Abstract: A method of making dispersion-strengthened alloy particles involves melting an alloy having a corrosion and/or oxidation resistance-imparting alloying element, a dispersoid-forming element, and a matrix metal wherein the dispersoid-forming element exhibits a greater tendency to react with a reactive species acquired from an atomizing gas than does the alloying element. The melted alloy is atomized with the atomizing gas including the reactive species to form atomized particles so that the reactive species is (a) dissolved in solid solution to a depth below the surface of atomized particles and/or (b) reacted with the dispersoid-forming element to form dispersoids in the atomized particles to a depth below the surface of said atomized particles. The atomized alloy particles are solidified as solidified alloy particles or as a solidified deposit of alloy particles.

Abstract: Genetic markers for identifying bovine carriers of dwarfism in cattle, particularly Angus cattle is described. The genetic markers, including the microsatellite markers BMS4311 and AFR227 and the bovine PRKG2, BMP2K, BMP3, FGF5 genes, are located on bovine chromosome BTA6. One SNP, a polymorphism is located in the protein kinase domain within exon 15 of the bovine PRKG2 gene and is identified as being causative and diagnostic for dwarfism.

Abstract: Disclosed are compounds having the formula: wherein R21 is an alkyl, aryl, alkoxy, hydroxy, or amino group or a halogen atom; wherein R2 is hydrogen or an alkyl, aryl, alkoxy, or amino group; wherein R23 and R24 are independently selected from hydrogen, an alkyl, aryl, alkoxy, hydroxy, or amino group, and a halogen atom or wherein R23 and R24, taken together with the carbon atom to which they are bound, form a ring; wherein R25 is hydrogen, an alkyl, aryl, alkoxy, hydroxy, or O-silyl group or a halogen atom; wherein Z, taken together with the carbons to which it is bonded, forms a 5-12 membered ring; and wherein Y is an electron withdrawing group. These compounds can be used to prepare erogorgiaene congeners, such as erogorgiaene, pseudopterosin A, helioporin E, pseudopteroxazole, colombiasin A, elisapoterosin B, elisabethadione, p-benzoquinone natural products, ileabethin, sinulobtain B, sinulobtain C, and sinulobtain D.

Abstract: Improved catalytic enzyme preparations are provided which effectively catalyze reactions carried out in organic solvents. The preparations comprise nanoscale solid support particles (e.g., fumed silica or alumina) having enzyme molecules electrostatically adhered to the surfaces of the particles. The preparations are prepared by mixing together solid support particles and enzyme molecules in an aqueous system under pH conditions establishing opposite charges on the support particles and enzyme molecules, respectively. The water is then removed from the system, preferably by pre-freezing followed by lyophilization to yield free-flowing, particulate catalyst particles which can be used in liquid organic reactions or in packed bed reactors.

Abstract: A novel application of a transition metal oxo complex, a cationic oxorhenium(V) oxazoline, in the production of molecular hydrogen (H2) from the catalytic hydrolytic oxidation of organosilanes. The reaction is characterized by quantitative hydrogen yields, low catalyst loading, ambient conditions, high selectivity for silanols, water as the only co-reagent, and no solvent requirement. The amount of hydrogen produced is proportional to the water stoichiometry. For example, reaction mixtures of polysilyl organics such as HC(SiH3)3 and water contain potentially greater than 6 weight percent hydrogen. Kinetic and isotope labeling experiments reveal a new mechanistic paradigm for the activation of Si—H bonds by oxometalates.

Abstract: Applicants have produced a chromophore and a polymer that are highly sensitive to the presence of various agents, including organophosphates, pesticides, neurotoxins, metal ions, some explosives, and biological toxins. The detection is accomplished by detecting a change in the fluorescence characteristics of the chromophore or polymer when in the presence of the agent to be detected. The chromophore and polymer may be incorporated into sensors of various types, and they are adaptable for potential field use in areas where detection of these types of agents is desired.

