Abstract: A phantom for use in training persons in locating and aspirating tumors identified by X-ray in a human body part consists of a body of a tissue equivalent X-ray permeable material containing at least one aspiratable simulated tumor suspended in the interior of the body. A method of making the phantom also is disclosed.

Abstract: A method for forming a dual-gated Semiconductor-On-Insulator (SOI) field effect transistor for integrated circuits includes the formation of a gate/oxide/channel/oxide/gate stack on top of an insulating layer. The process begins with the formation of a first gate electrode and first oxide layer on an insulating layer. Then, a seed hole in the insulating layer is formed exposing the underlying substrate. This is followed by the epitaxial lateral overgrowth (ELO) of monocrystalline silicon, for example, from the seed hole to on top of the first oxide layer. This monocrystalline layer forms the device channel. A second oxide and second gate electrode layer are then grown and deposited, respectively. Subsequent etch steps employing sidewall spacers are then employed to form a multilayered stack having self-aligned first and second gate electrodes. Sidewall seed holes are then used to epitaxially grow monocrystalline source and drain regions from the channel.

Abstract: Physiologically active N.sup.6 -(hydrazinoiminomethyl)lysine or pharmaceutically acceptable acid addition salt thereof is administered in a nitric oxide synthesis inhibiting amount to a subject in need of such inhibition (e.g., a subject with low blood pressure, e.g., due to sepsis or to therapeutic administration of cytokines, or needing immunosuppressive effect) or is added to a medium containing isolated organs, intact cells, cell homogenates or tissue homogenates in an amount sufficient to inhibit nitric oxide formation to elucide or control the biosynthesis, metabolism or physiological role of nitric oxide. CompThis invention was made at least in part with Government support under National Institutes of Health grant number DK 37116. The Government has certain rights in the invention.

Abstract: A first-come first-serve arbitration protocol arbitrates between processing agents seeking access to a common bus. The system is an extension of a parallel contention arbiter in which each agent has an identity value made up of two portions, one a fixed portion and one a variable portion. The variable portion of each agent's identity is incremented depending on how long the agent has been waiting for access to the bus and the variable portion is the most significant portion of each agent's identity. Thus in each arbitration in which the highest identity value is awarded control of the bus, the agent which has waited the longest will gain access to the bus prior to those which have not waited as long.

Abstract: A method and apparatus for sharpening signal peaks in a signal representing the distribution of biological or chemical components of a mixture separated by a chromatographic technique such as, but not limited to, electrophoresis. A key step in the method is the use of a blind deconvolution technique, presently embodied as homomorphic filtering, to reduce the contribution of a blurring function to the signal encoding the peaks of the distribution. The invention further includes steps and apparatus directed to determination of a nucleotide sequence from a set of four such signals representing DNA sequence data derived by electrophoretic means.

Abstract: Novel discogens based on tricycloquinazoline derivatives and methods for their preparation are described. One method for their preparation is to nitrate veratraldehyde and after reducing the resulting nitrate to dimethoxy anthranil to obtain its trimerization thus producing a trisubstituted tricycloquinazoline. Another method is to start with dichlorotoluene and after its nitration to oxidize the nitrate into dichloronitrodiacetoxytoluene, its hydrolysis into benzaldehyde followed by a partial reduction to anthranil and finally by the trimerization of the anthranil to obtain the hexachlorotricycloquinazoline. The novel compounds are useful as fluorescent indicators for high performance oxygen sensors, organic conductors, liquid crystals and polymeric liquid crystals.

Abstract: Gene expression in a cell can be regulated or inhibited by incorporating into or associating with the genetic material of the cell a non-native nucleic acid sequence which is transcribed to produce an mRNA which is complementary to and capable of binding to the mRNA produced by the genetic material of said cell.

Abstract: A family of compounds effective in inhibiting interleukin-1 (IL-1) activity, tumor necrosis factor (TNF) activity, and the activity of other leukocyte derived cytokines is comprised of 7-(oxoalkyl) 1,3-dialkyl xanthines of the formula ##STR1## in which R.sub.1 and R.sub.2 are the same or different and are selected from the group consisting of straight-chain or branched alkyl radicals with 2 to 6 carbon atoms, cyclohexyl, alkoxyalkyl and hydroxyalkyl radicals, and A represents a hydrocarbon radical with up to 4 carbon atoms which can be substituted by a methyl group. Another family of effective compounds is identified as ##STR2## The inhibition of IL-1, TNF, and other cytokines in mammals is implicated in alleviation of a wide variety of disease conditions.

Abstract: Aqueous based compositions for eradicating insects comprise an insecticide, such as pyrethroid and a carrier therefor wherein the carrier is in the form of an aqueous dispersion comprising starch in an amount sufficient to provide a releasable powder-like coating of the starch and insecticide on an insect controlling device, such as a paperboard insect trap. The aqueous insecticides may be applied by printing on paper, paperboard, plastic film or textiles by means employed in the corrugated paperboard industry, but may also be applied using gluing machinery, and particularly in smaller runs on modified mimeograph type duplicating equipment with a colorant. The latter printing method provides for the uniform application of insecticide onto a substrate to deliver a predetermined amount of active ingredient.

