Abstract: A semiconductor chip for correcting an aligned error comprises a memory array; a transceiver circuit; and an Error Correction Code (ECC) circuit, wherein the ECC circuit is configured to: receive target data to be encoded, encode the target data by multiplying a generator matrix of a previously generated ECC by the target data, store the encoded target data in the memory array, check a data transformed from the encoded target data, and generate an error corrected data by correcting only a single error of the transformed data and an adjacent error that does not exceed a first value boundary of a predetermined number of bits by using a parity check matrix of the ECC, and output the error corrected data.

Abstract: A system may include a non-intrusive sensor circuitry configured to provide electrical measurement data, including, for example, current data, voltage data, power factor data, active power consumption data, reactive power consumption data, or a combination thereof. A transient event detector may sweep the electrical measurement data with a first window and a second window, the first window adjacent to the second window. The transient event detector may identify a start and end of transient activity based on electrical measurement data referenced by separate adjacent windows. The transient event detector may capture a transient activity data segment comprising a portion of the electrical measurement data between first index and the second index.

Abstract: A semiconductor device is provided. The semiconductor device includes: an equalizer circuit configured to output a first control signal corresponding to a first bit of original two-bit data and a second control signal corresponding to a second bit of the original two-bit data; and a driver circuit including a plurality of pull-up transistors connected between an output node and a first power node configured to provide a first power supply voltage, and a plurality of pull-down transistors connected between the output node and a second power node configured to provide a second power supply voltage, wherein the second power supply voltage is lower than the first power supply voltage, and the driver circuit is connected to the equalizer circuit in series.

Abstract: The present invention provides novel gold nanoclusters, a dopamine biosensor including the same that may exhibit reliability in a wide detection range, and a method of quantifying dopamine using the same, and provides a method of diagnosing a neurological disease that exhibits high selectivity for dopamine using the gold nanoclusters. In addition, the present invention provides a method of concentrating glycoproteins that may exhibit improved concentration efficiency and minimize non-specific binding using the gold nanoclusters. A method of analyzing disease-specific glycoproteins which includes the method of concentrating glycoproteins using the gold nanoclusters may be easily used for diagnosis of a disease by identifying different glycoproteins in a patient group compared to a normal group.

Abstract: Disclosed herein are recombinant AAV variant (e.g., variant serotype 3B (AAV3B)) capsid proteins and variant capsid protein-containing viral particles with enhanced ability to transduce hepatic cells. Viral particles containing these capsid variants are capable of evading neutralization by the host humoral immune response. The recombinant AAV3B variant proteins and viral particles disclosed herein were identified from a variant AAV3B capsid library that was engineered by making substitutions in only the variable regions of the capsid. Some embodiments of the AAV3B capsid variants disclosed herein comprise the AAV3B-DE5 variant, which contains 24 mutations relative to wild-type. Compositions of these variant AAV particles are provided that are useful for transducing and delivering therapeutic transgenes to cells, such as liver cells, and thus treat diseases and disorders pertaining to these cells.

Abstract: A method of making a filter, the resulting filter, and a method of using the filter to filter proteins from solution are described. The method includes contacting a porous, polymeric substrate with a transfer liquid comprising a solvent(s) and a charged polymeric solute. The transfer liquid and the polymeric substrate have a Hansen Solubility Parameter (“HSP”) distance of from about 10 to about 35. Contacting the polymeric substrate with the transfer solution causes the polymeric substrate to accept the charged polymeric solute by diffusion transfer, thereby yielding a functionalized filter medium. Removal of the transfer liquid from the polymeric substrate traps the charged polymeric solute on the surface of the polymeric substrate.

Abstract: The invention is directed towards compounds (e.g., Formula (I) or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof), their mechanism of action, and methods of modulating proliferation activity, and methods of treating diseases and disorders using the compounds described herein (e.g., Formula (I), or a pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof).

Abstract: Systems and methods are disclosed for generating cluster quantum states usable for quantum computing. An example system can generate a plurality of qumodes. The plurality of qumodes can include at least two successive qumodes in frequency domain, wherein a frequency spacing between two successive qumodes is equal to a free-spectral range of an optical frequency comb. The plurality of qumodes can include a plurality of bipartite entangled states. A cluster quantum state can be generated by modulating a phase of a portion of the optical fields associated with the plurality of qumodes received from the optical frequency comb, at one or more modulation frequencies. In some embodiments, each of the one or more modulation frequencies can be equal to an integral multiple of the free-spectral-range. In certain embodiments, a property of a cluster graph (such as a dimension of the cluster graph) associated with the cluster quantum state can be controlled by adjusting one or more modulation frequencies.

Abstract: Provided herein are nanoparticles complexed with binding agents and/or therapeutic agents (e.g., antibody-complexed albumin-bound paclitaxel/doxorubicin nanoparticles and antibody-complexed albumin-bound paclitaxel/SN38 nanoparticles) and pharmaceutical compositions thereof. Additionally, provided herein are methods of making nanoparticles complexed with binding agents and/or therapeutic agents (e.g., antibody-complexed albumin-bound paclitaxel/doxorubicin nanoparticles and antibody-complexed albumin-bound paclitaxel/SN38 nanoparticles) and methods of treating cancer in a patient in need thereof.

