Abstract: Systems and methods are described herein for predictive heart valve simulation. The systems and methods described herein can include segmenting anatomical region of a heart of a patient from image data characterizing the heart of the patient. Anatomical model data that can include three-dimensional shapes of the anatomical regions of the heart can be generated based on the image data. The anatomical model data can be used to generate anatomical model data. The analytical model data can include a three-dimensional mesh of the anatomical regions of the heart. A deformed analytical model that can be indicative of a deformed position of the anatomical regions of the heart and a deformed position of the surgical object can be generated based on the analytical model data.
Abstract: The present invention relates to a method for pretreating lignocellulose by using an acid-base mixture catalyst. The method pretreats lignocellulose, by using a mixture catalyst of an acid and a base, so as not to pass through additional neutralization steps, and carries out pretreatment and simultaneous saccharification and fermentation through an identical single reactor process, thereby having an effect of producing ethanol in an excellent production yield from lignocellulosic biomass while simplifying the total process and reducing equipment costs and total processing costs.
Type:
Application
Filed:
June 20, 2019
Publication date:
October 3, 2019
Applicant:
Korea University Research and Business Foundation
Abstract: This document relates to methods and materials for identifying and/or treating mammals having cancer (e.g., a SCD1-associated cancer). For example, methods and materials for using one or more stearoyl CoA desaturase 1 (SCD1) polypeptide inhibitors to treat a mammal having cancer (e.g., a SCD1-associated cancer) are provided.
Type:
Application
Filed:
March 28, 2019
Publication date:
October 3, 2019
Applicant:
Mayo Foundation for Medical Education and Research
Abstract: This disclosure provides method and kit for myocardial reperfusion and method for attenuating or reducing myocardial reperfusion injury. By administering protein tyrosine phosphatases inhibitor or a protein tyrosine kinases activator, cardiac injury caused by ischemia/reperfusion will be attenuated or reduced.
Type:
Application
Filed:
March 28, 2019
Publication date:
October 3, 2019
Applicants:
Academia Sinica, Buddhist Tzu Chi Medical Foundation
Inventors:
Tzu-Ching Meng, Chiu-Fen Yang, Michael Yu-Chih Chen
Abstract: This invention provides minimally invasive methods, reagents, diagnostic and prognostic markers useful for staging, prognosis and surveillance of colorectal cancers, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.
Type:
Application
Filed:
June 12, 2017
Publication date:
October 3, 2019
Applicant:
Wisconsin Alumni Research Foundation
Inventors:
Michael Richard Sussman, Melanie Mae Ivancic, Gregory D Kennedy, William Franklin Dove, Perry Joseph Pickhardt, Mark Reichelderfer
Abstract: Described herein is a chelator for radiolabels (e.g., 89Zr) for targeted PET imaging that is an alternative to DFO. In certain embodiments, the chelator for 89Zr is the ligand, 3,4,3-(LI-1,2-HOPO) (“HOPO”), which exhibits equal or superior stability compared to DFO in chemical and biological assays across a period of several days in vivo. As shown in FIG. 1, the HOPO is an octadentate chelator that stabilizes chelation of radiolabels (e.g., 89Zr). A bifunctional ligand comprising p-SCN-Bn-HOPO is shown in FIG. 4 and FIG. 5. Such a bifunctional ligand can eliminate (e.g., 89Zr) loss from the chelate in vivo and reduce uptake in bone and non-target tissue. Therefore, the bifunctional HOPO ligand can facilitate safer and improved PET imaging with radiolabeled antibodies.
Type:
Application
Filed:
September 9, 2016
Publication date:
October 3, 2019
Applicants:
Memorial Sloan Kettering Cancer Center, Research Foundation of the City University of New York
Inventors:
Jason S. Lewis, Melissa Deri, Lynn Francesconi, Shashikanth Ponnala
Abstract: Provided is a speech enhancement method and a system therefor. The speech enhancement method includes receiving at least one speech signal; generating a first speech signal by performing a primary speech enhancement on the at least one speech signal; selecting a noise removing gain corresponding to the first speech signal from pre-learned noise removing gain information; and generating a second speech signal by performing a secondary speech enhancement on the first speech signal based on the selected noise removing gain.
