Patents Assigned to Georgetown University
  • EXONUCLEASE CYCLING ASSAY
    Publication number: 20140349286
    Abstract: The present invention relates to a novel method for detecting a target polynucleotide having a target sequence, comprising hybridizing the target polynucleotide with a probe to form a hybrid; exposing the hybrid to a 5? exonuclease so that the probe in the hybrid is digested and the target polynucleotide is dissociated from the digested probe; repeating the hybridization step and the digestion step; and detecting the digested probes. The presence of the digested probes indicates the presence of the target polynucleotide.
    Type: Application
    Filed: March 14, 2014
    Publication date: November 27, 2014
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Mark Danielsen, Berenice Alfonso, Bolor Tumurpurev
  • Biosensor and system and process for forming
    Patent number: 8895340
    Abstract: A process for forming a carbon nanotube field effect transistor (CNTFET) device includes site-specific nanoparticle deposition on a CNTFET that has one or more carbon nanotubes, a source electrode, a drain electrode, and a sacrificial electrode on a substrate with an interposed dielectric layer. The process includes control of PMMA removal and electrodeposition in order to select nanoparticle size and deposition location down to singular nanoparticle deposition. The CNTFET device resulting in ultra-sensitivity for various bio-sensing applications, including detection of glucose at hypoglycemic levels.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: November 25, 2014
    Assignee: Georgetown University
    Inventors: Makarand Paranjape, Yian Liu
  • Transition metal-catalyzed C—H amination using unactivated amines
    Patent number: 8895781
    Abstract: One aspect of the invention relates to a method of animation or amidation, comprising the step of combining a substrate, comprising a reactive C—H bond, and an amine or amide, comprising a reactive N—H bond, in the presence of an oxidizing agent and a metal-containing catalyst, thereby forming a product with a covalent bond between the carbon of the reactive C—H bond and the nitrogen of the reactive N—H bond.
    Type: Grant
    Filed: September 3, 2009
    Date of Patent: November 25, 2014
    Assignee: Georgetown University
    Inventor: Timothy H. Warren
  • Compositions and Methods Comprising Biodegradable Scaffolds and Retinal Pigment Epithelial Cells
    Publication number: 20140341965
    Abstract: The invention relates to compositions comprising a monolayer of functional retinal pigment epithelial (RPE) cells attached to a transplantable, biodegradable scaffold. The invention also relates to methods of using these compositions.
    Type: Application
    Filed: March 14, 2014
    Publication date: November 20, 2014
    Applicant: Georgetown University
    Inventor: Nady Golestaneh
  • SYSTEMS MEDICINE PLATFORM FOR PERSONALIZED ONCOLOGY
    Publication number: 20140330583
    Abstract: The present invention is directed to a platform (e.g., Web-based) that enables basic and clinical research activities by integrating patient characteristics and clinical outcome data with a variety of high-throughput research data in a unified environment. While several rich data repositories for high dimensional research data exist in the public domain, most focus on a single data type and do not support integration across multiple technologies. The present invention in at least one embodiment includes a broad collection of bioinformatics and systems biology tools for analysis and visualization of four major “omics” types: DNA, mRNA, microRNA, and metabolites, as well as next-generation sequencing. The present invention helps facilitate systems medicine by providing easy identification of trends and patterns in integrated datasets and hence facilitate the use of better targeted therapies for cancer.
    Type: Application
    Filed: August 3, 2012
    Publication date: November 6, 2014
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Subha Madhavan, Michael A. Harris, Yuriy Gusev, Andrew Shinohara, David M. Tanenbaum, Kevin Rosso
  • System and method for detecting, collecting, analyzing, and communicating event-related information
    Patent number: 8881040
    Abstract: A system and method involves detecting operational social disruptive events on a global scale, assigning disease event staging and warnings to express data in more simplistic terms, modeling data in conjunction with linguistics analysis to establish responsive actions, generating visualization and modeling capabilities for communicating information, and modeling disease propagation for containment and forecasting purposes.
    Type: Grant
    Filed: December 2, 2009
    Date of Patent: November 4, 2014
    Assignee: Georgetown University
    Inventor: Peter C. Li
  • Methods for treating heat stress and related compositions
    Patent number: 8877819
    Abstract: Methods of treating, reducing, and/or preventing heat stress are provided. For example, provided is a method of treating or preventing heat stress in a subject comprising selecting a subject in need of heat stress treatment or prevention and administering an effective amount of one or more of astaxanthin and milk casein hydrolysate, or a derivative thereof to the subject. Also provided are methods of reducing the effects of a fever in a subject comprising administering an effective amount of one or more of astaxanthin, chromium and milk casein hydrolysate, or a derivative thereof, to the subject. Also provided are pharmaceutical compositions, comprising astaxanthin and one or more of chromium or milk casein hydrolysate.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: November 4, 2014
    Assignee: Georgetown University
    Inventor: Harry George Preuss
  • USE OF STRIGOLACTONES AND STRIGOLACTONE ANALOGS FOR TREATING PROLIFERATIVE CONDITIONS
    Publication number: 20140323563
    Abstract: Compound of formula X wherein P1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.