Abstract: A method of generating object surface texture in thermal infrared images is disclosed which includes receiving heat radiation from a scene by a spectropolarimetric imaging system, generating a plurality of spectral frames associated with the scene, each frame having a plurality of pixels, for each pixel from the generated plurality of spectral frames, extracting spectral information associated with the scene, including pixel-specific temperature representing an objects temperature, and thermal texture factor representing the objects texture, for each of a plurality of materials having a specific emissivity in a library, generating reference spectral information as a function of temperature and thermal texture, matching the extracted spectral information for each pixel from the generated plurality of spectral frames to the generated reference spectral information using a statistical method to minimize the associated variation, and extracting spectral metadata from the matched reference spectral information for

Abstract: Described herein, in various embodiments, are peptides comprising: (i) a cyclic cell-penetrating peptide sequence (cCPP) and (ii) a CAL-PDZ binding sequence, which is conjugated, directly or indirectly, to an N-terminus of an amino acid in the cCPP, to a C-terminus of an amino acid on the cCPP, or on a side chain of an amino acid in the cCPP. In other embodiments, the peptides further comprise a physiologically cleavable group, wherein after entering the cell, the physiologically cleavable group is reduced, thereby providing a linear peptide. Without being bound by theory, the inventors discovered that the amino acid sequence in the cCPP, which facilities cytosolic delivery of the CAL-PDZ binding sequence also, surprisingly and unexpectedly, synergistically improves binding of CAL-PDZ binding sequence to the CAL-PDZ binding domain. Additionally, the cCPP sequence may also improve selectivity of the CAL-PDZ binding sequence for the CAL-PDZ domain relative to other PDZ binding domains.

Abstract: One or more cameras capture objects at a higher resolution than the human eye can perceive. Objects are segmented from the background of the image and scaled to human perceptible size. The scaled-up objects are superimposed over the unscaled background. This is presented to a user via a display whereby the process selectively amplifies the size of the objects' spatially registered retinal projection while maintaining a natural (unmodified) view in the remainder of the visual field.

Abstract: Provided is a holographic display apparatus capable of providing an expanded viewing window when reproducing a holographic image via an off-axis technique. The holographic display apparatus includes a spatial light modulator comprising a plurality of pixels arranged two-dimensionally; and an aperture enlargement film configured to enlarge a beam diameter of a light beam coming from each of the plurality of pixels of the spatial light modulator. The beam diameter of each light beam enlarged by the aperture enlargement film may be greater than the width of an aperture of each pixel of the spatial light modulator.

Abstract: A tetraanionic OCO pincer ligand metal-oxo-alkylidene complex is prepared from a trianionic pincer ligand supported metal-alkylidyne. The metal can be tungsten or other group 5-7 transition metal. The tetraanionic pincer ligand metal-oxo-alkylidene complex, a trianionic OCO pincer ligand metal complex, or a trianionic ONO pincer ligand metal complex can be used to polymerize cycloalkenes. The poly(cycloalkene)s are predominantly cis-alkene macrocyclics.

Abstract: Embodiments of the present disclosure relate to a method, a device, a computer readable storage medium and a computer program product for transaction processing on a blockchain. In the method, the blockchain node for processing a transaction receives a transaction request including a plurality of fields, the plurality of fields including a transaction task field including a plurality of clauses and each clause of the plurality of clauses indicating one of a plurality of tasks of the transaction. The blockchain node processes the plurality of tasks and determines that the transaction is successfully processed only in response to successfully processing all the plurality of tasks. The transaction processing as provided in the present disclosure enables multiple tasks to be processed through a single transaction procedure on the blockchain in an efficient way.

Abstract: Drug delivery devices that have a flexible film, an array of nanoscopic, porous needles attached to a surface of the flexible film, and a therapeutic drug cargo loaded onto the needles. The drug delivery device may be applied to living tissue such that the surface of the flexible film contacts the living tissue and some or all of the needles are inserted into the tissue. The flexible film may then be dissolved while leaving the needles inserted in the tissue. The needles degrade in the living tissue over time causing release of the therapeutic drug cargo loaded onto the needles.

Abstract: Compositions and methods of use thereof for delivering an insecticide to water-borne insect larvae are provided. Whereas individual cells of the insecticidal bacteria such as Bacillus thuringiensis israelensis (Bti), are effective in killing insect larvae when ingested by same, their use in aqueous environments is restricted by the time that the bacterial cells remain suspended in water and hence available for ingestion by the larvae. To increase the time that the insecticidal bacteria remain in suspension, it has now been found advantageous to mix bacterial suspensions with nanoparticles comprising carbon that attach to the external surface of the cells.

Abstract: Livestock animals and progeny thereof comprising at least one edited chromosomal sequence that alters expression or activity of a somatostatin receptor (SSTR) protein are provided. Livestock animal cells that contain such edited chromosomal sequences are also provided. The livestock animals have improved growth performance and weight gain. Methods for producing livestock animals with increased growth performance are also provided.

Abstract: A method and apparatus for intra-prediction coding of video data are provided. The apparatus includes a decoder that is configured to decode, from a bitstream, a syntax element indicating an intra-prediction type of a current block of the video data, and an intra-predictor that is configured to generate a prediction block for the current block by selectively performing matrix based intra-prediction or regular intra-prediction based on the intra-prediction type of the current block indicated by the syntax element.

Abstract: A game system comprising a game surface generator configured to generate a game surface having: a primary game surface with a first edge; an additional game surface with a second edge, wherein the primary game surface and the additional game surface are each divided into a plurality of game spaces and the first edge of the primary game surface is coupled to the second edge of the additional game surface, there being a bijective mapping between the primary game surface and the additional game surface; a game piece control module configured to position a plurality of game pieces on the primary game surface such that each game piece is positioned on one of the game spaces and a plurality of additional game pieces are positioned on corresponding game spaces of the additional game surface according to the bijective mapping.