Abstract: Interconnect structures for integrated circuits and semiconductor chips are disclosed which employ patterned interfaces to minimize stress migration in the interconnects. The interfaces are patterned to have regions of substantially no adhesion and other regions of good adhesion. The regions of substantially no adhesion reduce stress migration in the interconnect, while the regions of good adhesion ensure adequate thermal contact, fabricability and mechanical integrity of the interconnect structures. The patterned interfaces can be formed either by treating the surfaces of the interconnect or adjacent insulator and passivation layers, or by forming patterned interlayers of material in the interfaces. Multiple layer interconnects can also be formed which incorporate similarly patterned interfaces.

Abstract: The production of artificial viral envelopes by a novel double-detergent dialysis technique is disclosed. Specifically exemplified is the production of HIV-1 and RSV viral envelopes. The resulting artificial viral envelopes are essentially identical to the natural virus with regard to characteristics which are relevant to immunogenicity.

Abstract: An elastomeric material, capable of reversibly contracting and relaxing by an inverse temperature transition, in a form suitable for use as a protective layer between a mammalian repair site and a second tissue site whereby adhesion involving said repair site and said second tissue site is substantially prevented.

Abstract: A modified hemoglobin comprising hemoglobin which is cross-linked with a cross-linking reagent. The cross-linking reagent is selected such that the .beta.-chains are cross-linked within the 2,3-diphosphoglycerate binding site and the linkage distance between the .beta.-chains is between about 5 to 9 angstroms. A method of preparing the modified hemoglobin and its use as a blood substitute or a plasma expander are also described.

Abstract: A microwave furnace having uniform power distribution via the induction of ergodic modes includes a base portion and a pair of planar spaced apart elongated sidewalls that extend upwardly from the base, with the distance between the sidewalls being within .+-.20% of the length of the sidewalls. A pair of arcuate end-walls are disposed at each end of the sidewalls with the end-walls having a radius of curvature within .+-.20% of one-half of the length of the sidewalls. A domed cover having a radius of curvature within .+-.20% of one-half of the length of the sidewalls rests atop the intermediate portion.

Abstract: Broadly, the present invention takes advantage of the ability of self-protonated sulfonated polyaniline (SPAN) to sense and/or modulate pH of a medium in the vicinity of a SPAN electrode. Accordingly, one aspect of the present invention is directed to a method for sensing pH of a medium in the vicinity of a sensing electrode wherein a SPAN electrode and a counter-electrode are placed in a medium and an indicia of said SAN correlative with the pH of said medium is monitored. As another aspect of the present invention, the pH of a medium in the vicinity of a sensing electrode is modulated by placing a SPAN electrode in the medium and applying a voltage to the electrode to controllably emit or absorb protons from said electrode to modulate the pH of the medium in the vicinity of the electrode. As a further aspect of the present invention, the activity/state of a biosensor/catalyst is sensed for the activity/state correlative with pH.

Abstract: This invention provides novel vitamin D-related compounds characterized by extended unsaturated side chain structures. Such compounds exhibit increased activity in arresting the proliferation and promoting the differentiation of malignant cells with only minimal calcemic activity and thus represents new therapeutic agents applicable and uniquely useful in differentiation therapy of malignant diseases. The activity characteristics of these compounds provide the basis of a method for the treatment of neoplastic diseases, specifically leukemoid diseases.

Abstract: A method and apparatus for diagnosing the mechanical condition of a machine. The method of the invention includes the following steps: sensing a reference vibrational signal of the machine; creating a reference set of events from the reference vibrational signal of the machine; saving the reference set of events; sensing a test vibrational signal of the machine; creating a test set of events from the test vibrational signal of the machine; and, comparing the test set of events with the reference set of events to determine the mechanical condition of the machine. The invention further includes a method of extracting a set of events from a vibrational signal of a machine wherein a subset of the events corresponds to a physical action of the machine. The invention also includes a method of determining a set of clustered events for a machine from a plurality of sets of events, wherein each of the sets has a number of events therein.

Abstract: Starch-based biodegradable packaging fillers are provided which have high volumes, low weights, and excellent compressibility and resiliency properties. The products of the invention are fabricated by extrusion of a starch substrate, most preferably normal wheat starch, in the presence of minor amounts of a polyalkylene glycol or derivative thereof and/or a particulate bubble-nucleating agent. Effective biodegradable packaging fillers can thus be fabricated without the use of expensive modified starch substrates; however, such substrates can also be employed if desired, and the additives of the invention improve these products as well. In preferred production procedures, the additives are mixed with the starch substrate, and the mixture is preconditioned and then extruded through a twin screw extruder.

Abstract: Polyphenylene is prepared by exposing a poly(1,2-disubstituted-cyclohexa-3,5-diene) precursor to ultraviolet light in the presence of an acid catalyst. The acid catalyst is activated by the ultraviolet radiation and forms polyphenylene by aromatizing the cyclohexene rings of the poly(1,2-disubstituted-cyclohexa-3,5-diene).

Abstract: A process for producing enhanced quality adsorbent carbons and environmentally acceptable materials for energy production from coal includes an initial step of physically cleaning the coal to remove organic sulfur and mineral tailings. Next, a coal slurry of feedstock and water is prepared. Phosphoric acid is then mixed into the water of the coal slurry to provide by volume 15-85% and more preferably 50-85% phosphoric acid. The slurry is then heated and held in a temperature range between 85.degree. and 230.degree. C. for a period of at least five minutes to allow the phosphoric acid to penetrate deeply into the coal. Then the coal slurry is carbonized at a temperature of between 200.degree.-700.degree. C. for at least five to sixty minutes. The processing produces unique products including a low ash content, low sulfur content carbon solid, a tar with a sulfur content of less than 0.05% of the original feedstock and a gas product having a hydrogen to methane ratio of at least 4:1.

