Patents Assigned to Foundation
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Patent number: 5245016Abstract: A protein isolated from Pseudomonas maltophilia is found to possess an exposed, immunologically accessible protein which binds to the FC region of several species of immunoglobulins. The protein is found to bind both IgG and IgA immunoglobulins and is found to have an effective molecular weight of approximately 30,000 daltons. The protein is found to be useful in isolation of IgA immunoglobulins from biological mixtures. The protein makes IgA immunoglobulins available for further analytical techniques, including identifying bacteria which contain IgA binding proteins. Because of the increased availability of IgA immunoglobulins, it is possible to diagnosis and treat IgA-related diseases and their sources.Type: GrantFiled: April 24, 1991Date of Patent: September 14, 1993Assignee: University of Utah Research FoundationInventors: William D. Odell, Sanjeev Grover, Zeil A. McGee
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Patent number: 5245282Abstract: A new three-dimensional (3D) MR imaging pulse sequence can produce over 100 high-resolution, high-contrast images in as little as 6 minutes of imaging time. Without additional imaging time, this same image data can be post-processed to yield high-resolution, high-contrast images in any arbitrary orientation. Thus, this new pulse sequence technique provides detailed yet comprehensive coverage. The method of this invention relates to a preparation-acquisition-recovery sequence cycle. The first step is magnetization preparation (MP) period. The MP period can emply a series of RF pulses, gradient field pulses, and/or time delays to encode the desired contrast properties in the form of longitudinal magnetization. A data acquisition period includes at least two repetitions of a gradient echo sequence to acquire data for a fraction of k-space. A magnetization recovery period is provided which allows T1 and T2 relaxation before the start of the next sequence cycle.Type: GrantFiled: June 28, 1991Date of Patent: September 14, 1993Assignee: University of Virginia Alumni Patents FoundationInventors: John P. Mugler, III, James R. Brookeman
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Patent number: 5245551Abstract: The extinction coefficient of fluorescent dyes in donor-acceptor energy transfer processes is determined for dye-protein conjugates by forming short polypeptide fragment-dye conjugates and measuring the change in ultraviolet light absorbance of the conjugates with changing concentration. The protein concentration is determined by comparing the absorption spectrum of a conjugate of donor dye, acceptor dye, and protein with the individual components thereof using a multiple linear regression technique based on the following model:A.sub.p-d =.alpha..multidot.A.sub.p +.beta..multidot.A.sub.d +.epsilon.where, A.sub.p-d, A.sub.p, A.sub.d are the absorption spectra of the dye-protein conjugate, the protein alone, and the dye-polypeptide compound, respectively, .alpha., .beta. are the regression coefficients to be determined, and .epsilon. is the error term.Type: GrantFiled: April 10, 1991Date of Patent: September 14, 1993Assignee: University of Utah Research FoundationInventors: James N. Herron, Ai-Ping Wei
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Patent number: 5245638Abstract: A testing system and method for benchmarking computer systems. The system includes a store containing a scalable set of tasks to be performed to produce a solution in ever-increasing degrees of resolution as a larger number of the tasks are performed. A timing and control module allots to each computer a fixed benchmarking interval in which to perform the stored tasks. Means are provided for determining, after completion of the benchmarking interval, the degree of progress through the scalable set of tasks and for producing a benchmarking rating relating to the degree of progress for each computer.Type: GrantFiled: October 29, 1990Date of Patent: September 14, 1993Assignee: Iowa State University Research Foundation, Inc.Inventor: John L. Gustafson
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Patent number: 5245077Abstract: The pure isomers L-buthionine-S-sulfoximine and L-buthionine-R-sulfoximine are provided. The L-S-isomer has utility, for example, in causing the depletion of glutathione, a major protectant molecule in tumors and certain parasites. The L-R-isomer has utility as a compound decreasing further uptake and thus effect of the L-S-isomer and for causing glutathione depletion specific to the kidney. The isolation of pure isomers from L-buthionine-SR-sulfoximine enables treatment at lower dosages without cross effects.The pure L-buthionine-S-sulfoximine isomer is obtained from L-buthionine-SR-sulfoximine by recrystallization preferably by forming a solution of L-buthionine-SR-sulfoximine in water at a concentration of 0.Type: GrantFiled: July 2, 1992Date of Patent: September 14, 1993Assignee: Cornell Research Foundation Inc.Inventor: Owen W. Griffith
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Patent number: 5244656Abstract: Disclosed herein is a method for producing antibodies against an antigen of interest. Animal cells are exposed to both the antigen of interest and a recombinant retroviral vector. The vector contains a combination of oncogenes capable of inducing plasmacytomas. Plasmacytoma formation takes place rapidly and takes place in the presence of the antigen. A very high proportion of the plasmacytomas that are recovered are antigen specific.Type: GrantFiled: September 19, 1991Date of Patent: September 14, 1993Assignees: Wisconsin Alumni Research Foundation, The United States of America as represented by the Department of Health and Human ServicesInventors: Rex G. Risser, David A. Largaespada, Joseph F. Mushinski, Eva M. Weissinger, Harald Mishak
