Abstract: A method of producing in a cell in vivo a clostridial neurotoxin light chain peptide by delivering into the cell in vivo a nucleic acid construct. The nucleic acid construct comprises (a) a nucleic acid encoding a clostridial neurotoxin light chain peptide and (b) a regulatory sequence operably linked to the nucleic acid to allow expression of the nucleic acid. The expression of the nucleic acid produces the clostridial neurotoxin light chain peptide in the cell in vivo.
Abstract: A cathode for use in a direct oxidation fuel cell (DOFC) comprises a gas diffusion medium (GDM) including a backing layer and a microporous layer comprising a fluoropolymer and an electrically conductive material, wherein loading of the fluoropolymer in the microporous layer is in the range from about 10 to about 60 wt. %. In use, a concentrated solution of a liquid fuel is supplied to an anode and an oxidant to the cathode of the fuel cell, and the fuel cell may be operated at a low oxidant stoichiometry ?c not greater than about 2.5.
Type:
Grant
Filed:
January 22, 2007
Date of Patent:
April 27, 2010
Assignees:
Panasonic Corporation, The Penn State Research Foundation
Abstract: The subject invention provides methods of inducing the loss of adipose tissue by providing a diet high in calcium. In one aspect of the invention, the calcium is provided in the form of dairy products. In yet another aspect of the invention, calcium is provided in the form of a dietary supplement, such as calcium carbonate, of vitamin supplements. Methods of suppressing [Ca2+]i levels in individuals are also provided. The subject invention also provides methods of stimulating lipolysis, inhibiting lipogenesis, and increasing the expression of white adipose tissue uncoupling protein 2 (UPC2). The subject invention also provides methods of increasing the core temperature of an individual.
Type:
Grant
Filed:
December 14, 2001
Date of Patent:
April 27, 2010
Assignee:
The University of Tennessee Research Foundation
Abstract: A broadband multi-phase output delay locked loop (DLL) circuit can be operated in a wide range of frequencies and generate various phases. Unlike conventional voltage control delay lines in which delay cells are connected in series, the DLL circuit utilizes a delay matrix in which a resistant network is used so that the number of delay cells connected in series is reduced, various phases can be outputted, and a delay interval error (phase error) due to the resistant network is minimized. The current of the delay cells is controlled so that the delay cells in the delay matrix can operate in a wide range of frequencies, and load capacitance values of capacitors connected in parallel in the delay cells can be controlled.
Type:
Grant
Filed:
February 11, 2008
Date of Patent:
April 27, 2010
Assignees:
Samsung Electronics Co., Ltd., POSTECH Academy Industry Foundation
Inventors:
Ho-young Kim, Dong-bee Jang, Jae-yoon Sim, Young-sang Kim
Abstract: Virtual navigation (2255) and examination of virtual objects are enhanced using methods of insuring that an entire surface to be examined has been properly viewed. A user interface (FIG. 23) identifies regions which have not been subject to examination and provides a mechanism (2250) to route the user to these regions in the 3D display. Virtual examination is further improved by the use of measuring disks (905) to enhance quantitative measurements such as diameter, distance, volume and angle. Yet another enhancement to the virtual examination of objects is a method of electronic segmentation, or cleaning, which corrects for partial volume effects occurring in an object.
Type:
Grant
Filed:
October 2, 2001
Date of Patent:
April 27, 2010
Assignee:
The Research Foundation of State University of New York
Inventors:
Kevin Kreeger, Sarang Lakare, Zhenrong Liang, Mark R. Wax, Ingmar Bitter, Frank Dachille, Dongqing Chen, Arie E. Kaufman
Abstract: Dielectrophoresis is used to attract particles to an electrode edge then to controllably allow the transport of particles along that edge under a fluid flow to a particular region. The particles may be bacteria which may be maintained in this process in a live state through capture, transport and release.
Abstract: It is an object of the present invention to provide a hollow fiber membrane module which maximizes the efficiency of removing scale-like contaminants generated at the water treatment using hollow fiber membranes, and a method of manufacturing the same. The hollow fiber membrane module includes hollow fiber membranes for making water treatment due to the pressure difference, and a collector fixing the hollow fiber membranes in bundle. A treated-water tube is extended to the inside of the collector, and communicated with the inner passage of the hollow fiber membranes to deliver the water treated through the hollow fiber membranes. A diffuser is installed at the collector to diffuse bubbles to the hollow fiber membranes. An air tube is extended to the collector, and connected to the diffuser to feed air. Dividers are installed over the collector to partition the hollow fiber membranes into a plurality of bundles.
Type:
Grant
Filed:
May 13, 2004
Date of Patent:
April 27, 2010
Assignee:
Industry-Academic Cooperation Foundation
Inventors:
Soo-Hong Noh, Oh-Sung Kwon, Jin-Ho Chang, Sang-Hoon Kim
Abstract: Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) assays, systems, methods and kits for the age determination of an individual from bloodstains or samples of unknown origin. The methodology is based on gene expression profiling analysis in which novel human newborn fetal specific genes are identified by detecting the presence of appropriate messenger RNA species.
