Abstract: Disclosed are compositions comprising an engineered intein designed such that the self-cleaving activity of the intein can be modulated by a zinc-binding motif as well as methods and systems for making and using the compositions.

Abstract: A checkpointing method for creating a file representing a restorable state of a virtual machine in a computing system, comprising identifying processes executing within the virtual machine that may store confidential data, and marking memory pages and files that potentially contain data stored by the identified processes; or providing an application programming interface for marking memory regions and files within the virtual machine that contain confidential data stored by processes; and creating a checkpoint file, by capturing memory pages and files representing a current state of the computing system, which excludes information from all of the marked memory pages and files.

Abstract: Methods for modulating quorum sensing in certain Gram-negative bacteria having multiple QS systems including Las, Rhl, and Pqs with associated receptors (LasR, RhlR and PqsR) which are modulated by small molecule modulators, particularly non-native modulators. Certain combinations of modulators of Las, Rhl and Pqs exhibit improved inhibition of virulence in comparison to the respective individual modulators. In particular, certain combinations of modulators exhibit improved inhibition in nutritionally depleted environments. More specifically, certain combinations of modulators exhibit improved inhibition in environments depleted in phosphate and/or environments depleted in iron. Nutrient depleted environments can mimic environments associated with bacterial infection in humans and non-human animals. The methods are useful in particular for modulating QS in Pseudomonas and Burkholderia.

Abstract: The present disclosure relates to a novel peptide for preventing or treating bone diseases. Further, the present disclosure relates to a polynucleotide encoding the peptide, a vector including the polynucleotide, a host cell transformed by the vector, and a method for producing the peptide by using the host cell. Furthermore, the present disclosure relates to a composition for preventing or treating bone diseases, including the novel peptide. The novel peptide according to the present disclosure induces mobilization of hematopoietic stem cells to blood and causes a decrease in the number of osteoclasts, and, thus, decreases bone erosion caused by osteoclasts, thereby suppressing progress of an osteoporotic lesion. Further, the novel peptide is safe since it does not cause rejection in the body. Furthermore, since the novel peptide is formed of 16 short amino acids, a low dose of the peptide can relieve symptoms of osteoporosis.

Abstract: The present invention relates to a novel oxindole derivative having anticancer activity, a preparation method thereof, and a method for treating cancer using the same. More specifically, the present invention relates to an oxindole derivative produced as a result of CH alkylation and subsequent intramolecular cyclization reaction using a rhodium (III) catalyst, a preparation method of the same, and a method for treating cancer containing the same as an active ingredient. The novel oxindole derivatives according to the present invention have excellent anticancer activity against various human cancer cell lines and are expected to be useful for the treatment of cancer. In addition, the preparation method of an oxindole derivative using the rhodium (III) catalyst of the present invention can be applied and introduced into a wide range of functional groups, and is a reaction having positional selectivity and chemical selectivity.

Abstract: Cell-targeted serine protease constructs are provided. Such constructs can be used in methods for targeted cell killing such as for treatment cell of proliferative diseases (e.g., cancer). In some aspects, recombinant serine proteases, such as Granzyme B polypeptides, are provided that exhibit improved stability and cell toxicity. Methods and compositions for treating lapatinib or trastuzumab-resistant cancers are also provided.

Abstract: The subject invention provides therapeutic compositions, and uses thereof for the treatment or amelioration of injury to small intestine mucosa. In preferred embodiments, the composition comprises one or more nutrients and/or electrolytes that acquire or retain considerable absorptive capacity.

Abstract: A resistive memory device and a fabricating method thereof are provided. The resistive memory device includes: a first electrode electrically coupled with a first wire; a second electrode facing the first electrode and electrically coupled with a second wire, the second electrode including an oxygen vacancy reservoir and a contact electrode, and a memory cell including a variable resistive layer and being disposed between the first electrode and the second electrode. The variable resistive layer has a conductive filament, which includes oxygen vacancies and connects the first electrode and the second electrode. The oxygen vacancy reservoir is disposed on the variable resistive layer, and the contact electrode is coupled to the oxygen vacancy reservoir and the second wire. The oxygen vacancy reservoir has a volume or oxidizing power to exchange a limited amount of oxygen ions and oxygen vacancies required for switching the conductive filament with the variable resistive layer.

Abstract: Automated, image-guided systems for automatically performing in vitro cell patch clamping are provided. The systems are configured for use with a patch-clamp arrangement and include a camera system for providing images from tissues under investigation and a computer to execute calibration, detection, and whole-cell patching algorithms based on the collected image data. Automated methods for carrying out in vitro cell patch clamping using this automated, image-guided system are also provided and include using images to automatically calibrate a manipulator relative to a tissue of interest, detect and extract coordinates for a plurality of cells, and utilizing the coordinates with a patch-clamp arrangement to automatically move a manipulator directly above each of the plurality of cells and initiate the performance of an automated patch clamp mechanism for each of the plurality of cells driven by the system.

