Abstract: A coupled via structure includes a plate via penetrating through an board body and having first and second plates spaced apart from each other by a first gap distance, a contact pad connected to the plate via on a surface of the board body and having first and second contacts connected to the first and second plates, respectively, and a connection line connected to the contact pad on the surface of the board body and having first and second lines connected to the first and second contacts, respectively, and spaced apart from the first line by a second gap distance. Accordingly, the deviation of the characteristic impedance is reduced (or, alternatively, minimized) between the coupled via structure and the coupled signal line.

Abstract: The present invention relates to a method of differentiating neural stem cells or neural precursor cells into dopamine neurons and more particularly, a method of differentiating into dopamine neurons, in which chromosomal stability is maintained by transfecting neural stem cells or neural precursor cells with mRNA of a dopamine neuron-inducing transcription factor under time-based control. The method of differentiating into dopamine neurons, according to the present invention, may enable preparation of mature and functional dopamine neurons having chromosomal stability by synthesizing a dopamine neuron-inducing transcription factor into a mRNA form, which has no risk of genetic modification, and transfecting the synthetic mRNA, unlike existing methods using retroviral vectors, and thus may be usefully used in the clinical field for the treatment of Parkinson's disease.

Abstract: The present disclosure relates to a resistive random access memory device and a preparing method thereof.

Abstract: Disclosed herein are functionalized hyaluronic acid (HA), a responsive elastic polymer system comprising functionalized HA, and methods of fabrication and utilization of the same. This polymer system may be used for controlled local or systemic drug delivery release of analgesics, anesthetics, antibiotics and other drugs as well as tissue engineering articles.

Abstract: Apparatuses and methods are provided to predict or diagnose an ischemic event, such as a stroke or a transient ischemic attack (TIA). A machine-learning model such as a neural network is generated that allows for recognition of an ECG consistent with an ischemic event. A system is trained and used to process a recording of ECG data from a patient to generate a prediction indicating a likelihood that the patient will experience a stroke. In other examples, a system is trained and used to process a recording of ECG data from a patient and detect an ischemic event for the patient who did not appear to have such an ischemic event.

Abstract: A microneedle patch includes: a patch layer which is a flat layer; and a microneedle which is disposed on one surface of the patch layer, includes an air-pocket therein, and formed of a polymer having at least one of swellability and solubility. The air-pocket is disposed in a lower end of the microneedle which is in contact with the patch layer. The patch layer includes a needle layer on one surface of the patch layer, and the microneedle is disposed on an opposite surface to one surface of the needle layer which is in contact with the patch layer.

Abstract: A composition of an omega-3 polyunsaturated fatty acid (PUFA)-taxoid conjugate formulated in an oil-in-water nanoemulsion (NE) drug delivery system in combination with an immune-oncology (IO) agent to enhance therapeutic efficacy in refractory cancers, such as PDAC. A method of treating cancer, by administering an effective amount of a pharmaceutical composition including an omega03 PUFA-taxoid conjugate in combination with an IO agent encapsulated in an NE drug delivery system to a subject in need of treatment, and treating cancer.

Abstract: Provided are a method of ex-vivo culture of natural killer (NK) cells by treating the cells with a reactive oxygen species (ROS) inhibitor and/or a p53 protein inhibitor; and a composition comprising the cultured NK cells. By reducing the activity of ROS and p53 proteins during ex-vivo culture, NK cells may have achieved greater expansion efficiency without altering their anti-tumor cytotoxicity.

Abstract: This document provides bioartificial liver (BAL) devices. Methods for making and using BAL devices also are provided.

Abstract: An improved DC circuit breaker is provided for automatically detecting and isolating a fault between a source and a ground. The DC circuit breaker comprises at least one switch, in electrical series with a first inductor between the source and a load, and a second inductor magnetically coupled to the first inductor wherein a first side of the second inductor is electrically connected to the load and a second side of the second inductor is grounded through a capacitor.

Abstract: A photoelectric conversion device may include a substrate, a photoactive layer disposed on the substrate, and a first electrode and a second electrode respectively connected to corresponding edges of the photoactive layer. The photoactive layer may include a first oxide semiconductor layer on the substrate, and a plurality of quantum dot layers and a plurality of second oxide semiconductor layers that are alternately formed on the first oxide semiconductor layer.