    Type: Application
    Filed: September 20, 2012
    Publication date: October 30, 2014
    Applicants: The State of Israel, Ministry of Agriculture & Rural Development, Agricultural Research Organizat, Georgetown University
    Inventors: Yoram Kapulnik, Hinanit Koltai, Ronit Yarden, Cristina Prandi
  • Use of a Rock Inhibitor to Sustain Primary Human Keratinocytes in a Proliferative State
    Publication number: 20140322809
    Abstract: Disclosed herein is the finding that treatment with a ROCK inhibitor increases proliferation and induces immortalization of primary keratinocytes. Accordingly, provided is a method of immortalizing primary keratinocytes by exposure to a ROCK inhibitor. Also provided are immortalized primary keratinocytes produced by the described method, as well as organotypic tissue equivalents and cell cultures comprising the immortalized primary keratinocytes. Furthermore, ROCK inhibitor-treated cells show a greatly increased ability to support viral DNA replication of both “low risk” and “high risk” HPV genomes, indicating that ROCK inhibitors will be useful for studying the life cycles of a wide range of HPVs.
    Type: Application
    Filed: November 20, 2013
    Publication date: October 30, 2014
    Applicants: The United States of America as Represented by the Secretary, Department of Health and Human Service, Georgetown University
    Inventors: Alison McBride, Sandra Chapman, Richard Schlegel, Xuefeng Liu
  • Viral vectors and their use in therapeutic methods
    Patent number: 8871193
    Abstract: The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease.
    Type: Grant
    Filed: June 24, 2013
    Date of Patent: October 28, 2014
    Assignees: Catherex, Inc., The General Hospital Corporation, Georgetown University
    Inventors: Paul Johnson, Robert L. Martuza, Samuel D. Rabkin, Tomoki Todo
  • Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
    Patent number: 8865127
    Abstract: Provided herein is an antibody- or antibody fragment-targeted cationic immunoliposome complex prepared by a method comprising the steps of (a) preparing an antibody or antibody fragment; (b) mixing the antibody or antibody fragment with a cationic liposome and to form a cationic immunoliposome wherein the antibody or antibody fragment is complexed with the cationic liposome, but is not chemically conjugated to the cationic liposome and wherein said antibody or antibody fragment does not comprise a lipid tag; and (c) mixing the cationic immunoliposome with a therapeutic or diagnostic agent to form the antibody- or antibody fragment-targeted cationic immunoliposome.
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: October 21, 2014
    Assignee: Georgetown University
    Inventors: Esther H. Chang, Kathleen F. Pirollo
  • System and method for the separation of analytes
    Patent number: 8859296
    Abstract: A separation module operates to fractionate or separate an analyte into fractions according to pI, i.e., pI bands, utilizing capillary isoelectric focusing (“CIEF”) within a first microchannel. The fractions are stacked to form plugs, the number of which is determined by a number of parallel second microchannels integrally connected to the first microchannel, into which the fractions are directed according to the buffer characteristics found in each of the individual microchannels. Within the microchannels the plugs are separated into proteins according to a different chemical property, i.e., “m/z,” utilizing capillary electrophoresis (“CE”).
    Type: Grant
    Filed: December 12, 2011
    Date of Patent: October 14, 2014
    Assignees: Leidos, Inc., Georgetown University
    Inventors: Thomas Wayne Schneider, James N. Baraniuk
  • Antibody fragment-targeted immunoliposomes for systemic gene delivery
    Patent number: 8859274
    Abstract: A targeted vector allowing enhanced gene transfer to human hepato-cellular carcinoma (HCC1) cells in vitro was developed using cationic liposomes covalently conjugated with the mAb AF-20. This high affinity antibody recognizes a rapidly internalized 180 kDa cell surface glycoprotein which is abundantly expressed on the surface of human HCC and other cancer cells. Quantitative binding analysis of liposomes with target cells by flow cytometry showed specific association of mAb-targeted liposomes with human HCC cells. Using mAb-targeted cationic liposomes containing 20% DOTAP, in the presence or absence of serum, gene expression in HuH-7 cells was enhanced up to 40-fold as compared to liposomes conjugated with an isotype-matched non-relevant control antibody. Transfection specificity was not observed in a control cell line that does not express the antigen recognized by mAb AF-20.
