Abstract: Provided are antigenic compositions and uses thereof that include at least two human herpesvirus (HHV) polypeptides involved in mediating HHV binding, fusion, and entry into host cells, such as gp350, gH, gL, and gB, or nucleic acids encoding the polypeptides. The two HHV polypeptides comprise any combination of: a gB polypeptide; a gp350 polypeptide; a gL polypeptide; and a gH polypeptide, and optionally any one or more of the following polypeptides: gp42, gM, gN, gl, gC, gE, gD, ORF68, BMRF-2, BDLF2, UL128, UL130, UL131A, and gpK8.1. Also disclosed are methods of inducing an immune response or treating or preventing an HHV infection in a subject by administering to the subject at least two of the HHV polypeptides or nucleic acid(s) encoding the same. Methods of passively transferring immunity using high-titer anti-HHV antibodies or immune cells are also disclosed.
Type:
Grant
Filed:
January 26, 2018
Date of Patent:
February 7, 2023
Assignee:
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
Abstract: Disclosed is a gas sensor. The gas sensor comprises: a substrate; a thermoelectric layer which is disposed on the substrate and has a metal nanowire; a first electrode and a second electrode disposed to be spaced apart from each other on the thermoelectric layer; and a catalyst layer which is disposed on the first electrode and has a composite structure in which a metal particle is bonded to a carbon structure.
Type:
Grant
Filed:
April 19, 2018
Date of Patent:
February 7, 2023
Assignee:
INDUSTRY-UNIVERSITY COOPERATION FOUNDATION
HANYANG UNIVERSITY ERICA CAMPUS
Inventors:
Yong Ho Choa, Tae-Yeon Hwang, Yo Seb Song, Se Il Kim, Gwang Myeong Go
Abstract: A free standing liquid membrane is disclosed that can selectively separate objects based on the kinetic energy value of the objects such that either an object having a first kinetic energy value can pass through the free standing liquid membrane while retaining the membrane and/or an object having a second kinetic energy value is prevented from passing through the membrane while retaining the membrane. Advantageously, the free standing liquid membrane can remain intact for seconds to hours with multiple objects passing through the membrane.
Abstract: Devices that may couple two or more apparatuses, such as an organ-on-a-chip device and a microfluidic device. Devices that include an organ-on-a-chip device, a microfluidic device, and a cap that couples the organ-on-a-chip device and the microfluidic device. Systems that include the devices and a detection unit. Methods for quantitation of insulin.
Type:
Grant
Filed:
April 29, 2020
Date of Patent:
February 7, 2023
Assignee:
The Florida State University Research Foundation, Inc.
Inventors:
Michael G. Roper, Rafael Arturo Masitas Castillo, Basel Bandak, Wesley James Eaton, Joel Elinam Alfred Adablah
Abstract: A switching circuit for a current source inverter includes a first inverter leg, a second inverter leg, and a controller. The first inverter leg includes a first reverse-voltage-blocking (RB) switch, a second RB switch, and a third RB switch that are connected in series between a first bus line and a second bus line. The second inverter leg includes a fourth RB switch, a fifth RB switch, and a sixth RB switch are connected in series between the first bus line and the second bus line. The controller is configured to control a switch between an on-state and an off-state for each RB switch. When in the on-state, a reverse voltage is blocked by a respective RB switch, and a current with a positive polarity is conducted through the respective RB switch. When in the off-state, a voltage and the current are blocked by the respective RB switch.
Type:
Grant
Filed:
September 1, 2021
Date of Patent:
February 7, 2023
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Thomas Merlin Jahns, Hang Dai, Bulent Sarlioglu, Renato Amorim Torres
Abstract: Cyanines which selectively bind to G-quadruplex DNA complexes, particularly quadruplexes expressed in cancer cells, and methods of making and using thereof are described herein. The cyanine can be a symmetrical or unsymmetrical streptocyanine, hemicyanine, closed chain cyanine, or combinations thereof. The cyanine is preferably substituted with one or more groups that minimize or prevent aggregation of the cyanine and/or inhibit binding of the cyanine to duplex DNA. One or more of the cyanines can be formulated with one or more pharmaceutical excipients and/or carrier to prepare pharmaceutical compositions suitable for administration to a patient, particular a human patient. The compounds and compositions described herein can be used to treat diseases or disorders characterized by the expression of G-quadruplex DNA, such as cancer.
Type:
Grant
Filed:
July 18, 2012
Date of Patent:
February 7, 2023
Assignee:
GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
Abstract: An ASG system for polygeneration with CC includes a devolatilizer that pyrolyzes solid fuel to produce char and gases. A burner adds exothermic heat by high-pressure sub-stoichiometric combustion, a mixing pot causes turbulent flow of the gases to heat received solid fuel, and a riser micronizes resulting friable char. A devolatilizer cyclone separates the micronized char by weight providing micronized char, steam and gases to a gasifier feed and oversized char to the mixing pot. An indirect fluid bed gasifier combustion loop includes a gasifier coupled to the gasifier feed, a steam input to provide oxygen for gasification and to facilitate sand-char separation, and an output for providing syngas. A burner provides POC to a mixing pot which provides hot sand with POC to a POC cyclone via a riser, where the POC cyclone separates sand and POC by weight and provides POC and sand for steam-carbon reaction.
