Patents Assigned to Georgetown University
  • Patent number: 8513295
    Abstract: Novel classes of viral and fungal inhibitors are disclosed. These compounds are useful in treating, preventing, and/or ameliorating viral infections such as, for example, Hepatitis C Virus, West Nile Virus, Dengue Virus, and Japanese Encephalitis Virus, and fungal infections such as, for example, candidiasis.
    Type: Grant
    Filed: September 23, 2009
    Date of Patent: August 20, 2013
    Assignees: Georgetown University, Wichita State University
    Inventors: Radhakrishnan Padmanabhan, William C. Groutas, Brent E. Korba
  • Publication number: 20130183318
    Abstract: The present invention relates to compositions and methods for the treatment of prostate cancer. In certain embodiments, the invention relates to compositions and methods for the inhibition of prostate cancer cell growth, comprising inhibiting the activity of Stat5 in prostate cancer cells.
    Type: Application
    Filed: May 22, 2012
    Publication date: July 18, 2013
    Applicant: GEORGETOWN UNIVERSITY
    Inventor: MARJA T. NEVALAINEN
  • Patent number: 8470577
    Abstract: The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
    Type: Grant
    Filed: March 11, 2010
    Date of Patent: June 25, 2013
    Assignees: Catherex, Inc., The General Hospital Corporation, Georgetown University
    Inventors: Paul Johnson, Robert L. Martuza, Samuel D. Rabkin, Tomoki Todo
  • Patent number: 8471051
    Abstract: One aspect of the present invention relates to a method for the transition metal (e.g., Cu(I)) mediated amidation of C—H bonds using electron-rich aliphatic azides. In certain embodiments, the methods are useful for the C—H insertion of nitrenes generated and stabilized by a ?-diketiminato metal catalyst. In certain embodiments, said nitrenes are generated from organoazides, or by oxidation of the corresponding amine. Another aspect of the present invention relates to olefin aziridination using said ?-diketiminato metal catalysts. In addition, the methods of the present invention include stereoselective C—H bond aminations and olefin aziridinatons. In certain embodiments, the methods are conducted in an aerobic environment. In certain embodiments, the present invention relates to the use of O2 as an oxidant, wherein water is the byproduct of oxidation; this fact avoids the generation of toxic byproducts and renders the methods atom economical.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: June 25, 2013
    Assignee: Georgetown University
    Inventor: Timothy H. Warren
  • Publication number: 20130158063
    Abstract: Disclosed are compounds, compositions and methods related PPAR antagonists. Certain compounds are effective at inhibiting PPARs. The compositions can be used to inhibit PPARs, treat cancer and treat metabolic disorders.
    Type: Application
    Filed: August 24, 2011
    Publication date: June 20, 2013
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Milton Lang Brown, Yali Kong, Yong Liu, Robert Glazer, York Tomita
  • Publication number: 20130158111
    Abstract: The invention is directed towards methods of treating abnormal tissues in a subject or sensitizing an abnormal tissue to a chemotherapeutic agent. The methods comprise screening at least a portion of an abnormal tissue for at least one mutant form of p53 protein, and administering at least one isothiocyanate (ITC) to the subject or abnormal tissue if the abnormal tissue is positive for the at least one mutant form of p53.
    Type: Application
    Filed: December 20, 2012
    Publication date: June 20, 2013
    Applicant: Georgetown University
    Inventor: Georgetown University
  • Publication number: 20130143805
    Abstract: Provided herein are methods of treating central nervous system injury (e.g., spinal cord injury) using GGF2 and compositions comprising GGF2. For example, provided is a method of treating spinal cord injury in a subject, comprising administering at least one dosage of less than 1 mg/kg of GGF2 to the subject. Also provided are methods of promoting proliferation of neural stem cells and of promoting revascularization comprising using GGF2 and compositions comprising GGF2.
    Type: Application
    Filed: August 12, 2011
    Publication date: June 6, 2013
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Matthew Whittaker, Jean R. Wrathall
  • Publication number: 20130131002
    Abstract: The present invention relates to methods of treating pulmonary hypertension in a subject including administering to the subject a therapeutically effective dose of at least one anthracycline.
