Abstract: The present invention relates to a novel beta-glucosidase for producing glucose and a laminarioligosaccharide from seaweed. More particularly, the present invention may produce glucose from a beta-glucosidase exhibiting transglycosylase activity while showing exo-type glucanase activity against beta-glucan, as well as produce a laminarioligosaccharide by exhibiting transglycosylase activity against laminarin under different reaction conditions.

Abstract: A controller for individual sites of the microgrid controls loads, sources, the importing of power, and the exporting of power as a function of the energy storage at the site. A microgrid of such sites provides the benefits of improved energy storage without the need for real-time communication between sites.

Abstract: Disclosed herein is a cell death-inducing peptide that rapidly acts. The peptide is derived from Noxa protein and comprises 16 amino acid residues including MTD. The peptide is designated extended MTD (eMTD) because it contains the 10-mer MTD. eMTD rapidly exhibits potent necrotic cell death in various cell lines and, as such, can be applied to the treatment of various diseases including cancer when used in conjugation with peptides or materials for targeting specific cells.

Abstract: The present disclosure relates to an enzyme complex of arabinose isomerase, agarase and 3,6-anhydro galactosidase and a method for producing tagatose by degrading agar using the same. By using the enzyme complex according to the present disclosure, agar obtained from marine biomass can be degraded effectively and useful physiologically active substances such as tagatose can be obtained effectively therefrom.

Abstract: This document describes intraocular lenses and methods for their use. For example, this document describes intraocular lenses that are shaped with a concave posterior peripheral portion that mitigates occurrences of dysphotopsia. The intraocular lenses described herein are designed to reduce positive and negative dysphotopsias after cataract surgery.

Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.

Abstract: Disclosed is an apparatus for generating an artificial-neural-network-based prediction model. The apparatus includes an input data conversion unit configured to convert input data of an L-dimensional array (L is a natural number) into normalized vector data and input the normalized vector data, a modeling unit configured to model an artificial-neural-network-based prediction model for learning the input vector data and output a value predicted through the modeling, and an adjustment unit configured to compare the value predicted by the modeling unit with an actually measured value to calculate an error value and adjust learning parameters of an artificial neural network using the error value and a back-propagation algorithm.

Abstract: The present invention to provides methods, kits, and compositions for: i) detecting the level of 3-bromotyrosine in a sample that has been treated to liberate 3-bromotyrosine from 4-O-glucuronide-3-bromotyrosine, and/or ii) detecting the level of 4-O-glucuronide-3-bromotyrosine, and/or the combined level of both 4-O-glucuronide-3-bromotyrosine and 3-bromotyrosine, in a sample that has not been treated to liberate 3-bromotyrosine from 4-O-glucuronide-3-bromotyrosine. In certain embodiments, such detected levels are used to: i) identify the presence, severity, or risk of an eosinophilic disorder (e.g., asthma or a TH2-high eosinophilic disorder); ii) identify therapy effective for treating asthma or an eosinophilic disorder; or iii) identify patients suitable for treatment with therapeutic agents targeted to asthma or an eosinophilic disorder.

Abstract: Provided are a neural network method and an apparatus, the method including obtaining a set of floating point data processed in a layer included in a neural network, determining a weighted entropy based on data values included in the set of floating point data, adjusting quantization levels assigned to the data values based on the weighted entropy, and quantizing the data values included in the set of floating point data in accordance with the adjusted quantization levels.

Abstract: Provided are macrocyclic compounds having a macrocyclic core which has at least one macrocyclic donor and at least one pendant group which has at least one donor group. The macrocyclic compounds can be complexed to Fe(II) and Ni(II). The macrocyclic compounds can be used in imaging methods. For example, the compounds can be used MRI paraCEST contrast agents.

Abstract: A memory cell is disclosed which includes a conductive layer, an insulating layer disposed atop the conducting layer, a semiconductor layer disposed atop the insulating layer, a first electrode coupled to the semiconductor layer, a second electrode coupled to the semiconductor layer, wherein the first and second electrodes are separated from one another and wherein the semiconductor layer extends beyond the first and second electrodes forming a first wing, a third electrode coupled to the conductive layer, a first magnetic tunnel junction (MTJ) disposed on the first wing, and a first read electrode coupled to the first MTJ.

