Abstract: Provided are multiply functional charged telodendrimers. The telodendrimers can be used for protein encapsulation and delivery. The charged telodendrimers may have one or more crosslinking groups (e.g., boronic acid/catechol reversible crosslinking groups). The telodendrimers can aggregate to form nanoparticles. Cargo such as combinations of proteins and other materials may be sequestered in the core of the nanoparticles via non-covalent or covalent interactions with the telodendrimers. Such nanoparticles may be used in protein delivery applications.

Abstract: The present disclosure relates to a method of analysis by an optical marker, including: irradiating a broadband light source onto a spherical dielectric material; measuring an interference spectrum of reflected light from the spherical dielectric material; and analyzing the reflected light using thin-film interference theory.

Abstract: An apparatus for processing multi-type sensor signals on the basis of multi-modal deep learning, the apparatus including: an individual sensor failure diagnosis unit configured to measure a normality of a sensor output of a single modal sensor at each sampling period, and sense an abnormal operation of the sensor on the basis of the measured normality; an inter-sensor mutual failure diagnosis unit including a multi-modal deep auto encoder, and configured to learn a correlation existing between multi-modalities, extract shared representation between modalities from multi-modal inputs on the basis of the learned correlation, and perform an inter-sensor mutual failure diagnosis; and a reconstruction target sensor output value reconstructing unit configured to, when an output value of a specific sensor is missing, predict and reconstruct the output value of the sensor using other sensor information using the shared representation extracted from other modal sensors.

Abstract: Clostridium difficile infection is the leading cause of hospital acquired antibiotic-associated diarrhea in the US (Bartlett, in 2006). The increased prevalence of circulating C. difficile strains poses a significant health threat to US health care facilities. Strains expressing the toxin C. difficile Transferase (CDT), in addition to Toxins A and B (TcdA and TcdB), are more virulent and are associated with higher mortality rates (Bacci et al., 2011). We recently identified a protective role for eosinophils against C. difficile pathogenesis (Buonomo et al., 2016). We have also defined CDT's ability to increase host inflammation and suppress protective eosinophils through a TLR2 dependent mechanism (Cowardin et al., 2016). How CDT promotes virulence and eosinophil suppression via TLR2 is still under investigation.

Abstract: Provided are a method and apparatus for manufacturing a radiation beam intensity modulator.

Abstract: Provided are a cell carrier for skin tissue regeneration using chitooligosaccharide and a method for producing the same. The cell carrier according to the present invention includes fish-derived collagen (FC), alginate (A), and chitooligosaccharide (COS1) of 1 to 3 kDa, and thus has excellent biocompatibility with dermal fibroblasts and has an excellent effect of being utilized as a cell carrier for skin tissue regeneration.

Abstract: A high-order optical fiber multi-wavelength filter includes a polarization beam splitter configured to form a polarization-diversity loop configuration by splitting light received from a broadband light source into two polarization components, combining circulated and input light of the two polarization components, and outputting the combined light, a pair of polarization controllers each including at least one wave plate in combination, and configured to change a polarization state of input light, and a pair of polarization-maintaining fibers configured to form interference spectrums by assigning phase differences through birefringence.

Abstract: Disclosed are a network coding method and apparatus for reliable communication in a LoRa communication system. The network coding apparatus may include a network server connected to an end node over a network to receive a packet transmitted by the end node in a LoRa communication system, a stationary gateway positioned between the network server and the end node to deliver the packet, transmitted by the end node, to the network server, and a temporary gateway positioned between the stationary gateway and the end node to deliver the packet, transmitted by the end node, to the stationary gateway.

Abstract: Single crystals of the new semiconducting oxychalcogenide phase were synthesized using a novel crystal growth method. The crystals had low defects and homogeneous composition as characterized by single crystal X-ray diffraction and scanning electron microscopy, respectively. Heat capacity and resistivity measurements were in agreement with the calculated band structure calculations indicating semiconductivity, with a band gap of about 3 eV.

Abstract: The invention provides for isolated population of pulp marrow similar cells (DPMSCs) and methods for isolating and using these cells. The population of DPMSCs are highly homogenous for CD10, CD29, CD13, CD44, CD49a, CD49d, CD59, CD73, CDw90, CD105, Oct-4 Isoform A and B, Nanog, Sox-2, and SSEA-4.

