Abstract: The present invention relates to a method for activation of TRPA1 (transient receptor potential cation channel, subfamily A, member 1) using acetaldehyde, more precisely a method for selecting a candidate for TRPA1 activation blocker from neurons activated by acetaldehyde. Acetaldehyde of the present invention works on TRPA1 specifically so that it facilitates the isolation of sensory neurons expressing TRPA1. Therefore, acetaldehyde of the invention can be effectively used for the studies on TRPA1 mechanisms and the development of a TRPA1 based anodyne.
Type:
Application
Filed:
April 24, 2008
Publication date:
October 29, 2009
Applicant:
Korea University Industry and Academy Cooperation Foundation
Abstract: The present invention provides a method of treatment for ischemic heart disease administering a scar formation accelerator containing at least one selected from SFRP2, SFRP4, Midkine, Pleiotrophin and Thymosin beta-10 as an effective ingredient to promote scar formation less fibrosis and retaining elasticity, and thereby improving cardiac function.
Type:
Application
Filed:
November 8, 2006
Publication date:
October 29, 2009
Applicant:
Foundation For Biomedical Research and Innovation
Abstract: The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
Type:
Application
Filed:
April 8, 2009
Publication date:
October 29, 2009
Applicant:
WARF - Wisconsin Alumni Research Foundation
Inventors:
Samuel Helmer Gellman, Pil Seok Chae, Philip D. Laible, Marc J. Wander
Abstract: The present invention provides methods for treating anxiety or irritability in a subject. The methods comprise administering to the subject an effective amount of an antagonist of allopregnanolone (THP), or a regulator which decreases expression of the alpha 4 subunit of GABA such as gabadoxbol (THIP), or a vector comprising an isolated nucleic acid molecule encoding a mutant alpha 4 subunit GABAA receptor protein having a neutral or non-basic amino acid residue substituted for the arginine residue at position 353 of the wild type mature protein, wherein this nucleic acid molecule is operably linked to a promoter which functions in the human brain. Such methods are useful in treating a subject undergoing a stage such as entering or having reached puberty, suffering from pre-menstrual syndrome (PMS), entering or having reached post-partem stage, entering or having reached menopause, and/or suffering from chronic stress.
Type:
Application
Filed:
March 10, 2008
Publication date:
October 29, 2009
Applicant:
The Research Foundation of State University of New York
Abstract: A method for preparing a quantum dot-inorganic matrix composite includes preparing an inorganic matrix precursor solution containing one or more quantum dot precursors, spin-coating the precursor solution on a substrate to form an inorganic matrix thin film, and heating the inorganic matrix thin film to form an inorganic matrix, while growing the quantum dot precursors into quantum dots in the inorganic matrix, thereby yielding a quantum dot-inorganic matrix composite. The quantum dot-inorganic matrix composite thus obtained has a structure in which the quantum dots have a high efficiency and are densely filled in an inorganic matrix. The quantum dot-inorganic matrix composites can be prepared using a low temperature process, and can be used for various displays and electronic device material applications.
Type:
Application
Filed:
January 12, 2009
Publication date:
October 29, 2009
Applicants:
Samsung Electronics Co., Ltd, Pohang University of Science and Technology Academy-Industry Foundation
Abstract: The present invention provides novel methods and compositions for the diagnosis, prognosis and treatment of cancer in a subject, by administering to the subject a polynucleotide encoding a functional WWOX gene product.
Type:
Application
Filed:
October 4, 2006
Publication date:
October 29, 2009
Applicant:
The Ohio State University Research Foundation
Inventors:
Carlo M. Croce, Muller Fabbri, Francesco Trapasso
Abstract: Ternary optical data storage method and apparatus for Write Once Read Many Times (WORM) optical data storage with two-photon fluorescent writing and readout. The data storage capacity is limited by the optical resolution of a system. In CD/DVD systems, an increase in the aerial data density has been primarily achieved by decreasing the bit dimension. However, the size of the optical spot (bit) is restricted by limitations imposed by the diffraction of light (Rayleigh criterion). Therefore, technologies that can effectively create and detect spot sizes beyond the diffraction limit (sub-Rayleigh) hold promise to achieving high-density optical storage.