    Type: Grant
    Filed: November 2, 2006
    Date of Patent: October 14, 2014
    Assignees: SynerGene Therapeutics, Inc., Georgetown University
    Inventors: Liang Xu, Cheng-Cheng Huang, William Alexander, WenHua Tang, Esther H. Chang
  • Polynucleotides that home to atherosclerotic plaque
    Patent number: 8853378
    Abstract: Described herein are homing polypeptides that home to atherosclerotic plaque(s) in mammals and nucleic acids that encode such polypeptides. Also described are methods for detecting and treating conditions or disorders associated with, or characterized, by elevated levels of homing polypeptides that home to atherosclerotic plaque and/or vulnerable plaque.
    Type: Grant
    Filed: October 9, 2010
    Date of Patent: October 7, 2014
    Assignees: Georgetown University, MedStar Health Research Institute, Inc.
    Inventors: Anton Wellstein, Stephen E. Epstein, Mary Susan Burnett
  • ANTI-PLEIOTROPHIN ANTIBODIES AND METHODS OF USE THEREOF
    Publication number: 20140294845
    Abstract: The present invention concerns antibodies that neutralize at least one biological activity of pleiotrophin. The antibodies can inhibit cancer cell growth and angiogenesis in vitro or in vivo. The present invention provides for methods of inhibiting cancer cell growth or angiogenesis in a subject comprising administering to said subject an effective amount of the antibodies described herein. The present invention also provides for methods of making the neutralizing antibodies described herein.
    Type: Application
    Filed: February 3, 2014
    Publication date: October 2, 2014
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: J. Yun Tso, Anton Wellstein, Debra Chao
  • METHODS OF TREATING BACTERIAL INFECTIONS WITH 1,2-BENZISOTHIAZOLINONE AND ISOINDOLINONE DERIVATIVES
    Publication number: 20140296310
    Abstract: Methods of treating, preventing and ameliorating bacteria! infections with 1,2-benzisothiazolinone and isoindolinone derivatives are disclosed. Pharmaceutical compositions containing 1,2-benzisothiazolinone and isoindolinone derivatives are useful for treating bacteria! infections caused by drug resistant strains of bacteria, including but not limited to methicillin and vancomycin bacterial organisms.
    Type: Application
    Filed: August 16, 2012
    Publication date: October 2, 2014
    Applicant: GEORGETOWN UNIVERSITY
    Inventors: Deepu Alex, Richard Calderone, Stephen Peters
  • TREATMENT FOR EXPOSURE TO NERVE AGENT
    Publication number: 20140294926
    Abstract: The present application provides methods of preventing and treating the toxic effects of exposure to organophosphate agents. In embodiments, targeted cationic liposome complexes delivering nucleic acid molecules encoding butyrylcholinesterase and a polyproline rich peptide are administered. Suitably, the administration is via inhalation or via aerosol. Also provided are cationic liposome complexes and methods of making the complexes for such administration.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 2, 2014
    Applicant: Georgetown University
    Inventors: Esther H. CHANG, Kathleen F. Pirollo
  • Detection And Assessment Of Cancer Risk Using Telomere Health
    Publication number: 20140287409
    Abstract: Compositions and methods related to assessing the risk of cancer, such as breast cancer, lung cancer and bladder cancer, through analyzing the length of telomeres, such as chromosome 9p, 15p, and/or Xp telomere, such as the short arm of the 9p, 15p, and/or Xp telomere.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 25, 2014
    Applicant: Georgetown University
    Inventor: Yun-Ling Zheng
  • INCREASING PARKIN ACTIVITY BY ADMINISTERING A DEUBIQUITINATING ENZYME INHIBITOR
    Publication number: 20140271668
    Abstract: Provided herein are methods of promoting parkin activity in a subject, comprising: selecting a subject with a disorder associated with decreased Parkin activity; and administering to the subject an effective amount of a composition that increases parkin activity, wherein the composition is an inhibitor of a deubiquitinating enzyme.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Georgetown University
    Inventor: Charbel Moussa
  • SEQUENCE-SPECIFIC DETECTION OF NUCLEOTIDE SEQUENCES
    Publication number: 20140256577
    Abstract: A method for detecting the presence of a target nucleotide sequence in a sample of DNA is described herein in which a test sample comprising single stranded DNA is exposed to a DNA probe and a nicking endonuclease under conditions that would permit sequence-specific hybridization of the probe to a complementary target sequence. The probe comprises a sequence complementary to the target sequence to be detected and this sequence also includes a recognition sequence for the nicking endonuclease. If the sample contains the target sequence, the probe hybridizes to the target and is cleaved by the nicking endonuclease, which leaves the target intact. Observing the presence of probe cleaved by the nicking endonuclease indicates the presence of the target nucleotide sequence in the sample of DNA.
    Type: Application
    Filed: February 3, 2014
    Publication date: September 11, 2014
    Applicant: Georgetown University
    Inventors: Mark DANIELSEN, Joel Credle, Eugene A. Davidson, Kenneth L. Dretchen