Abstract: This invention relates to 4-substituted isoquinoline compounds and their derivatives and uses thereof for treatment of cancer, for example, acute myeloid leukemia.

Abstract: Disclosed are an inductor layout and an integrated circuit device with improved isolation between inductors through shielding magnetic coupling between the inductors. first and second inductor coils are horizontally spaced apart from each other. A conductor loop is disposed in parallel above the first inductor coil and shields magnetic coupling between the first and second inductor coils in the manner that a part of magnetic flux of a first time-varying magnetic field generated by the second inductor coil is cancelled by magnetic flux of a second magnetic field generated by an induction current that flows in the conductor loop magnetically interlinked with the first time-varying magnetic field. The inductor layout can be applied to an RFIC device to reduce magnetic coupling between inductors of a power amplifier and an oscillator. Improved performance of the device and a very small RFIC can be achieved.

Abstract: A method of calibrating a crank arm-mounted power meter includes receiving an angle measurement from a first sensor disposed on a crank arm, the angle measurement corresponding to an angular orientation of the crank arm. A predicted load measurement is then calculated based on the angle measurement and weight data for the crank assembly including the crank arm and stored in memory. A load measurement corresponding to a load on the crank arm is obtained and a zero offset value is then calculated by determining a difference between the predicted load measurement and the load measurement. Power calculation logic for determining power applied to the crank arm is then updated using the zero offset value.

Abstract: This document provides methods and materials for using low coverage whole genome sequencing techniques to assess genomes. For example, methods and materials for using targeted nucleic acid amplification and/or capture techniques in combination with low coverage whole genome sequencing techniques to obtain high coverage sequencing data for one or more pre-selected regions of a genome are provided.

Abstract: Some embodiments of the present invention intend to provide a method and an apparatus for diagnosing health state of a 3D printer which collects collection data in a 3D printing process by using sensors attached to the 3D printer (for example, an acceleration sensor and an acoustic emission sensor), extracts feature elements of the sensor data, applies machine learning to an equipment health state diagnosis model based on the extracted feature elements, and thereby enables diagnosing equipment health state of 3D printer components in an objective and consistent manner.

Abstract: An apparatus for blacklisting a local channel in an Internet-of-Things (IoT) multi-hop network includes: a local blacklist creator configured to create a blacklist based on channel quality estimation (CQE) value; an energy detection performer configured to transmit a scanned received signal strength indicator (RSSI) value to a non-intrusive channel quality measurer; the non-intrusive channel quality measurer configured to calculate channel quality information and transmit the calculated channel quality information to the local blacklist creator; a nearby neighboring node information manager configured to receive a local blacklist from the local blacklist creator and store the local blacklist with a blacklist of a communication partner node; a frequency selector configured to receive a created link mask from the nearby neighboring node information manager and allow for communication considering the link mask in a case of a dedicated slot.

Abstract: An assay and a method for identifying a prebiotic to treat a subject in need thereof to promote intestinal barrier integrity or to blunt an inflammatory response are provided.

Abstract: Disclosed are a medical device apparatus, system, and method. A method includes receiving biometric information, by an external device external to a body of a user, of the user from an internal device within the body of the user, and wirelessly transmitting stimulus information configured to specify a stimulus based on the biometric information, and power to the internal device configured to drive the internal device and to apply the stimulus in response to the transmitted stimulus information. A method also includes wirelessly transmitting, from an internal device in a body of a user, biometric information of the user to an external device located outside the body of the user, and wirelessly receiving from the external device stimulus information configured to specify a stimulus, and power configured to drive the internal device and to apply the stimulus to the user in response to the received stimulus information.

Abstract: Provided is a surface structure having freezing-delaying performance and freezing layer-separating performance. The surface structure includes a microstructural layer formed in the form of microscale irregularities and a plurality of nanopores formed in the microstructural layer. A freezing-delaying layer is formed on a surface of the microstructural layer to delay a freezing phenomenon. Also, a hygroscopic material is accommodated in the nanopores, so that when a surface of the freezing-delaying layer starts to freeze, the hygroscopic material is discharged from the nanopores to form a hygroscopic material film, and thus adhesion between the freezing-delaying layer and ice is reduced to allow the ice to be detached from the freezing-delaying layer.

Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer.