Abstract: The present disclosure provides methods for accurately predicting the dynamics of symptom response to drugs or other interventions for the treatment of major depressive disorder or other psychological conditions. These methods can allow for a shortening of the time period necessary for the evaluation of a drug or other therapeutic intervention. These predictive methods are based on measured and/or self-reported symptom severity measures at two or more points in time. These measures are then discretized into symptom classes (e.g., low, moderate, severe) and the symptom classes are then applied to the predictive model to predict the progression of symptoms and/or the effectiveness of a drug or other therapeutic intervention.

Abstract: This document provides methods and materials involved in treating cardiovascular conditions such as calcific aortic valve stenosis. For example, methods and materials for using sGC agonists or a combination of sGC agonists and PDE5A inhibitors to reduce calcification of heart valves and/or vessels or to slow progression of aortic sclerosis to calcific aortic valve stenosis are provided.

Abstract: A system for detecting fake information about a vehicle location may include a radio signal receiver configured to receive a radio signal from a communication system; a message receiver configured to receive the radio signal to generate a message and determine the message to generate information about a location of the communication system; a radio signal incident angle calculator configured to generate a radio signal incident angle; an azimuth calculator configured to generate a location information azimuth angle by use of the information about locations of the communication system and a receiving vehicle, and a fake vehicle generated by the communication system; and a location information fake detector configured to determine whether location information of the fake vehicle is faked by use of a difference value between an angle corresponding to a reference axis of the location information azimuth angle and the location information azimuth angle.

Abstract: Disclosed is a trajectory data processing method and system. The trajectory data processing method includes, in response to a smoothing instruction related to a trajectory of a moving object being generated by a web application server, identifying trajectory data associated with the trajectory, smoothing the trajectory by applying a selected algorithm to the trajectory data, and providing the web application server with a smoothed trajectory generated by the smoothing.

Abstract: A method is provided for treating a rare earth metal-bearing scrap material by melting an extractant selected from the group consisting of bismuth (Bi) and lead (Pb) and contacting the melted extractant and the scrap material at a temperature and time to recover at least one of the light rare earth metal content and the heavy rare earth metal content as a metallic extractant alloy, which can be subjected to vacuum distillation or sublimation to recover the rare earth metal(s). The method can be practiced to recover the light rare earth metal content and the heavy rare earth metal content concurrently in a one-step process or separately and sequentially in a two-step process.

Abstract: The present invention provides a new therapeutic method for modeling neuronal responses. Human induced pluripotent stem cells (hiPSCs) emerge recently as alternative sources of primary brain cells to establish Alzheimer's disease (AD) models in vitro. While previous investigations demonstrate the potential of hiPSCs in modeling AD, the 2-D cultures used in these studies cannot fully recapitulate AD-associated neuropathology. 3-D cortical spheroids (forebrain-like structure) were derived from human induced pluripotent stem cells in a bioreactor culture, which can be used to recapitulate AD-associated neuropathology, to screen the therapeutic drugs and to predict neurotoxicity.

Abstract: Disclosed is a phase-shifted square wave modulation technique for single-phase and three-phase IM2DC applications in HVDC/MVDC systems. A square wave based modulation waveform is applied to each cell of IM2DC and compared to the phase-shifted carrier waveforms to generate device gate signals. As a result, a higher equivalent switching frequency can be achieved, and square wave based arm and AC link waveforms will be generated. In addition, power flow of IM2DC can be controlled by a phase shift angle of the square modulation waveforms between HVS and LVS. The converter cell capacitors can be reduced in size because they are only required to smooth high switching frequency ripple components. In addition, lower TDR can be achieved due to the higher power transferring capability of square waves.

Abstract: Trace data are compressed by storing a compression table in a memory. The table corresponds to results of processing a set of training trace data using a table-driven compression algorithm. The trace data are compressed using the table according to the algorithm. The stored compression table is accessed read-only. The table can be determined by automatically processing a set of training trace data using the algorithm and transforming the compression table produced thereby into a lookup-efficient form. A network device includes a network interface, memory, and a processor that stores the table in the memory, compresses the trace data using the stored compression table according to the table-driven compression algorithm, the stored table being accessed read-only during the compressing, and transmits the compressed trace data via the network interface.

Abstract: A mobile robot to which a shadow removal method and system for surveillance camera-based mobile robot control according to the present invention is applied acquires images from two closely installed surveillance cameras indoors and performs shadow removal at an improved speed compared to the conventional speed, to recognize the obstacle in the image to avoid it and travel. It is anticipated that through the mobile robot using the surveillance camera-based shadow removal method and system of the present invention, the practical use of an intelligent image surveillance system that can automatically analyze images and recognize a dangerous situation to take quick action may be accelerated.