Abstract: The disclosure provides methods of treating obesity, reducing weight, or preventing weight gain using a combination therapy of GDF15 polypeptide and a myostatin inhibitor (e.g., a myostatin propeptide).

Abstract: A method of designing a radar, comprises receiving data pertaining to a set of reflected signals received from a distribution of objects by a respective set of receiving antennas at a respective set of locations, and feeding the data and the locations as training data to a machine learning procedure. The machine learning procedure calculates, simultaneously, a set of learned antenna locations and a set of learned parameters associating the signals with the objects, thereby providing a trained machine learning procedure parametrized by the set of learned parameters.

Abstract: A method for decoding an image signal according to the present invention may comprise the steps of: determining whether there is a brightness change between a current image including a current block and a reference image of the current image; if it is determined that there is a brightness change between the current image and the reference image, determining weight prediction parameter candidates for the current block; determining a weight prediction parameter for the current block on the basis of index information which specifies any one of the weight prediction parameter candidates; and performing a prediction on the current block on the basis of the weight prediction parameter.

Abstract: Provided is a spatial light modulator configured to modulate light, the spatial light modulator including a first reflective layer, a resonance layer on the first reflective layer, and a second reflective layer on the resonance layer, the second reflective layer including a plurality of grating structures space apart from each other, wherein the plurality of grating structures include silicon (Si) having an extinction coefficient k that is less than or equal to 1e-5 with respect to light in the predetermined wavelength band.

Abstract: Disclosed is a computing-in-memory device, which includes a memory cell array including an analog multiplication unit that performs a multiply-accumulate (MAC) operation on a pre-stored weight and a first analog voltage corresponding to multi-bit input data, and a driver that applies the multi-bit input data to the analog multiplication unit, and the analog multiplication unit includes a digital-to-analog converter that converts the multi-bit input data into the first analog voltage.

Abstract: The present invention provides methods of treating myopia comprising administering composition comprising a cop-per-containing agent to an eye of a subject in need thereof.

Abstract: Embodiments of the present disclosure are directed to forwarding a large amount of data in a machine-to-machine (M2M) system, and a method for operating a first device may include: transmitting, to a second device, a request message for bulk data transfer; and receiving, from the second device, an acknowledgment message for notifying completion of the bulk data transfer, wherein the request message may include at least one of information for identifying data to be included in bulk data, information on a target common service entity (CSE) in a target platform that receives the bulk data, information for indicating processing of source data after the bulk data transfer, and information for accessing the target CSE.

Abstract: The present disclosure relates to compositions and methods for treatment of degenerative conditions of large weight-bearing joints, such as osteoarthritis, by intra-articular delivery of a codon-modified IL-1Ra encoding gene.

Abstract: A temperature sensor including a sapphire optical fiber and a nanoporous cladding layer covering at least a portion of the sapphire optical fiber.

Abstract: A method of audio signal processing comprising Hybrid Expansive Frequency Compression (hEFC) via a digital signal processor, wherein the method includes: classifying an audio signal input, wherein the audio signal input includes frication high-frequency speech energy, into two or more speech sound classes followed by selecting a form of input-dependent frequency remapping function; and performing hEFC including, re-coding of one or more input frequencies of the speech sound via the input-dependent frequency remapping function to generate an audio output signal, wherein the output signal is a representation of the audio signal input having a lower sound frequency.

Abstract: Effective human-robot collaboration (HRC) requires extensive communication among the human and robot teammates, because their actions can potentially produce conflicts, synergies, or both. An augmented reality-driven, negotiation-based (ARN) framework is provided for HRC, where ARN supports planning-phase negotiations within human-robot teams. Experiments in an office environment, where multiple mobile robots work on delivery tasks, where the robots could not complete the tasks on their own, but sometimes need help from their human teammate, making human-robot collaboration necessary. In comparison to a non-AR baseline, ARN significantly improved the human users' work efficiency, and their cognitive load, while reducing the overall task completion time of the whole team.