Abstract: The present invention relates to a manufacturing method of organic modifier-free exfoliated nano clay-polymer composite. The manufacturing method of organic modifier-free exfoliated nano clay-polymer composite includes (S1) dispersing layered clay nanoparticles and dissolving a thermoplastic polymer in an acidic solvent; (S2) adding the product of step (S1) to a polymer non-solvent incapable of dissolving the polymer, but capable of dissolving the organic modifier separated from the organized layered clay nanoparticles; and (S3) separating an organic modifier-free exfoliated nano clay-polymer composite from the product of step (S2). The inventive manufacturing method can maximally improve the physical properties of composites through the addition of the exfoliated clay nanoparticles by removing the organic modifier that may deteriorate physical properties of the composite from the exfoliated clay nanoparticles dispersed therein.

Abstract: In one aspect, the invention is directed to a method of detecting Cowden syndrome (CS) or CS-like syndrome in an individual comprising detecting the presence of a mutated succinate dehydrogenase B (SDHB), mutated succinate dehydrogenase D (SDHD) or combination thereof in the individual, wherein detection of a mutated SDHB, SDHD or a combination thereof indicates that the individual is positive for CS or CS-like syndrome. In another aspect, the invention is directed to a method of determining whether an individual is at risk for developing Cowden syndrome (CS) or CS-like syndrome comprising detecting the presence of a mutated succinate dehydrogenase B (SDHB), mutated succinate dehydrogenase D (SDHD) or combination thereof in the individual, wherein detection of a mutated SDHB, SDHD or a combination thereof indicates that the individual is at risk for developing for CS or CS-like syndrome.

Abstract: Methods of converting silica to silicon and fabricating silicon photonic crystal fiber (PCF) are disclosed. Silicon photonic crystal fibers made by the fabrication methods are also disclosed. One fabrication method includes: sealing silica PCF and a quantity of magnesium within a container, the quantity of magnesium defined by 2Mg(g)+SiO2(s)?2MgO(s)+Si(s); converting silica PCF to a reacted PCF through magnesiothermic reduction; and converting the reacted PCF to the fabricated silicon PCF by selective dissolution of the reacted PCF in an acid. Another fabrication method includes: adding silica PCF and a quantity of solid magnesium to an unsealed container, the quantity of magnesium substantially in excess of that defined by 2Mg(g)+SiO2(s)?2MgO(s)+Si(s); converting silica PCF to a reacted PCF through magnesiothermic reduction; and converting the reacted PCF to the fabricated silicon PCF by selective dissolution of the reacted PCF in an acid.

Abstract: A method is provided for manufacturing porous titanium dioxide with uniform pore sizes within several nanometers by means of a template and a titanium precursor. In this method, a cyclodextrin or cyclodextrin derivative is used as a template for forming pores, and the cyclodextrin or then derivative reacts with the titanium precursor in a sulfuric acid solution. The manufacturing method according to the present invention allows the control of pore size and morphology using various kinds of cyclodextrin or cyclodextrin derivatives, supports a facile removal of the cyclodextrin used as the template, and is capable of manufacturing anatase type porous titanium dioxide with excellent photoactivity without a separate sintering process.

Abstract: A fingerprint information storage apparatus includes a fingerprint information generating unit that extracts minutiae information from an authenticated user's fingerprint image and generates fingerprint information by inserting chaff minutiae information into the extracted minutiae information, a fingerprint information distributing unit that classifies the fingerprint information according to the extent that minutiae are distributed relative to the center of the fingerprint and distributively outputs the fingerprint information classified according to the distribution, and a first fingerprint information storage unit and a second fingerprint information storage unit that store the fingerprint information and distributively output according to the distribution, wherein the authenticated user's fingerprint information registered in the first fingerprint information storage unit is partially aligned and input fingerprint information is converted based on the information so that the converted input fingerprint i

Abstract: A method and pharmaceutical compositions useful for inhibiting the growth of solid tumors are provided. Specifically, the method is effected by administering to a subject in need thereof an agent capable of upregulating the expression level and/or activity of at least a functional portion of Sef, wherein the functional portion being capable of inhibiting RTK-mediated cell proliferation. Also provided are methods and kits for diagnosing and staging of cancer by detecting the expression level of hSef in a tissue sample, wherein a decrease in hSef expression level is indicative of cancer.