Abstract: The present disclosure relates to support blocks that can be used for decks and foundations fabricated from polymer concrete. Yet further, the present disclosure relates to deck, floor, and foundation systems comprising the disclosed support blocks. The support blocks can mate with or otherwise serve as foundation elements for use in conjunction with construction elements such as posts, joists, stringers, mounting frames, and equipment, among other things.

Abstract: The present document generally relates to additive manufacturing techniques for forming an article having a desired shape and other properties. More particularly, but not exclusively, in one embodiment a method for additive manufacturing an article includes adding a dispersant to an article forming material in the absence of binder to prepare a slurry or suspension including the material and the dispersant. The pH of the slurry may be adjusted to control the viscosity and/or coagulation rate of the slurry. The slurry may then be passed through an extrusion-based three-dimensional printing apparatus to form or print the article in a desired form or shape, and the article may thereafter be sintered. In one aspect, through control of the pH of the slurry, the viscosity and/or coagulation rate properties of the slurry may be tailored for use with different operating parameters of the extrusion-based three-dimensional printing apparatus.

Abstract: A motorised vehicle comprises a first wheel located laterally on a first side of the vehicle, and a second wheel located laterally on a second side of the vehicle opposite the first side. The vehicle comprises a steering system configured to modify the orientation of the wheels and to turn the vehicle. The vehicle comprises a trajectory modifier configured to vary the speed of rotation of the first wheel and to modify the trajectory of the vehicle in the event of failure of the steering system.

Abstract: Compositions, devices, grafts and methods for reducing or preventing anti-neointima following cardiovascular injuries and interventions are disclosed. The compositions, devices, and grafts typically include an effective amount of a CTP synthase 1 inhibitor to reduce proliferation of vascular smooth muscle cells, without substantial reducing the proliferation of endothelial cells. Methods of reducing neointima formation, accelerating re-endothelialization, and reducing restenosis in a subject using the compositions, devices, and grafts are also disclosed.

Abstract: A method of creating a functionally-graded multi-material (FGM) part in multi-material additive manufacturing includes providing a part digitized into voxels, generating a lattice structure having a series of repeating unit cells, where each is the smallest nonrepeating constituent of the lattice structure and is generated by a continuous surface defined by a continuous function. The method further includes taking an inverse volume of the lattice structure within the part, creating a material gradient by varying a thickness of the surface at the boundary between the lattice structure and the inverse volume, assigning one of the two FGM component materials to the voxels in the volume occupied by the lattice structure and assigning the other to the voxels occupied by the inverse volume, outputting the voxels each with a designated material, the lattice structure and the inverse volume forming a mechanical interlock at the interface of the two component materials.

Abstract: A polycyclic aromatic compound in which a plurality of aromatic rings are connected by a boron atom and an oxygen atom, a sulfur atom or a selenium atom and substituted by a specific aryl such as anthracene, is useful as a material for an organic device. By the polycyclic aromatic compound, an organic EL device having at least one of efficiency and device life can be provided.

Abstract: A regulator includes a switch array, a feedback circuit, first and second voltage-controlled oscillators, and a switch driver. The switch array generates an output voltage based on a number of enabled switches from among a plurality of switches. The feedback circuit generates a feedback voltage which depends on a level of the output voltage. The first voltage-controlled oscillator generates a first signal having a first frequency which depends on a difference between a reference voltage and the feedback voltage. The second voltage-controlled oscillator generates a second signal having a second frequency which depends on a difference between the feedback voltage and the reference voltage. The switch driver determines a turn-on time point of each of the plurality of switches based on the first signal and determining a turn-off time point of each of the plurality of switches based on the second signal.

Abstract: A method of making of 1,2,5,6-hexanetetrol (“tetrol”). The method includes the steps of contacting a reaction solution containing water as well as levoglucosenone, dihydrolevoglucosenone, and/or levoglucosanol, with a catalyst containing metal and acid functionalities, at temperature of from about 100° C. to about 175° C., and a hydrogen partial pressure of from about 1 bar to about 50 bar (about 0.1 MPa to about 5 MPa), and for a time wherein at least a portion of the reactant is converted into 1,2,5,6-hexanetetrol.