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Patent number: 5244800Abstract: Crystals of human complement factor D that are triclinic are disclosed. They are made by a method of crystallization known as the "hanging drop" technique. The technique uses 1.0-1400 mM NaCl and polyethylene glycol maintained at a pH of 5.2-7.0, more preferably 5.3-6.1.Type: GrantFiled: April 27, 1990Date of Patent: September 14, 1993Assignee: The UAB Research FoundationInventors: Lawrence J. DeLucas, John E. Volanakis
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Patent number: 5244805Abstract: A method and composition for improving the level of expression of a gene or collection of genes by providing a novel baculovirus promoter to which a heterologous gene is attached. The novel promoter may contain a modification of a natural viral promoter or may be totally synthetic. The novel baculovirus promoter may also comprise a combination promoter such as a promoter with a double start site or a combination of two different promoters. Foreign gene placement in a novel location or genomic orientation is also included.Type: GrantFiled: January 17, 1991Date of Patent: September 14, 1993Assignee: University of Georgia Research Foundation, Inc.Inventor: Lois K. Miller
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Patent number: 5244658Abstract: A bacterial inoculant is disclosed for controlling root rot in peas caused by Aphanomyces fungus. The inoculum is obtained from general bacterial strains including strains of Pseudomonas cepacia, Pseudomonas fluorescens, Corynebacterium flaccumfaciens, and two other Bacillus strains of uncertain taxonomy.Type: GrantFiled: December 10, 1992Date of Patent: September 14, 1993Assignee: Wisconsin Alumni Research FoundationInventor: Jennifer L. Parke
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Patent number: 5243455Abstract: Discretely and continuously tunable single and multiple-stage polarization interference filters employing chiral smectic liquid crystal cells as electronically rotatable retarders are provided. Discretely tunable filters of this invention include those which employ bistable surface-stabilized ferroelectric liquid crystal cells. Continuously tunable filters of this invention include those that employ chiral smectic A ferroelectric liquid crystal cells. Single stage filters include fixed birefringent elements in combination with chiral smectic liquid crystal cells and multiple stage filters can include only chiral smectic liquid crystal cells or can include chiral smectic liquid crystal cells in combination with fixed birefringent elements. Blocking filters useful for color generation and color displays are also provided. The FLC filters provided can be temporally multiplexed.Type: GrantFiled: May 15, 1992Date of Patent: September 7, 1993Assignee: The University of Colorado Foundation, Inc.Inventors: Kristina M. Johnson, Gary D. Sharp
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Patent number: 5242179Abstract: A four limb exercising attachment for wheelchairs which will permit the occupant of the wheelchair to exercise all four limbs simultaneously, thereby affording proper bilateral movement of the arms and legs. The exercising attachment will also propel the wheelchair when operated in a suitable manner. The attachment may be used with most standard wheelchairs of the type having right and left front and rear wheels. The attachment includes right and left mounting assemblies, each mounting assembly being securable to the frame of a standard 4 wheel wheelchair at three or more spaced apart locations. A common input shaft will extend between the left and right mounting assemblies after they are mounted upon the wheelchair.Type: GrantFiled: October 11, 1991Date of Patent: September 7, 1993Assignee: Research Foundation of the State University of New YorkInventors: David W. Beddome, William H. Macy, Joseph C. Mollendorf, Kenneth L. Peebles, Thomas G. Dressing
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Patent number: 5242801Abstract: The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.Type: GrantFiled: August 6, 1990Date of Patent: September 7, 1993Assignees: University of Iowa Research Foundation, Regents of the University of MinnesotaInventors: Kevin P. Campbell, C. Michael Knudson, Steven D. Kahl, Charles F. Louis, James R. Mickelson
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Patent number: 5243060Abstract: The present invention provides linear organosilicon polymers including diethynyl-(substituted)arylene units, and a process for their preparation. These novel polymers possess useful properties including electrical conductivity, liquid crystallinity, and/or photoluminescence. These polymers possess good solubility in organic solvents. A preferred example is produced according to the following reaction scheme. ##STR1## These polymers can be solvent-cast to yield excellent films and can also be pulled into fibers from concentrated solutions. All possess substantial crystallinity as revealed by DSC analysis and observation through a polarizing microscope, and possess liquid crystalline properties.Type: GrantFiled: April 10, 1992Date of Patent: September 7, 1993Assignee: Iowa State University Research Foundation, Inc.Inventors: Thomas J. Barton, Yiwei Ding
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Patent number: 5242798Abstract: Synthetic polypeptides whose sequences correspond substantially to amino acid residue sequences of at least portions of naturally occurring proteinoids translated from brain-specific mRNAs are disclosed as are receptors, methods and diagnostics that utilize those synthetic polypeptides. The synthetic polypeptides have molecular weights less than those of their corresponding proteinoids, and induce the production of antibodies that bind to the naturally occurring proteinoid, or a derivative thereof when bound to a carrier as a conjugate and are introduced into an animal.Type: GrantFiled: February 7, 1990Date of Patent: September 7, 1993Assignee: Scripps Clinic and Research FoundationInventor: J. Gregor Sutcliffe