Type:
Grant
Filed:
May 25, 2007
Date of Patent:
April 27, 2010
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: An highly porous electrically conducting film that includes a plurality of carbon nanotubes, nanowires or a combination of both. The highly porous electrically conducting film exhibits an electrical resistivity of less than 0.1 O·cm at 25 C and a density of between 0.05 and 0.70 g/cm3. The film can exhibit a density between 0.50 and 0.85 g/cm3 and an electrical resistivity of less than 6×10?3 O·cm at 25 C. Also included is a method of forming these highly porous electrically conducting films by forming a composite film using carbon nanotubes or nanowires and sacrificial nanoparticles or microparticles. At least a portion of the nanoparticles or microparticles are then removed from the composite film to form the highly porous electrically conducting film.
Type:
Grant
Filed:
September 12, 2007
Date of Patent:
April 27, 2010
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Andrew G. Rinzler, John R. Reynolds, Rajib Kumar Das
Abstract: An actuator including a first and second conductor on a dielectric, wherein application of a voltage to the first conductor creates a plasma, thereby modifying a fluid flow in communication with the actuator. Related systems and methods are also provided.
Type:
Grant
Filed:
October 17, 2006
Date of Patent:
April 27, 2010
Assignee:
The University of Kentucky Research Foundation
Abstract: This invention provides androgen receptor targeting agents (ARTA). The agents define a new subclass of compounds, which are selective androgen receptor modulators (SARM). Several of the SARM compounds have been found to have an unexpected androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor. Other SARM compounds have been found to have an unexpected antiandrogenic activity of a nonsteroidal ligand for the androgen receptor.
Type:
Grant
Filed:
February 24, 2003
Date of Patent:
April 27, 2010
Assignee:
University of Tennessee Research Foundation
Inventors:
James T. Dalton, Duane D. Miller, Mitchell S. Steiner, Karen A. Veverka, Dong Jin Hwang, Jiyun Chen
Abstract: The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the patient. The invention further provides a method of identifying tumor antigens.
Type:
Grant
Filed:
March 2, 2006
Date of Patent:
April 27, 2010
Assignees:
University of Pittsburgh - of the Commonwealth System of Higher Education, University of Virginia Patent Foundation
Inventors:
Olivera J. Finn, Henry Kao, Donald F. Hunt, Jarrod A. Marto
Abstract: Compounds of formula I are provided where X1, X2 and X3 are independently selected from H or hydroxy protecting groups. Such compounds are used in preparing pharmaceutical compositions and are useful in treating a variety of biological conditions.
Type:
Grant
Filed:
April 6, 2007
Date of Patent:
April 27, 2010
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Hector F. DeLuca, Lori A. Plum, Margaret Clagett-Dame, Rafal Barycki
Abstract: The invention relates to carrier complexes and methods for delivering molecules to cells. The carrier complexes comprises a molecule and an aromatic cationic peptide in accordance with the invention. In one embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a carrier complex. In another embodiment, the method for delivering a molecule to a cell comprises contacting the cell with a molecule and an aromatic cationic peptide.
Type:
Grant
Filed:
May 3, 2004
Date of Patent:
April 27, 2010
Assignee:
Cornell Research Foundation, Inc.
Inventors:
Hazel H. Szeto, Kesheng Zhao, Hugh D. Robertson, Alex V. Birk
Abstract: Method and system for secure computational outsourcing and disguise of data, computer programs, pictures, and databases from unauthorized access, theft, and tampering using disguising and tamperproofing operations. In some embodiments, the disguising operation includes generating a random number for each data element, and modifying each data element with the random numbers. In some embodiments, the computer program, written in a first programming language, is partitioned into first and second programs; the first program determines whether access to the data is authorized, the second program entangles the second program and the data; and the second program is translated into a second programming language. An embodiment of the present invention comprises a method for identifying the subject of a first picture by comparison to a second picture. Embodiments comprise securing a computer program with real programming code by creating dummy program code and mixing the dummy and real program code.
Abstract: An embryo that is transferred into the uterus of a recipient female is protected from embryotoxic effects of prostaglandin F2? by exposing the embryo to a prostaglandin antagonist.
Type:
Grant
Filed:
January 19, 2005
Date of Patent:
April 27, 2010
Assignee:
University of Tennessee Research Foundation
Abstract: In a method and an apparatus for acquiring magnetic resonance data, a region of a subject is exposed to a spin echo magnetic resonance pulse sequence that includes a refocusing radio-frequency pulse flip angle evolution that causes magnetic resonance signals to be emitted from the region with a signal evolution following each excitation radio-frequency pulse. The signal evolution is sampled to extract two or more sets of sampled data therefrom respectively with different contrast weightings of tissues in the region. The multiple sets of sampled data are made available as respective outputs in a form allowing multiple different images of the region to be generated therefrom, respectively with said different contrast weightings. For example, a spin density-weighted image and a T2-weighted image, or a T2-weighted image and a heavily T2-weighted image, thus can be generated by sampling from the same variable-flip-angle echo train.
Type:
Grant
Filed:
August 20, 2008
Date of Patent:
April 27, 2010
Assignees:
Siemens Aktiengesellschaft, University of Virginia, Patent Foundation