Type:
Grant
Filed:
September 23, 2015
Date of Patent:
October 1, 2019
Assignees:
Samsung Electronics Co., Ltd, Industry-University Cooperation Foundation Hanyang University
Inventors:
Seung-yeol Lee, Joon-hyuk Chang, Byeong-seob Ko, Song-kyu Park, Tae-jun Park
Abstract: Provided is a light scattering cell classification technology which can classify cells into various types and at the same time classify cells with very high accuracy despite the rotation of the cells. A cell analysis apparatus using a plurality of lasers, according to an embodiment of the present invention, comprises: a plurality of laser generators which are installed around a movement path through which cells to be classified are moved, and which irradiate laser beams at one measurement point on the movement path at different angles; a plurality of photodetectors, installed around the one measurement point, which collect a second laser beam, which is a laser beam generated as the laser beams irradiated from the laser generators are incident on the cells and then scattered; and a cell analysis unit which classifies the cells to be classified according to the second laser beam collected by the photodetectors.
Type:
Grant
Filed:
October 28, 2015
Date of Patent:
October 1, 2019
Assignee:
The Catholic University of Korea Industry—Academic Cooperation Foundation
Abstract: System and method directed towards providing full and even illumination of a patient's retina through lighting integrated into a handheld fundus lens. By integrating the lighting, the method and system reduces and even eliminate many lens artifacts and reflections. By increasing the accuracy, quality, and field of view afforded during clinical examination of the retina, the method and system will allow practitioners to make more accurate diagnoses and will increase safety during retinal surgical procedures.
Type:
Grant
Filed:
January 12, 2018
Date of Patent:
October 1, 2019
Assignee:
University of Virginia Patent Foundation
Abstract: The disclosure provides helix grafted proteins, methods of producing helix grafted proteins and methods of use of helix grafted proteins as inhibitors of protein-protein interactions involved in disease pathogenesis.
Type:
Grant
Filed:
November 9, 2015
Date of Patent:
October 1, 2019
Assignee:
Colorodo State University Research Foundation
Inventors:
Brian R. McNaughton, Susanne N. Walker, Rachel L. Tennyson, Alan J. Kennan
Abstract: The invention relates to nucleic acids encoding a p-coumaroyl-CoA:monolignol transferase and to inhibitory nucleic acids adapted to inhibit the expression and/or translation of a p-coumaroyl-CoA:monolignol transferase RNA. Inhibition of p-coumaroyl-CoA:monolignol transferase in plants improves the incorporation of monolignol ferulates into the lignin of plants, giving rise to plant biomass that is more easily processed into useful products such as paper and biofuels.
Type:
Grant
Filed:
December 14, 2012
Date of Patent:
October 1, 2019
Assignees:
Board of Trustees of Michigan State University, Wisconsin Alumni Research Foundation, The Board of Trustees of Illinois State University
Inventors:
Curtis Wilkerson, John Ralph, Saunia Withers, John Sedbrook
Abstract: The present invention relates to a compound represented by the general formula (A), a base generator comprising the compound, a base-reactive composition which comprises the base generator and a base-reactive compound, as well as a method for generating a base, etc.
Type:
Grant
Filed:
June 25, 2014
Date of Patent:
October 1, 2019
Assignees:
FUJIFILM Wako Pure Chemical Corporation, Tokyo University of Science Foundation
Inventors:
Nobuhiko Sakai, Kosuke Yanaba, Koji Arimitsu
Abstract: An imaging system can include an optical fiber and a light source for providing optical stimulation to a region of interest along the optical fiber. A camera can capture emission such as fluorescence resulting from the optical stimulation. A cannula configured for implantation into a subject can be configured to direct the emission from the subject. A mating sleeve coupling the cannula to the optical fiber, and configured to support the camera, can include a dichroic mirror to allow the optical stimulation to pass from the optical fiber to the cannula and to redirect the emission from the cannula to the camera.