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Patent number: 5242508Abstract: A method for making an isotropic permanent magnet comprises atomizing a melt of a rare earth-transition metal alloy (e.g., an Nd--Fe--B alloy enriched in Nd and B) under conditions to produce protectively coated, rapidly solidified, generally spherical alloy particles wherein a majority of the particles are produced/size classified within a given size fraction (e.g., 5 to 40 microns diameter) exhibiting optimum as-atomized magnetic properties and subjecting the particles to concurrent elevated temperature and elevated isotropic pressure for a time effective to yield a densified, magnetically isotropic magnet compact having enhanced magnetic properties and mechanical properties.Type: GrantFiled: April 15, 1992Date of Patent: September 7, 1993Assignee: Iowa State University Research Foundation, Inc.Inventors: R. William McCallum, Kevin W. Dennis, Barbara K. Lograsso, Iver E. Anderson
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Patent number: 5241029Abstract: The present invention provides linear organosilicon polymers including acetylene and vinylene moieties, and a process for their preparation. These diorganosilacetylenealt-diorganosilvinylene linear polymers can be represented by the formula: --[--(R.sup.1)(R.sup.2)Si--C.ident.C--(R.sup.3)(R.sup.4)Si--CH=CH--].sub.n --, wherein n.gtoreq.2; each R.sup.1, R.sup.2, R.sup.3, and R.sup.4 is independently selected from the group consisting of hydrogen, halogen, alkyl, alkenyl, aryl, and aralkyl radicals. The polymers are soluble in organic solvents, air stable, and can be pulled into fibers or cast into films. They can be thermally converted into silicon carbide ceramic materials.Type: GrantFiled: January 7, 1992Date of Patent: August 31, 1993Assignee: Iowa State University Research Foundation, Inc.Inventors: Thomas J. Barton, Sina Ijadi-Maghsoodi, Yi Pang
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Patent number: 5240890Abstract: This invention provides a method of manufacturing a hydrocarbon conversion catalyst by spray-drying a slurry containing alumina-magnesia and a crystalline aluminosilicate zeolite, which is characterized in that the alumina-magnesia is treated with phosphoric acid containing solution before or after the slurry is subjected to a treatment of spray-drying.Type: GrantFiled: November 25, 1991Date of Patent: August 31, 1993Assignees: Nippon Oil Co., Ltd., Petroleum Energy Center FoundationInventors: Takashi Ino, Seigou Shibata
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Patent number: 5240108Abstract: A sharps disposal system (2) includes a fiberboard container (6) mounted to a wall (8) by a lockable cage (4). The container has an entrance opening (70) formed through the top (20), sized for the deposit of sharps into its interior. A baffle (60) extends within the interior from the back downwardly and forwardly and is sized and positioned to discourage manual access to the interior while directing sharps into the interior. The container also includes a lid (84) hinged to the top for movement between stable opened and closed positions to permit one hand operation when opened. For disposal the lid is secured to the top using a foam adhesive strip (104) to provide a secure, substantially leakproof seal. The container is coated on the inside surface with a hydrophobic material and has the seams and corners sealed to make the interior of the container substantially leakproof. A view port (50) can be provided to permit the user to determine when the container is full.Type: GrantFiled: January 28, 1992Date of Patent: August 31, 1993Assignee: Kaiser Foundation HospitalsInventor: Patrick R. Tonna
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Patent number: 5240497Abstract: Alkali-free layers of pure metals such as copper, nickel and cobalt were deposited on noble metal or noble metal sensitized substrates by electroless deposition using pure quaternary ammonium hydroxides or quaternary phosphonium hydroxides to generate the hydroxyl ion (OH.sup.-) needed to produce electrons for the metal reduction.Using the new alkaline-free electroless compositions, uniform, continuous and reproducible metal layers were selectively deposited with excellent electrical properties. With the improved compositions and process, nanosize copper lines having widths in the range of 100 to 500 nm were prepared.Type: GrantFiled: October 8, 1991Date of Patent: August 31, 1993Assignee: Cornell Research Foundation, Inc.Inventors: Yosef Y. Shacham, Roman Bielski
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Patent number: 5240841Abstract: A method for conferring resistance to a parasite to a host of the parasite, which comprises isolating a gene fragment from the parasite and inserting the gene fragment or a DNA or RNA segment substantially homologous to the gene fragment or to a DNA or RNA sequence functionally equivalent to the gene fragment into the host, wherein (1) transcription of the gene fragment or the DNA or RNA segment in the host occurs in an anti-sense direction, (2) the gene fragment or the DNA or RNA segment is expressed as a gene product in the host, wherein the gene product is capable of disrupting an essential activity of the parasite, or (3) the gene fragment or the DNA or RNA segment is a binding site capable of competing with a native binding site in the parasite, is disclosed along with hosts produced by this process. Particularly preferred is conferring resistance using a gene fragment from a replicase gene of an RNA virus.Type: GrantFiled: March 25, 1992Date of Patent: August 31, 1993Assignees: Duke University, Cornell Research Foundation, Inc.Inventors: Stephen A. Johnston, John C. Sanford