Abstract: Certain new 1,2-dihydroellipticine compounds having activity against CNS specific cancer cell lines because of their ease of passage across the blood-brain barrier are disclosed along with formulations and methods for treating CNS cancers employing these compounds.

Abstract: A simple immunoassay method is provided which distinguishes pathogenic from nonpathogenic forms Entamoeba histolytica in biological samples. This assay utilizes monoclonal antibody preparations which are specific for designated epitopes of the 170 kd subunit of the Gal/GalNAc lectin. When pathogenic forms, specifically, are to be detected, at least one antibody which is immunospecific for an epitope unique to the forms of the 170 kd lectin found in pathogenic strains is used in the assay. The invention further includes monoclonal antibodies which are immunospecific for epitopes 1-3 of the 170 kd subunit of the Gal/GalNAc lectin of either pathogenic or nonpathogenic forms and to monoclonal antibodies specifically immunoreactive with epitopes unique to nonpathogenic derived 170 kd subunit, as well as purified forms of the Gal/GalNAc lectin from both pathogenic and nonpathogenic forms.

Abstract: An artificial zona pellucida is provided for implantation in the peritoneal cavities of small laboratory animals. The assembly includes a hydrogel cartridge for containing one or more nude isolated blastomeres which can be cultured therein to an implant stage in the peritoneal cavity of a small animal such as a mouse. The combination is particularly advantageous for culturing of nude isolated blastomeres of a species different from the host small laboratory animal, such as blastomeres of domestic animals.

Abstract: An apparatus for converting single phase input power to three phase output power supplied to a motor includes a pair of input lines, and a pair of DC bus lines, a pair of capacitors, a pair of diodes, and a pair of controlled switching devices which are each connected between the DC bus lines. One of the input lines is connected to the node between the capacitors and the other input line is connected to the node between the diodes. Two output lines are connected to the input line and a third output line is connected to the node between the two switching devices, with the three output lines being connected to a motor to supply three phase power to the motor. The switching devices are switched in a pulse width modulated manner to provide a voltage between the third output line and the other two output lines which provides the three phase power. During motor startup, at least one startup capacitor is switched in between one or both of the input lines and the output lines to provide startup torque for the motor.

Abstract: A method for diagnosing a neurological disease comprising detecting a neurological disease-specific biochemical marker macromolecule within a sample of extracted cerebral spinal fluid is disclosed. In particular, a radioactively labeled photoaffinity probe is used to diagnose a neurological disease. For instance, Alzheimer's disease can be diagnosed by detecting a disease-specific protein having a molecular weight of about 42,000 daltons, i.e., glutamine synthetase.

Abstract: A laser using a distributed phase shift structure is disclosed. The active medium is formed in the shape of a stripe having first and second surfaces and two ends. The stripe includes a large central portion and two end portions with the central portion being of different widths than the two end portions. A laser device which utilizes the active medium of the present invention further includes at least one P-guide layer and at least one N-guide layer, both having a higher bandgap energy than the active medium. The P-guide layer and the N-guide layer are located on opposing surfaces of the active medium. A current which is injected through the N-guide layer, the P-guide layer and the active medium induces single mode, narrow linewidth coherent light to issue from the active medium.

Abstract: There is described a biocatalytic method for the synthesis of cathecol from a renewable source such as glucose. The method comprises inducing a divergent pathway in the shikimate pathway of a host cell. Additionally, there are described methods for making precursors to cathecol such as protocatechuate.

Abstract: A combined microwave and conventionally heated oven includes first and second chambers separated from one another by a partition including first and second spaced panels which define a cavity therebetween. These panels are both metallic, except where the microwave waveguide passes through rectangular gaps in them, in which are situated rectangular, non-metallic, infrared-absorbing panels of the same size. A microwave generator is provided in the second chamber for generating microwaves for use in heating a product positioned in the first chamber. Convention heater(s) (gas and/or electrical resistance) is/are also provided. A stream of cooling air reduces the temperature within the cavity in order to insulate the second chamber from the transfer of heat emitted from the first chamber in operation of the conventional heater(s).

Abstract: Methods and apparatus are provided wherein air gap flux magnitude and relative position are determined from stator voltage harmonic components and stator current in operating alternating current machines having a stator, a rotor and an air gap therebetween. Such determinations have various uses, such as for efficiency control. Various new and improved efficiency controllers are provided which utilize these measurements.

Abstract: A method for permformation of microporous ceramic membranes onto a porous support includes placing a colloidal suspension of metal or metal oxide particles on one side of the porous support and exposing the other side of the porous support to a drying stream of gas or a reactive gas stream so that the particles are deposited on the drying side of the support as a gel. The gel so deposited can be sintered to form a supported ceramic membrane useful for ultrafiltration, reverse osmosis, or molecular sieving having mean pore sizes less than 100 Angstroms.