Patents Assigned to FRED
  • Patent number: 5604090
    Abstract: The invention includes methods for increasing the efficiency of transduction of cells, including non-dividing cells, by recombinant AAV vectors. The methods utilize agents that alter certain aspects of DNA metabolism, more specifically, that affect DNA synthesis and/or affect repair, that impact on maintenance of chromosomal integrity, and/or that cause damage to the cellular DNA. Agents and vectors can now also be preselected and screened for transducing ability and/or transducing agents for their effect on DNA metabolism. These agents include tritiated nucleotides such as thymidine, gamma irradiation, UV irradiation, cis-platinum, etoposide, hydroxyurea and aphidicolin.
    Type: Grant
    Filed: June 6, 1994
    Date of Patent: February 18, 1997
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Ian E. Alexander, David W. Russell, A. Dusty Miller
  • Patent number: 5585380
    Abstract: The specification discloses methods for modulating cellular metabolism in a subject, modulating being desirable to mitigate a condition of the subject. Disclosed methods include processes for administering to said subject an effective amount of a compound of the formula ##STR1## wherein one and only one of R.sup.1 and R.sup.3 is a straight-chain or branched-chain .omega.-hydroxyalkyl (5-8C), or is a branched-chain (.omega.-1)-hydroxyalkyl (5-8C), or is an (.omega.-1)-oxoalkyl (5-8C), or is an (.omega., .omega.-1) or (.omega.-1, .omega.-2)-dihydroxyalkyl (5-8C), or is an alkenyl substituent (5-8C), and the other is alkyl (1-12C) optionally containing one or two non-adjacent oxygen atoms in place of C.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: December 17, 1996
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: James A. Bianco, Stuart L. Bursten, Jack W. Singer
  • Patent number: 5576690
    Abstract: Push button controlled wireless transmitters send digitally encoded signals to a plug-in receiver/signaling device. The receiver/signaling device has a microprocessor suitably programmed to respond to signals from a transmitter bearing the discrete address of the receiver, and to decode a transmitter identification code. Thereupon the microprocessor supplies an audio output circuit with signals to simulate selectively mechanical front or back door chimes, and supplies signals to energize a strobe lamp to emit bursts of multiple flashes, the number of flashes in a burst identifying the specific transmitter, whereby a person with a hearing deficiency is informed as to which transmitter is being actuated.
    Type: Grant
    Filed: August 7, 1995
    Date of Patent: November 19, 1996
    Assignee: Fred M. Schildwachter & Sons, Inc.
    Inventors: David Waugh, Leslie M. Orloff
  • Patent number: 5568018
    Abstract: An improved fluorescent light ballast circuit extends the on/off life of a florescent lamp within a lighting circuit having a pair of series connected fluorescent lamps. The ballast circuit includes a DC pulse generation circuit, filtering and voltage regulation circuitry, a step-up voltage transformer, and a current altering circuit which alters the current within selected filaments within the lamps. The current altering circuit includes a diode and a coil winding which connect across a filament within one of the fluorescent lamps. The net effect of the current altering circuit is to increase the voltage supplied across the lamp connected to the current altering circuit so that the voltage levels across both lamps are balanced.
    Type: Grant
    Filed: March 17, 1995
    Date of Patent: October 22, 1996
    Assignee: Fred A. Muzic
    Inventor: Fred A. Muzic
  • Patent number: 5543319
    Abstract: An avian/mammalian microcell hybrid immortalized pre B cell line containing a mammalian chromosome that carries a selectable marker has been produced. The avian/mammalian microcell hybrid immortalized pre B cell line can be used for introducing predetermined point mutations into specific mammalian chromosomal loci via high frequency homologous recombination.
    Type: Grant
    Filed: March 31, 1995
    Date of Patent: August 6, 1996
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: R. E. Keith Fournier, Mark T. Groudine, Ellen S. Dieken, Elliot M. Epner
  • Patent number: 5504194
    Abstract: A lymphoid cell line cDNA that encodes an adhesion receptor for high endothelial venules (HEV).
    Type: Grant
    Filed: May 15, 1992
    Date of Patent: April 2, 1996
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Thomas P. St. John, W. Michael Gallatin, Rejean L. Idzerda
  • Patent number: 5494011
    Abstract: An intake manifold for a combustion engine is provided. The intake manifold has a body with a front end, a back end, a top and a bottom. The bottom has a first angled portion, a second angled portion and a horizontal portion located therebetween. The intake manifold further has a front end plate and a back end plate connected to respective ends of the body. The top plate has at least one opening for connecting at least one carburetor system to the intake manifold. The intake manifold further has a first and a second engine mounting plate and a plurality of straight tubes each having a first and a second end. The straight tubes are connected at their first end to the body of the intake manifold and at their second end to the engine mounting plates. The plurality of straight tubes are preferably extruded metal.