Abstract: A method including receiving one or more datasets of audio data of a key child captured in a natural sound environment of the key child. The method also includes segmenting each of the one or more datasets of audio data to create audio segments. The audio segments include cry-related segments and non-cry segments. The method additionally includes determining periods of the cry-related segments that satisfy one or more threshold non-sparsity criteria. The method further includes performing a classification on the periods to classify each of the periods as either a cry period or a fussiness period. Other embodiments are described.

Abstract: The present invention relates to a polymeric hollow fiber membrane and a carbon molecular sieve hollow fiber membrane, both of which have excellent gas separation performance, and processes for preparing the same. Specifically, the present invention relates to a hybrid polymeric hollow fiber membrane that comprises a glassy polymer containing fluorine and a ladder-structured polysilsesquioxane, a hybrid carbon molecular sieve hollow fiber membrane prepared by pyrolysis thereof, and processes for preparing the same. The hybrid polymeric hollow fiber membrane and the hybrid carbon molecular sieve hollow fiber membrane according to the embodiments of the present invention are excellent in gas flux and selectivity and can have a large surface area per unit volume. Thus, they can be advantageously used for separating gases with a high energy efficiency on a large scale.

Abstract: By introducing deuterium at a natural abundance ratio or higher into a novel polycyclic aromatic compound in which a plurality of aromatic rings is linked via a boron atom, an oxygen atom, or the like, options of a material for an organic device such as a material for an organic EL element are increased. Furthermore, by using a novel deuterium-substituted polycyclic aromatic compound as a material for an organic EL element, for example, an organic EL element having excellent luminous efficiency and element lifetime is provided.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating diabetes, and controlling a side effect from peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation, wherein the pharmaceutical composition comprises (a) an amodiaquine compound or a pharmaceutically acceptable salt thereof and (b) an antidiabetic drug as active ingredients. Specifically, the composition prevents or treats simultaneously one or more selected from the group consisting of type 2 diabetes reactive to PPAR-gamma activation, and obesity, dyslipidemia, cardiovascular diseases, and fatty cirrhosis reactive to peroxisome proliferator-activated receptor-alpha (PPAR-alpha) activation.

Abstract: Provided herein are compositions and methods related to treating repeat expansion diseases that feature the sequestration of Muscleblind-like (MBNL) proteins by the toxic repeat RNA transcripts within distinct nuclear foci that are expressed from the expanded repeat tracts. Certain compositions of synthetic MBLN proteins can be used to displace endogenous MBNL from the toxic RNAs or replace endogenous MBNL within the cell for normal function.

Abstract: A system for directing the motion of a vehicle, comprising receiving commands in natural language using a processor, the commands specifying a relative path to be taken by the vehicle with respect to other objects in the environment; and determining an absolute path for the vehicle to follow based on the relative path using the processor, the absolute path comprising a series of coordinates in the environment; and directing the vehicle along the absolute path. Also provided is a system for training a lexicon of a natural language processing system, comprising receiving a data set containing a corpus of absolute paths driven by a vehicle annotated with natural language descriptions of the absolute paths using a processor, and determining parameters of the lexicon based on the data set.

Abstract: An apparatus for managing deterministic and synchronous multi-channel extension (DSME) network fluctuations in an industrial wireless sensor network includes: a network congestion rate measurer configured to measure a network congestion rate on the basis of a number of times an association request message is received and a number of times carrier sensing is performed, a DSME-guaranteed time slot (GTS) allocation information collector configured to continuously collect DSME-GTS allocation information using coordinators, a DSME-GTS maintenance determiner configured to determine whether to maintain or collect DSME-GTSs on the basis of collected network information, a slot reallocation determiner configured to determine whether data is received without collision from two nodes to which a slot is redundantly allocated and transmit a DSME-GTS expiration request to a sensor node for reallocation of empty slots.

Abstract: The present disclosure relates to novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide, and methods to make and use the novel cleavable conjugates of antibiotics and an antibacterial cell-penetrating peptide.

Abstract: A thermally releasable adhesive member including a base resin and microcapsules dispersed and disposed in the base resin. The microcapsule includes a core part, a shell part wrapping the core part, and an organic solvent disposed in the core part, and an average diameter of the microcapsules is in a range from about 50 nm to about 500 nm. The adhesive member may maintain high optical transmittance and may be easily detached at a high temperature.

Abstract: The geo-security method and system uses spatio-temporal radio channel information during authentication to grant permission to access, use and/or operate the intended device. The geo-security method and system uses a wideband radio channel impulse response (or transfer function of radio channel) from antenna of RF source to antenna of a RF receiver at the device position to determine the legitimacy of the intended device's location.