    Type: Application
    Filed: April 15, 2011
    Publication date: May 23, 2013
    Applicant: Georgetown University
    Inventor: Yuichiro Suzuki
  • Publication number: 20130129247
    Abstract: Disclosed are embodiments for a system, method, and computer program product for performing an process on an original image, the process being implemented by a computer system performs a comprising the at least one computer: performing an process on an image that renders the processed image legible than then the original image, wherein the analysis segregates dark pixels of the image from light pixels of the image. The method can comprise: first converting the image into a grayscale image. The method comprises processing a pixel area for each pixel of the image is a dark pixel or a light pixel and determining if a pixel is proximate to an edge.
    Type: Application
    Filed: November 21, 2011
    Publication date: May 23, 2013
    Applicant: Georgetown University
    Inventors: Jon Parker, Gideon Frieder, Ophir Frieder
  • Patent number: 8438174
    Abstract: Methods and systems are provided for a proactive approach for computer forensic investigations. The invention allows organizations anticipating the need for forensic analysis to prepare in advance. Forensic signatures are created including a digital fingerprint and other information associated with a file. In one aspect, informational signatures are created, which may assist in determining what information is included in a file. In another aspect, the digital fingerprint may represent contents of the file and is resistant to minor modification of the file. In another aspect, fingerprints can be compared in parallel on different computers.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: May 7, 2013
    Assignee: Georgetown University
    Inventors: Thomas Clay Shields, Ophir Frieder, Marcus A. Maloof
  • Patent number: 8420590
    Abstract: Described herein are polypeptides that home to developing microvasculature, (also referred to as developing microvessels), such as newly developing microvasculature in mammals, particularly in humans, and to DNA that encodes such polypeptides. These polypeptides are referred to herein as developing microvasculature homing polypeptides. In a specific embodiment, the homing peptides are collateral vessel endothelia (CVE) homing polypeptides, which have been shown to home to collateral vessel endothelia after ischemia.
    Type: Grant
    Filed: November 30, 2007
    Date of Patent: April 16, 2013
    Assignees: Georgetown University, MedStar Health Research Institute, Inc.
    Inventors: Anton Wellstein, Marcel O. Schmidt, Stephan Zbinden, Mary Susan Burnett, Stephen E. Epstein
  • Publication number: 20130065963
    Abstract: The invention provides novel classes of HDAC inhibitors. Methods of sensitizing a cancer cell to the cytotoxic effects of radiotherapy are also provided as well as methods for treating cancer and methods for treating neurological diseases. Additionally, the invention further provides pharmaceutical compositions comprising an HDAC inhibitor of the invention, and kits comprising a container containing an HDAC inhibitor of the invention.
    Type: Application
    Filed: July 17, 2012
    Publication date: March 14, 2013
    Applicant: Georgetown University
    Inventors: Alan P. Kozikowski, Anatoly Dritschilo, Mira Jung, Pavel A. Petukhov, Bin Chen
  • Patent number: 8394849
    Abstract: In certain aspects, the invention relates to methods of treating proliferative oropharyngeal cancer, laryngeal cancer and esophageal cancer by administering artemisinin-related compounds.
    Type: Grant
    Filed: July 11, 2011
    Date of Patent: March 12, 2013
    Assignee: Georgetown University
    Inventors: Richard Schlegel, Dan-Paul Hartmann, Astrid Baege
  • Publication number: 20130056140
    Abstract: Reversibly and irreversibly-linking amino-polysiloxanes, methods of making such amino-polysiloxanes, and systems and methods of using such amino-polysiloxanes for the containment and/or remediation of a release and/or spill of a crude oil, a petroleum product and/or a chemical is described. Gels and/or emulsions formed from the combination and/or contacting of such an amino-polysiloxane with these materials can be used to recover these oils or chemicals while allowing the amino-polysiloxane to be recovered and reused to clean up or contain additional materials. Such amino-polysiloxanes can be used as well for the selective uptake of one component of liquid mixtures when such mixtures contain more and less lipophilic components. Methods of making and using adhesive and sealants containing such amino-polysiloxanes are described.