Type:
Grant
Filed:
April 9, 2004
Date of Patent:
October 27, 2009
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: A process for synthesizing nanostructures is disclosed. The process involves forming a liquid crystalline template by combining a block copolymer, a first reactant in a polar phase, and a nonpolar phase, then contacting the template with a gas phase composed of a second reactant, under conditions effective to form nanostructures.
Type:
Grant
Filed:
March 28, 2006
Date of Patent:
October 27, 2009
Assignee:
The Research Foundation of State University of New York
Inventors:
Paschalis Alexandridis, Georgios N. Karanikolos, Triantafillos J. Mountziaris
Abstract: An electrical machine is provided. The machine includes at least one rotor mounted for rotation about a central axis and at least two stator sections mounted axially adjacent to and on opposite sides of the rotor. The rotor includes two circumferentially arrayed rows of alternating segments of permanent magnet and ferromagnetic pole pieces. One of the rows is spaced radially inwardly from the other row. The permanent magnet and ferromagnetic pole pieces are separated by a non-ferromagnetic material. The pole pieces are arranged so that the permanent magnet segments in the first row are radially adjacent to ferromagnetic segments in the second row so that the N-S magnetic fields of the permanent magnet segments are aligned axially. Each stator section includes a ferromagnetic stator frame, at least a first AC winding wound in circumferential slots in the stator frame, and a DC field winding wound on the stator frame.
Type:
Grant
Filed:
September 1, 2005
Date of Patent:
October 27, 2009
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Metin Aydin, Thomas A. Lipo, Surong Huang
Abstract: A volume Bragg laser including a resonator comprising photo-thermo-refractive (PTR) volume diffractive elements that can be used in a laser emitting window of transparency of PTR glass to provide control of the lasers spectral and angular parameters, and methods, devices, apparatus and systems related thereto. The high efficiency volume Bragg gratings recorded in photo-thermo-refractive (PTR) glass preferably has an absolute diffraction efficiency exceeding approximately 95% in transmitting and reflecting modes is used for selection of a transverse and longitudinal mode for thermal, optical and mechanical stabilization of the volume Bragg lasers and coherent coupling of different lasers. Robustness, compactness, thermal and laser stability along with the ability to place several elements in the same space allows the use of sophisticated optical system according to the invention in fields of military lasers, optical communications, data storage and processing, and the like.
Type:
Grant
Filed:
October 26, 2007
Date of Patent:
October 27, 2009
Assignee:
University of Central Florida Research Foundation, Inc.
Inventors:
Leonid B. Glebov, Vadim I. Smirnov, George Venus
Abstract: The present invention provides an effective data structure in finding frequent itemsets over data streams and finds necessary information using the data structure. The data structure proposed in the present invention is defined as a compressed prefix tree structure, and the compressed prefix tree merges or splits nodes during the mining operation by comparing the prefix tree structure applied to the conventional data mining to manage a plurality of items in a single node, thus dynamically and flexibly adjusting the tree size. Such dynamic adjustment function dynamically merges and splits nodes in the prefix tree, if the variation of itemsets that are most likely to be frequent itemsets due to the variation of the data stream, thus maximizing the accuracy of the mining result in a restricted memory space, i.e., the accuracy of frequent itemsets found.
Type:
Grant
Filed:
November 27, 2006
Date of Patent:
October 27, 2009
Assignee:
Industry-Academic Cooperation Foundation, Yonsei University
Abstract: An electromagnet having at least one access port oriented perpendicularly to the electromagnet's central axis. The magnet has a conventional helical winding along its central axis. However, at some point along the length of the axis, the pitch of the helical winding is greatly increased in order to create a region with a comparatively low turn density. One or more ports are provided in this region. These ports provide access from the magnet's central bore to the magnet's exterior. A sample can be placed in the central bore near the ports. A beam traveling down the central bore, or through one of the radial ports, will strike the sample and be scattered in all directions. The ports allow access for instrumentation which is used to evaluate the scattered beam.
