Patents Assigned to Foundation
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Patent number: 10434068Abstract: A microparticle for cell encapsulation is provided, having a core which comprises continuous fibers of decellularized extracellular matrix (ECM) and, optionally, an outer layer. Also provided are methods of encapsulating cells in the microparticle, pharmaceutical compositions comprising the microparticle, and methods of treating disease in animals employing the microparticles of the invention, for example, treating Diabetes.Type: GrantFiled: September 25, 2018Date of Patent: October 8, 2019Assignee: Technion Research & Development Foundation LimitedInventors: Marcelle Machluf, Deborah Chaimov
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Patent number: 10435755Abstract: Provided herein is technology for esophageal disorder screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of esophageal disorders (e.g., Barrett's esophagus, Barrett's esophageal dysplasia, etc.). In addition, the technology provides methods, compositions and related uses for distinguishing between Barrett's esophagus and Barrett's esophageal dysplasia, and between Barrett's esophageal low-grade dysplasia, Barrett's esophageal high-grade dysplasia, and esophageal adenocarcinoma within samples obtained through endoscopic brushing or nonendoscopic whole esophageal brushing or swabbing using a tethered device (e.g. such as a capsule sponge, balloon, or other device).Type: GrantFiled: March 23, 2016Date of Patent: October 8, 2019Assignees: Exact Sciences Development Company, LLC, Mayo Foundation for Medical Education and ResearchInventors: David A. Ahlquist, William R. Taylor, John B. Kisiel, Douglas W. Mahoney, Tracy C. Yab, Graham P. Lidgard, Hatim T. Allawi
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Patent number: 10437525Abstract: Methods for distributed storage in accordance with embodiments of the invention enable secret sharing. One embodiment includes encoding source data using an encoding system to produce a plurality of sets of encoded data, where: the source data can be recovered from at least a portion of less than all of the plurality of sets of encoded data; and the source data cannot be recovered using less than a threshold number of the plurality of sets of encoded data; storing each of the plurality of sets of encoded data on a storage device from a set of storage devices on which encoded data is stored; determining a set of storage devices that are available using a decoding system, where the set of storage devices that are available does not include all of the storage devices in the set of storage devices on which encoded data is stored.Type: GrantFiled: May 27, 2016Date of Patent: October 8, 2019Assignees: California Institute of Technology, The Research Foundation For the State University of New York, New Jersey Institute of TechnologyInventors: Wentao Huang, Michael Langberg, Joerg Kliewer, Jehoshua Bruck
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Patent number: 10433544Abstract: Provided herein are SDH substrates that have use as herbicides in treating pre-emergent and post-emergent weed control. The presently-disclosed subject matter includes an herbicide including SDH substrates such as ribitol and a growth inhibitive effective amount of another adjuvant SDH substrate and/or adjuvant. Methods of treating pre-emergent and post-emergent weeds comprising applying the herbicides disclosed herein in an effective amount to suppress weed growth are also provided.Type: GrantFiled: March 29, 2017Date of Patent: October 8, 2019Assignee: University of Kentucky Research FoundationInventors: Douglas Archbold, Marta Nosarzewski
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Patent number: 10435068Abstract: A suspension system for a vehicle may include a knuckle rotatably supporting a wheel and a plurality of arms connecting the knuckle with a vehicle body wherein an arm among the plurality of arms may be a virtual link formed by a virtual link module and a point at which the virtual link applies a constraint force to the knuckle may be formed at a virtual space.Type: GrantFiled: August 10, 2017Date of Patent: October 8, 2019Assignees: Hyundai Motor Company, Kia Motors Corporation, Seoul National University R&DB FoundationInventors: Seungmin Kwon, Yong Sub Yi, Seung Hoon Woo, Yoon Young Kim, Suh In Kim
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Patent number: 10435740Abstract: The subject invention pertains to a method of determining methylation state and chromatin structure of target loci. The method comprises treating the genetic material obtained from the cells with DNA methyltransferase, capturing target genetic loci using a set of oligonucleotides, ligating the target loci with oligonucleotide patches that flank the target loci, treating the target loci flanked by oligonucleotide patches with bisulfite, optionally amplifying the target loci by polymerase chain reaction, sequencing the PCR products, and analyzing the sequences to determine methylation state and chromatin structure of the target loci. The current invention also provides a method to identify genes associated with a disease. The invention also provides a method to detect cells suffering from a disease in a group of cells. The current invention also provides kits suitable for carrying out the method of determining methylation state and chromatin structure of the target loci.Type: GrantFiled: April 1, 2014Date of Patent: October 8, 2019Assignee: University of Florida Research Foundation, IncorporatedInventors: Michael P. Kladde, Nancy H. Nabilsi, Carolina E. Pardo
