Abstract: A system and method for scheduling the receipt of desired movies and other forms of data from a network which simultaneously distributes many sources of such data to many customers, as in a cable television system. Customer profiles are developed for the recipient describing how important certain characteristics of the broadcast video program, movie or other data are to each customer. From these profiles, an "agreement matrix" is calculated by comparing the recipient's profiles to the actual profiles of the characteristics of the available video programs, movies, or other data. The agreement matrix thus characterizes the attractiveness of each video program, movie, or other data to each prospective customer. "Virtual" channels are generated from the agreement matrix to produce a series of video or data programming which will provide the greatest satisfaction to each customer.
Type:
Grant
Filed:
February 23, 1998
Date of Patent:
February 1, 2000
Assignee:
Fred Herz
Inventors:
Frederick Herz, Lyle Ungar, Jian Zhang, David Wachob, Marcos Salganicoff
Abstract: A pinch type control valve uses an elastic sleeve having main flanges at each end of a center pinch section with flange gasket extensions on each end. The flanges of the flange gasket extensions project through metal backing flanges and each cooperates with a machined countersunk annular face groove on such metal backing flanges to pull the flange of the gasket extension radially outwardly as it is compressed. Offset annular beads on the opposite faces of the flange of the gasket extension help in achieving the required radial tensioning regardless of the type of flanging of the system. The annular face groove in the metal flange readily accommodates either flat or raised face pipe flanging. The metal backing flange fits between the main flange and the gasket flange and doesn't require the presence of the valve housing. This enables the sleeve to be tested without complete assembly.
Abstract: Polynucleotide molecules encoding CTCF are isolated and purified and sequenced. The CTCF proteins and antibodies thereto can be used to identify mutant CTCFs in methods of diagnosis.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
October 26, 1999
Assignees:
Fred Hutchinson Cancer Research Center, Cancer Research Campaign Technology, Ltd.
Inventors:
Victor L. Lobanenkov, Paul E. Neiman, Elena M. Klenova, Graham H. Goodwin, Galina N. Filippova, Steven J. Collins, Robert H. Nicolas
Abstract: An electric fence has a series of posts connected by an elastically-stretchable, electrically-conductive string to form an enclosure for animals. The string has a unique structure which is comprised of electrically conductive and electrically nonconductive threads intertwined around a rubber core material. The threads are braided in such a way that the string may be substantially stretched without the braided threads severing. The elastically-stretchable construction prevents the string from breaking when moving animals collide with the electrified string.
Abstract: Inhibitors of the p27 cyclin dependent kinase inhibitor protein or sequences encoding the protein modulate vertebrate cell cycle progression and increase the proportion of dividing cells to non-dividing cells in a population of treated cells. As the proportion of dividing cells increases, the cell population, e.g., hematopoietic progenitor (stem) cells, is more efficiently used for gene therapy applications.
Type:
Grant
Filed:
January 18, 1996
Date of Patent:
September 28, 1999
Assignee:
Fred Hutchinson Cancer Research Center
Inventors:
James M. Roberts, Steven R. Coats, Matthew L. Fero
Abstract: A phone patch 26 for interfacing between a radio 12 and a telephone network 32 includes means for electrically coupling audio signals between the radio 12 and the telephone network 32. A monitoring means is operationally coupled to the coupling means and may adjust the audio signals through operator controls 42. The monitoring means allows an operator to communicate with both the radio and telephone user and modify the audio signals to provide sufficient volume without overmodulation.
Abstract: Canine granulocyte macrophage colony stimulating factor (caGM-CSF) corresponding to that found in canine serum and/or tissues, structural variants thereof, genes that encode these materials, related expression vectors and cells, recombinant methods for making caGM-CSF, and veterinary treatments therewith.
Abstract: A novel gene, Inhibitor of MyoD Family (I-mf), is provided which encodes novel proteins, I-mfa, I-mfb and I-mfc, involved in regulation of myogenesis during vertebrate development. I-mf is highly expressed in the sclerotome of developing vertebrates and is postulated to play an important role in patterning of the somite and determination sclerotomal cell fate. A unique, C-terminal interactional domain of the I-mf protein mediates physical interactions between I-mfa and members of the MyoD family of transcriptional activators and functions to inhibit transactivation of muscle specific genes by MyoD family members, thereby repressing myogenesis. Further characterization of I-mf activity shows that I-mf associates with MyoD family member proteins and retains them in the cytoplasm by masking their nuclear localization signals.
Type:
Grant
Filed:
August 27, 1996
Date of Patent:
March 23, 1999
Assignee:
Fred Hutchinson Cancer Research Center
Inventors:
C. M. Amy Chen, Norbert Kraut, Mark Groudine, Harold Weintraub, deceased
Abstract: Immortalized human stromal cell lines sustain and expand human hematopoietic precursor cells. The precursor cells are obtained from a blood product and inoculated into a culture medium conditioned by exposure to a human stromal cell line. Preferred human stromal cell lines secrete SCF, LIF, MIP1.alpha., and IL-6, as exemplified by a human stromal cell line designated HS-1. The conditioned culture medium may be supplemented with additional growth factors, such as interleukin-3. After expansion the human hematopoietic precursor cells are harvested and returned to a patient or frozen and stored. The immortalized human stromal cell lines can also be used as feeder layers in ex vivo bone marrow cultures or in colony forming assays.
Type:
Grant
Filed:
May 23, 1997
Date of Patent:
March 9, 1999
Assignee:
Fred Hutchinson Cancer Research Center
Inventors:
Beverly Torok-Storb, Bryan A. Roecklein, Gretchen Johnson
Abstract: Methods are provided for determining in biological material the presence or amount human cyclin E polypeptide and/or cyclin E:cell division kinase complexes.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
January 19, 1999
Assignee:
Fred Hutchinson Cancer Research
Inventors:
James M. Roberts, Motoaki Ohtsubo, Andrew C. Koff, Frederick Cross
Abstract: There is disclosed a method for screening for inhibitors of cellular second messenger signaling regulated by lysophosphatidic acid acyl transferase (LPAAT) and phosphatidic acid phosphohydrolase (PAPH), which method comprises contacting target cells or appropriate subcullular elements under appropriate conditions of stimulation with a candidate drug and assessing the levels of the relevant subsets of phosphatidic acid (PA) and diacylglycerol (DAG) in the presence and absence of the candidate drug.
Type:
Grant
Filed:
February 14, 1994
Date of Patent:
January 5, 1999
Assignee:
Fred Hutchinson Cancer Research Center
Inventors:
James A. Bianco, Stuart L. Bursten, Jack W. Singer
Abstract: A sequentially timed vacuum grip system holds a sheet and transports it through a folding nip defined by a pair of folding cylinders. At the nip, the folded edge of the sheet is released and simultaneously picked-up by the paired companion cylinder. Additional folds are achieved in the same manner by the use of additional cylinder pairs.