Abstract: Compositions and methods are provided that are useful for diagnosing, treating, and monitoring alcohol dependence and disorders, susceptibility to alcohol dependence disorders, as well as drug related dependence and disorders. The methods include treating patients with an antagonist of the serotonin receptor 5-HT3 for such disorders, wherein the patient's serotonin transporter gene SLC6A4 is known to have particular genotypes.

Abstract: A method of in situ point spread function (PSF) retrieval is disclosed which includes encoding 3D location of molecules into PSFs, receiving molecule-generated images containing PSFs, segmenting the images into sub-PSFs, initializing template PSFs from a pupil function, determining a maximum normalized cross correlation (NCC) coefficient (NCCmax) between the sub- and template PSFs, associating each of the sub-PSFs with a template PSF based on the NCCmax and storing the sub-PSFs in associated bins, aligning and averaging the binned sub-PSFs, applying a phase retrieval algorithm to the averaged sub-PSFs to update the pupil function, regenerating the template PSFs, repeating until a difference between a new and a prior generation pupil function is below a predetermined threshold, generating in situ PSFs from the last pupil function, and applying a maximum likelihood estimation algorithm based on the in situ PSFs and the sub-PSFs to thereby generate lateral and axial locations of molecules.

Abstract: Various implementations include a fluidic oscillator having at least one control port. The at least one control port is for introducing a control fluid into the fluidic oscillator or suctioning the fluid stream from the fluidic oscillator. The introduction of a control fluid into the fluidic oscillator or suction of the fluid stream from the fluidic oscillator alters the frequency and sweeping angle of the oscillating fluid stream as it exits the fluidic oscillator. Various other implementations include a fluidic oscillator having a first control port defined by the first portion of the outlet nozzle and a second control port defined by the second portion of the outlet nozzle. The introduction of a control fluid into the fluidic oscillator or suction of the fluid stream from the fluidic oscillator through the control ports alters the exit angle of the oscillating fluid stream as it exits the fluidic oscillator.

Abstract: An inverse quantization method is implemented by an inverse quantization device, the method configured for acquiring quantized coefficients, estimating a quantization parameter in quantization groups or quantization parameter prediction group units, generating an inverse quantization matrix for adaptive quantization, and generating transform coefficients from the quantized coefficients using the quantization parameter and the inverse quantization matrix.

Abstract: The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to die cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5? end of exon 5 of the G6PC gene with c.648C>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).

Abstract: Upgraded coal, method of forming the same, and graphene films and quantum dots made therefrom. A method of upgrading coal includes cleaning coal to form a cleaned coal residue. The method also includes (A) reacting the cleaned coal residue with an oxidizable inorganic metallic agent, or (B) reacting the cleaned coal residue with a reducing agent, or a combination thereof, to form the upgraded coal.

Abstract: Disclosed is a positive electrode material for a lithium secondary battery. The positive electrode material includes a positive electrode active material formed of Li—[Mn—Ti]-M-O-based material including a transition metal (M) to enable reversible intercalation and deintercalation of lithium and molybdenum oxide. The positive electrode active material is coated with the molybdenum oxide to form a coating layer on a surface thereof.

Abstract: A compliant transmission system includes a rotatable wave generator and a sleeve fitted on the wave generator. The rotatable wave generator has an external surface including pattern extending both annularly and in a longitudinal direction. The sleeve is configured to be deformable and to be impressed on its outer surface with waves extending along the longitudinal direction during rotation of the pattern of the wave generator within the sleeve.

Abstract: A printed radiation sensor that includes a substrate, an interdigitated electrode, and a conductive polymeric film. The interdigitated electrode including a first electrode with a plurality of first electrode digits and a second electrode with a plurality of second electrode digits. The interdigitated electrode disposed on the substrate. The conductive polymeric film including a blend of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) and polyvinyl alcohol (PVA). The PEDOT:PSS is configured to provide an electrically conductive medium. The PVA is configured to provide ductility and stability of the printed radiation sensor. Upon radiation exposure, the PVA is further configured to crosslink within a material matrix of the printed radiation sensor militating against the recombination of chain scission by forming a semi-interpenetrating polymer network (SIPN) with the PEDOT:PSS to provide an enhanced and stable impedance reading.