Abstract: An RF coil structure used for a magnetic resonance imaging (MRI) system includes an RF shield, an RF coil provided inside the RF shield, and a high dielectric material arranged between the RF shield and the RF coil, in which an interval between the RF shield and the RF coil is changed or a thickness of the high dielectric material is changed.
Type:
Grant
Filed:
January 2, 2015
Date of Patent:
October 1, 2019
Assignees:
Samsung Electronics Co., Ltd., Samsung Life Public Welfare Foundation
Abstract: A peptide comprising the rhinovirus immunogen peptide of the rhinovirus structural protein 1 (VP1) of rhinovirus C and related vaccines and therapeutic compositions is disclosed.
Type:
Grant
Filed:
April 19, 2017
Date of Patent:
October 1, 2019
Assignees:
Wisconsin Alumni Research Foundation, Purdue Research Foundation
Inventors:
Ann C. Palmenberg, Marchel Goldsby Hill, Kelly Elizabeth Watters, Michael G. Rossman, Yue Liu
Abstract: Provided is a self-repairing energy generating element using a shape memory polymer, including a first electrode; a shape memory friction layer made of the shape memory polymer on the first electrode and having a microbump pattern formed on a surface thereof; a second electrode disposed apart from the shape memory friction layer; and an opposing layer formed on the second electrode and configured to face the shape memory friction layer.
Type:
Grant
Filed:
September 23, 2015
Date of Patent:
October 1, 2019
Assignee:
Research & Business Foundation Sungkyunkwan University
Inventors:
Sang-Woo Kim, Jeong Hwan Lee, Hey Jung Park, Keun Young Lee, Sang Hyun Kim
Abstract: A process to produce an aqueous solution of carbohydrates that contains C6-sugar-containing oligomers, C6 sugar monomers, C5-sugar-containing oligomers, C5 sugar monomers, or any combination thereof is presented. The process includes the steps of reacting biomass or a biomass-derived reactant with a solvent system including a lactone and water, and an acid catalyst. The reaction yields a product mixture containing water-soluble C6-sugar-containing oligomers, C6-sugar monomers, C5-sugar-containing oligomers, C5-sugar monomers, or any combination thereof.
Type:
Grant
Filed:
June 28, 2017
Date of Patent:
October 1, 2019
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
James A. Dumesic, Jeremy S. Luterbacher
Abstract: The invention encompasses methods of treating a patient with cancer, such as glioblastoma. The methods may include the administration of one or more pharmaceutical compositions that are capable of inhibiting TROY to treat the patient with cancer.
Type:
Grant
Filed:
December 14, 2017
Date of Patent:
October 1, 2019
Assignees:
The Translational Genomics Research Institute, Mayo Foundation for Medical Education and Research
Inventors:
Nhan Tran, Joseph C. Loftus, Harshil Dhruv
Abstract: The present invention relates to a first intraocular lens (120) embodiment having a retainer plate (124) with an annular region surrounding a central opening and an optical lens (122) removably attached to the retainer plate within the central opening. Also disclosed is a second intraocular lens embodiment having a retainer plate with a porous or perforated annular region surrounding a central opening. An optical lens (122) is integral with the retainer plate (124) within the central opening. Methods of implanting these intraocular lens (120) embodiments into a patient's eye are disclosed. Also described here are methods of replacing the first intraocular lens embodiment after it has been implanted in a patient's eye.
Type:
Grant
Filed:
July 21, 2005
Date of Patent:
October 1, 2019
Assignees:
University of Houston, Cornell Research Foundation, Inc.
Abstract: Systems and methods for determining body weight predictions and human conditions are disclosed. A body weight may be predicted by capturing at least one image of a human, and determining, from the image, a body weight prediction of the human by processing the at least one image with a data processor. The body weight prediction may further be based on an age-based weight factor. A model such as a neural network model may be used to predict body weight.
Type:
Grant
Filed:
October 1, 2014
Date of Patent:
October 1, 2019
Assignee:
University of Kentucky Research Foundation