Abstract: The present invention relates to novel thiazoline acids and derivatives thereof useful as chelators of trivalent metals in therapeutic applications. For example, the thiazoline acid derivatives are useful in diagnosing and treating pathological conditions associated with an excess of trivalent metals in humans and animals.

Abstract: A broadband circularly-polarized spidron fractal antenna is disclosed. The broadband antenna of the present invention can realize a bandwidth exceeding 70% without using a multilayer substrate to implement the broadband properties, by forming a geometric structure of a slot, i.e., a spidron fractal, which has not been used in the conventional antennas, on the ground surface of the antenna. The present invention can also induce the radiation properties of a circularly-polarized wave from the properties of the spidron fractal shape, without employing an additional secondary circuit such as a phase distribution circuit for implementing the circularly-polarized wave. Due to such properties described above, the present invention can implement a small broadband circularly-polarized antenna that costs less to manufacture.

Abstract: An isolated composition of matter is provided comprising a heterogeneous population of cells seeded on a surface of a scaffold, wherein the heterogeneous population of cells comprises at least one pancreatic islet, endothelial cells and fibroblast cells. Methods of generating same and uses thereof are also provided.

Abstract: Provided are methods of forming nano-devices. One of the methods includes forming a nano-scale self-assembly material layer on a substrate formed of at least one layer, forming a mask layer on the self-assembly material layer, performing a surface treatment process on the substrate using the mask layer as a mask, and removing the self-assembly material layer. Accordingly, it is possible to fabricate nano-devices through a nano-scale substrate patterning process, ion implantation process and etching process, without using a light source.

Abstract: Compositions are provided according to embodiments of the present invention which include an isolated fusion protein including an E3 protein RING motif bonded to an UCE E2 protein. In preferred embodiments, the C-terminus of the E3 protein RING motif is bonded to the N-terminus of the UCE E2 protein by an intervening peptide linker. Optionally, the peptide linker is 5-50 amino acids. Preferred is a peptide linker of 15-20 amino acids. Methods of identifying ubiquitylation modulators are provided according to embodiments of the present invention which include contacting an isolated fusion protein including an E3 protein RING motif bonded to an UCE E2 protein with a ubiquitylation substrate in the presence of a test substance. Ubiquitylation of the ubiquitylation substrate is then detected to determine the effect of the test substance on ubiquitylation of the ubiquitylation substrate.

Abstract: A relatively non-toxic desazadesferrithiocin analog having the formula (I): wherein: R1, R2, R4 and R5 may be the same or different and may be H, straight or branched chain alkyl having up to 14 carbon atoms, e.g., methyl, ethyl, propyl and butyl, or arylalkyl wherein the aryl portion is hydrocarbyl and the alkyl portion is straight or branched chain, the arylalkyl group having up to 14 carbon atoms, R2 optionally being alkoxy having up to 14 carbon atoms; R3 is [(CH2)n—O]x—[(CH2)n—O]y-alkyl; n is, independently, an integer from 1 to 8; x is an integer from 1 to 8; y is an integer from O to 8, and R3O may occupy any position on the phenyl ring except the 4-position, or a salt, hydrate or solvate thereof; and methods and compositions for treating the effects of trivalent metal, i.e., iron, overload.

Abstract: Embodiments of the present invention provide a Gaussian adaptive filter for ground clutter filtering and signal parameter estimation for weather radars in the time domain. In some embodiments, the filtering can be applied to dual polarization radar systems. In some embodiments, the clutter component of the signal can be transformed to noise. An interpolation procedure can then be used to recover the transformed part of the weather. A unique filter can be designed to use for both H and V channels for dual-polarization parameter estimation. In addition, the filter can be directly extended for staggered PRT 2/3 sampling scheme.

Abstract: A process of forming a double strand cleavage in DNA includes providing a reaction mixture containing double stranded DNA having a break in a first strand defining a target site in a second strand. The method continues by adding to the reaction mixture a photoreactive lysine conjugate selected from a lysine-enediyne conjugate, a lysine-acetylene conjugate or a combination thereof, for a time sufficient for the lysine conjugate to bind to the DNA adjacent the target site. The reaction mixture is then irradiated with electromagnetic radiation sufficient to photoactivate the lysine conjugate to cleave the second strand adjacent the target site.