Type:
Grant
Filed:
March 9, 2007
Date of Patent:
October 27, 2009
Assignee:
Florida State University Research Foundation
Inventors:
Mark D. Bird, Scott T. Bole, Scott R. Gundlach, Jack Toth
Abstract: Transposase proteins that are modified relative to and have higher transposase activities than the wild-type Tn5 transposase are disclosed. A transposase protein of the present invention differs from the wild-type Tn5 transposase at amino acid position 41, 42, 450, or 454 and has greater avidity than the wild-type Tn5 transposase for at least one of a Tn5 outside end sequence as defined by SEQ ID NO:3, a Tn5 inside end sequence as defined by SEQ ID NO:4, and a modified Tn5 outside end sequence as defined by SEQ ID NO:5. Also disclosed are various systems and methods of using the transposase proteins of the present invention for in vitro or in vivo transposition.
Type:
Grant
Filed:
August 2, 2005
Date of Patent:
October 27, 2009
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
William S. Reznikoff, Richard J. Gradman
Abstract: A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate non-submucosal sources, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance the initiation of vessel-like structures in the grant. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired.
Abstract: In retransmitting data at high speed by a PHY layer in a mobile communication system, when data to be transmitted to the receiver is received from the MAC layer of the transmitter, the PHY layer of the transmitter transmits the data to the PHY layer of the receiver, receives first information representing normal reception or abnormal reception of the data from the PHY layer of the receiver, notifies the MAC layer of the transmitter of the normal reception of the data when the first information represents the normal reception, and retransmits the data to the PHY layer of the receiver when the first information represents the abnormal reception.
Type:
Grant
Filed:
November 30, 2005
Date of Patent:
October 27, 2009
Assignees:
Samsung Electronics Co., Ltd, Seoul National University Industry Foundation
Abstract: The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit. In one embodiment the result is achieved mechanically. In another embodiment, the result is achieved by aerosol formulation. In another aspect, the invention assures the result when aerosol is delivered directly to the airways distal of the ventilator circuit. The treatment means eliminates the dosage variability that ventilator systems engender when aerosols are introduced via the ventilator circuit.
Type:
Grant
Filed:
November 30, 2004
Date of Patent:
October 27, 2009
Assignee:
The Research Foundation of State University of New York
Abstract: Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I interferon response to eukaryotic cells. Suppression of the eukaryotic Type I interferon response allows improved expression of the encoded transgene.
Type:
Grant
Filed:
September 12, 2007
Date of Patent:
October 27, 2009
Assignee:
Aeras Global TB Vaccine Foundation
Inventors:
Jerald C. Sadoff, Mohamad F. Jamiluddin, Ravi P. Anantha, John F. Fulkerson, Jr.
Abstract: The present invention relates to HIV-1 envelope proteins from a donor with non-progressive HIV-1 infection whose serum contains broadly cross-reactive, primary virus neutralizing antibody. The invention also relates to isolated or purified proteins and protein fragments that share certain amino acids at particular positions with the foregoing HIV-1 proteins.
Type:
Grant
Filed:
June 23, 2006
Date of Patent:
October 27, 2009
Assignee:
The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
Abstract: A load supporting device, and method for supporting a building in fixed relation relative to the surface of the earth is disclosed and which includes a base member which rests on a supporting surface; and an arm member mounted on the base member and which extends laterally outwardly relative thereto, and wherein the load is supported on each of the base member and the arm member, and further a method for employing the present load supporting device for supporting a building.
Abstract: A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.
Type:
Grant
Filed:
October 24, 2001
Date of Patent:
October 27, 2009
Assignees:
The Johns Hopkins University, Astrazeneca United Kingdom, Ltd., Cancer Institute, Japanese, Foundation for Cancer Research, The University of Utah
Inventors:
Bert Vogelstein, Kenneth W. Kinzler, Hans Albertsen, Rakesh Anand, Mary Carlson, Joanna Groden, Philip Hedge, Geoff Joslyn, Alexander Fred Markham, Yusuke Nakumura, Andrew Thliveris, Raymond White