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Patent number: 10434322Abstract: A bio-stimulation robot includes a stationary platform, a plurality of drive modules coupled to the stationary platform, and a motion platform coupled to the drive modules to operate to change a position of the motion platform. Each of the drive modules includes a first guide member having an arc shape, a motion member coupled to the first guide, and a leg member having a first end coupled to the motion member and a second end fixed to the motion platform. The motion member slides along the first guide member. The second end of the leg member is rotatably connected to the motion platform. The second end of the leg member is rotatably connected to the motion platform.Type: GrantFiled: May 17, 2016Date of Patent: October 8, 2019Assignees: Center of Human-Centered Interaction for Coexistence, Industry University-Cooperation Foundation Hanyang University Erica CampusInventors: Sungon Lee, Jun-Woo Kim, Woo-Seok Ryu, Sung-Teak Cho, Hyung-Min Kim, Bum-Jae You
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Patent number: 10438700Abstract: Time-varying hyperglycemic stresses are derived from actual ICU patients and applied to non-critically ill virtual patients, using any model of normal glucose-insulin physiology that fulfills certain requirements, in order to model and simulate stress hyperglycemia. Other aspects provide: 1) a methodology to perform sensitivity analyses of the parameters of ICU insulin infusion therapy protocols and to improve the protocols; and 2) a training system for clinicians about the course and management of stress hyperglycemia in the ICU or other facility.Type: GrantFiled: August 5, 2013Date of Patent: October 8, 2019Assignee: University of Virginia Patent FoundationInventors: Edward A. Ortiz, Stephen D. Patek, Marc D. Breton, Leon S. Farhi, Boris P. Kovatchev
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Patent number: 10437627Abstract: Standard nested virtualization allows a hypervisor to run other hypervisors as guests, i.e. a level-0 (L0) hypervisor can run multiple level-1 (L1) hypervisors, each of which can run multiple level-2 (L2) virtual machines (VMs), with each L2 VM is restricted to run on only one L1 hypervisor. Span provides a Multi-hypervisor VM in which a single VM can simultaneously run on multiple hypervisors, which permits a VM to benefit from different services provided by multiple hypervisors that co-exist on a single physical machine. Span allows (a) the memory footprint of the VM to be shared across two hypervisors, and (b) the responsibility for CPU and I/O scheduling to be distributed among the two hypervisors. Span VMs can achieve performance comparable to traditional (single-hypervisor) nested VMs for common benchmarks.Type: GrantFiled: October 23, 2017Date of Patent: October 8, 2019Assignee: The Research Foundation for the State University of New YorkInventors: Yaohui Hu, Kartik Gopalan
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Patent number: 10440752Abstract: The present disclosure relates to a 5th Generation (5G) or pre-5G system to be provided to support a higher data transfer rate after a 4G communication system such as Long Term Evolution (LTE). The present invention is for performing random access in a wireless communication system, and a base station includes a communication unit for transmitting system information including a plurality of thresholds, and a control unit for determining a random access result for each mode on the basis of a detection result on a preamble transmitted from at least one terminal.Type: GrantFiled: May 26, 2016Date of Patent: October 8, 2019Assignees: Samsung Electronics Co., Ltd., Research & Business Foundation Sungkyunkwan UniversityInventors: Seung-Hoon Park, Min-Gyu Lee, Tae-Jin Lee, Jung-Min Moon, Jungsoo Jung
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Patent number: 10434513Abstract: A method and microfluidic device are provided for containing a droplet having an outer surface at a predetermined location. The microfluidic device includes a plate having an upper surface and a central region communicating with the upper surface. The central region is adapted for receiving a droplet of fluid thereon. The central region includes an outer periphery that defines a first fluid constraint configured for discouraging fluid on the central region from flowing therepast. A second fluid constraint extends about the first fluid constraint. The second fluid constraint is configured for discouraging fluid flowing therepast. A third fluid constraint extends about the second fluid constraint. The third fluid constraint configured for discouraging fluid flowing therepast.Type: GrantFiled: June 8, 2016Date of Patent: October 8, 2019Assignee: Wisconsin Alumni Research FoundationInventors: David J. Beebe, David J. Guckenberger, Jr., Scott M. Berry, Hannah M. Pezzi
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Patent number: 10434083Abstract: Methods for transmammary administration of an analgesic to offspring swine are disclosed, which are useful for mitigating, inhibiting, and/or reducing pain in offspring swine prior to undergoing processing procedures that would cause or result in pain. The methods generally comprise administering, via injection, a cyclooxygenase-2 inhibitor class analgesic directly to a lactating female swine. The analgesic is passed indirectly to the offspring swine through the milk of the treated lactating female swine and has beneficial effects, including increases in weight gain, performance, and decreases in pain. A single dosage form injected into the lactating female is suitable for achieving indirect therapeutically effective levels of the cyclooxygenase-2 inhibitor class analgesic in the milk for the offspring.Type: GrantFiled: February 19, 2019Date of Patent: October 8, 2019Assignee: Iowa State University Research Foundation, Inc.Inventor: Johann F. Coetzee