    Type: Grant
    Filed: October 14, 1994
    Date of Patent: February 27, 1996
    Assignee: Fred T. Haller
    Inventor: Fred T. Haller
  • Patent number: 5470726
    Abstract: Retrovirus packaging cell lines PG13 (ATCC No. CRL 10686) and PG13/LNc8 (ATCC No. CRL 10685), and retroviruses packaged by said cells.
    Type: Grant
    Filed: August 11, 1993
    Date of Patent: November 28, 1995
    Assignees: Fred Hutchinson Cancer Research Center, The United States of America as represented by the Department of Health and Human Services
    Inventors: A. Dusty Miller, Jose V. Garcia-Martinez, Maribeth V. Eiden, Carolyn A. Wilson
  • Patent number: 5470730
    Abstract: The present invention relates to cytotoxic T lymphocytes (CTLs) which have been converted to a helper T cell independent phenotype by introducing a recombinant expression vector encoding IL-1 receptor into the CTL. The resulting CTLs have the ability to grow or function independent of T cell help.
    Type: Grant
    Filed: August 8, 1994
    Date of Patent: November 28, 1995
    Assignees: Immunex, Fred Hutchinson Cancer Research Center
    Inventors: Phillip D. Greenberg, Robert W. Overell
  • Patent number: 5466576
    Abstract: Method for affecting viability of a eucaryotic cell by contacting the cell with a modulator of the activity of a PIF-1-type helicase in the cell. Such contacting specifically increases or decreases the specific activity of the helicase in the cell.
    Type: Grant
    Filed: July 2, 1993
    Date of Patent: November 14, 1995
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Vincent P. Schulz, Virginia A. Zakian
  • Patent number: 5449755
    Abstract: Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence residing between positions 1 and 1185 of the human cyclin E cDNA sequence shown in FIG. 2 . Polypeptides encoded by such nucleic acid molecules, and immunologic binding partners directed to such polypeptides.
    Type: Grant
    Filed: September 16, 1992
    Date of Patent: September 12, 1995
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: James M. Roberts, Motoaki Ohtsubo, Andrew C. Koff, Frederick Cross
  • Patent number: 5440976
    Abstract: A sugar stick is provided to stir coffee until a desired sweetness is attained. The dispensing device for solid granular material is user adjusted from zero to a maximum by simply adjusting a movable cover, such as a sleeve or shutter to the indicated extent for the desired amount. The stirrer includes at least one dose separator disks attached to a central portion ending in an enlarged end section to be used as a handle, which fits into a perforated tube. The product granules, e.g. an artificial or natural sweetener, which are larger in size than the perforations, are housed in the spaces between the at least one separator disk. A transparent movable outer cover, such as a sleeve, encloses the perforations and seals them from contact with the liquid beverage. By pulling the movable outer cover up, the perforations corresponding to the desired level of sweetness dose can be easily exposed.
    Type: Grant
    Filed: August 23, 1994
    Date of Patent: August 15, 1995
    Assignee: Fred Giuliano
    Inventors: Fred Giuliano, John V. Mizzi
  • Patent number: 5433563
    Abstract: A tool for preparing a substrate edge of a counter-top to accept a molded apron having at least two perpendicular appendages. The tool includes cutters for cutting a channel and/or a rabbet into the substrate edge. The spacing between the cutting edges of the cutters corresponds to a spacing between the perpendicular appendages of the molded apron.
    Type: Grant
    Filed: August 25, 1994
    Date of Patent: July 18, 1995
    Assignee: Fred M. Velepec Co., Inc.
    Inventor: Fredric A. Velepec
  • Patent number: D364628
    Type: Grant
    Filed: October 13, 1994
    Date of Patent: November 28, 1995
    Assignee: Fred T. Haller
    Inventor: Fred T. Haller
  • Patent number: D366223
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: January 16, 1996
    Assignee: Fred, S.A.
    Inventor: Henri Samuel
  • Patent number: D368047
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: March 19, 1996
    Assignee: Fred, S.A.
    Inventor: Henri Samuel
  • Patent number: D369987
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: May 21, 1996
    Assignee: Fred S.A.
    Inventor: Henri Samuel
  • Patent number: D373967
    Type: Grant
    Filed: March 22, 1994
    Date of Patent: September 24, 1996
    Assignee: Fred S.A.
    Inventor: Henri Samuel
  • Patent number: D375466
    Type: Grant
    Filed: April 25, 1995
    Date of Patent: November 12, 1996
    Assignee: Fred S.A.
    Inventor: Henri Samuel
  • Patent number: D378877
    Type: Grant
    Filed: November 6, 1995
    Date of Patent: April 22, 1997
    Assignee: Fred M. Lawrence Co., Inc
    Inventor: Christopher Lanci