Abstract: Disclosed are methods for inhibiting angiogenesis using cyclin dependent kinase inhibitors (CDKi) and fusion proteins thereof, recombinant viruses comprising transgenes and nucleic acid sequences encoding the same, and liposomes carrying the same as angiogenesis-inhibiting reagents.
Type:
Grant
Filed:
December 9, 1999
Date of Patent:
July 16, 2002
Assignees:
Cell Genesys, Inc., GPC Biotech Inc.
Inventors:
Salil Patel, James McArthur, Jeno Gyuris
Abstract: A system for wireless communication comprises an hierarchical system of connected routers between a data network and a base station having connected transceivers for wireless transmission and reception of data, and a plurality of hand-held communicators adapted for users to communicate with the network via the transceivers through the routers. The system is adapted to provide wireless Data Network Telephony (DNT) and to perform dynamic address translation as a user carrying one of the hand-held communicators moves between areas covered by the connected transceivers, causing updating of routing tables in the routers and the base station.
Type:
Grant
Filed:
July 12, 1999
Date of Patent:
July 16, 2002
Assignee:
Genesys Telecommunications Laboratories, Inc.
Abstract: A process for forming an integrated circuit device structure. The process includes forming a first gate layer on a thickness of material on a donor substrate. The donor substrate has a cleave region underlying the gate layer. The process also includes joining the donor substrate to a handle substrate where the gate layer face the handle substrate; and separating the thickness of material at the cleave region from the donor substrate to define a handle substrate comprising the gate layer and an overlying thickness of material. The process forms a plurality of second gate structures on the thickness of material, where at least one of the first gate structures facing one of the second gate structures forming a channel region therebetween.
Abstract: A wireless access protocol service provider (WAP-SP), providing access to Internet data for WAP-enabled appliances is enhanced with software for facilitating telephony calls, enabling, for example, connection of a user of the WAP-enabled appliance, communicating with a Web site through the WAP-SP, to an agent of an enterprise that hosts the Web site.
Type:
Grant
Filed:
April 14, 2000
Date of Patent:
July 9, 2002
Assignee:
Genesys Telecommunications Laboratories, Inc.
Abstract: Disclosed are methods for using &Dgr;E1/&Dgr;E4 recombinant adenoviruses encoding cyclin dependent kinase inhibitors (CDKi's) as reagents for inhibiting smooth muscle cell proliferation. Also disclosed are recombinant lentiviruses encoding cyclin dependent kinase inhibitors (CDKi's).
Type:
Grant
Filed:
December 9, 1999
Date of Patent:
July 2, 2002
Assignees:
Cell Genesys, Inc., GPC Biotech Inc.
Inventors:
James McArthur, Mitchell H. Finer, Jeno Gyuris
Abstract: A technique for forming a film of material (12) from a donor substrate (10). The technique has a step of introducing energetic particles (22) in a selected manner through a surface of a donor substrate (10) to a selected depth (20) underneath the surface, where the particles have a relatively high concentration to define a donor substrate material (12) above the selected depth and the particles for a pattern at the selected depth. An energy source is directed to a selected region of the donor substrate to initiate a controlled cleaving action of the substrate (10) at the selected depth (20), whereupon the cleaving action provides an expanding cleave front to free the donor material from a remaining portion of the donor substrate.
Abstract: A technique for forming a film of material (12) from a donor substrate (10). The technique has a step of forming a weakened region in a selected manner at a selected depth (20) underneath the surface. An energy source is directed to a selected region of the donor substrate to initiate a controlled cleaving action of the substrate (10) at the selected depth (20), whereupon the cleaving action provides an expanding cleave front to free the donor material from a remaining portion of the donor substrate.
Abstract: A process for synthesis of lower isoparaffins from synthesis gas that is a mixture of hydrogen and carbon monoxide, wherein straight chain hydrocarbons are synthesized while isoparaffins and isoolefins are also produced through decomposition of hydrocarbons having a higher carbon number by use of a solid acid catalyst in the first stage, and isoparaffins are synthesized in the second stage. The straight chain hydrocarbons are produced by contacting the synthesis gas with a Fischer-Tropsch synthesis catalyst that is mixed with a solid acid catalyst for mainly hydrocracking long chain hydrocarbons. The isoparaffins are produced by contacting the straight chain hydrocarbons synthesized in the first stage, with a mixture of a hydrogenation catalyst for hydrogenating olefins and a solid acid catalyst for hydrocracking and isomerizing the straight chain hydrocarbons.