Abstract: An autophagic cell targeted peptide and its use are described. More particularly, a polypeptide comprising an amino acid sequence represented by the general formula (I) and specifically binding to an autophagic cell and a composition for detecting autophagic cells comprising the same as an active ingredient are described. Also described are a drug delivery composition containing the same peptide as an active ingredient and a composition for imaging comprising the same peptide as an active ingredient. The peptide specifically binds to the cell membrane of autophagic cells and can be applied to various kinds of tissues and cells. The detection and imaging effect of autophagy is remarkable in vitro and in vivo.

Abstract: A method includes receiving, by a server computer, a selection of patient records. The method further includes aggregating the patient records by geographic unit based on at least one healthcare metric. In addition, the method includes accessing a map of a geographic region covered by the selected patient records. Further, the method includes annotating the map based on a geographic variance of the at least one healthcare metric. The method also includes receiving, by the server computer, a selection of at least one environmental factor. Additionally, the method includes aggregating, by the server computer, environmental data for the environmental factor by the geographic unit. The method further includes annotating the map based on a geographic variance of the environmental factor.

Abstract: Methods for typing a strain of an organism are provided, the methods comprising the steps of amplifying, in a single reaction mixture containing nucleic acid from the organism, dividing the reaction mixture into a plurality of sets of second-stage reaction wells, each set of second-stage reaction wells containing a different pair of second-stage primers, subjecting each of the second-stage reaction wells to amplification conditions to generate a plurality of second-stage amplicons, melting the second-stage amplicons to generate a melting curve for each second-stage amplicon, and identifying the strain of the organism from the melting curves.

Abstract: Described are stable nanoparticle complexes comprising paclitaxel, albumin and alemtuzumab. The nanoparticle complexes are suitable for the treatment of cancer.

Abstract: A metal fin tube foundation includes a pair of coupled metal plates, each plate being comprised of a plurality of flat panels, wherein each panel is positioned at an angle relative to an adjacent panel, and each plate including a fin on each lateral end of each plate, wherein each fin overlaps a fin of the other metal plate forming two pairs of overlapped fins, wherein the plates are coupled along each of the two pairs of overlapped fins; wherein the plurality of panels of the coupled two metal plates form a closed perimeter polygon shape having an open interior and wherein each pair of overlapped fins form a combined fin element which extends away from the perimeter of the polygon.

Abstract: A composition is provided that comprises a therapeutic agent encapsulated by a milk-derived microvesicle. The compositions can include therapeutic agents such as phytochemical agents or chemotherapeutic agents, while the milk-derived microvesicle can be derived from raw milk or colostrum. Further provided are methods for isolating a microvesicle that includes the steps of obtaining an amount of milk, and subjecting the milk to a series of sequential centrifugations configured to yield greater than about 300 mg of microvesicle protein per 100 ml of milk. Methods of modifying an immune response and treating a cancer in which a milk-derived microvesicle composition is administered are also provided.

Abstract: Provided herein are cyclodecynes, including chiral cyclodecynes, and methods of making cyclodecynes. The methods may include providing a 1,1?-biaryl compound substituted independently at the 2-position and the 2?-position with a hydroxyl or an amino group; and contacting the 1,1?-biaryl compound with a protected but-2-yne-1,4-diol to form the cyclodecyne.

Abstract: The current invention is directed to a class of compounds that inhibit the function of Thymidylate synthase. Thymidylate synthase inhibition was noted to result in inhibition of tumor cell grow and killing of tumor cells. Thymidylate synthase inhibition is, thus, useful for treatment of various types of cancers, including but not limited to, acute lymphoblatic leukemia (ALL), acute myelogenous leukemia (AML), acute promyelocytic leukemia, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute monocytic leukemia (AMOL), hairy cell leukemia, large cell immunoblastic lymphoma, plasmacytoma, multiple myeloma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, leukemia, brain cancer, lung cancer, central nervous system (CNS) cancer, melanoma, renal cancer, prostate cancer, colon cancer, ovarian cancer and breast cancer. The compounds disclosed herein can be used alone or in combination with other cancer treatment regimens (e.g.

Abstract: A method is provided for deep tissue imaging using multi-photon excitation of a fluorescent agent. The fluorescent agent is irradiated with an ultrafast laser to produce an excited singlet state (Sn) which subsequently undergoes non-radiative relaxation to a first singlet state (S1). The S1 state undergoes fluorescence to the ground state S0 to produce an emission wavelength. Both the excitation and emission wavelengths are within the near infrared optical window, thereby permitting deep tissue penetration for both the incoming and outgoing signals.

Abstract: Devices, systems, and methods for determining a distance between at least two points are disclosed and described, wherein interferometry technology is utilized to determine such distances.