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Patent number: 10437083Abstract: A mask array apparatus includes a monolithic structure that includes a substrate layer transmissive for at least a portion of an infrared wavelength band and an array of individually addressed pixel structures. Each pixel structure is in stacked relation above or below the substrate layer, and includes at least one micro-plate heating element layer, circuitry, and at least one phase change material (PCM) element. The heating element layer is transmissive for the wavelength band, and has switchable on and off states configured to produce temperature changes. The circuitry is configured to individually address the heating element layer, separately from heating element layers in other pixel structures, to switch the heating element layer between the on and off states. The PCM is in stacked relation above or below the heating element layer and configured to change transmissive states in the wavelength band in response to the temperature changes.Type: GrantFiled: October 20, 2014Date of Patent: October 8, 2019Assignees: Lockheed Martin Corporation, The Penn State Research FoundationInventors: Clara Rivero Baleine, Theresa S. Mayer, Xiaoming Liu, Christina H. Drake
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Patent number: 10434146Abstract: The subject invention relates to methods for improving a subject's vasculature to normalize maternal hemodynamics, particularly in subjects attempting to conceive via assisted reproductive technologies, and comprises increasing relaxin levels in a subject or increasing any one or more of: relaxin synthesis, relaxin receptor synthesis, relaxin binding to the relaxin receptor, or relaxin receptor activity.Type: GrantFiled: June 2, 2016Date of Patent: October 8, 2019Assignee: University of Florida Research Foundation, Inc.Inventor: Kirk P. Conrad
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Patent number: 10434216Abstract: The present invention relates to an ultra-thin film silk fibroin/collagen composite implant for tissue engineering and a manufacturing method therefor. The ultra-thin film silk fibroin/collagen silk fibroin/collagen composite implant according to the present invention has no cytotoxicity and can minimize the influence on cell growth, due to the combined use of a refined silk fibroin aqueous solution, collagen and various biomaterials, and thus can be widely used as an ultra-thin film implant for implanting.Type: GrantFiled: July 10, 2015Date of Patent: October 8, 2019Assignee: Industrial Cooperation Foundation Chonbuk National UniversityInventors: Gil Son Khang, Eun Young Kim, Jae Won Yang, Jeong Eun Song, Se Rom Cha
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Patent number: 10440348Abstract: Embodiments are directed to an optical privatizing device (100), system and methods of use. The device includes a removable frame (101) removably attachable to a sensor housing (1A). A device includes a blurring lens (130) coupled to the removable frame (101) and configured to optically modify light passing to a depth sensor wherein the optical modified light has a privatizing blur level to neutralize a profile of an object sensed by the depth sensor within a working volume of the depth sensor to an unidentifiable state while maintaining a depth parameter sensed by the depth sensor.Type: GrantFiled: March 24, 2016Date of Patent: October 8, 2019Assignee: University of Florida Research Foundation, Inc.Inventors: Sanjeev Jagannatha Koppal, Francesco Pittaluga
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Publication number: 20190305228Abstract: Disclosed is an organic light-emitting compound having a phosphorescent characteristic at room temperature and a phosphorescent organic light-emitting device containing the same.Type: ApplicationFiled: March 28, 2019Publication date: October 3, 2019Applicant: Research & Business Foundation Sungkyunkwan Univer sityInventors: Jun Yeob LEE, Dong Ryun LEE
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Publication number: 20190298514Abstract: A heart valve therapeutic device (1) has an elongate anchor (7) wherein the anchor has a stiffness to hold its shape and location to support the valve element. The anchor may have a stylet or a shaped or stiff collar (70) arranged to provide a desired shape to the anchor (7) and it may be lockable. A prosthetic valve element (15) has leaflets (17) and is supported on the anchor by coupler (16, 50) at a desired location. There is an actuator for changing relative axial position of the proximal and distal couplers (16, 50) on the anchor. The anchor stiffness may be sufficient to provide sufficient support to resist axial forces from the ventricle in use without necessarily having a fixing element engaging heart tissue. The prosthetic leaflets (240) may extend proximally and radially outwardly, so that there is excellent co-apting of the native leaflets (NL) against the prosthetic leaflets (240).Type: ApplicationFiled: June 17, 2019Publication date: October 3, 2019Applicant: The Provost, Fellows Foundation Scholars, and The Other Member of the Board, of the College of the HInventor: Martin QUINN
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Publication number: 20190300532Abstract: The present invention provides a compound having the structure:Type: ApplicationFiled: May 19, 2017Publication date: October 3, 2019Applicant: The Research Foundation for the State University of New YorkInventor: Mark Lukin
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Publication number: 20190302101Abstract: The present invention relates to a use of leucine-zipper protein for diagnosis or treatment of fatty liver. According to the present invention, it could be confirmed that a particular fragment present at the leucine-zipper protein, especially, the N-terminal region thereof, plays an important role in the lipid metabolism in liver tissue by regulating transcriptional activity of Apolipoprotein A4, and therefore, the protein of the present invention or a fragment thereof can be utilized as a target for diagnosis, prevention, or treatment of fatty liver.Type: ApplicationFiled: November 20, 2017Publication date: October 3, 2019Applicant: Korea University Research and Business FoundationInventors: Jesang KO, Min-Soo KANG