Abstract: An apparatus for charging a mobile terminal includes an energy harvesting device provided in shoes and generating energy generated by a movement of a human body, a charge control module attached to trousers and controlling charging of a mobile terminal using energy harvested by the energy harvesting device, and a resonant coil module wirelessly transmitting energy harvested by the energy harvesting device to the charge control module, wherein the resonant coil module includes a transmission resonant coil unit provided in the shoes and a reception resonant coil unit provided in the trousers, spaced apart from the transmission resonant coil unit by a predetermined distance, and magnetically coupled to the transmission resonant coil unit.

Abstract: Described herein are compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic. Also described are lyophilized compositions of antibodies and carrier proteins and methods of making and using the same, in particular, as a cancer therapeutic.

Abstract: Some embodiments are directed to managing transactions in a computer system, which receives information indicating a first node has at least one right with regard to a second node such that the first node is associated with the second node. An identity network is created, based, on the association between the first node and the second node, representing undirected ties between a plurality of nodes, the plurality of nodes including at least the first and second node. Using the identity network, a rights network is created representing directed ties between the plurality of nodes based, at least in part, on the undirected ties of the identity network and the at least one right the first node has with regard to the second node. The rights network is used to determine whether a transaction initiated by the first node is permissible based, at least in part, on the rights network.

Abstract: The invention generally relates to systems and methods for continuous or batch wise sampling of a surface for analysis of trace chemical constituents that may be present on the surface by mass spectrometry. Integration of time and place of the sampling and analysis processes allows real-time on-the-spot response to the analytical data and can take into account that material is not necessarily uniformly distributed on a surface. A further feature of the systems and methods of the invention is that the swabbing process also cleans the surface being analyzed. Accordingly, systems and methods of the invention provide an integrated approach that allows for a surface to be cleaned, sampled and analyzed in real-time, providing a faster and more efficient way to verify or validate whether a manufacturing vessel is sufficiently clean to start another production.

Abstract: A disc brake caliper includes actuator and reaction portions disposed on opposite sides of a rotor and a bridge portion extending between the actuator and reaction portions and disposed radially outward of the rotor. The actuator portion houses a piston and a lever and defines a mounting flange for a brake actuator. Movement of the lever by the brake actuator causes the piston and the reaction portion to urge brake pads against opposite sides of the rotor. The mounting flange defines a pushrod bore and a fastener bore that receive a pushrod of the actuator and a shank of a fastener extending from the actuator, respectively. The fastener bore has a diameter that varies along at least a portion of a length of the bore beginning from a first end of the bore proximate the actuator and tapering moving towards a second end of the bore distant from the actuator.

Abstract: The present disclosure is generally related to methods for combining chemotherapy and immunotherapy for the treatment of a cancer. The methods also relate to generating a drug-resistant cytotoxic immune cell line and uses thereof in conjunction with cytotoxic drugs.

Abstract: Disclosed are a memory apparatus having a plurality of information storage tables managed by separate virtual regions and a control method thereof. That is, a fault repair is applied in a memory system having a plurality of information storage tables managed by a separate virtual region, so that the entire information storage space is uniformly used for every region to improve a performance of the entire system and maximize efficiency of the information storage space by utilizing the information storage space.

Abstract: Single nucleotide polymorphic sites of the bovine MAP1B, PPP1R11, and DDX4 genes are associated with improved bull fertility as measured by e.g. sire conception rates. Nucleic acid molecules, arrays, kits, methods of genotyping and marker-assisted bovine breeding methods based on these SNPs are disclosed.

Abstract: ‘UF16-64-1’ is a new coleus plant with novel characteristics that include a vigorous compact mounded growth habit, an excellent heat tolerance, and consistent brightly colored leaves. It has superior stability in foliage color in both sun and shade conditions, maintaining stable color in all conditions. ‘UF16-64-1’ has not been observed to produce flowers in any trial we have conducted to date, and thus it has long season performance as an annual plant in the landscape until late Fall.

Abstract: ‘UF16-88-9’ is a new Coleus plant with novel characteristics that include a vigorous compact mounded growth habit, an excellent heat tolerance, and consistent maroon leaves with bright pink centers. It has superior stability in foliage color in both sun and shade conditions, maintaining stable color in all conditions. ‘UF16-88-9’ has not been observed to produce flowers in any trial we have conducted to date, and thus it has long season performance as an annual plant in the landscape until late Fall.

Abstract: ‘UF16-1-20’ is a new coleus plant with novel characteristics that include a vigorous upright and spreading growth habit, an excellent heat tolerance, and consistent bright orange colored foliage. It has superior foliage color stability in both sunny and shady garden conditions. ‘UF16-1-20’ has been observed to have long season performance as an annual plant in the landscape, growing well and providing color from late Spring until late Fall.