Type:
Grant
Filed:
April 3, 2001
Date of Patent:
June 25, 2002
Assignees:
Toyota Jidosha Kabushiki Kaisha, Genesis Research Institute, Inc.
Abstract: Novel isolated polynucleotides and polypeptides associated with the lignin biosynthetic pathway are provided, together with constructs including such sequences. Methods for the modulation of lignin content, lignin structure and lignin composition in target organisms are also disclosed, the methods comprising incorporating one or more of the polynucleotides of the present invention into the genome of a target organism.
Type:
Grant
Filed:
July 12, 2000
Date of Patent:
June 25, 2002
Assignees:
Genesis Research & Development Corporation Ltd., Fletcher Challenge Forests Ltd.
Abstract: The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae soluble protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate or delipidated M. vaccae cells are also provided.
Type:
Grant
Filed:
November 5, 1998
Date of Patent:
June 25, 2002
Assignee:
Genesis Research & Development Corp. Ltd.
Abstract: A system for enabling Data Network Telephony (DNT) communication through a WEB page includes a Web server hosting an interactive WEB page and having an Internet port, a link in the WEB page adapted for launching a DNT-capable telephone module, and a DNT-capable telephone module associated with the link. In this system, upon selection of the link by a person accessing the WEB page over the Internet using a computer platform, an instance of the IP telephone module is downloaded to computer platform, and an IP call is launched to an IP address pre-stored and associated with the link. The DNT network may be the Internet. In a preferred embodiment the system first investigates the computer platform for hardware and software characteristics, and attaches the determined characteristics to the instance of the IP telephone module to be downloaded. The downloaded module then self-launches and configures, and then launches the associated call.
Type:
Grant
Filed:
September 3, 1998
Date of Patent:
June 25, 2002
Assignee:
Genesys Telecommunications Laboratories, Inc.
Abstract: Methods of reducing pre-existing humoral immunity to a viral immunogenic therapeutic agent such as adenovirus, using immunoapheresis are disclosed. Antibodies specific for the viral immunogenic therapeutic agent are selectively removed from the blood of an individual prior to administration of the viral immunogenic therapeutic agent by reaction extracorporeally with an immunosorbent which specifically binds the antibody. After the antibody is selectively removed from the blood, the blood is reinfused into the patient and the viral immunogenic therapeutic agent is administered. The invention also provides kits and compositions for selective removal of anti-viral antibody.
Type:
Grant
Filed:
October 6, 1999
Date of Patent:
June 18, 2002
Assignee:
Cell Genesys, Inc.
Inventors:
Daniel R. Henderson, Yu Chen, De Chao Yu
Abstract: An agent station at a telephone call center has a telephone and a computer platform with a sound card. The telephone has a speaker line connected to at least a microphone input at the sound card. In some instances the speaker line is connected to both the microphone and speaker ports to the sound card. Agent stations in the call center are interconnected on a LAN such that a supervisor at one station may monitor telephone conversations at another station having the connected telephone and sound card. In some instances a file-sharing application is used, allowing a supervisor to view a screen at the agent station as well as to monitor and participate in telephone conversations. The system provides a complete monitoring a service-observing capability in the call center.
Type:
Grant
Filed:
March 31, 2000
Date of Patent:
June 18, 2002
Assignee:
Genesys Telecommunications Laboratories, Inc.
Abstract: The present invention provides polypeptides comprising an immunogenic portion of a M. vaccae protein and DNA molecules encoding such polypeptides, together with methods for their use in the diagnosis and treatment of mycobacterial infection. Methods for enhancing the immune response to an antigen including administration of M. vaccae culture filtrate, delipidated M. vaccae cells or delipidated and deglycolipidated M. vaccae cells are also provided.