Abstract: An asymmetric process for the preparation of enantiomerically pure .beta.-L-(-)-1,3-oxathiolane-nucleosides that includes the initial preparation of the key chiral intermediates (2R,5R) and (2R,5S)-5-(O-protected)-2-(protected-oxymethyl)-1,3-oxathiolane from 1,6-thioanhydro-L-gulose. The 2R,5(R,S)-5-(O-protected)-2-(protected-oxymethyl)-1,3-oxathiolane is condensed with a desired heterocyclic base, typically a purine or pyrimidine base, to provide the product nucleoside. The synthesis can be used to prepare the pharmaceutically important compound, .beta.-L-(-)-1-[(2.beta.,4.beta.)-2-(hydroxymethyl)-4-(1,3-thioxolane)]cyt osine (.beta.-L-(-)BCH-189).

Abstract: A process is provided for removing sulfur oxides from gaseous mixtures such as flue gases or tail gases. The process involves contacting the gaseous mixture with a non-functionalized polymeric sorbent which is essentially hydrophobic, such as styrenic polymers. The process may utilize pressure swing adsorption techniques, and is capable of producing a desorption stream with an SO.sub.2 concentration suitable for immediate conversion to elemental sulfur by the Claus process.

Abstract: A method of separating a pair of stereoisomers, and especially enantiomers, using monoclonal receptor molecules containing an antibody combining site that binds to substantially only one of that pair of stereoisomers is disclosed.

Abstract: This invention provides a novel class of vitamin D-related compounds, namely the 1.alpha.-hydroxy-19-nor-vitamin D analogs, as well as a general method for their chemical synthesis. The compounds exhibit pronounced activity in arresting the proliferation of undifferentiated cells, including malignant cells, and in inducing their differentiation, and thus represent novel therapeutic agents for the treatment of malignant and other diseases characterized by the proliferative growth of undifferentiated cells. Formulations for therapeutic use and treatment methods are also provided.

Abstract: The entropy-based signal receiver uses the entropy of a received signal or a quantity that is closely related to entropy as the means to measure changes in the signal as a function of time or origin. The changes that are of interest are those associated with either signal level or signal structure. Entropy is a measure that responds in some fashion to either type of change. The entropy-based signal receiver transforms time segments of a received signal into entropy-related quantities. By comparing entropy-related quantities of received signals, one can obtain information about the emitters of the received signals and the nature of the medium through which the signals were propagated. The sensitivity of the entropy-based receiver is significantly better than the more conventional energy-based receiver in detecting the changes in a signal that result from reflection or scattering by inhomogeneities in a wave-propagating medium.

Abstract: A synthesis of 1.alpha.,24(R)- and 1.alpha.,24(S)-dihydroxy-22(E)-dehydrovitamin D.sub.3 compounds. This process involves two major operations, namely, (a) the attachment of the required side chain to an existing vitamin D-22-aldehyde derivative to obtain an enone derivative as an intermediate, and (b) the stereoselective reduction of the ketone group of said enone intermediate to obtain the desired 24(R)- and 24(S)-hydroxyvitamin D compounds. The vitamin D enone derivatives generated as intermediates in the process are also new compounds.

Abstract: A dipole coil for use in a superconducting electromagnet employs two saddle-shaped coils in a diametrically opposed relationship. Each of the saddle-shaped coils includes central linearly extending portions, and curved saddle portions at the ends of the coil, respectively. A trapezoidal curved portion spacer is wedged into place against part of the saddle portion of the coil at the end thereof so as to exert a compressive force on such part which will inhibit displacement of the coil windings when an electromagnetic force acts thereon. In this way, friction at the coil is suppressed so as to prevent quenching. At the other end of the coil, the trapezoidal spacer includes a triangular member and a trapezoidal member spaced from one another so as to define a passageway. Leads of the coil are respectively accommodated in such passageways to prevent an excessive force from acting thereon. In this way, damage to the leads is also prevented.

Abstract: An improved foundation repairing system includes a plurality of pierheads secured to exposed portions of a foundation. Each of the pierheads has an angular ledge abutting an outer surface and a bottom surface of the foundation. A pier is driven, section by section, vertically downwardly through a pier guide of a respective one of the pierheads by a pier driver in conjunction with a pier driving bracket in order to obtain the necessary support from the underlying ground. The pier driver has a pair of opposing first upright members straddling the pier guide, which are temporarily attached to the foundation and a pair of opposing first foot members operably extending beneath the foundation. A plurality of secondary lifting mechanisms, in cooperation with piers previously installed by the pier driver, are adapted to cooperatively elevate the foundation. The pier guides of the pierheads are fixedly connected to the respective piers to provide permanent support for the foundation.

Abstract: Root organ cultures of the monocot genus Allium were successfully grown in culture medium. In a preferred bioreactor system, the roots themselves can be grown and harvested as a source of various Allium flavors and/or the growing roots can be reacted with various nutrients to produce Allium flavor compounds independent of the root harvesting. The root cultures of the present invention produce quantities of onion and onion-like flavor compounds comparable to those found in onion bulbs.Flavor precursors arThis invention was made in part under NSF Grant No. 85-03183. The U.S. Government has certain rights to this invention.