    Type: Application
    Filed: March 22, 2011
    Publication date: March 7, 2013
    Applicant: Georgetown University
    Inventors: Richard G. Weiss, Tao Yu, Koji Wakuda
  • Publication number: 20130029865
    Abstract: Compositions and methods related to stromal antigen 2 (STAG2) and its role in diverse human cancers, including nucleic acids, polypeptides, vectors, cells and cell lines.
    Type: Application
    Filed: July 12, 2012
    Publication date: January 31, 2013
    Applicant: Georgetown University
    Inventors: David SOLOMON, Jung-Sik Kim, Todd Waldman
  • Patent number: 8361978
    Abstract: Eliciting a systemic antitumor immune response, in a patient who presents with or who is at risk of developing multiple metastatic tumors of a given cell type, entails, in one embodiment, inoculating a tumor in the patient with a pharmaceutical composition consisting essentially of (A) a herpes simplex virus (HSV) that infects tumor cells but that does not spread in normal cells and (B) a pharmaceutically acceptable vehicle for the virus, such that an immune response is induced that is specific for the tumor cell type and that kills cells of the inoculated tumor and of a non-inoculated tumor. In another embodiment, the pharmaceutical composition also comprises a defective HSV vector which contains an expressible nucleotide sequence encoding at least one immune modulator. In another embodiment, the pharmaceutical composition contains a second HSV that infects tumor cells but that does not spread in normal cells.
    Type: Grant
    Filed: August 20, 2008
    Date of Patent: January 29, 2013
    Assignee: Georgetown University
    Inventors: Samuel D. Rabkin, Masahiro Toda, Robert L. Martuza
  • Publication number: 20130023560
    Abstract: Methods and compositions for the treatment of iron toxicity using nitroxides, particularly 4-hydroxy-2,2,6,6-tetramethyl-1-piperidine-1-oxyl (Tempol), N-acetylcysteine (NAC), and combinations thereof.
    Type: Application
    Filed: March 20, 2012
    Publication date: January 24, 2013
    Applicant: Georgetown University
    Inventors: Christopher S. Wilcox, Pouneh Nouri
  • Publication number: 20130013332
    Abstract: A method and system for tracking patient's response during a clinical trial of a drug, includes publishing an informational item about the clinical trial at a social media platform or a file sharing website; inducing patients to post trial related response at the social media platform or to obtain the informational item from the file sharing website; aggregating patients' responses from the social media platform, download information of the informational item published on the file sharing website, or search queries from search engines; and analyzing aggregated patients' responses, download information, or search queries to obtain knowledge related to the clinical trial.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 10, 2013
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Ophir Frieder, Howard Federoff
  • Patent number: 8349584
    Abstract: The present invention relates to a method for creating two- and three-dimensional arrays. Plates of sample materials are stacked to create primary stacks. Primary stacks are sliced to form combs. Combs are stacked to form secondary stacks. Secondary stacks are sliced to form tertiary plates or two-dimensional arrays. Tertiary plates can be stacked to form three-dimensional arrays. The two- and three-dimensional arrays can be used in large-scale parallel processing of samples, pattern printing, tissue engineering, microfluidics, microelectronics, and microconstruction.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: January 8, 2013
    Assignee: Georgetown University
    Inventors: Hallgeir Rui, Matthew J. LeBaron
  • Patent number: RE44401
    Abstract: Methods, systems and kits for the simultaneous or sequential analysis of one or more hormones by mass spectrometry are disclosed. The methods require minimal sample size and minimal preparation time. The methods include ionizing the hormones and analyzing the hormones by mass spectrometry. In addition, methods, systems and kits for the simultaneous or sequential analysis of thyroid hormones are disclosed including ionization of the thyroid hormones in the negative mode using an electrospray source.
    Type: Grant
    Filed: November 17, 2011
    Date of Patent: July 30, 2013
    Assignee: Georgetown University
    Inventor: Steven J. Soldin