Abstract: The present invention relates to a method for inhibiting the adhesion of one cell to another comprising interfering with the interaction between the extracellular matrix receptor and its ligand.The invention is based upon the discovery that the .alpha.4.beta.1 extracellular matrix receptor promotes adhesion of lymphocytes to endothelial cells via attachment to a defined peptide sequence. Prior to the present invention, the ligand of the .alpha.4.beta.1 receptor had not been identified, nor had the function of the .alpha.4.beta.1 receptor in lymphocyte attachment been known. By preventing the interaction between the .alpha.4.beta.1 receptor and its ligands using antibodies or defined peptide sequences, the present invention enables, for the first time, specific intervention in the migration of lymphocytes through the vascular endothelium and into tissues.

Abstract: An improved method 20 of playing the game of poker between which can be applied as an adjunct to virtually any of the numerous variations of the game. Each player places a wager 500 of the same amount. The conventional game is then played in accordance with the selected rules of play. After the conclusion of conventional play, an action player is selected. The action player compares hands with a first sequential player. The Winner of the comparison takes the wager 500 of the other player and then compares hands with the next sequential player. The Winner of that comparison takes the wager 500 of the other player and then compares hands with the next sequential player. This sequence continues until all players have participated.

Abstract: Canine granulocyte macrophage colony stimulating factor (caGM-CSF) corresponding to that found in canine serum and/or tissues, structural variants thereof, genes that encode these materials, related expression vectors and cells, recombinant methods for making caGM-CSF, and veterinary treatments therewith.

Abstract: Neurogenic differentiation genes and proteins are identified, isolated, and sequenced. Expression of neuroD has been demonstrated in neural, pancreatic, and gastrointestinal cells. Ectopic expression of neuroD in non-neuronal cells of Xenopus embryos induced formation of neurons.

Abstract: The disclosed bifurcated (fork-like) device is for use in a tube coupler to hold male and female members in sealing contact with one another. Each rail of the device has a laterally-outwardly-extending "hook-like" projection. When used in a coupler, such projections engage retention shoulders to retain the device on the coupler. Guide members help urge the projections toward such shoulders. A related tube coupler has a locking mechanism which is biased toward and automatically engages the device when such device is pushed into the de-coupling position. The coupler also has a trip surface which urges the mechanism to its unlatch position when the male member and the female member are moved to sealing contact with one another. Unlatching the mechanism permits the device to return to its coupling position.

Abstract: Nucleic acid molecules capable of hybridizing under stringent conditions to the nucleotide sequence of the max cDNAs shown in SEQ ID NO: 1 or SEQ ID NO: 2, or to the nucleotide sequence of the mad cDNAs shown in SEQ ID NO: 5. The Max polypeptide when associated with the Myc or Mad polypeptide is capable of binding to nucleotide sequences containing CACGTG.

Abstract: The subject invention provides an isolated protein having an apparent molecular weight of about 27 kD and capable of binding to and inhibiting the activation of a cyclin E-Cdk2 complex. The subject invention further provides a recombinant nucleic acid molecule which encodes the p27 protein of the subject invention, and related vectors and host vector systems. The subject invention further provides a method for producing the p27 protein of the subject invention using the host vector system. The subject invention further provides methods of determining whether an agent is capable of specifically inhibiting or enhancing the ability of p27 protein to inhibit the activation of cyclin E-Cdk2 complex. Finally, this subject invention provides different uses of the isolated protein, the recombinant nucleic acid molecule encoding the isolated protein and the agent capable of inhibiting or enchancing the ability of p27 protein to inhibit the activation of cyclin E-Cdk2 complex.

Abstract: Human checkpoint huCDC34, huRAD9.sub.compA, and huRAD9.sub.compB cDNAs shown in SEQ ID Nos:7-9.

Abstract: An extendible and tiltable shim is provided having a hingeably connected leg that is extendable. The leg can extend to adjust the height and the angle of the shim. The shim is mounted to a structure member and abuts to a frame member. The structure member can comprise a rough opening in a wall. The frame member can comprise a door jamb or a window jamb. The method of the invention includes an initial step of attaching the bottom plate of the shim to a structure, extending the leg to contact the frame member, and adjusting the extension of the leg to center and plumb the frame member. The shim accurately and reliably adjusts a door jamb or window jamb within a rough opening in a wall for proper alignment. The shim tilts at an angle and offsets to accommodate crooked and misaligned wall structure. The shim can easily retrofit to a standard door jamb or a window frame for the purpose of aiding in the square alignment of the door jamb or window jamb within a rough opening in wall structure.