Type:
Grant
Filed:
December 4, 1998
Date of Patent:
June 18, 2002
Assignee:
Genesis Research and Development Corporation Limited
Inventors:
Paul Tan, Elizabeth Visser, Ross Prestidge, James D. Watson
Abstract: Chimeric proteins and DNA encoding chimeric proteins are provided, where the chimeric proteins are characterized by an extracellular domain capable of binding to a ligand in a non-MHC restricted manner, a transmembrane domain and a cytoplasmic domain capable of activating a signaling pathway. The extracellular domain and cytoplasmic domain are not naturally found together. Binding of ligand to the extracellular domain results in transduction of a signal and activation of a signaling pathway in the cell, whereby the cell may be induced to carry out various functions relating to the signalling pathway. A wide variety of extracellular domains may be employed as receptors, where such domains may be naturally occurring or synthetic. The chimeric DNA may be used to modify lymphocytes as well as hematopoietic stem cells as precursors to a number of important cell types.
Type:
Grant
Filed:
June 7, 1995
Date of Patent:
June 18, 2002
Assignees:
Cell Genesys, Inc., Regents of the University of California
Inventors:
Daniel J. Capon, Arthur Weiss, Brian A. Irving, Margo R. Roberts, Krisztina Zsebo
Abstract: A zero gravity robotic tool includes a robotic arm having a distal end. A motor is mounted on the distal end of the robotic arm and is rotated about a motor axis which passes through the center of gravity of the motor and the tool. A prime mover is connected to the robotic arm and to a pivot mechanism for causing the rotation of the motor and the tool about the motor axis.
Abstract: An Internet system for providing call-back services for a subscriber includes a web page having a call-back link to a subscription server; a call-back application operating on the subscription server and adapted for accepting input from a browsing person linked to the subscription server by the call-back link; and a call-switching system connected to and responsive to the call-back application on the subscription server. In this system the browsing person, upon activating the call-back link, is linked to the call back application on the subscription server and prompted for input including a call-back number, and the subscription server, after accepting the input, directs the call-switching system in establishing a telephony link between the subscriber and the browsing person. In some instances the telephony switch is part of a call-center with connected agents, and agents are assigned to represent selected subscribers. In this instance call-back connection is made between a browsing person and an agent.
Type:
Grant
Filed:
September 12, 1997
Date of Patent:
May 21, 2002
Assignee:
Genesys Telecommunications Laboratories, Inc.
Abstract: A method for treating a film of material, which can be defined on a substrate, e.g., silicon. The method includes providing a substrate comprising a cleaved surface, which had a porous silicon layer thereon. The substrate may have a distribution of hydrogen bearing particles defined from the cleaved surface to a region underlying said cleaved surface. The method also includes increasing a temperature of the cleaved surface to greater than about 1,000 Degrees Celsius while maintaining the cleaved surface in a etchant bearing environment to reduce a surface roughness value by about fifty percent and greater. Preferably, the value can be reduced by about eighty or ninety percent and greater, depending upon the embodiment.
Abstract: A computerized Internet-Protocol Network Telephony (IPNT) routing system has a routing processor for receiving and forwarding IPNT calls based on information stored in an associated database regarding operation and status of possible destinations for the call. In some embodiments destinations are call centers adapted for receiving IPNT calls at workstations associated with a central processor, and the information in the database at the routing processor is collected and processed at the call centers that are potential destinations for the calls. The information is collected processed and forwarded to the database for the purpose of enhancing call-routing efficiency and accuracy.
Type:
Grant
Filed:
May 17, 2000
Date of Patent:
May 21, 2002
Assignee:
Genesys Telecommunications Laboratories, Inc.
Abstract: A technique for forming a film of material (12) from a donor substrate (10). The technique has a step of forming a weakened region in a selected manner at a selected depth (20) underneath the surface. An energy source is directed to a selected region of the donor substrate to initiate a controlled cleaving action of the substrate (10) at the selected depth (20), whereupon the cleaving action provides an expanding cleave front to free the donor material from a remaining portion of the donor substrate.