Type:
Grant
Filed:
November 24, 2020
Date of Patent:
February 7, 2023
Assignees:
Wormser Energy Solutions, Inc., Energy & Environmental Research Center Foundation
Inventors:
Douglas M. Todd, John Parkes, Scott G. Tolbert, Michael L. Swanson, Surya B. Reddy Karri, Teddy M. Knowlton
Abstract: Embodiments of the systems can be configured to receive electromagnetic emissions of a substrate (e.g., a build material of a part being made via additive manufacturing) by a detector (e.g., a multi-spectral sensor) and generate a ratio of the electromagnetic emissions to perform spectral analysis with a reduced dependence on location and orientation of a surface of the substrate relative to the multi-spectral sensor. The additive manufacturing process can involve use of a laser to generate a laser beam for fusion of the build material into the part. The system can be configured to set the multi-spectral sensor off-axis with respect to the laser (e.g., an optical path of the multi-spectral sensor is at an angle that is different than the angle of incidence of the laser beam). This can allow the multi-spectral sensor to collect spectral data simultaneously as the laser is used to build the part.
Type:
Grant
Filed:
March 21, 2022
Date of Patent:
February 7, 2023
Assignee:
THE PENN STATE RESEARCH FOUNDATION
Inventors:
Abdalla R. Nassar, Alexander J. Dunbar, Edward W. Reutzel
Abstract: Formamide group-containing monomers and polymers made by polymerizing the monomers are provided. Also provided are methods of polymerizing the monomers and methods of synthesizing functionalized polymers by pre- and/or post-polymerization functionalization. The monomers are non-toxic and can generate highly reactive isocyanate and isonitrile precursors in a one-pot synthesis that enables the incorporation of complex functionalities into the side-chain of the polymers that are synthesized from the monomers.
Type:
Grant
Filed:
March 11, 2020
Date of Patent:
February 7, 2023
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Padma Gopalan, Balamurugan Ayyakkalai, Ri Chen
Abstract: A nonvolatile memory device and a method of operating the same are provided. The nonvolatile memory device may include a memory cell array having a vertical stack-type structure, a control logic, and a bit line. The memory cell array may include memory cells that each include corresponding portions of a semiconductor layer and a resistance change layer. The control logic, in a read operation, may be configured to apply a first voltage to a non-select memory cell and a second voltage to a non-select memory cell. The first voltage turns on current only in the semiconductor layer portion of the non-select memory cell. The second voltage turns on current in both the semiconductor layer and resistance change layer portions of the select memory cell. The bit line may be configured to apply a read voltage to the select memory cell during the read operation.
Type:
Grant
Filed:
July 26, 2021
Date of Patent:
February 7, 2023
Assignees:
Samsung Electronics Co., Ltd., Seoul National University R&DB Foundation
Inventors:
Jungho Yoon, Cheol Seong Hwang, Soichiro Mizusaki, Youngjin Cho
Abstract: Provided is a method for treating cancer by administering to an individual who has the cancer a MAD1 peptide. The peptide can enhance the effect of a chemotherapeutic agent that is administered to the individual in combination with the peptide.
Type:
Grant
Filed:
February 22, 2021
Date of Patent:
February 7, 2023
Assignee:
The Penn State Research
Foundation
Inventors:
Scott Hammond Medina, Andrew William Simonson, Matthew Aronson
Abstract: Devices and methods can be used to treat dermatologic disorders, hyperhidrosis, and wrinkles using DC electroporation. In some cases, such electroporation is essentially non-thermal modulation that can be used to ablate keratinocyte neoplasms, such as seborrheic keratosis, and other non-keratinocyte derived neoplasms of the skin and adnexal structures and related structures in other anatomic sites. In some implementations, the devices and methods described herein can be used for therapy delivery for the treatment of early or pre-malignant skin cancers. In some implementations, the devices and methods described herein can be used for treatment of hyperhidrosis and cosmetic issues.
Type:
Grant
Filed:
June 10, 2019
Date of Patent:
February 7, 2023
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Spencer A. Bezalel, Clark C. Otley, Samuel J. Asirvatham, Christian Lee Baum
Abstract: Provided is a bubble removal apparatus for removing a bubble on a substrate during a process of manufacturing a display panel or a semiconductor using a liquid, and more particularly, to a bubble removal apparatus using acoustic waves that collects a bubble on a substrate using an acoustic wave and removes the bubble by moving the bubble to a desired position, and a bubble removal method using the same.
Type:
Grant
Filed:
April 28, 2021
Date of Patent:
February 7, 2023
Assignee:
INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY
Abstract: Provided are a method and an apparatus for streaming a multi-view 360 degree video, and a method for streaming a 360 degree video according to an embodiment of the present disclosure includes: encoding a multi-view video to a bitstream of a base layer and a bitstream of a tile layer constituted by at least one tile; selecting a tile included in a user view video in the encoded bitstream of the tile layer by using user view information received from a 360 degree video rendering apparatus, and video information of the multi-view video; extracting tile data included in the selected user view video from the encoded bitstream of the tile layer, and generating a tile bitstream corresponding to the extracted tile data; and transmitting the encoded bitstream of the base layer and the generated tile bitstream to the 360 degree video rendering apparatus.