Abstract: A router bit for trimming the overhanging edge of a plastic laminate is provided having a rotatable shaft. A cutting tool is connected to the shaft and a cutting flute or wing is connected to the cutting tool. A ball-bearing guide rides along the apron of a plastic laminated top holding the cutting flute or wing in a spaced relationship to the plastic laminate. The shape of the cutting flute or wing employs two straight edges connected by a small radial section. A first straight edge is provided which lies at an angle of 5.degree. to 7.degree. with a portion of the side edge of the laminate. The second straight edge is provided which lies at an angle of 40.degree. to 60.degree. with a portion of the side edge and the top edge of the plastic laminate. The radial section, connecting the first straight edge to the second straight edge, has a small radius of curvature of 0.005 inches to 0.015 inches.

Abstract: Whole cell or cell-free test systems for screening and identifying compounds that modulate or alter Cyclin E activity. Whole cell assays measure the G1 phase of cells in the presence or absence of the test compound. Additional whole cell or cell-free assays measure binding of cyclin E to a cell division kinase, measure cyclin E activity directly, or measure the cell division kinase activity directly in the presence or absence of the test compound.

Abstract: Glucosidase I inhibitors as therapeutic agents for combatting nondefective retroviral pathogens, including the aetiological agents of AIDS and feline leukemia. Administration of a processing glucosidase I inhibitor, preferably castanospermine, interrupts the replication of the retrovirus in infected cells, alleviates pathogenic effects associated with the presentation of vital env glycoproteins on infected cells, and may furthermore prevent infection of target cells by interrupting expression of endogenous receptors recognized by the virion.

Abstract: A remote annunciator system in which the emission of an acoustic signal by a first annunciator is detected by an acoustic signal detector which causes a radio frequency transmitter to transmit a radio frequency signal. A radio frequency receiver which receives the signal operates a second annunciator which is remote from the first annunciator, to cause the second annunciator to emit an audible or visual signal. Preferably, the radio frequency signal is encoded and is decoded at the receiver, and if the first annunciator can emit two different accoustic signals, the transmitted signal is encoded dependent upon which acoustic signal is emitted and the receiver decoder causes the second annunciator to emit an audible signal or a visual signal which depends on the transmitted signal encoding.

Abstract: The present invention is an improved paint brush holder constructed from a single piece of plastic which spans the opening of a conventional paint can. On each end of the holder are hooked shaped fingers which secure to the perimeter receptacle of a conventional paint can. A slat which spans the paint can opening provides a surface area available for dragging a paint brush across allowing removal of excess paint. The inclined surface directs the excess paint to flow back into the paint can. The slat further provides a location for holding the paint brush wherein the wet portion of the brush is placed on the slat allowing excess paint to drip back into the container while the brush rests over the side of the can for ease of grasping. A horizontally disposed tab engages the underside of the perimeter receptacle which works in conjunction with the hook shaped ends to prevent movement of the device.

Abstract: An isolated nucleic acid molecule capable of hybridizing under stringent conditions to the mSinA nucleotide sequence shown in FIG. 22 (SEQ ID NO:11), the mSin9A nucleotide sequence shown in FIG. 28 (SEQ ID NO:17), and/or the mSinB nucleotide sequence shown in FIG. 30 (SEQ ID NO:19). This isolated nucleic acid molecule preferably encodes a recombinant polypeptide which associates with a Mad polypeptide to form a recombinant polypeptide:Mad complex, which preferably associates with a Max polypeptide to form a recombinant polypeptide:Mad:Max complex, which preferably binds to a nucleotide sequence comprising CACGTG (SEQ ID NO:16). An isolated nucleic acid molecule capable of hybridizing under stringent conditions to a nucleotide sequence selected from among clone 10 shown in FIG. 24 (SEQ ID NO:9), clone 18 shown in FIG. 25 (SEQ ID NO:10), clone 19 shown in FIG. 26 (SEQ ID NO:11), and clone 20 shown in FIG. 27 (SEQ ID NO:12).