ang-(1-7) would require stability and ease of administration to increase patient compliance. Chloroplast expression of therapeutic proteins enables their bioencapsulation within plant cells to protect from acids and gastric enzymes; fusion to a transmucosal carrier facilitates effective systemic absorption. Oral feeding of rats with bioencapsulated ACE2 or Ang-(1-7) attenuated monocrotaline (MCT)-induced increase in right ventricular systolic pressure, decreased pulmonary vessel wall thickness and improved right heart function in both prevention and reversal protocols.

Abstract: In shotgun proteomics, generally only a fraction of peptides from a parent protein are actually detected. Because a large portion of the protein sequence is not detected, it is often impossible to determine whether the expressed protein is present in a modified, spliced, or truncated form. Provided herein are methods and systems for analyzing polypeptides which allow for the increase of the mean sequence coverage of a protein concomitant with bioinformatics analysis in order to distinguish putative proteoforms with improved amino acid resolution. Aspects of the invention include (1) a deep sequencing strategy to provide more protein sequence coverage than is typically achieved, and (2) a computational approach to view protein expression across its full length and identify regions of the protein that are potentially subject to such regulation. This technology has global utility in proteomics and will be of particular use for the analysis of biosimilar protein drug therapeutics.

Abstract: Disclosed embodiments include computer-implemented methods and systems that can efficiently generate highly relevant recommended search terms to clinicians. A hybrid collaborative filtering model recommends search terms for a specific patient to the clinician. The model draws on information from patients' clinical encounters and the searches that were performed during the clinical encounters. To generate recommendations, the model uses search terms which are (1) frequently co-occurring with the ICD codes recorded for the patient and (2) highly relevant to the most recent search terms. One variation of the model uses only the most recent ICD codes assigned to the patient. Another variation uses all ICD codes. Comprehensive experiments of embodiments of the methods and systems have demonstrate high levels of performance.

Abstract: The present invention provides phenazine derivatives, such as compounds of Formula (I). The compounds of the invention are expected to be antimicrobial agents and may act by a microbial warfare strategy (e.g., a reactive oxygen species (ROS)-based competition strategy). The present invention also provides compositions, kits, uses, and methods that involve the compounds of the invention, which may be useful in preventing or treating a microbial infection (e.g., a bacterial infection or mycobacterial infection) in a subject, inhibiting the growth and/or reproduction of a microorganism (e.g., a bacterium or mycobacterium), killing a microorganism (e.g., a bacterium or mycobacterium), inhibiting the formation and/or growth of a biofilm, reducing or clearing a biofilm, and/or disinfecting a surface.

Abstract: A surgical system includes a skull attachment device that includes a support base configured to seat against a skull of a patient and one or more pins extending from a bottom surface of the support base and configured to pierce the scalp to seat the skull attachment device against the skull. The surgical system also includes an interface disposed along a top surface of the support base and having a shape that compliments a profile of a mating feature of a stereotactic device for defining a position and an orientation of the stereotactic device with respect to the support base while the interface is engaged with the mating feature.

Abstract: The present disclosure provides compositions and methods for decreasing permissiveness to infection by PRRSV. The methods involve inserting peptides or oligopeptides into the CD163 SRCR domain 5 to disrupt the protein structure and thereby prevent PRRSV infection. The deletion of the exon 13 region of PSTII eliminates infection. The replacement of cysteine residues with alanines in SRCR5 as a means to disrupt disulfide bond formation. The final method is the deletion of, or amino acid substitution within the SRCR4-5 interdomain region.

Abstract: A method and system of neural stimulation and imaging of nervous system of a subject. The method includes the steps of providing an interface device operable to generate an ultrasonic beam for neuroniodulation and imaging of a targeted neural structure of a subject, implanting the interface device in the subject, and providing and disposing an external coil array over the targeted neural structure of the subject, wherein the external coil array is wirelessly powering and communicating with the interface device.