Type:
Grant
Filed:
October 13, 2021
Date of Patent:
February 7, 2023
Assignee:
Research & Business Foundation Sungkyunkwan University
Inventors:
Jong Beom Jeong, Soon Bin Lee, Eun Seok Ryu
Abstract: An electronic apparatus is provided. The electronic apparatus includes an acceleration sensor, a gyro sensor, a geomagnetic sensor, and a processor configured to compare geomagnetic data of the geomagnetic sensor and gyro data of the gyro sensor and correct the gyro data, determine a first value based on a principal component analysis (PCA) of acceleration data of the acceleration sensor, and determine a second value based on a PCA of the gyro data, and estimate a moving direction of the electronic apparatus based on the first value and the second value.
Type:
Grant
Filed:
July 30, 2019
Date of Patent:
February 7, 2023
Assignees:
Samsung Electronics Co., Ltd., Seoul National University R&DB Foundation
Abstract: The disclosure relates to a 5G communication system or a 6G communication system for supporting higher data rates beyond a 4G communication system such as long term evolution (LTE). The disclosure relates to a technique for controlling a base station power using an artificial intelligence based technology to improve an energy efficiency of a communication network. A method performed by a base station of a communication system according to an embodiment of the disclosure may include acquiring state information, determining an active/sleep request indicator (ASRI) based on at least a part of the state information, transmitting at least one of the state information and the ASRI to a central unit, receiving, from the central unit, power control information determined based on the at least one of the state information and the ASRI, and performing a power control based on the received power control information.
Type:
Grant
Filed:
February 25, 2021
Date of Patent:
February 7, 2023
Assignees:
Samsung Electronics Co., Ltd., Seoul National University R&DB Foundation
Inventors:
Youngjoon Kim, Hyungyu Ju, Byonghyo Shim, Hyojin Lee
Abstract: The present disclosure relates to a method and a system for collecting and managing terminal use pattern information generated during a process of controlling screen display of a user terminal for eye protection and management. The method, according to the present disclosure, comprises the steps of: measuring a distance between a user terminal and a user; measuring a use time of the user terminal; converting and processing image information displayed on a screen of the user terminal by a predetermined image processing method, when the distance and/or the use time satisfy/satisfies a predetermined condition; and collecting terminal use pattern information comprising at least one of image conversion processing information, distance, and use time when a predetermined reaction is sensed from a user.
Type:
Grant
Filed:
July 27, 2018
Date of Patent:
February 7, 2023
Assignee:
Industry-Academic Cooperation Foundation, Yonsei University
Abstract: An apparatus for estimating an uncertainty includes a processor configured to receive a first tracking coordinate corresponding to a reference coordinate, the reference coordinate being included in first image data acquired by a camera sensor, image data acquired after the first image data; acquire, based on motion data acquired from a motion sensor and a depth value of the first image data, a second tracking coordinate corresponding to the reference coordinate, the second tracking coordinate including a motion-based tracking coordinate in the second image data; calculate a target coordinate distribution in the second image data based on the first tracking coordinate and the second tracking coordinate; acquire an estimated target coordinate and an uncertainty of the estimated target coordinate based on the calculated target coordinate distribution; and update the first tracking coordinate based on the estimated target coordinate.
Type:
Application
Filed:
March 30, 2022
Publication date:
February 2, 2023
Applicants:
SAMSUNG ELECTRONICS CO., LTD., Korea University Research and Business Foundation
Inventors:
Yuntae KIM, Sanghoon Sull, Jaehyun Kim, Seongwook Yoon, Donghoon Sagong, Hojin Ju, Jaehwan Pi
Abstract: System and methods for high accuracy, non-intrusive current sensing are provided. A system may include two magnetic field sensors configured for differential sensing. The system may further include frontend circuitry configured to remove direct current (DC) offset of the magnetic field sensors, upconvert the outputs of the magnetic field sensors, and filter out at least one frequency component from the up-converted signals. The system may receive output signals from the front-end circuitry corresponding to each sensor. The system may further calculate a differential signal based on the output signals. The system may apply optimal detection based on the differential signal and a reference signal to calculate a measurement of current flow. The system may determine a phase angle measurement between the differential signal and the reference signal to calculate a direction of the current flow in the conductor and output various measurement information related to the detected current.
Abstract: Disclosed is a synaptic device, a reservoir computing device using the synaptic device, and a reservoir computing method using the reservoir computing device. The synaptic device includes a substrate and a plurality of units cells on the substrate, wherein the unit cells each include a channel layer and a first electrode and second electrode intersecting the channel layer, wherein the first electrode and the second electrode are spaced apart from each other, and define a gap region exposing a portion of the channel layer, and the channel layer includes a 2-dimensional semiconductor material or a 2-dimensional ferroelectric material.
Type:
Application
Filed:
May 5, 2022
Publication date:
February 2, 2023
Applicants:
KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY, RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY